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GABA Receptor

The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory compound in the mature vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors); whereas GABAB receptors are G protein-coupled receptors, also called metabotropic receptors.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T10618 Broflanilide 1207727-04-5 98.95%
Broflanilide
Broflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL ...
T11061 DMCM hydrochloride 1215833-62-7 98.95%
DMCM hydrochloride
DMCM hydrochloride is a non-selective fully inverse agonist of benzodiazepine. DMCM showed significant differences in human recombinant GABAA αxβ3γ2 receptor sub...
T38205 3-Aminopropylphosphonic Acid 13138-33-5 98.9%
3-Aminopropylphosphonic Acid
3-aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding as...
T23339 SCS 3232-36-8 98.89%
SCS
SCS is a GABAA receptor antagonist.
T11277 FG 7142 78538-74-6 98.81%
FG 7142
FG 7142 (LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 can increase tyrosine hydroxylati...
T22301 L-838417 D9 1213669-91-0 98.81%
L-838417 D9
L-838417 D9 (C-21191) is a novel deuterated subtype-selective GABAA positive allosteric modulator, acting as a partial agonist at α2, α3 and α5 subtypes[1].
T23104 Ocinaplon 96604-21-6 98.78%
Ocinaplon
Ocinaplon (DOV 273547) is a GABAA receptors modulator.
T28900 T-2000 97846-21-4 98.75%
T-2000
T-2000 (DMMDPB) is a GABA receptor agonist that can be used to study myoclonus and essential tremor.
TN1217 2'-O-Methylisoliquiritigenin 51828-10-5 98.75%
2'-O-Methylisoliquiritigenin
2'-O-Methylisoliquiritigenin, a compound synthesized by enzymes specifically induced in NR.2'-O-Methylisoliquiritigenin, isolated from the Arachis species, up-re...
T12930 SKF89976A hydrochloride 85375-15-1 98.72%
SKF89976A hydrochloride
SKF89976A hydrochloride (d,l-SKF89976A hydrochloride) is a selective inhibitor GABA transporter such as GAT-1 (IC50s = 0.28 μM), GAT-2 (IC50s = 137.34 μM) and GA...
T15212 Emamectin Benzoate 155569-91-8 98.68%
Emamectin Benzoate
Emamectin Benzoate (MK-244), by binding gamma-aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods,...
T3318 Wogonoside 51059-44-0 98.66%
Wogonoside
Wogonoside (Wogonin 7-O-glucuronide) acts as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor.
T11822 LAU159 2055050-87-6 98.65%
LAU159
LAU159 is a functionally selective positive α1β3 GABA(A) receptor modulator(EC50 : 2.2 μM).
T77796 DL-Borneol 507-70-0 98.61%
DL-Borneol
DL-Borneol ((endo)-Borneol) is a small molecule extracted from traditional Chinese medicine (TCM). It is an orally bioadjuvant that improves drug delivery to the...
T27310 Fengabine 80018-06-0 98.54%
Fengabine
Fengabine (SL-79229) is a GABA receptor agonist with antidepressant activity and is used to treat depression.
T28887 Suriclone 53813-83-5 98.52%
Suriclone
Suriclone (RP 31264) is a selective cyclic pyrrolidone analog with sedative and anxiolytic activity, but not significant sedative effects.Suriclone shows its eff...
T3782 Jujuboside A 55466-04-1 98.49%
Jujuboside A
Jujuboside A is a glycoside extracted from Semen Ziziphi Spinosae, having neurophysiological inhibitory effects, used as a potential therapeutic agent for the tr...
T1860 Imepitoin 188116-07-6 98.45%
Imepitoin
Imepitoin (AWD 131-138) is a new low-affinity partial benzodiazepine receptor agonist. It shows potent anticonvulsant and anxiolytic properties in rodent models....
T14983 Clomethiazole 533-45-9 98.43%
Clomethiazole
Clomethiazole (Distraneurin) is an orally active GABAA agonist and it is an anticonvulsant agent. It also has the potential for treating convulsive status epilep...
TQ0151 L-655708 130477-52-0 98.41%
L-655708
L-655708 is a selective and highly potent GABAA receptor reverse agonist with a Ki value of 0.45 nM.
Broflanilide
T10618
Broflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL ...
DMCM hydrochloride
T11061
DMCM hydrochloride is a non-selective fully inverse agonist of benzodiazepine. DMCM showed significant differences in human recombinant GABAA αxβ3γ2 receptor sub...
3-Aminopropylphosphonic Acid
T38205
3-aminopropylphosphonic acid (3-APPA) is a phosphonic analog of GABA that acts as a partial agonist of GABAB receptors (IC50 = 1.5 μM in a radioligand binding as...
SCS
T23339
SCS is a GABAA receptor antagonist.
FG 7142
T11277
FG 7142 (LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 can increase tyrosine hydroxylati...
L-838417 D9
T22301
L-838417 D9 (C-21191) is a novel deuterated subtype-selective GABAA positive allosteric modulator, acting as a partial agonist at α2, α3 and α5 subtypes[1].
Ocinaplon
T23104
Ocinaplon (DOV 273547) is a GABAA receptors modulator.
T-2000
T28900
T-2000 (DMMDPB) is a GABA receptor agonist that can be used to study myoclonus and essential tremor.
2'-O-Methylisoliquiritigenin
TN1217
2'-O-Methylisoliquiritigenin, a compound synthesized by enzymes specifically induced in NR.2'-O-Methylisoliquiritigenin, isolated from the Arachis species, up-re...
SKF89976A hydrochloride
T12930
SKF89976A hydrochloride (d,l-SKF89976A hydrochloride) is a selective inhibitor GABA transporter such as GAT-1 (IC50s = 0.28 μM), GAT-2 (IC50s = 137.34 μM) and GA...
Emamectin Benzoate
T15212
Emamectin Benzoate (MK-244), by binding gamma-aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods,...
Wogonoside
T3318
Wogonoside (Wogonin 7-O-glucuronide) acts as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor.
LAU159
T11822
LAU159 is a functionally selective positive α1β3 GABA(A) receptor modulator(EC50 : 2.2 μM).
DL-Borneol
T77796
DL-Borneol ((endo)-Borneol) is a small molecule extracted from traditional Chinese medicine (TCM). It is an orally bioadjuvant that improves drug delivery to the...
Fengabine
T27310
Fengabine (SL-79229) is a GABA receptor agonist with antidepressant activity and is used to treat depression.
Suriclone
T28887
Suriclone (RP 31264) is a selective cyclic pyrrolidone analog with sedative and anxiolytic activity, but not significant sedative effects.Suriclone shows its eff...
Jujuboside A
T3782
Jujuboside A is a glycoside extracted from Semen Ziziphi Spinosae, having neurophysiological inhibitory effects, used as a potential therapeutic agent for the tr...
Imepitoin
T1860
Imepitoin (AWD 131-138) is a new low-affinity partial benzodiazepine receptor agonist. It shows potent anticonvulsant and anxiolytic properties in rodent models....
Clomethiazole
T14983
Clomethiazole (Distraneurin) is an orally active GABAA agonist and it is an anticonvulsant agent. It also has the potential for treating convulsive status epilep...
L-655708
TQ0151
L-655708 is a selective and highly potent GABAA receptor reverse agonist with a Ki value of 0.45 nM.
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TargetMol