T79294 |
NC-R17
|
|
98%
|
|
NC-R17, an RSL3-based noncovalent GPX4 degrader implicated in ferroptosis, demonstrates anti-tumor activity and is utilized in the design of noncovalent GPX4-tar...
|
T79638 |
Lepadin E
|
444914-19-6
|
98%
|
|
Lepadin E, a notably cytotoxic compound, effectively stimulates ferroptosis via the canonical p53-SLC7A11-GPX4 pathway. By elevating p53 and repressing SLC7A11 a...
|
T79940 |
Moracin N
|
135248-05-4
|
98%
|
|
Moracin N, a ferroptosis inhibitor derived from mulberry leaves, exhibits neuroprotective activity by mitigating oxidative stress [1].
|
T80056 |
Glutathione Peroxidase
|
9013-66-5
|
98%
|
|
Glutathione Peroxidase (GSH-Px; EC 1.11.1.9), a member of the peroxidase family, catalyzes the oxidation of reduced glutathione (GSH) to oxidized glutathione (GS...
|
T74846 |
GPX4-IN-4
|
2920221-53-8
|
98%
|
|
GPX4-IN-4 (Compound 24) serves as a potent inhibitor of GPX4, applicable in cancer research [1].
|
T38063L |
N-Acetyl lysyltyrosylcysteine amide acetate
|
|
98%
|
|
N-Acetyl lysyltyrosylcysteine amide acetate is an effective and selective tripeptide inhibitor of myeloperoxidase (MPO). N-Acetyl lysyltyrosylcysteine amide ace...
|
T22776 |
Ezatiostat hydrochloride
|
286942-97-0
|
98%
|
|
Ezatiostat hydrochloride (TLK199 HCl) is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the pote...
|
T0133 |
Cefdinir
|
91832-40-5
|
99.94%
|
|
Cefdinir (FK-482) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, proven effective for common bacterial infect...
|
TJS0338 |
4-Methylesculetin
|
529-84-0
|
99.84%
|
|
4-Methylesculetin (Methylesculetin) is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities.
|
T8970 |
ML162
|
1035072-16-2
|
99.78%
|
|
ML162 is an inhibitor of GPX4 that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-typ...
|
T3511 |
PF-1355
|
1435467-38-1
|
99.77%
|
|
PF-1355 (PF 06281355) is a selective 2-thiouracil mechanism-based MPO inhibitor. PF-1355 is used for treatment of vasculitic diseases.
|
T3646 |
RSL3
|
1219810-16-8
|
99.23%
|
|
RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM). RSL3 is a VDAC-independent activator of iron death that ...
|
T25131 |
AZD8309
|
333742-48-6
|
99.17%
|
|
AZD8309 is a potent, orally available antagonist of the chemokine receptor CXCR2 that regulates neutrophil transport, significantly reduces MPO in the pancreas a...
|
T5463 |
Verdiperstat
|
890655-80-8
|
99.16%
|
|
Verdiperstat (AZD 3241) is a selective, irreversible and orally active myeloperoxidase inhibitor, with an IC50 of 630 nM, and can be used in the research of neur...
|
T5340 |
MPO-IN-28
|
37836-90-1
|
99.02%
|
|
MPO-IN-28 is a novel potent, irreversible Myeloperoxidase (MPO) inhibitor with IC50 of 44 nM.
|
T1258 |
Nabumetone
|
42924-53-8
|
98.91%
|
|
Nabumetone (BRL14777)(BRL14777) is a non-steroidal anti-inflammatory drug and its active metabolite 6MNA inhibits the enzymes cyclo-oxygenase I and II.
|
T1659 |
Melatonin
|
73-31-4
|
98.71%
|
|
Melatonin (Melatonine) is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in...
|
T61028 |
Mitiperstat
|
1933460-19-5
|
98.36%
|
|
Mitiperstat is a potent myeloperoxidase (MPO) inhibitor that is effective in preventing cardiovascular diseases such as heart failure and coronary artery disease...
|
T38063 |
N-Acetyl lysyltyrosylcysteine amide
|
1287585-40-3
|
98.08%
|
|
N-Acetyl lysyltyrosylcysteine amide is a non-toxic myeloperoxidase (MPO) tripeptide inhibitor that is potent, reversible, and specific.N-Acetyl lysyltyrosylcyste...
|
T4090 |
PF-06282999
|
1435467-37-0
|
98%
|
|
PF-06282999 is a potent and selective myeloperoxidase inhibitor which is potentially useful for the treatment of cardiovascular diseases.
|