HCV Protease

NS2-3 protease (of hepatitis C virus, HCV) is an enzyme responsible for proteolytic cleavage between NS2 and NS3, which are non-structural proteins that form part of the HCV virus particle. NS3 protease of hepatitis C virus, on the other hand, is responsible for the cleavage of non-structural protein downstream. Both of these proteases are directly involved in HCV genome replication, that is, during the viral life-cycle that leads to virus multiplication in the host that has been infected by the virus.

Cat. No.	Product name	CAS No.	Purity
T15282	Filibuvir	877130-28-4	99.68%
T15282	Filibuvir (PF-00868554) is a selective and noncovalent inhibitor of HCV NS5B RNA-dependent RNA polymerase. Filibuvir inhibits genotype 1a and 1b replicons with E...
TQ0162	R-1479	478182-28-4	99.68%
TQ0162	R-1479 (4'-Azidocytidine) is an RdRp inhibitor with an IC50 value of 1.28 μM for HCV RNA replication in the HCV subgenomic replicon system.
T11539	HCV-IN-29	1009119-83-8	99.66%
T11539	HCV-IN-29 is a hepatitis C virus (HCV) inhibitor.
T3489	Dasabuvir	1132935-63-7	99.62%
T3489	Dasabuvir (ABT-333) is a non-nucleoside inhibitor of the hepatitis C virus (HCV) non-structural protein 5B (NS5B), an RNA-dependent RNA polymerase, with potentia...
T3226	Paritaprevir	1221573-85-8	99.57%
T3226	Paritaprevir (ABT-450) is an orally bioavailable, synthetic acylsulfonamide inhibitor of the hepatitis C virus (HCV) protease complex comprised of non-structural...
T6025	Danoprevir	850876-88-9	99.52%
T6025	Danoprevir (RG7227) is a peptidomimetic inhibitor of the NS3/4A protease(IC50=0.2-3.5 nM) of hepatitis C virus (HCV).
T67788	BAY-43-9695	233255-39-5	99.51%
T67788	BAY-43-9695 is a non-nucleoside compound with anti-human cytomegalovirus (HCMV) activity. It is the major metabolite of BAY-38-4766.
T2774	Lycorine hydrochloride	2188-68-3	99.49%
T2774	Lycorine hydrochloride (Narcissine hydrochloride) is VE-cadherin inhibitor,and has IC50 of 1.2μM in Hey1B cell.It is an HCV inhibitor with strong activity.
T11760	KIN101	610753-87-2	99.46%
T11760	KIN101 (3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene), an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KI...
T21537L	TMC647055 Choline Hydroxide Salt	T21537L	99.44%
T21537L	TMC647055 Choline Hydroxide Salt is a novel and potent non-nucleoside inhibitor of the HCV NS5B polymerase which potentially for the treatment of HCV infection. ...
T16088	MK-0608	443642-29-3	99.42%
T16088	MK-0608 is an orally bioavailable HCV replication inhibitor in vitro(EC50 = 0.3 μM and EC90=1.3 μM in the subgenomic-replicon assay).
T14489	Azvudine	1011529-10-4	99.42%
T14489	Azvudine (FNC) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine inhibits NRTI-resistant viral...
T7607	PSI-6130	817204-33-4	99.36%
T7607	PSI-6130 (R 1656) is a potent and selective HCV NS5B polymerase inhibitor. PSI-6130 inhibits HCV replication with a mean IC50 of 0.6 μM.
T4547	Grazoprevir	1350514-68-9	99.36%
T4547	Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Ki of 0.01 ...
T2117	PSI-6206	863329-66-2	99.33%
T2117	PSI-6206 (RO 2433) (RO2433) is a selective HCV RNA polymerase inhibitor.
T27586	IDX184	1036915-08-8	99.29%
T27586	IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3 ...
T26815	BILB-1941	494856-61-0	99.24%
T26815	BILB-1941 (BILB-1941ZW) is an inhibitor of HCV NS5B polymerase and can be used in studies about HCV infection.
TQ0122L	VCH-916 free acid(1200133-34-1 free base)	914778-92-0	99.19%
TQ0122L	VCH-916 is a novel nonnucleoside HCV NS5B polymerase inhibitor.
T4988	Boceprevir	394730-60-0	99.16%
T4988	Boceprevir (SCH 503034) is a novel, potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with Ki of 14 nM in both enzyme assay and EC90 of 35...
T5126	Glecaprevir	1365970-03-1	99.16%
T5126	Glecaprevir (ABT-493) is an HCV NS3/4A protease inhibitor, (IC50s: 3.5-11.3 nM).