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GPR

G-protein coupled receptors (GPRs) are a family of seven-transmembrane receptors, which play an important role in the response to peptide hormones, neurotransmitters, and free fatty acids.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T10084 CRTh2 antagonist 1 1379445-54-1 97.39%
CRTh2 antagonist 1
CRTh2 antagonist 1 is a CRTh2 antagonist (IC50: 89 nM).
T77601 (2-{[2-(2-fluorophenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid 303134-93-2 97.13%
(2-{[2-(2-fluorophenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid
(2-{[2-(2-fluorophenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid is a prostaglandin-like CRTH2 antagonist with an IC50 < 10 μM, which can be used in stud...
T10938 D-Kynurenine 13441-51-5 97.08%
D-Kynurenine
D-Kynurenine (ZINC901103) is a metabolite of D-tryptophan and an agonist of GPR109B. D-Kynurenine activates AhR and promotes the conversion of the epithelium to ...
T15718 Latanoprost acid 41639-83-2 96.97%
Latanoprost acid
Latanoprost acid is a selective agonist of prostanoid receptors and inhibits RANKL-induced osteoclastogenesis and function through the inhibition of c-fos/NFATc1...
T11411 GLPG1205 1445847-37-9 95.97%
GLPG1205
GLPG1205 is a potent, orally active GPR84 (G protein-coupled receptor) antagonist with anti-inflammatory activity. GLPG1205 shows good PK/PD characteristics and ...
TP1970L Prosaptide TX14(A) acetate TP1970L 95.29%
Prosaptide TX14(A) acetate
Prosaptide TX14(A) acetate is a potent GPR37L1 and GPR37 agonist. Prosaptide Tx14(A) TFA increases both ERK1 and ERK2 phosphorylation in Schwann cells.
T50078 2-(pentylsulfanyl)pyrimidine-4,6-diol 489403-70-5 95.00%
2-(pentylsulfanyl)pyrimidine-4,6-diol
2-(pentylsulfanyl)pyrimidine-4,6-diol is a novel GRP84 agonist.
T15810 LY2922470 1423018-12-5 93.34%
LY2922470
LY2922470 reduces glucose levels along with significant enhancements in insulin and GLP-1, which is the potential for the treatment of type 2 diabetes mellitus (...
TN2268 Tetrahydromagnolol 20601-85-8 100%
Tetrahydromagnolol
Tetrahydromagnolol can activate cannabinoid (CB) receptors.
T34967 TUG-469 1236109-67-3 100%
TUG-469
TUG-469 is an agonist of free fatty acid 1(FFA) receptor.
T67791 BMS-903452 1339944-47-6 100%
BMS-903452
BMS-903452 is a potent and selective GPR119 agonist with EC50 of 14 nM. BMS-903452 is indicated for the treatment of acute and chronic rodent diabetes. GPR119 wa...
T8004 SNAP 94847 hydrochloride 1781934-47-1 100%
SNAP 94847 hydrochloride
SNAP 94847 hydrochloride is a melanin-concentrating hormonereceptor1 (MCHR1) antagonist(Ki= 2.2 nM)
TP1737L Urotensin II (114-124), human acetate TP1737L 100%
Urotensin II (114-124), human acetate
Urotensin II (114-124), human acetate is an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.
T2036 6-OAU 83797-69-7
6-OAU
6-OAU (GTPL5846)(GTPL5846; 6-n-octylaminouracil) is a surrogate agonist of GPR84; activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an E...
TN1560 Dehydroeffusol 137319-34-7
Dehydroeffusol
Dehydroeffusol (Dehydro Effusol) possesses anti-cancer, anxiolytic and sedative properties. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity...
T4312 GPR120 Agonist 2 1234844-11-1
GPR120 Agonist 2
GPR120 Agonist 2 is a potent and selective GPR120 receptor agonist.
T12095 Monomethyl fumarate 2756-87-8
Monomethyl fumarate
Monomethyl fumarate is a potent agonist of GPR109A .
