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Endocrinology/Hormones Glucocorticoid Receptor

Glucocorticoid Receptor

The glucocorticoid receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response.
Cat No. product name
T0083 Eplerenone Eplerenone is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy of hypertension. Eplerenone therapy has been associated with...
T0188 Fluticasone propionate Fluticasone propionate, derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist...
T0343 Nimodipine Nimodipine, a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.
T0354 Canrenone Canrenone is an aldosterone antagonist with potassium-sparing diuretic activity.
T1541 Drospirenone Drospirenone is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.
T3096 Potassium canrenoate Potassium canrenoate is a synthetic pregnadiene derivative with anti-aldosterone activity.
T3962 TPI-1 TPI-1 is a SHP-1 inhibitor.
T6022 LY404039 LY404039 is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM).
T4602 Hydrocortisone 21-hemisuccinate Hydrocortisone 21-hemisuccinate is a corticosteroid used as an analytical and chromatography reagent.
TQ0225 AZD7594 AZD7594 is an effective and selective nonsteroidal glucocorticoid receptor modulator (IC50: 0.9 nM).
T14301 Apararenone Apararenone is a novel antagonist of non-steroidal mineralocorticoid receptor, and for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis...
T15246 Esaxerenone Esaxerenone is a highly potent and selective non-steroidal antagonist of the mineralocorticoid receptor.
Eplerenone
T0083CAS 107724-20-9
Eplerenone is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy of hypertension. Eplerenone therapy has been associated with...
Fluticasone propionate
T0188CAS 80474-14-2
Fluticasone propionate, derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist...
Nimodipine
T0343CAS 66085-59-4
Nimodipine, a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.
Canrenone
T0354CAS 976-71-6
Canrenone is an aldosterone antagonist with potassium-sparing diuretic activity.
Drospirenone
T1541CAS 67392-87-4
Drospirenone is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.
Potassium canrenoate
T3096CAS 2181-04-6
Potassium canrenoate is a synthetic pregnadiene derivative with anti-aldosterone activity.
TPI-1
T3962CAS 79756-69-7
TPI-1 is a SHP-1 inhibitor.
LY404039
T6022CAS 635318-11-5
LY404039 is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM).
Hydrocortisone 21-hemisuccinate
T4602CAS 2203-97-6
Hydrocortisone 21-hemisuccinate is a corticosteroid used as an analytical and chromatography reagent.
AZD7594
TQ0225CAS 1196509-60-0
AZD7594 is an effective and selective nonsteroidal glucocorticoid receptor modulator (IC50: 0.9 nM).
Apararenone
T14301CAS 945966-46-1
Apararenone is a novel antagonist of non-steroidal mineralocorticoid receptor, and for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis...
Esaxerenone
T15246CAS 1632006-28-0
Esaxerenone is a highly potent and selective non-steroidal antagonist of the mineralocorticoid receptor.