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GPR

G-protein coupled receptors (GPRs) are a family of seven-transmembrane receptors, which play an important role in the response to peptide hormones, neurotransmitters, and free fatty acids.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T23434 GPR35 agonist 2 494191-73-0 98.40%
GPR35 agonist 2
GPR35 agonist 2 (TC-G 1001) is a potent GPR35 agonist.The EC50 values of GPR35 agonist 2 in the β-arrestin and Ca2+ release assays were 26 and 3.2 nM, respective...
TP2073L BigLEN (mouse) acetate TP2073L 98.34%
BigLEN (mouse) acetate
BigLEN (mouse) acetate is a potent and selective agonist of orphan G protein-coupled receptor 171 (GPR171), with a Kd of ∼0.5 nM.
T7713 Benzyl nicotinate 94-44-0 98.22%
Benzyl nicotinate
Benzyl nicotinate (Pycaril) is a agonist of GPR109A receptor and GPR109B receptor
T62420 P2Y2R/GPR17 antagonist 1 2395016-49-4 98.21%
P2Y2R/GPR17 antagonist 1
P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y2R (IC50: 3.17 μM) and GPR17 (IC50: 1.67 μM) antagonist.
T15364 G-1 881639-98-1 98.14%
G-1
G-1 is a nonsteroidal, high-affinity and selective GPR30 agonist (Ki: 11 nM).
TQ0020 AMG 837 calcium hydrate 1259389-38-2 98.07%
AMG 837 calcium hydrate
AMG 837 calcium hydrate is a potent GPR40 agonist with an EC50 of 13 nM. AMG 837 calcium hydrate also shows highly selective over GPR41, GPR43, and GPR120 (EC50 ...
T77673 7-FluorotryptaMine HCl 159730-09-3 98.06%
7-FluorotryptaMine HCl
7-FluorotryptaMine HCl is a potent aromatic monoamine GPRC5A agonist that induces GPRC5A-mediated β-arrestin recruitment.7-FluorotryptaMine HCl can be used to st...
T14565 BI-671800 1093108-50-9 98.06%
BI-671800
BI-671800 (AP-761) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2). With IC50 values of 4.5 n...
T15432 GSK256073 862892-90-8 98.03%
GSK256073
GSK256073 is an orally active GPR109A agonist. GSK256073 also is a long-lasting and non-flushing HCA2 (hydroxy-carboxylic acid receptor 2) full agonist (pEC50: 7...
T8901 YUM70 423145-35-1 98.01%
YUM70
YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length pro...
T6855 HA15 1609402-14-3 98%
HA15
HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells t...
T20939 Bimatoprost acid 38344-08-0 98%
Bimatoprost acid
Bimatoprost acid (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and has a potential antagonistic activity for the FP receptor. It has a relat...
T7398 ONC212 1807861-48-8 98%
ONC212
ONC212, a fluorinated-ONC201 analogue, is a selective agonist of GPR132.
T7261 Grp94 Inhibitor-1 2234897-35-7 98%
Grp94 Inhibitor-1
Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor (IC50 : 2 nM).
T7482 3-chloro-5-hydroxybenzoic Acid 53984-36-4 98%
3-chloro-5-hydroxybenzoic Acid
3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 : 16 μM)
T3965 Fevipiprant 872365-14-5 98%
Fevipiprant
Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist.
T5828 MS21570 65373-29-7 98%
MS21570
MS21570 as a GPR171 antagonist based on its ability to block,with an IC50 of 220 Nm,that reduces anxiety-like behavior and fear conditioning in mice.
T1915 AM251 183232-66-8 97.88%
AM251
AM251 is a effective CB1 receptor antagonist (IC50/Ki: 8 /7.49 nM) that displays 306-fold selectivity over CB2 receptors; also effective GPR55 agonist (EC50: 39 ...
TP2165 Urotensin II, mouse acetate (9047-55-6 free base) TP2165 97.86%
Urotensin II, mouse acetate (9047-55-6 free base)
Urotensin II, mouse acetate (9047-55-6 free base) is an endogenous ligand for the orphan GPR14 or SENR. It is a potent vasoconstrictor.
T9719 3-Hydroxyoctanoic Acid 14292-27-4 97.82%
3-Hydroxyoctanoic Acid
3-Hydroxyoctanoic Acid is one of the hydroxy-carboxylic acids (HCAs) that serve as intermediates of energy metabolism. It is an agonist of the orphan receptor GP...
GPR35 agonist 2
T23434
GPR35 agonist 2 (TC-G 1001) is a potent GPR35 agonist.The EC50 values of GPR35 agonist 2 in the β-arrestin and Ca2+ release assays were 26 and 3.2 nM, respective...
BigLEN (mouse) acetate
TP2073L
BigLEN (mouse) acetate is a potent and selective agonist of orphan G protein-coupled receptor 171 (GPR171), with a Kd of ∼0.5 nM.
Benzyl nicotinate
T7713
Benzyl nicotinate (Pycaril) is a agonist of GPR109A receptor and GPR109B receptor
P2Y2R/GPR17 antagonist 1
T62420
P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y2R (IC50: 3.17 μM) and GPR17 (IC50: 1.67 μM) antagonist.
G-1
T15364
G-1 is a nonsteroidal, high-affinity and selective GPR30 agonist (Ki: 11 nM).
AMG 837 calcium hydrate
TQ0020
AMG 837 calcium hydrate is a potent GPR40 agonist with an EC50 of 13 nM. AMG 837 calcium hydrate also shows highly selective over GPR41, GPR43, and GPR120 (EC50 ...
7-FluorotryptaMine HCl
T77673
7-FluorotryptaMine HCl is a potent aromatic monoamine GPRC5A agonist that induces GPRC5A-mediated β-arrestin recruitment.7-FluorotryptaMine HCl can be used to st...
BI-671800
T14565
BI-671800 (AP-761) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2). With IC50 values of 4.5 n...
GSK256073
T15432
GSK256073 is an orally active GPR109A agonist. GSK256073 also is a long-lasting and non-flushing HCA2 (hydroxy-carboxylic acid receptor 2) full agonist (pEC50: 7...
YUM70
T8901
YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length pro...
HA15
T6855
HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells t...
Bimatoprost acid
T20939
Bimatoprost acid (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and has a potential antagonistic activity for the FP receptor. It has a relat...
ONC212
T7398
ONC212, a fluorinated-ONC201 analogue, is a selective agonist of GPR132.
Grp94 Inhibitor-1
T7261
Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor (IC50 : 2 nM).
3-chloro-5-hydroxybenzoic Acid
T7482
3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 : 16 μM)
Fevipiprant
T3965
Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist.
MS21570
T5828
MS21570 as a GPR171 antagonist based on its ability to block,with an IC50 of 220 Nm,that reduces anxiety-like behavior and fear conditioning in mice.
AM251
T1915
AM251 is a effective CB1 receptor antagonist (IC50/Ki: 8 /7.49 nM) that displays 306-fold selectivity over CB2 receptors; also effective GPR55 agonist (EC50: 39 ...
Urotensin II, mouse acetate (9047-55-6 free base)
TP2165
Urotensin II, mouse acetate (9047-55-6 free base) is an endogenous ligand for the orphan GPR14 or SENR. It is a potent vasoconstrictor.
3-Hydroxyoctanoic Acid
T9719
3-Hydroxyoctanoic Acid is one of the hydroxy-carboxylic acids (HCAs) that serve as intermediates of energy metabolism. It is an agonist of the orphan receptor GP...
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TargetMol