T36818 Questiomycin A 1916-59-2
Questiomycin A
Questiomycin A is an antibiotic produced in crème fraiche with antibacterial and anticancer activities. Questiomycin A suppresses expression of GRP78, a cell-pro...
T2351 Fasiglifam 1000413-72-8
Fasiglifam
Fasiglifam (TAK875) is a potent, selective and orally bioavailable GPR40 agonist.
T5406 SNAP 94847 487051-12-7
SNAP 94847
SNAP 94847 (SNAP-94847) is a selective and competitive MCH1 receptor (MCH1-R) antagonist (Ki: 2.2 nM). It has anxiolytic and antidepressant activity and reduces ...
CRTh2 antagonist 1
T10084
CRTh2 antagonist 1 is a CRTh2 antagonist (IC50: 89 nM).
(2-{[2-(2-fluorophenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid
T77601
(2-{[2-(2-fluorophenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid is a prostaglandin-like CRTH2 antagonist with an IC50 < 10 μM, which can be used in stud...
D-Kynurenine
T10938
D-Kynurenine (ZINC901103) is a metabolite of D-tryptophan and an agonist of GPR109B. D-Kynurenine activates AhR and promotes the conversion of the epithelium to ...
Latanoprost acid
T15718
Latanoprost acid is a selective agonist of prostanoid receptors and inhibits RANKL-induced osteoclastogenesis and function through the inhibition of c-fos/NFATc1...
GLPG1205
T11411
GLPG1205 is a potent, orally active GPR84 (G protein-coupled receptor) antagonist with anti-inflammatory activity. GLPG1205 shows good PK/PD characteristics and ...
Prosaptide TX14(A) acetate
TP1970L
Prosaptide TX14(A) acetate is a potent GPR37L1 and GPR37 agonist. Prosaptide Tx14(A) TFA increases both ERK1 and ERK2 phosphorylation in Schwann cells.
2-(pentylsulfanyl)pyrimidine-4,6-diol
T50078
2-(pentylsulfanyl)pyrimidine-4,6-diol is a novel GRP84 agonist.
LY2922470
T15810
LY2922470 reduces glucose levels along with significant enhancements in insulin and GLP-1, which is the potential for the treatment of type 2 diabetes mellitus (...
Tetrahydromagnolol
TN2268
Tetrahydromagnolol can activate cannabinoid (CB) receptors.
TUG-469
T34967
TUG-469 is an agonist of free fatty acid 1(FFA) receptor.
BMS-903452
T67791
BMS-903452 is a potent and selective GPR119 agonist with EC50 of 14 nM. BMS-903452 is indicated for the treatment of acute and chronic rodent diabetes. GPR119 wa...
SNAP 94847 hydrochloride
T8004
SNAP 94847 hydrochloride is a melanin-concentrating hormonereceptor1 (MCHR1) antagonist(Ki= 2.2 nM)
Urotensin II (114-124), human acetate
TP1737L
Urotensin II (114-124), human acetate is an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.
6-OAU
T2036
6-OAU (GTPL5846)(GTPL5846; 6-n-octylaminouracil) is a surrogate agonist of GPR84; activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an E...
Dehydroeffusol
TN1560
Dehydroeffusol (Dehydro Effusol) possesses anti-cancer, anxiolytic and sedative properties. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity...
GPR120 Agonist 2
T4312
GPR120 Agonist 2 is a potent and selective GPR120 receptor agonist.
Monomethyl fumarate
T12095
Monomethyl fumarate is a potent agonist of GPR109A .
Questiomycin A
T36818
Questiomycin A is an antibiotic produced in crème fraiche with antibacterial and anticancer activities. Questiomycin A suppresses expression of GRP78, a cell-pro...
Fasiglifam
T2351
Fasiglifam (TAK875) is a potent, selective and orally bioavailable GPR40 agonist.
SNAP 94847
T5406
SNAP 94847 (SNAP-94847) is a selective and competitive MCH1 receptor (MCH1-R) antagonist (Ki: 2.2 nM). It has anxiolytic and antidepressant activity and reduces ...
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TargetMol