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GPR

G-protein coupled receptors (GPRs) are a family of seven-transmembrane receptors, which play an important role in the response to peptide hormones, neurotransmitters, and free fatty acids.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T60184 TUG-499 1206629-08-4 99.59%
TUG-499
TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist (EC50: 7.39).TUG-499 has an affinity for FFAR1 or GPR40 over the related receptors FFA...
T27850 LP-471756 413605-11-5 99.59%
LP-471756
LP-471756 is a specific antagonist of GPR139 and inhibits LP-360924-stimulated cAMP production (IC50 = 640 nM).
T15388 GLPG0974 1391076-61-1 99.58%
GLPG0974
GLPG0974 is an antagonist of FFA2/GPR43 with IC50 of 9 nM.
T8642 4-CMTB 300851-67-6 99.57%
4-CMTB
4-CMTB is a selective agonist of FFA2 and GPR43.It also is a positive allosteric modulator (pEC50=6.38).
TP1996 MCH(human, mouse, rat) 128315-56-0 99.55%
MCH(human, mouse, rat)
MCH(human, mouse, rat) is a potent endogenous agonist at melanin-concentration hormone (MCH) receptors (IC50 values are 0.3 and 1.5 nM and EC50 values are 3.9 an...
T6399 AZD1981 802904-66-1 99.54%
AZD1981
AZD1981 is an effective and specific CRTh2 (DP2) receptor antagonist (IC50: 4 nM), showing >1000-fold selectivity over more than 340 other enzymes and receptors,...
T10889 CRTh2 antagonist 2 780763-95-3 99.53%
CRTh2 antagonist 2
CRTh2 antagonist 2 is a selective and potent CRTH2 antagonist, IC50≤10 nM. CRTh2 antagonist 2 can be used to study the direction of androgenic alopecia.
T9162 CID1231538 354126-20-8 99.51%
CID1231538
CID1231538 is a potent GPR35 antagonist.
T19438 Myristyl nicotinate 273203-62-6 99.50%
Myristyl nicotinate
Myristyl nicotinate (Tetradecyl nicotinate) is an ester prodrug being developed for delivery of nicotinic acid (NIC) into the skin for prevention of actinic kera...
T9317 TAK-041 1929519-13-0 99.49%
TAK-041
TAK-041 (NBI-1065846) is a potent and selective GPR139 agonist.
T1237 Azathioprine 446-86-6 99.49%
Azathioprine
Azathioprine (BW 57-322), an immunosuppressive agent, inhibits purine synthesis and GTP-binding protein Rac1 activation.
T60199 NCRW0005-F05 342779-66-2 99.48%
NCRW0005-F05
NCRW0005-F05 is a potent agonist of orphan G-protein coupled receptor GPR139 with an IC 50 value of 0.21 μM. NCRW0005-F05 can be used to research diabetes, obesi...
T27328 FL104 885672-81-1 99.46%
FL104
FL104 is a potent agonist of small-molecule urotensin II receptor, pEC50= 7.11.
T8329 AR 231453 733750-99-7 99.45%
AR 231453
AR 231453 is a selective and orally available GPR119 agonist,can stimulate β-cell replication and improve islet graft function.
T9437 1-methoxycyclopropanecarboxylic acid 100683-08-7 99.44%
1-methoxycyclopropanecarboxylic acid
1-methoxycyclopropanecarboxylic acid is an agonist of free fatty acid receptor 3 (FFAR3, human).
T7796 TUG-1375 2247372-59-2 99.41%
TUG-1375
TUG-1375 is an Agonist of Thiazolidine Free Fatty Acid Receptor 2
T12883 Fezagepras 1002101-19-0 99.38%
Fezagepras
Fezagepras (Setogepram) is an orally active GPR40 agonist and is an antagonist or inverse agonist of GPR84 with anti-inflammatory, anti-fibrotic, and anti-prolif...
T13423L (1S,2R)-2-PCCA 99.34%
(1S,2R)-2-PCCA
(1S,2R)-2-PCCA is a novel and potent small molecule GPR88 receptor agonist with an EC50 value of 3 nM in the non-cellular system and 603 nM in the cellular syste...
