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GABA Receptor

The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory compound in the mature vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors); whereas GABAB receptors are G protein-coupled receptors, also called metabotropic receptors.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T7595 L-DABA 1758-80-1 98%
L-DABA
L-DABA (L-2,4-Diaminobutyric acid) is an inhibitor of GABA transaminase (IC50 > 500 μM).
T5754 Kavain 3155-48-4 98%
Kavain
Kavain, a compound extracted from the Kava plant, Piper methysticum, is found to be involved in TNF-α expression in human and mouse cells via regulation of trans...
TMS0418 Dihydroergotoxine mesylate 8067-24-1 98%
Dihydroergotoxine mesylate
Dihydroergotoxine mesylate (Ergoloid mesylates) is mainly used to improve symptoms and physical symptoms of mental degeneration related to aging.
T27838 Lirequinil 143943-73-1 97.86%
Lirequinil
Lirequinil (Ro 41-3696) is a small molecule GABAA receptor agonist used to study neurological disorders.
TN1432 Bacopasaponin C 178064-13-6 97.85%
Bacopasaponin C
Bacopasaponin C may have antioxidant activity, it also shows anti-leishmanial property.
T4522 SSD114 HCl 2319790-02-6 97.83%
SSD114 HCl
SSD114 is a novel GABAB receptor positive allosteric modulator.
T5S1882 Songorine 509-24-0 97.34%
Songorine
Songorine (Napellonine) shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking...
T28159 Nerisopam 102771-12-0 97.27%
Nerisopam
Nerisopam is an agonist of gamma-aminobutyric acid (GABA) receptor.
T23445 Anxiolytic/nonsedative agent-1 355022-97-8 97.05%
Anxiolytic/nonsedative agent-1
Anxiolytic/nonsedative agent-1 (TCS 1205) is a potent and selective GABAA agonist. Anxiolytic/nonsedative agent-1 shows appreciable affinity for the BzR in bovin...
T16831 (S)-SNAP5114 157604-55-2 97%
(S)-SNAP5114
(S)-SNAP5114 is a selective inhibitor of GABA transport with IC50s of 5 μM for hGAT-3 and 21 μM for rGAT-2. (S)-SNAP5114 has anticonvulsant properties.
T27186 Divaplon 90808-12-1 96.90%
Divaplon
Divaplon is a GABA receptor agonist (IC50: 0.056 µM) that displays non-sedating anxiolytic behavioral characteristics in a rat model of anxiety.
T24540 NO-711ME 127586-66-7 96.14%
NO-711ME
NO-711ME (N-O711 Methyl ester) is a prodrug of NO-711. It also is a potent and selective GABA uptake inhibitor.
T11137 (E)-GABAB receptor antagonist 1 1611483-29-4 95.26%
(E)-GABAB receptor antagonist 1
(E)-GABAB receptor antagonist 1 is a trans-GABAB receptor antagonist 1. (E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) produ...
T0169 Nefiracetam 77191-36-7 100%
Nefiracetam
Nefiracetam (DM9384) are underway in Phase 2 trials. Nefiracetam, a GABAergic、 cholinergic、and monoaminergic neuronal system enhancer, is used for Ro 5-4864-indu...
TN3174 6-Methoxyflavanone 3034-04-6 100%
6-Methoxyflavanone
6-Methoxyflavanone (6-MeOF) is A positive allosteric modulator of the GABA response of human recombinant GABA A receptor, with antianxiety and anti-inflammatory ...
TN2268 Tetrahydromagnolol 20601-85-8 100%
Tetrahydromagnolol
Tetrahydromagnolol can activate cannabinoid (CB) receptors.
T2990 Phenibut 1078-21-3 100%
Phenibut
Phenibut (Aminophenylbutyric acid) is a central depressant and derivative of the naturally occurring inhibitory neurotransmitter γ-aminobutyric acid (GABA).
T4176 Rac-BHFF 123557-91-5 100%
rac-BHFF
rac-BHFF ((R,S)-BHFF) is potent and selective GABA B receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149...
T8568 Suritozole 110623-33-1 100%
Suritozole
Suritozole (MDL-26479) is a negative modulator at the gamma-aminobutyric acidA (GABAA) receptor
T27845 Losigamone 112856-44-7 100%
Losigamone
Losigamone (AO-33) is an agonist of GABA receptor and can be used in studies about the treatment of partial seizures.
L-DABA
T7595
L-DABA (L-2,4-Diaminobutyric acid) is an inhibitor of GABA transaminase (IC50 > 500 μM).
Kavain
T5754
Kavain, a compound extracted from the Kava plant, Piper methysticum, is found to be involved in TNF-α expression in human and mouse cells via regulation of trans...
Dihydroergotoxine mesylate
TMS0418
Dihydroergotoxine mesylate (Ergoloid mesylates) is mainly used to improve symptoms and physical symptoms of mental degeneration related to aging.
Lirequinil
T27838
Lirequinil (Ro 41-3696) is a small molecule GABAA receptor agonist used to study neurological disorders.
Bacopasaponin C
TN1432
Bacopasaponin C may have antioxidant activity, it also shows anti-leishmanial property.
SSD114 HCl
T4522
SSD114 is a novel GABAB receptor positive allosteric modulator.
Songorine
T5S1882
Songorine (Napellonine) shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking...
Nerisopam
T28159
Nerisopam is an agonist of gamma-aminobutyric acid (GABA) receptor.
Anxiolytic/nonsedative agent-1
T23445
Anxiolytic/nonsedative agent-1 (TCS 1205) is a potent and selective GABAA agonist. Anxiolytic/nonsedative agent-1 shows appreciable affinity for the BzR in bovin...
(S)-SNAP5114
T16831
(S)-SNAP5114 is a selective inhibitor of GABA transport with IC50s of 5 μM for hGAT-3 and 21 μM for rGAT-2. (S)-SNAP5114 has anticonvulsant properties.
Divaplon
T27186
Divaplon is a GABA receptor agonist (IC50: 0.056 µM) that displays non-sedating anxiolytic behavioral characteristics in a rat model of anxiety.
NO-711ME
T24540
NO-711ME (N-O711 Methyl ester) is a prodrug of NO-711. It also is a potent and selective GABA uptake inhibitor.
(E)-GABAB receptor antagonist 1
T11137
(E)-GABAB receptor antagonist 1 is a trans-GABAB receptor antagonist 1. (E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) produ...
Nefiracetam
T0169
Nefiracetam (DM9384) are underway in Phase 2 trials. Nefiracetam, a GABAergic、 cholinergic、and monoaminergic neuronal system enhancer, is used for Ro 5-4864-indu...
6-Methoxyflavanone
TN3174
6-Methoxyflavanone (6-MeOF) is A positive allosteric modulator of the GABA response of human recombinant GABA A receptor, with antianxiety and anti-inflammatory ...
Tetrahydromagnolol
TN2268
Tetrahydromagnolol can activate cannabinoid (CB) receptors.
Phenibut
T2990
Phenibut (Aminophenylbutyric acid) is a central depressant and derivative of the naturally occurring inhibitory neurotransmitter γ-aminobutyric acid (GABA).
rac-BHFF
T4176
rac-BHFF ((R,S)-BHFF) is potent and selective GABA B receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149...
Suritozole
T8568
Suritozole (MDL-26479) is a negative modulator at the gamma-aminobutyric acidA (GABAA) receptor
Losigamone
T27845
Losigamone (AO-33) is an agonist of GABA receptor and can be used in studies about the treatment of partial seizures.
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TargetMol