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Endocrinology/Hormones Glucocorticoid Receptor

Glucocorticoid Receptor

The glucocorticoid receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response.
Cat No. product name
T0034 Cortisone acetate Cortisone Acetate is the acetate salt form of cortisone, a synthetic or semisynthetic analog of the naturally occurring cortisone hormone produced by the ad...
T0034 Cortisone acetate Cortisone Acetate is the acetate salt form of cortisone, a synthetic or semisynthetic analog of the naturally occurring cortisone hormone produced by the ad...
T0083 Eplerenone Eplerenone is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy of hypertension. Eplerenone therapy has been associated with...
T0094 Budesonide Budesonide, an anti-inflammatory corticosteroid, has shown the effective glucocorticoid activitie and few mineralocorticoid activities. According to reports, Bu...
T0107 Halcinonide Halcinonide, a high-efficiency corticosteroid, is served as an anti-inflammatory agent used in topical preparations.
T0181 Loteprednol etabonate Loteprednol Etabonate is an ophthalmic analog of the corticosteroid prednisolone with anti-inflammatory activity.
T0188 Fluticasone propionate Fluticasone propionate, derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist...
T0208 Prednisolone phosphate sodium Prednisolone disodium phosphate, a synthetic glucocorticoid, has immunomodulating and anti-inflammatory properties.
T0261 Amcinonide Amcinonide is a Corticosteroid. The mechanism of action of amcinonide is as a Corticosteroid Hormone Receptor Agonist.
T0270 Hydrocortisone butyrate Hydrocortisone Butyrate is a synthetic glucocorticoid receptor agonist with antiinflammatory, antipruritic and vasoconstrictive effects.
T0337 Prednisolone-21-acetate Prednisolone Acetate is the acetate salt form of prednisolone, a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
T0343 Nimodipine Nimodipine, a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.
T0354 Canrenone Canrenone is an aldosterone antagonist with potassium-sparing diuretic activity.
T0367 Fluocinolone acetonide Fluocinolone acetonide is a glucocorticoid derivative used topically in the treatment of various skin disorders. It is usually employed as a cream, gel, lotion,...
T0485 Deflazacort Deflazacort is a glucocorticoid served as an immunosuppressant and anti-inflammatory. It can be used to treat autoimmune diseases due to inhibiting the immune s...
T0798 Triamcinolone Triamcinolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry,  triamcinolone binds to and activates th...
T0820 Triamcinolone acetonide Triamcinolone acetonide is a Corticosteroid. The mechanism of action of triamcinolone acetonide is as a Corticosteroid Hormone Receptor Agonist. It is an anti-i...
T0947 Dexamethason acetate Dexamethasone Acetate is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to bin...
T0948L Corticosterone Corticosterone is a sensitive inhibitor of monoamine transport.
T0977 Medrysone Medrysone is a topical, synthetic glucocorticoid with metabolic, anti-inflammatory and anti-allergic properties. Medrysone exerts its effect by interacting with...
T1018 Prednisone Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
T1076 DexamethasoneHOT Dexamethasone is a glucocorticoid receptor agonist and an IL receptor modulator.Dexamethasone inhibits production of exosomes containing inflammatory microRNA-1...
T1102 Mifepristone Mifepristone is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
T1124 Flumethasone Flumethasone is a glucocorticoid receptor agonist, with anti-inflammatory, antipruritic and vasoconstrictive properties.
T1127 Beclomethasone dipropionate Beclomethasone Dipropionate is the dipropionate ester of a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface r...
T1163 Betamethasone 17-valerate Betamethasone Valerate is a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory actions.
T1168 Desonide Desonide is a synthetic glucocorticosteroid for topical use, with anti-inflammatory activity. Desonide binds to glucocorticoid receptors in the cytoplasm, and t...
T1171 Methylprednisolone Methylprednisolone is a PREDNISOLONE derivative with similar anti-inflammatory action.
T1243 Hydrocortisone acetate Hydrocortisone acetate is the synthetic acetate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties.
T1284 Megestrol acetate Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties....
T14301 Apararenone Apararenone is a novel antagonist of non-steroidal mineralocorticoid receptor, and for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis...
T15246 Esaxerenone Esaxerenone is a highly potent and selective non-steroidal antagonist of the mineralocorticoid receptor.
T1531 Mometasone furoate Mometasone furoate is a pregnadienediol derivative ANTI-ALLERGIC AGENT and ANTI-INFLAMMATORY AGENT that is used in the management of ASTHMA and ALLERGIC RHINITI...