TP1896L1 Kisspeptin 234 acetate(1145998-81-7 free base) TP1896L1 99.34%
Kisspeptin 234 acetate(1145998-81-7 free base)
Kisspeptin 234 acetate is a kisspeptin receptor antagonist. Kisspeptin 234 inhibits kisspeptin-10 stimulation of IP (IC50 = 7 nM) and release of GnRH.
T67892 BTB09089 245728-44-3 99.31%
BTB09089
BTB09089 (GPR65 agonist ) is a T cell death-associated gene 8 (TDAG8/GPR65)-specific agonist.BTB09089 induces TDAG8 expression and regulates cytokine production ...
TUG-499
T60184
TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist (EC50: 7.39).TUG-499 has an affinity for FFAR1 or GPR40 over the related receptors FFA...
LP-471756
T27850
LP-471756 is a specific antagonist of GPR139 and inhibits LP-360924-stimulated cAMP production (IC50 = 640 nM).
GLPG0974
T15388
GLPG0974 is an antagonist of FFA2/GPR43 with IC50 of 9 nM.
4-CMTB
T8642
4-CMTB is a selective agonist of FFA2 and GPR43.It also is a positive allosteric modulator (pEC50=6.38).
MCH(human, mouse, rat)
TP1996
MCH(human, mouse, rat) is a potent endogenous agonist at melanin-concentration hormone (MCH) receptors (IC50 values are 0.3 and 1.5 nM and EC50 values are 3.9 an...
AZD1981
T6399
AZD1981 is an effective and specific CRTh2 (DP2) receptor antagonist (IC50: 4 nM), showing >1000-fold selectivity over more than 340 other enzymes and receptors,...
CRTh2 antagonist 2
T10889
CRTh2 antagonist 2 is a selective and potent CRTH2 antagonist, IC50≤10 nM. CRTh2 antagonist 2 can be used to study the direction of androgenic alopecia.
CID1231538
T9162
CID1231538 is a potent GPR35 antagonist.
Myristyl nicotinate
T19438
Myristyl nicotinate (Tetradecyl nicotinate) is an ester prodrug being developed for delivery of nicotinic acid (NIC) into the skin for prevention of actinic kera...
TAK-041
T9317
TAK-041 (NBI-1065846) is a potent and selective GPR139 agonist.
Azathioprine
T1237
Azathioprine (BW 57-322), an immunosuppressive agent, inhibits purine synthesis and GTP-binding protein Rac1 activation.
NCRW0005-F05
T60199
NCRW0005-F05 is a potent agonist of orphan G-protein coupled receptor GPR139 with an IC 50 value of 0.21 μM. NCRW0005-F05 can be used to research diabetes, obesi...
FL104
T27328
FL104 is a potent agonist of small-molecule urotensin II receptor, pEC50= 7.11.
AR 231453
T8329
AR 231453 is a selective and orally available GPR119 agonist,can stimulate β-cell replication and improve islet graft function.
1-methoxycyclopropanecarboxylic acid
T9437
1-methoxycyclopropanecarboxylic acid is an agonist of free fatty acid receptor 3 (FFAR3, human).
TUG-1375
T7796
TUG-1375 is an Agonist of Thiazolidine Free Fatty Acid Receptor 2
Fezagepras
T12883
Fezagepras (Setogepram) is an orally active GPR40 agonist and is an antagonist or inverse agonist of GPR84 with anti-inflammatory, anti-fibrotic, and anti-prolif...
(1S,2R)-2-PCCA
T13423L
(1S,2R)-2-PCCA is a novel and potent small molecule GPR88 receptor agonist with an EC50 value of 3 nM in the non-cellular system and 603 nM in the cellular syste...
Kisspeptin 234 acetate(1145998-81-7 free base)
TP1896L1
Kisspeptin 234 acetate is a kisspeptin receptor antagonist. Kisspeptin 234 inhibits kisspeptin-10 stimulation of IP (IC50 = 7 nM) and release of GnRH.
BTB09089
T67892
BTB09089 (GPR65 agonist ) is a T cell death-associated gene 8 (TDAG8/GPR65)-specific agonist.BTB09089 induces TDAG8 expression and regulates cytokine production ...
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TargetMol