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Glucokinase

Glucokinase is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucokinase occurs in cells in the liver and pancreas of humans and most other vertebrates. In each of these organs it plays an important role in the regulation of carbohydrate metabolism by acting as a glucose sensor, triggering shifts in metabolism or cell function in response to rising or falling levels of glucose, such as occur after a meal or when fasting. Mutations of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia.Glucokinase (GK) is a hexokinase isozyme, related homologously to at least three other hexokinases. All of the hexokinases can mediate phosphorylation of glucose to glucose-6-phosphate (G6P), which is the first step of both glycogen synthesis and glycolysis.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T67874 PFKFB3-IN-2 794552-84-4 99.12%
PFKFB3-IN-2
PFKFB3-IN-2 is a 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) inhibitor. Anti-sense treatment against PFKFB3 was shown to reduce tumor growth ...
T3104L (1S,2R)-Globalagliatin 2514278-46-5 99%
(1S,2R)-Globalagliatin
(1S,2R)-Globalagliatin is a highly potent glucokinase (GK) activator for the study of type 2 diabetes.
T2455 PFK-015 4382-63-2 98.94%
PFK-015
PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).
T14365 AZ PFKFB3 26 1704740-52-2 98.91%
AZ PFKFB3 26
AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 nM. The IC50s for PFKFB1 and PFKFB2 are 2.06 and 0.384 μM, respectively.
TQ0055 AMG-3969 1361224-53-4 98.89%
AMG-3969
AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).
T0714 Oxfendazole 53716-50-0 98.81%
Oxfendazole
Oxfendazole (RS-8858), a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.
T3260 (E)-3PO 13309-08-5 98.8%
(E)-3PO
(E)-3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase) inhibitor.
T30142 ARRY-403 1138669-65-4 98.69%
ARRY-403
ARRY-403 is a novel glucokinase activator that reduces fasting and postprandial blood glucose in patients with type 2 diabetes.
T16479 PF-04937319 1245603-92-2 98.61%
PF-04937319
PF-04937319 is an activator of glucokinase (EC50 =154.4  μM). PF-04937319 maintains glucose-lowering efficacy while mitigating the risk of hypoglycemia observed ...
T60048 WAY-640509 851185-20-1 98.59%
WAY-640509
WAY-640509 is a glucocerebrosidase inhibitor.
T12056 MK-0941 free base 752240-01-0 98.55%
MK-0941 free base
MK-0941 free base is an orally active glucokinase activator, exhibiting strong glucose-lowering activity and is a potential therapeutic agent for treatment of ty...
T8990 ML266 1462267-08-8 98.45%
ML266
ML266 is glucocerebrosidase (GCase) molecule chaperone, IC50 = 2.5 µM. ML266 binds to GCase and transports of the mutant protein to the lysosome, and resume the ...
T8986 ML198 1380716-06-2 98.31%
ML198
ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase. ML198 serves as a starting point to develop a novel approach towards small molecul...
T3104 Globalagliatin 1234703-40-2 98.26%
Globalagliatin
Globalagliatin (LY2608204) has been used in trials studying the treatment of Diabetes Mellitus, Type 2.
T14212 AMG-1694 1361217-07-3 97.97%
AMG-1694
AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, i...
T77784 WAY-297848 404360-27-6 98%
WAY-297848
WAY-297848 is a novel glucokinase activator for the prevention or treatment of hyperglycemia, diabetes mellitus, obesity, dyslipidemia, and metabolic syndrome.
T23552 YZ9 6093-71-6 98%
YZ9
PFKFB3 inhibitor
T33412 MitoPQ 1821370-28-8 98%
MitoPQ
MitoPQ (MitoParaquat) is a mitochondria-targeted small molecule compound that selectively enhances mitochondrial superoxide and hydrogen peroxide levels and inhi...
T3105 PFK-158 1462249-75-7 98%
PFK-158
PFK-158 is an effective and specific inhibitor PFKFB3.
PFKFB3-IN-2
T67874
PFKFB3-IN-2 is a 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) inhibitor. Anti-sense treatment against PFKFB3 was shown to reduce tumor growth ...
(1S,2R)-Globalagliatin
T3104L
(1S,2R)-Globalagliatin is a highly potent glucokinase (GK) activator for the study of type 2 diabetes.
PFK-015
T2455
PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).
AZ PFKFB3 26
T14365
AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 nM. The IC50s for PFKFB1 and PFKFB2 are 2.06 and 0.384 μM, respectively.
AMG-3969
TQ0055
AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).
Oxfendazole
T0714
Oxfendazole (RS-8858), a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.
(E)-3PO
T3260
(E)-3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase) inhibitor.
ARRY-403
T30142
ARRY-403 is a novel glucokinase activator that reduces fasting and postprandial blood glucose in patients with type 2 diabetes.
PF-04937319
T16479
PF-04937319 is an activator of glucokinase (EC50 =154.4  μM). PF-04937319 maintains glucose-lowering efficacy while mitigating the risk of hypoglycemia observed ...
WAY-640509
T60048
WAY-640509 is a glucocerebrosidase inhibitor.
MK-0941 free base
T12056
MK-0941 free base is an orally active glucokinase activator, exhibiting strong glucose-lowering activity and is a potential therapeutic agent for treatment of ty...
ML266
T8990
ML266 is glucocerebrosidase (GCase) molecule chaperone, IC50 = 2.5 µM. ML266 binds to GCase and transports of the mutant protein to the lysosome, and resume the ...
ML198
T8986
ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase. ML198 serves as a starting point to develop a novel approach towards small molecul...
Globalagliatin
T3104
Globalagliatin (LY2608204) has been used in trials studying the treatment of Diabetes Mellitus, Type 2.
AMG-1694
T14212
AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, i...
WAY-297848
T77784
WAY-297848 is a novel glucokinase activator for the prevention or treatment of hyperglycemia, diabetes mellitus, obesity, dyslipidemia, and metabolic syndrome.
YZ9
T23552
PFKFB3 inhibitor
MitoPQ
T33412
MitoPQ (MitoParaquat) is a mitochondria-targeted small molecule compound that selectively enhances mitochondrial superoxide and hydrogen peroxide levels and inhi...
PFK-158
T3105
PFK-158 is an effective and specific inhibitor PFKFB3.
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TargetMol