Glucocorticoid Receptor

The glucocorticoid receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response.

Cat. No.	Product name	CAS No.	Purity
T1284	Megestrol acetate	595-33-5	99.72%
T1284	Megestrol acetate (BDH1298) is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic pr...
T0276	Hydrocortisone Valerate	57524-89-7	99.69%
T0276	Hydrocortisone Valerate (Westcort) has anti-inflammatory, antipruritic and vasoconstrictive properties.
T67742	EX-A5386	2452396-89-1	99.69%
T67742	EX-A5386 (Glucocorticoid receptor modulator-1) is a potent glucocorticoid receptor modulator, IC50/EC50<100nM.
T8777	Beclometasone	4419-39-0	99.68%
T8777	Beclometasone is a prototype glucocorticoid receptor agonist. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of asthma....
T15246	Esaxerenone	1632006-28-0	99.68%
T15246	Esaxerenone (XL-550) is a highly potent and selective non-steroidal antagonist of the mineralocorticoid receptor.
T34383	Rofleponide	144459-70-1	99.67%
T34383	Rofleponide is a synthetic glucocorticosteroid with a high affinity for the rat thymus glucocorticoid receptor.
T0188	Fluticasone (propionate)	80474-14-2	99.65%
T0188	Fluticasone propionate (CCI-187881), derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid recep...
T14301	Apararenone	945966-46-1	99.65%
T14301	Apararenone (MT-3995) is a receptor antagonist of mineralocorticoid receptor which can be used to treat non-alcoholic steatohepatitis and diabetic nephropathy.
T0476	Spironolactone	52-01-7	99.63%
T0476	Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.
T15451	GW-870086	827319-43-7	99.63%
T15451	GW-870086 is an effective anti-inflammatory agent. GW-870086 also plays a role in a glucocorticoid receptor agonist (pIC50: 10.1 in A549 cells expressing NF-κB)....
T22367	Methylprednisolone succinate	2921-57-5	99.60%
T22367	Methylprednisolone succinate (Methylprednisolone hemisuccinate) is a synthetic glucocorticoid and is widely used as an anti-inflammatory agent.
T21404	Fluticasone furoate	397864-44-7	99.58%
T21404	Fluticasone furoate (Avamys) is a synthetic trifluorinated corticosteroid derived from fluticasone with a Kd of 0.3 nM. Fluticasone furoate has potent anti-infla...
T1243	Hydrocortisone acetate	50-03-3	99.58%
T1243	Hydrocortisone acetate (Cortisol 21-acetate) is the synthetic acetate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive ...
T1531	Mometasone furoate	83919-23-7	99.56%
T1531	Mometasone furoate (Sch32088) is a pregnadienediol derivative ANTI-ALLERGIC AGENT and ANTI-INFLAMMATORY AGENT that is used in the management of ASTHMA and ALLERG...
T0343	Nimodipine	66085-59-4	99.56%
T0343	Nimodipine (BAY-e 9736), a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.
T0337	Prednisolone acetate	52-21-1	99.55%
T0337	Prednisolone acetate (Omnipred) is the acetate salt form of prednisolone, a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
T0798	Triamcinolone	124-94-7	99.54%
T0798	Triamcinolone (Aristocort) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry, triamcinolone binds to and acti...
T32114	Hydrocortisone aceponate	74050-20-7	99.53%
T32114	Hydrocortisone aceponate (Hydrocortisone 17-propionate 21-acetate) is an effective topical glucocorticoid used in the form of a cream to treat various skin disea...
T37908	Glucocorticoid receptor agonist-1	2166375-82-0	99.51%
T37908	Glucocorticoid receptor agonist-1 is a potent glucocorticoid receptor agonist with an IC50 of 2.8 nM[1].
T21395	Finerenone	1050477-31-0	99.45%
T21395	Finerenone (BAY-948862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist with IC50 of 18 nM for the...