T15389L Glucagon hydrochloride (16941-32-5 free base) Glucagon hydrochloride is a peptide hormone, produced by pancreatic α-cells. It activates HNF4α and increases HNF4α phosphorylation. Glucagon hydrochloride s...
T15389L Glucagon hydrochloride (16941-32-5 free base) Glucagon hydrochloride is a peptide hormone, produced by pancreatic α-cells. It activates HNF4α and increases HNF4α phosphorylation. Glucagon hydrochloride s...
T1541 Drospirenone Drospirenone is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.
T15451 GW-870086 GW-870086 is an effective anti-inflammatory agent. GW-870086 also plays a role in a glucocorticoid receptor agonist (pIC50: 10.1 in A549 cells expressing NF-κB...
T1559 Betamethasone dipropionate Betamethasone Dipropionate is the 17, 21-dipropionate ester of betamethasone, a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory...
T1560 Prednisolone Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
T1561 Clobetasol propionate Clobetasol propionate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor-mediated gene expr...
T1573 Flunisolide Flunisolide is a synthetic corticosteroid with anti-inflammatory and antiallergic properties.
T1614 Hydrocortisone Hydrocortisone, a glucocorticoid receptor agonist, promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium, and suppr...
T1652 Betamethasone Betamethasone, a glucocorticoid steroid, has immunosuppressive and anti-inflammatory properties.
T1666 Fludrocortisone acetate Fludrocortisone, a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of...
T16727 Relacorilant Relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor(Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 n...
T16727 Relacorilant Relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor(Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 n...
T16727 Relacorilant Relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor(Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 n...
T1749 AL082D06 AL 082D06(D-06), a selective nonsteroidal glucocorticoid receptor (GR) antagonist (Ki: 210 nM), exhibits outstanding selectivity against AR, ER, MR and PR(Ki > ...
T21395 Finerenone Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist with IC50 of 18 nM for the treatment ...
T2526 Ciclesonide Ciclesonide(RPR251526) is a glucocorticoid used for the treatment of obstructive airway diseases.
T2548 Diflorasone Diflorasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. Like other glucocorticoids, diflorasone enters the cell by di...
T2748 Cortodoxone Cortodoxone is a glucocorticoid steroid hormone that is an intermediate in the biosynthesis of cortisol in the adrenal gland.
T2810 (20S)-Protopanaxatriol (20S)-Protopanaxatriol(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.
T2884 Cortisone Cortisone is a corticosteroid with potent glucocorticoid activity.
T3096 Potassium canrenoate Potassium canrenoate is a synthetic pregnadiene derivative with anti-aldosterone activity.
T3316 Fluoromethalone Fluorometholone is a corticosteroid, most often used after laser-based refractive surgery. It is marketed under the brand names FML (Allergan) and Flarex (Alcon...
T3962 TPI1 TPI-1 is a SHP-1 inhibitor.
T4602 Hydrocortisone 21-hemisuccinate Hydrocortisone 21-hemisuccinate is a corticosteroid used as an analytical and chromatography reagent.
T6022 LY404039 LY404039 is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM).
T6502 Fluocinonide Fluocinonide (Vanos) is an effective glucocorticoid steroid, utilized in the treatment as the skin disorders anti-inflammatory agent.
T6503 Fluorometholone Acetate Fluorometholone Acetate is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.
T6580 Meprednisone Betapar(Meprednisone) is a glucocorticoid and a methylated derivative of prednisone.
T8396 Prednisone acetate Prednisone acetate is a glucocorticoid receptor agonist with immunomodulating properties and anti-inflammatory.
T8777 BecloMethasone BecloMethasone is a prototype glucocorticoid receptor agonist. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of asth...
TQ0225 AZD7594 AZD7594 is an effective and selective nonsteroidal glucocorticoid receptor modulator (IC50: 0.9 nM).
Cortisone acetate
T0034CAS 50-04-4
Cortisone Acetate is the acetate salt form of cortisone, a synthetic or semisynthetic analog of the naturally occurring cortisone hormone produced by the ad...
Cortisone acetate
T0034CAS 50-04-4
Cortisone Acetate is the acetate salt form of cortisone, a synthetic or semisynthetic analog of the naturally occurring cortisone hormone produced by the ad...
Eplerenone
T0083CAS 107724-20-9
Eplerenone is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy of hypertension. Eplerenone therapy has been associated with...
Budesonide
T0094CAS 51333-22-3
Budesonide, an anti-inflammatory corticosteroid, has shown the effective glucocorticoid activitie and few mineralocorticoid activities. According to reports, Bu...
Halcinonide
T0107CAS 3093-35-4
Halcinonide, a high-efficiency corticosteroid, is served as an anti-inflammatory agent used in topical preparations.
