Search Result

Search Results for " glutathione peroxidase "

Targets

Glutathione Peroxidase Glutathione Peroxidase

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T80056	Glutathione Peroxidase	GSH-Px,EC 1.11.1.9	Glutathione Peroxidase
	Glutathione Peroxidase (GSH-Px; EC 1.11.1.9), a member of the peroxidase family, catalyzes the oxidation of reduced glutathione (GSH) to oxidized glutathione (GSSG) by forming a disulfide bridge, concurrently reducing hy...		Glutathione Peroxidase
T37314	JKE-1674		GPX
	JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210.		GPX
T5340	MPO-IN-28		Glutathione Peroxidase
	MPO-IN-28 is a novel potent, irreversible Myeloperoxidase (MPO) inhibitor with IC50 of 44 nM.		Glutathione Peroxidase
T8375	ML-210	CID 49766530	Ferroptosis , GPX , Glutathione Peroxidase , Ras
	ML-210 (CID 49766530) is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity		Ferroptosis , GPX , Glutathione Peroxidase , Ras
T4090	PF-06282999		Glutathione Peroxidase
	PF-06282999 is a potent and selective myeloperoxidase inhibitor which is potentially useful for the treatment of cardiovascular diseases.		Glutathione Peroxidase
T14379	AZD5904		Glutathione Peroxidase
	AZD5904 is a potent and irreversible human Myeloperoxidase (MPO) inhibitor(IC50 of 140 nM and has similar potency in mouse and rat).		Glutathione Peroxidase
T12189	NBDHEX		Apoptosis , Glutathione Peroxidase , Autophagy
	NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1) .		Apoptosis , Glutathione Peroxidase , Autophagy
T8970	ML162		Ferroptosis , GPX , Glutathione Peroxidase
	ML162 is an inhibitor of GPX4 that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively)		Ferroptosis , GPX , Glutathione Peroxidase
T5463	Verdiperstat	AZD3241,AZD 3241	Glutathione Peroxidase
	Verdiperstat (AZD 3241) is a selective, irreversible and orally active myeloperoxidase inhibitor, with an IC50 of 630 nM, and can be used in the research of neurodegenerative brain disorders.		Glutathione Peroxidase
T83780	GPX4 24	Phospholipid Hydroperoxide Glutathione Peroxidase 24,PHGPx 24,Glutathione Peroxidase 4 24
	GPX4 24, a derivative of (1S,3R)-RSL3, acts as a potent inhibitor of glutathione peroxidase 4 (GPX4) through covalent binding in a concentration-dependent manner within 4T1 murine mammary carcinoma cells. This compound e...
T3646	RSL3	RSL3 1S,1S,3R-RSL3	Ferroptosis , GPX , Glutathione Peroxidase
	RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM). RSL3 is a VDAC-independent activator of iron death that is selective for tumor cells carrying oncogenic RAS.		Ferroptosis , GPX , Glutathione Peroxidase
T4313	Tinoridine hydrochloride	Nonflamin,Y-3642 hydrochloride	COX , Glutathione Peroxidase
	Tinoridine hydrochloride (Y-3642 hydrochloride) is a non-steroidal anti-inflammatory drug. Tinoridine hydrochloride (5-100 μM), produced a concentration-dependent inhibition on the simultaneous increases in lipid peroxid...		COX , Glutathione Peroxidase
T26389	4-POBN	NSC-640,NSC640,4-Aminobenzohydrazide,NSC 640,Myeloperoxidase Inhibitor 1,4-ABAH	Glutathione Peroxidase
	4-POBN (Myeloperoxidase Inhibitor 1) is a potent and irreversible inhibitor of myeloperoxidase (IC50 = 0.3 µM). 4-POBN can be used in studies about subacute stroke.		Glutathione Peroxidase
T0825	Ebselen	SPI-1005,PZ-51,CCG-39161	Phosphatase , Virus Protease , Calcium Channel , COX , HIV Protease
	Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced b...
T36935	PKUMDL-LC-101-D04	GPX4-Activator-1d4,PKUMDL-LC-101-D04	GPX
	PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of iron death. GPX4 activity was increased to 150% of control levels when used at a concentration of 20 μM in a cell-free...		GPX
T67498	3-Amino-1,2,4-triazole	Amitrole,3-AT,1H-1,2,4-Triazol-5-amine,Trapidil impurity B	Reactive Oxygen Species
	3-Amino-1,2,4-triazole (Trapidil impurity B) is an inhibitor of catalase, capable of inducing the compensatory mechanism for hydrogen peroxide detoxification. This mechanism involves increasing the activities of glutathi...		Reactive Oxygen Species
T11357	Gamma-glutamylcysteine TFA	γ-glutamylcysteine (TFA),Gamma-glutamylcysteine (TFA)	IL Receptor
	Gamma-glutamylcysteine (TFA) ((γ-glutamylcysteine (TFA)), a crucial dipeptide in glutathione (GSH) synthesis and a vital cofactor for the enzyme glutathione peroxidase (GPx), significantly modulates inflammatory response...		IL Receptor
T37805	JKE-1716
	JKE-1716 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of the GPX4 inhibitor ML-210 .1JKE-1716 reduces viability of LOX-IMVI cancer cells in a concentration-dependent manner and in a panel of additi...
T63729	GPX4-IN-3
	GPX4-IN-3 (26a) is a potent inhibitor of glutathione peroxidase 4 (GPX4), selectively inducing ferroptosis. It demonstrates a 71.7% inhibition rate of GPX4 at a concentration of 1 μM [1].
T36516	RC574	RC574
	RC574 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It inhibits glutamate-induced cell death in HT22 cells (IC50= 276.2 nM) and mouse primary cortical neurons...
T36515	RC363
	RC363 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It reduces 2,2-diphenyl-1-picrylhydrazyl radicals by approximately 40% in a cell-free assay when used at a...
T36610	(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine
	(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP) is a stilbene derivative with antioxidant and anticancer activities. It stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM). CSTMP r...

