hcv-protease — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T25268	Coblopasvir		Others
	Coblopasvir is a pan-genotypic non-structural protein 5A (NS5A) inhibitor. It can be used to study chronic hepatitis C virus infection.		Others
T4197	HZ-1157	HZ1157,DHFR-inhibitor	HCV Protease
	HZ-1157 (DHFR-inhibitor) is a hepatitis C virus (HCV) inhibitor with inhibitory activities toward HCV NS3/4A protease.		HCV Protease
T1822	Clemizole		HCV Protease , Histamine Receptor
	Clemizole is an H1 histamine receptor antagonist, can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.		HCV Protease , Histamine Receptor
T19862	Voxilaprevir		HCV Protease
	Voxilaprevir is an inhibitor of hepatitis C virus (HCV) nonstructural (NS) protein 3/4A protease.		HCV Protease
T5126	Glecaprevir	ABT-493	HCV Protease , SARS-CoV
	Glecaprevir (ABT-493) is an HCV NS3/4A protease inhibitor, (IC50s: 3.5-11.3 nM).		HCV Protease , SARS-CoV
T4547	Grazoprevir	MK-5172	HCV Protease , SARS-CoV
	Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Ki of 0.01 nM (gt1a), 0.08 nM (gt2a), 0.90 nM (gt3a), 0.01 nM (gt1b), ...		HCV Protease , SARS-CoV
T4474	Asunaprevir	BMS-650032	HCV Protease , SARS-CoV
	Asunaprevir (BMS-650032) is an effective hepatitis C virus (HCV) NS3 protease inhibitor.		HCV Protease , SARS-CoV
T1822L	Clemizole hydrochloride		HCV Protease , Histamine Receptor
	Clemizole hydrochloride is an antagonist for H1 histamine receptor. According to the research, Clemizole hydrochloride can inhibit hepatitis C virus (HCV) replication and NS4B's RNA binding.		HCV Protease , Histamine Receptor
T25268L	Coblopasvir dihydrochloride	Coblopasvir dihydrochloride(1312608-46-0 Free base)	HCV Protease
	Coblopasvir dihydrochloride can be used to study chronic HCV infection and is a pan-genotypic nonstructural protein 5A (NS5A) inhibitor.		HCV Protease
T4988	Boceprevir	SCH 503034,EBP 520	HCV Protease , SARS-CoV
	Boceprevir (SCH 503034) is a novel, potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with Ki of 14 nM in both enzyme assay and EC90 of 350 nM in cell-based replicon assay.		HCV Protease , SARS-CoV
T9567	Samatasvir	ATOLIHZIXHZSBA-BTSKBWHGSA-N,IDX719	HCV Protease
	Samatasvir (ATOLIHZIXHZSBA-BTSKBWHGSA-N) is a pan-genotypic inhibitor of the HCV non-structural protein 5A.		HCV Protease
T22394	Paritaprevir	ABT450,ABT-450,Veruprevir	HCV Protease
	Paritaprevir (ABT450) is an inhibitor of non-structural protein 3/4A protease with EC50 values of 1 and 0.21 nM for HCV 1a and HCV 1b, respectively.		HCV Protease
T6190	Telaprevir	VX-950,LY-570310,Incivek,MP-424	HCV Protease , SARS-CoV
	Telaprevir (Incivek) (VX-950) is an effective inhibitor of HCV NS3-4A serine protease (IC50: 0.35 μM).		HCV Protease , SARS-CoV
T4686	Simeprevir	TMC435,TMC-435350,Olysio	HCV Protease , SARS-CoV
	Simeprevir (TMC435) is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM.		HCV Protease , SARS-CoV
T6025	Danoprevir	R7227,ITMN-191,RG7227,RO5190591	HCV Protease , SARS-CoV
	Danoprevir (RG7227) is a peptidomimetic inhibitor of the NS3/4A protease(IC50=0.2-3.5 nM) of hepatitis C virus (HCV).		HCV Protease , SARS-CoV
T28830	Sovaprevir	ACH 0141625,ACH0141625,ACH-0141625,ACH1625,ACH 1625,ACH-1625	HCV Protease
	Sovaprevir is a non-structural 3 (NS3) protease inhibitor with antiviral activity for the treatment of HCV infection.		HCV Protease
T3226	Paritaprevir	ABT-450,Veruprevir	HCV Protease
	Paritaprevir (ABT-450) is an orally bioavailable, synthetic acylsulfonamide inhibitor of the hepatitis C virus (HCV) protease complex comprised of non-structural protein 3 and 4A (NS3/NS4A), with potential activity again...		HCV Protease
T14555	BI-1230		HCV Protease
	BI-1230 is a potent inhibitor of HCV NS3 protease, exhibiting efficacy in the low nanomolar range, and notably suppresses viral replication. This compound demonstrates high selectivity, distinguishing effectively between...		HCV Protease
T71131	IDX-320
	IDX-320 is an HCV protease inhibitor.
T35043	Vedroprevir	GS9451,GS 9451,GS-9451
	Vedroprevir, also known as GS9451, is a selective hepatitis C virus (HCV) NS3 protease inhibitor in the development of the treatment of genotype 1 (GT1) HCV infection.
T10535	BI 653048		P450
	BI 653048 is a selective and orally active agonist of nonsteroidal glucocorticoid (IC50: 55 nM). BI 653048 is also an HCV NS3 protease inhibitor.		P450
T71006	BI-1388
	BI-1388 is a highly potent inhibitor of HCV NS3 protease activity, inhibiting viral replication for various HCV genotypes and for resistant mutants D168V and R155K.
T71215	Faldaprevir sodium
	Faldaprevir sodium is a potent NS3/NS4A protease inhibitor potentially for the treatment of HCV infection. Faldaprevir is known to inhibit P-glycoprotein, CYP3A4, and UDP-glucuronosyltransferase 1A1.
T71653	GS-9256		HCV Protease
	GS-9256 is a selective inhibitor of the HCV NS3 protease, exhibiting favorable pharmacokinetic properties and antiviral activity [1].		HCV Protease
T19685	Faldaprevir	BI-201335,BI201335,BI 201335
	Faldaprevir is an effective NS3/NS4A protease inhibitor potentially for the treatment of HCV infection. Faldaprevir is known to inhibit P-glycoprotein, CYP3A4, and UDP-glucuronosyltransferase 1A1.
T39503	Hepatitis Virus C NS3 Protease Inhibitor 2
	Hepatitis Virus C NS3 Protease Inhibitor 2 is a peptide inhibitor derived from a product that targets the NS3 protease of the hepatitis C virus (HCV). Its inhibitory activity against the NS3 protease is characterized by ...
T76521	HCV NS4A Protein (18-40) (JT strain)
	HCV NS4A Protein (18-40) (JT strain) is a peptide derived from residues 18 to 40 of the HCV NS4A protein. It enhances the catalytic efficiency of NS3 protease [1].
T76525	Ac-EEVVAC-pNA
	Ac-EEVVAC-pNA serves as a chromogenic substrate specifically designed for the continuous spectrophotometric assay of the HCV NS3 protease. Its sequence, EEVVAC, originates from the 5A-5B cleavage junction within the HCV ...
T19627	Ciluprevir	BILN 2061ZW,BILN 2061,BILN-2061ZW,BILN-2061,BILN2061ZW,BILN2061
	Ciluprevir is an effective and selective HCV NS3 protease inhibitor with proven antiviral effect in humans. Ciluprevir may be an antiviral agent for individuals infected with non-genotype-1 HCV. In vitro sensitivity stud...
T76524	Hepatitis C Virus S5A/5B
	Hepatitis C Virus S5A/5B, a synthetic peptide substrate, replicates the NS5A/5B junction of the nonstructural protein (NS), serving as the substrate for examining HCV NS3 protease activity [1].
T76526	Ac-D-DGla-LI-Cha-C
	Ac-D-DGla-LI-Cha-C is a potent peptide inhibitor of the HCV protease, applicable in research targeting a range of diseases, including cancer, autoimmune, fibrotic, inflammatory, neurodegenerative, infectious, lung, heart...
T73898	Paritaprevir dihydrate
	Paritaprevir dihydrate (ABT-450), a highly effective and orally administered antiviral, acts as a non-structural protein 3/4A (NS3/4A) protease inhibitor, displaying EC50 values of 1 and 0.21 nM against HCV genotypes 1a ...