Loteprednol etabonate
T0181CAS 82034-46-6
Loteprednol Etabonate is an ophthalmic analog of the corticosteroid prednisolone with anti-inflammatory activity.
Fluticasone propionate
T0188CAS 80474-14-2
Fluticasone propionate, derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist...
Prednisolone phosphate sodium
T0208CAS 125-02-0
Prednisolone disodium phosphate, a synthetic glucocorticoid, has immunomodulating and anti-inflammatory properties.
Amcinonide
T0261CAS 51022-69-6
Amcinonide is a Corticosteroid. The mechanism of action of amcinonide is as a Corticosteroid Hormone Receptor Agonist.
Hydrocortisone butyrate
T0270CAS 13609-67-1
Hydrocortisone Butyrate is a synthetic glucocorticoid receptor agonist with antiinflammatory, antipruritic and vasoconstrictive effects.
Prednisolone-21-acetate
T0337CAS 52-21-1
Prednisolone Acetate is the acetate salt form of prednisolone, a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
Nimodipine
T0343CAS 66085-59-4
Nimodipine, a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.
Canrenone
T0354CAS 976-71-6
Canrenone is an aldosterone antagonist with potassium-sparing diuretic activity.
Fluocinolone acetonide
T0367CAS 67-73-2
Fluocinolone acetonide is a glucocorticoid derivative used topically in the treatment of various skin disorders. It is usually employed as a cream, gel, lotion,...
Deflazacort
T0485CAS 14484-47-0
Deflazacort is a glucocorticoid served as an immunosuppressant and anti-inflammatory. It can be used to treat autoimmune diseases due to inhibiting the immune s...
Triamcinolone
T0798CAS 124-94-7
Triamcinolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry,  triamcinolone binds to and activates th...
Triamcinolone acetonide
T0820CAS 76-25-5
Triamcinolone acetonide is a Corticosteroid. The mechanism of action of triamcinolone acetonide is as a Corticosteroid Hormone Receptor Agonist. It is an anti-i...
Dexamethason acetate
T0947CAS 1177-87-3
Dexamethasone Acetate is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to bin...
Corticosterone
T0948LCAS 50-22-6
Corticosterone is a sensitive inhibitor of monoamine transport.
Medrysone
T0977CAS 2668-66-8
Medrysone is a topical, synthetic glucocorticoid with metabolic, anti-inflammatory and anti-allergic properties. Medrysone exerts its effect by interacting with...
Prednisone
T1018CAS 53-03-2
Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
Dexamethasone HOT
T1076CAS 50-02-2
Dexamethasone is a glucocorticoid receptor agonist and an IL receptor modulator.Dexamethasone inhibits production of exosomes containing inflammatory microRNA-1...
Mifepristone
T1102CAS 84371-65-3
Mifepristone is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
Flumethasone
T1124CAS 2135-17-3
Flumethasone is a glucocorticoid receptor agonist, with anti-inflammatory, antipruritic and vasoconstrictive properties.
Beclomethasone dipropionate
T1127CAS 5534-09-8
Beclomethasone Dipropionate is the dipropionate ester of a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface r...
Betamethasone 17-valerate
T1163CAS 2152-44-5
Betamethasone Valerate is a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory actions.
Desonide
T1168CAS 638-94-8
Desonide is a synthetic glucocorticosteroid for topical use, with anti-inflammatory activity. Desonide binds to glucocorticoid receptors in the cytoplasm, and t...
Methylprednisolone
T1171CAS 83-43-2
Methylprednisolone is a PREDNISOLONE derivative with similar anti-inflammatory action.
Hydrocortisone acetate
T1243CAS 50-03-3
Hydrocortisone acetate is the synthetic acetate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties.
Megestrol acetate
T1284CAS 595-33-5
Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties....
Apararenone
T14301CAS 945966-46-1
Apararenone is a novel antagonist of non-steroidal mineralocorticoid receptor, and for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis...
Esaxerenone
T15246CAS 1632006-28-0
Esaxerenone is a highly potent and selective non-steroidal antagonist of the mineralocorticoid receptor.
Mometasone furoate
T1531CAS 83919-23-7
Mometasone furoate is a pregnadienediol derivative ANTI-ALLERGIC AGENT and ANTI-INFLAMMATORY AGENT that is used in the management of ASTHMA and ALLERGIC RHINITI...
Glucagon hydrochloride (16941-32-5 free base)
T15389LCAS 28270-04-4
Glucagon hydrochloride is a peptide hormone, produced by pancreatic α-cells. It activates HNF4α and increases HNF4α phosphorylation. Glucagon hydrochloride s...