Compounds

Glutathione Peroxidase

T80056

Synonym: GSH-Px,EC 1.11.1.9

Target: Glutathione Peroxidase

Target: Glutathione Peroxidase

ML-210

T8375

Synonym: CID 49766530

Target: Ferroptosis, GPX, Glutathione Peroxidase, Ras

PF-06282999

T4090

Synonym:

Target: Glutathione Peroxidase

AZD5904

T14379

Synonym:

Target: Glutathione Peroxidase

NBDHEX

T12189

Synonym:

Target: Apoptosis, Glutathione Peroxidase, Autophagy

ML162

T8970

Synonym:

Target: Ferroptosis, GPX, Glutathione Peroxidase

Verdiperstat

T5463

Synonym: AZD3241,AZD 3241

Target: Glutathione Peroxidase

GPX4 24

T83780

Synonym: Phospholipid Hydroperoxide Glutathione Peroxidase 24,PHGPx 24,Glutathione Peroxidase 4 24

Target:

RSL3

T3646

Synonym: RSL3 1S,1S,3R-RSL3

Target: Ferroptosis, GPX, Glutathione Peroxidase

Tinoridine hydrochloride

T4313

Synonym: Nonflamin,Y-3642 hydrochloride

Target: COX, Glutathione Peroxidase

4-POBN

T26389

Synonym: NSC-640,NSC640,4-Aminobenzohydrazide,NSC 640,Myeloperoxidase Inhibitor 1,4-ABAH

Target: Glutathione Peroxidase

Ebselen

T0825

Synonym: SPI-1005,PZ-51,CCG-39161

Target: Phosphatase, Virus Protease, Calcium Channel, COX, HIV Protease

PKUMDL-LC-101-D04

T36935

Synonym: GPX4-Activator-1d4,PKUMDL-LC-101-D04

Target: GPX

3-Amino-1,2,4-triazole

T67498

Synonym: Amitrole,3-AT,1H-1,2,4-Triazol-5-amine,Trapidil impurity B

Target: Reactive Oxygen Species

Gamma-glutamylcysteine TFA

T11357

Synonym: γ-glutamylcysteine (TFA),Gamma-glutamylcysteine (TFA)

(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine

T36610

Synonym:

Target:

Cat No.	Product Name	Synonyms	Targets
T5372	L-SelenoMethionine	L-(+)-Selenomethionine	Apoptosis , Amino Acids and Derivatives , Endogenous Metabolite
	L-SelenoMethionine (L-(+)-Selenomethionine) is a naturally occurring amino acid. It promotes cell cycle progression and elevates the expression of the antioxidant enzymes thioredoxin reductase, glutathione reductase.
TJS0338	4-Methylesculetin	4-Methyl-6,7-dihydroxycoumarin,Methylesculetin	Antioxidant , Glutathione Peroxidase
	4-Methylesculetin (Methylesculetin) is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities.		Antioxidant , Glutathione Peroxidase
T19117	3-Deoxyglucosone	3-Deoxy-D-glucosone,2-keto-3-Deoxyglucose	GPX , Glucagon Receptor
	3-Deoxyglucosone(3-Deoxy-D-glucosone) is synthesized by the intermediate pathway of the melad and polyol reactions.3-Deoxyglucosone reacts rapidly with protein amino groups to form advanced glycosylated end proteins (AGE...		GPX , Glucagon Receptor

Natural Products

L-SelenoMethionine

T5372

Synonym: L-(+)-Selenomethionine

Target: Apoptosis, Amino Acids and Derivatives, Endogenous Metabolite

4-Methylesculetin

TJS0338

Synonym: 4-Methyl-6,7-dihydroxycoumarin,Methylesculetin

Target: Antioxidant, Glutathione Peroxidase

3-Deoxyglucosone

T19117

Synonym: 3-Deoxy-D-glucosone,2-keto-3-Deoxyglucose

Target: GPX, Glucagon Receptor

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02843	GPX7 Protein, Human, Recombinant (hFc)	Human	HEK293
	GPX7 gene contains 3 distinct gt-ag introns. Transcription produces 4 different mRNAs, 3 alternatively spliced variants, and 1 unspliced form. There are 5 validated alternative polyadenylation sites. The mRNAs appear to ...
TMPH-01296	GPX5 Protein, Human, Recombinant (GST & His)	Human	E. coli
	Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective syste...
TMPH-03443	GPX2 Protein, S. cerevisiae, Recombinant (His & Myc)	Saccharomyces cerevisiae	E. coli
	Glutathione peroxidase-like protein that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress. Plays an important role in the oxidative stress-induced response in the pres...
TMPH-03108	GPX5 Protein, Pig, Recombinant (E. coli, His & Myc)	Sus scrofa (Pig)	E. coli
	May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. Since the purified porcine enzyme has very little activity towards hydrogen peroxide or organic hydroperoxi...
TMPH-03109	GPX5 Protein, Pig, Recombinant (His & Myc)	Sus scrofa (Pig)	Yeast
	May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. Since the purified porcine enzyme has very little activity towards hydrogen peroxide or organic hydroperoxi...
TMPY-02201	Peroxiredoxin 6 Protein, Human, Recombinant (His)	Human	E. coli
	PRDX6, a member of antioxidant protein superfamily, plays an important role in oxidative stress, catabolism of lipids and phospholipid lipisomes. Peroxiredoxin 6 (PRDX6) is involved in redox regulation of the cell and is...
TMPJ-00690	PGDS Protein, Human, Recombinant	Human	E. coli
	Hematopoietic Prostaglandin D Synthase (HPGDS) belongs to the GST superfamily and Sigma family. HPGDS contains one GST C-terminal domain and one GST N-terminal domain. HPGDS is highly expressed in adipose tissue, macroph...

GPX7 Protein, Human, Recombinant (hFc)

TMPY-02843

Species: Human

Expression System: HEK293

GPX5 Protein, Human, Recombinant (GST & His)

TMPH-01296

Species: Human

Expression System: E. coli

GPX2 Protein, S. cerevisiae, Recombinant (His & Myc)

TMPH-03443

Species: Saccharomyces cerevisiae

Expression System: E. coli

GPX5 Protein, Pig, Recombinant (E. coli, His & Myc)

TMPH-03108

Species: Sus scrofa (Pig)

Expression System: E. coli

GPX5 Protein, Pig, Recombinant (His & Myc)

TMPH-03109

Species: Sus scrofa (Pig)

Expression System: Yeast

Peroxiredoxin 6 Protein, Human, Recombinant (His)

TMPY-02201

Species: Human

Expression System: E. coli

PGDS Protein, Human, Recombinant

TMPJ-00690

Species: Human

Expression System: E. coli

Cat No.	Product Name
L2900	Oxidation-Reduction Compound Library		1279 compounds
	1279 small molecule compounds with pro-oxidant or anti-oxidant activity for high-throughput and high-content screening.

Libraries

Oxidation-Reduction Compound Library

L2900

Compounds: 1279