GPR

G-protein coupled receptors (GPRs) are a family of seven-transmembrane receptors, which play an important role in the response to peptide hormones, neurotransmitters, and free fatty acids.

Cat. No.	Product name	CAS No.	Purity
T23204	PSN 375963	388575-52-8	99.24%
T23204	PSN 375963 (PSN 375963 hydrochloride) hydrochloride is a synthetic agonist of the endogenous ligand for GPR119.
T3433	TUG-891	1374516-07-0	99.21%
T3433	TUG-891 is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty ac...
T2701	GSK1292263	1032823-75-8	99.16%
T2701	GSK1292263 is a GPR119 agonist and has been investigated for the treatment of DIABETES MELLITUS, TYPE 2.
T3520	Setipiprant	866460-33-5	99.16%
T3520	Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 ...
T5036	Cangrelor tetrasodium	163706-36-3	99.15%
T5036	Cangrelor tetrasodium is a reversible and selective antagonist of platelet P2Y12, with prompt and potent antiplatelet effects.
T22967	MEDICA16	87272-20-6	99.13%
T22967	MEDICA16 is a selective agonist for GPR40 as well as a partial agonist for GPR120. MEDICA16, an ATP-citrate lyase inhibitor, significantly reduces intracellular ...
T4626L	TC-O 9311	444932-31-4	99.12%
T4626L	TC-O 9311 (TCO-9311) is an effective agonist of GPR139 (EC50 = 39 nM in CHO-K1 cells expressing human GPR139).
T15352	FTBMT	1358575-02-6	99.12%
T15352	FTBMT is a selective GPR52 agonist (EC50: 75 nM) and has antipsychotic and procognitive properties.
T21874	CID 2745687	264233-05-8	99.11%
T21874	CID 2745687 is a GPR35 antagonist that inhibited the effects at human GPR35 of cromolyn disodium and zaprinast, two agonists that share an overlapping binding s...
TQ0108	MK-6892	917910-45-3	99.03%
TQ0108	MK-6892 is a selective and full agonist for the high-affinity nicotinic acid receptor GPR109A (Ki: 4 nM; GTPγS EC50: 16 nM).
T5100	DJ-V-159	2253744-53-3	99%
T5100	DJ-V-159 is a GPRC6A agonist, targeting the G protein-coupled receptor family C group 6 member A (GPRC6A).
T7010	VER-155008	1134156-31-2	98.88%
T7010	VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold se...
T9346	CVN424	2254706-21-1	98.8%
T9346	CVN424 is a selective and novel GPR6 Inverse agonist effective in models of Parkinson Disease.
T21622	Tyrphostin A25	118409-58-8	98.76%
T21622	Tyrphostin A25 (Tyrphostin AG 82) is a specific EGFR tyrosine kinase inhibitor and GPR35 agonist with an IC50 value of 0.94 μM for GPR35 and an EC50 value of 5.3...
T22547	Acifran	72420-38-3	98.65%
T22547	Acifran (AY 25712) is an HM74A/GPR109A and GPR109B agonist and displays antihyperlipidemic activity.
T37527L	[Orn8]-Urotensin II acetate		98.63%
T37527L	[Orn8]-Urotensin II acetate is a Urotensin receptor ligand and a partial agonist at Urotensin receptors.
T8407	AF64394	1637300-25-4	98.55%
T8407	AF64394 is a selective inverse agonist of GPR3(pIC50 : 7.3)
T9452	PW0787	2624131-45-7	98.52%
T9452	PW0787 is a potent, selective, orally active, and brain-penetrant GPR52 agonist (EC50=135 nM).
T2058	Palosuran	540769-28-6	98.46%
T2058	Palosuran (ACT-058362) (ACT-058362) is a new potent and specific antagonist of the human UT receptor.
T8958	PU-H54	1454619-13-6	98.42%
T8958	PU-H54 is a purine-based inhibitor of Grp94. It is a Grp94-selective resorcinol-based inhibitor isolated through probing of the exclusive binding region of S2 s...