Compounds

Coblopasvir

T25268

Synonym: HZ1157,DHFR-inhibitor

Target: HCV Protease

Clemizole

T1822

Synonym:

Target: HCV Protease, Histamine Receptor

Voxilaprevir

T19862

Synonym:

Target: HCV Protease

Glecaprevir

T5126

Synonym: ABT-493

Target: HCV Protease, SARS-CoV

Grazoprevir

T4547

Synonym: MK-5172

Target: HCV Protease, SARS-CoV

Asunaprevir

T4474

Synonym: BMS-650032

Target: HCV Protease, SARS-CoV

Clemizole hydrochloride

T1822L

Synonym:

Target: HCV Protease, Histamine Receptor

Coblopasvir dihydrochloride

T25268L

Synonym: Coblopasvir dihydrochloride(1312608-46-0 Free base)

Target: HCV Protease

Boceprevir

T4988

Synonym: SCH 503034,EBP 520

Target: HCV Protease, SARS-CoV

Samatasvir

T9567

Synonym: ATOLIHZIXHZSBA-BTSKBWHGSA-N,IDX719

Target: HCV Protease

Paritaprevir

T22394

Synonym: ABT450,ABT-450,Veruprevir

Target: HCV Protease

Telaprevir

T6190

Synonym: VX-950,LY-570310,Incivek,MP-424

Target: HCV Protease, SARS-CoV

Simeprevir

T4686

Synonym: TMC435,TMC-435350,Olysio

Target: HCV Protease, SARS-CoV

Danoprevir

T6025

Synonym: R7227,ITMN-191,RG7227,RO5190591

Target: HCV Protease, SARS-CoV

Sovaprevir

T28830

Synonym: ACH 0141625,ACH0141625,ACH-0141625,ACH1625,ACH 1625,ACH-1625

Target: HCV Protease

Paritaprevir

T3226

Synonym: ABT-450,Veruprevir

Target: HCV Protease

BI-1230

T14555

Synonym:

Target: HCV Protease

Synonym: GS9451,GS 9451,GS-9451

Target: HCV Protease

Faldaprevir

T19685

Synonym: BI-201335,BI201335,BI 201335

Target:

Hepatitis Virus C NS3 Protease Inhibitor 2

T39503

Synonym:

Target:

HCV NS4A Protein (18-40) (JT strain)

Synonym: BILN 2061ZW,BILN 2061,BILN-2061ZW,BILN-2061,BILN2061ZW,BILN2061

Target:

Hepatitis C Virus S5A/5B

Paritaprevir dihydrate

T73898

Synonym:

Target:

Cat No.	Product Name	Species	Expression System
TMPY-00323	Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST)	HCV	E. coli
	HCV NS3 displays three enzymatic activities: serine protease, NTPase, and RNA helicase. HCV NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A, and NS5A-NS5B...

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Targets

Compounds

Recombinant Proteins

Compounds

Recombinant Proteins