Glucagon hydrochloride (16941-32-5 free base)
T15389LCAS 28270-04-4
Glucagon hydrochloride is a peptide hormone, produced by pancreatic α-cells. It activates HNF4α and increases HNF4α phosphorylation. Glucagon hydrochloride s...
Drospirenone
T1541CAS 67392-87-4
Drospirenone is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.
GW-870086
T15451CAS 827319-43-7
GW-870086 is an effective anti-inflammatory agent. GW-870086 also plays a role in a glucocorticoid receptor agonist (pIC50: 10.1 in A549 cells expressing NF-κB...
Betamethasone dipropionate
T1559CAS 5593-20-4
Betamethasone Dipropionate is the 17, 21-dipropionate ester of betamethasone, a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory...
Prednisolone
T1560CAS 50-24-8
Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
Clobetasol propionate
T1561CAS 25122-46-7
Clobetasol propionate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor-mediated gene expr...
Flunisolide
T1573CAS 3385-03-3
Flunisolide is a synthetic corticosteroid with anti-inflammatory and antiallergic properties.
Hydrocortisone
T1614CAS 50-23-7
Hydrocortisone, a glucocorticoid receptor agonist, promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium, and suppr...
Betamethasone
T1652CAS 378-44-9
Betamethasone, a glucocorticoid steroid, has immunosuppressive and anti-inflammatory properties.
Fludrocortisone acetate
T1666CAS 514-36-3
Fludrocortisone, a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of...
Relacorilant
T16727CAS 1496510-51-0
Relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor(Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 n...
Relacorilant
T16727CAS 1496510-51-0
Relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor(Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 n...
Relacorilant
T16727CAS 1496510-51-0
Relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor(Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 n...
AL082D06
T1749CAS 256925-03-8
AL 082D06(D-06), a selective nonsteroidal glucocorticoid receptor (GR) antagonist (Ki: 210 nM), exhibits outstanding selectivity against AR, ER, MR and PR(Ki > ...
Finerenone
T21395CAS 1050477-31-0
Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist with IC50 of 18 nM for the treatment ...
Ciclesonide
T2526CAS 126544-47-6
Ciclesonide(RPR251526) is a glucocorticoid used for the treatment of obstructive airway diseases.
Diflorasone
T2548CAS 2557-49-5
Diflorasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. Like other glucocorticoids, diflorasone enters the cell by di...
Cortodoxone
T2748CAS 152-58-9
Cortodoxone is a glucocorticoid steroid hormone that is an intermediate in the biosynthesis of cortisol in the adrenal gland.
(20S)-Protopanaxatriol
T2810CAS 34080-08-5
(20S)-Protopanaxatriol(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.
Cortisone
T2884CAS 53-06-5
Cortisone is a corticosteroid with potent glucocorticoid activity.
Potassium canrenoate
T3096CAS 2181-04-6
Potassium canrenoate is a synthetic pregnadiene derivative with anti-aldosterone activity.
Fluoromethalone
T3316CAS 426-13-1
Fluorometholone is a corticosteroid, most often used after laser-based refractive surgery. It is marketed under the brand names FML (Allergan) and Flarex (Alcon...
TPI1
T3962CAS 79756-69-7
TPI-1 is a SHP-1 inhibitor.
Hydrocortisone 21-hemisuccinate
T4602CAS 2203-97-6
Hydrocortisone 21-hemisuccinate is a corticosteroid used as an analytical and chromatography reagent.
LY404039
T6022CAS 635318-11-5
LY404039 is an effective agonist of recombinant human mGlu2(Ki =149 nM)/mGlu3(Ki =92 nM).
Fluocinonide
T6502CAS 356-12-7
Fluocinonide (Vanos) is an effective glucocorticoid steroid, utilized in the treatment as the skin disorders anti-inflammatory agent.
Fluorometholone Acetate
T6503CAS 3801-06-7
Fluorometholone Acetate is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.
Meprednisone
T6580CAS 1247-42-3
Betapar(Meprednisone) is a glucocorticoid and a methylated derivative of prednisone.
Prednisone acetate
T8396CAS 125-10-0
Prednisone acetate is a glucocorticoid receptor agonist with immunomodulating properties and anti-inflammatory.
BecloMethasone
T8777CAS 4419-39-0
BecloMethasone is a prototype glucocorticoid receptor agonist. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of asth...
AZD7594
TQ0225CAS 1196509-60-0
AZD7594 is an effective and selective nonsteroidal glucocorticoid receptor modulator (IC50: 0.9 nM).