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HCV Protease

NS2-3 protease (of hepatitis C virus, HCV) is an enzyme responsible for proteolytic cleavage between NS2 and NS3, which are non-structural proteins that form part of the HCV virus particle. NS3 protease of hepatitis C virus, on the other hand, is responsible for the cleavage of non-structural protein downstream. Both of these proteases are directly involved in HCV genome replication, that is, during the viral life-cycle that leads to virus multiplication in the host that has been infected by the virus.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T67787 Adafosbuvir PM 1613589-04-0 97.08%
Adafosbuvir PM
Adafosbuvir PM (AL-335 PM) is a small molecule NS5B inhibitor that can be used to study chronic hepatitis C.
T68015 Ruzasvir 1613081-64-3 97.01%
Ruzasvir
Ruzasvir (MK-8408) is a novel and potent pan-genotypic inhibitor of hepatitis C virus NS5A with antiviral activity.
T0392 Artemisinin 63968-64-9 97%
Artemisinin
Artemisinin (Qinghaosu) is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of mala...
T6190 Telaprevir 402957-28-2 96.9%
Telaprevir
Telaprevir (Incivek) (VX-950) is an effective inhibitor of HCV NS3-4A serine protease (IC50: 0.35 μM).
T6729 Lomibuvir 1026785-55-6 100%
Lomibuvir
Lomibuvir (VCH-222) (VX-222) is a selective, non-nucleoside allosteric inhibitor of HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1...
T24480 MK-8325 1334314-19-0 100%
MK-8325
MK-8325 is a potent and orally available HCV NS5A inhibitor with replicative activity against a wide range of genotypes.MK-8325 has demonstrated bioavailability ...
T9331 Bemnifosbuvir hemisulfate 2241337-84-6 98%
Bemnifosbuvir hemisulfate
Bemnifosbuvir hemisulfate (AT-527) is a potent inhibitor of HCV virus replication.
T78226 Methyl 2-amino-5-bromobenzoate 52727-57-8 98%
Methyl 2-amino-5-bromobenzoate
Methyl 2-amino-5-bromobenzoate (Methyl 5-Bromoanthranilate) is a hepatitis C virus NS5b RNA polymerase inhibitor with antimicrobial activity that inhibits Pseudo...
TQ0122L VCH-916 free acid(1200133-34-1 free base) 914778-92-0 98%
VCH-916 free acid(1200133-34-1 free base)
VCH-916 is a novel nonnucleoside HCV NS5B polymerase inhibitor.
TN2089 Platycodin D3 67884-03-1 98%
Platycodin D3
Platycodin D3 is a NF-κB inhibitor, it could as expectorants in diverse inflammatory pulmonary diseases, it can regulate the production and secretion of airway m...
T38237 2′-O-Methylcytidine 2140-72-9 98%
2′-O-Methylcytidine
2'-O-Methylcytidine is a nucleoside derivative and an inhibitor of hepatitis C virus (HCV) non-structural protein 5B (NS5B; IC50= 3.8 μM).1It inhibits HCV replic...
T50024 7-benzyl-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 56344-53-7 98%
7-benzyl-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
7-benzyl-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a inhibitor of Hepatitis C Virus(HCV).
T25268L Coblopasvir dihydrochloride 1966138-53-3 98%
Coblopasvir dihydrochloride
Coblopasvir dihydrochloride can be used to study chronic HCV infection and is a pan-genotypic nonstructural protein 5A (NS5A) inhibitor.
T7607 PSI-6130 817204-33-4 98%
PSI-6130
PSI-6130 (R 1656) is a potent and selective HCV NS5B polymerase inhibitor. PSI-6130 inhibits HCV replication with a mean IC50 of 0.6 μM.
T16165 Myriocin 35891-70-4 98%
Myriocin
Myriocin (Thermozymocidin), a metabolite derived from Myriococcum albomyces, is a serine-palmitoyltransferase (SPT) inhibitor with potential antitumour, anticanc...
TN6508 Trachelogenin 34209-69-3 98%
Trachelogenin
Trachelogenin ((-)-Trachelogenin), an HCV entry inhibitor, has antiproliferative effects, and its mechanism is related to affecting the phosphorylation of key pr...
T9717 Chlorcyclizine 82-93-9 98%
Chlorcyclizine
CHLORCYCLIZINE is a histamine H1 antagonist and a potent hepatitis C virus (HCV) entry inhibitor.
T19073 Tris(4-aminophenyl)methane 548-61-8 98%
Tris(4-aminophenyl)methane
Tris(4-aminophenyl)methane (Leucopararosaniline), a triphenylmethane dye, is a weak HCV helicase inhibitor.
T22489 2'-MeCCPA 205171-12-6 98%
2'-MeCCPA
2'-MeCCPA is a potent and highly selective A1 adenosine receptor (A1AR) agonist with a K-value of 1.8 nM for AR.2'-MeCCPA inhibits trichostatin-stimulated adenyl...
T5938 4-Phenoxybenzylamine 107622-80-0 98%
4-Phenoxybenzylamine
4-Phenoxybenzylamine inhibits the function of the NS3 protein by stabilizing an inactive conformation with an IC50 of about 500 μM against HCV NS3/4a .
Adafosbuvir PM
T67787
Adafosbuvir PM (AL-335 PM) is a small molecule NS5B inhibitor that can be used to study chronic hepatitis C.
Ruzasvir
T68015
Ruzasvir (MK-8408) is a novel and potent pan-genotypic inhibitor of hepatitis C virus NS5A with antiviral activity.
Artemisinin
T0392
Artemisinin (Qinghaosu) is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of mala...
Telaprevir
T6190
Telaprevir (Incivek) (VX-950) is an effective inhibitor of HCV NS3-4A serine protease (IC50: 0.35 μM).
Lomibuvir
T6729
Lomibuvir (VCH-222) (VX-222) is a selective, non-nucleoside allosteric inhibitor of HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1...
MK-8325
T24480
MK-8325 is a potent and orally available HCV NS5A inhibitor with replicative activity against a wide range of genotypes.MK-8325 has demonstrated bioavailability ...
Bemnifosbuvir hemisulfate
T9331
Bemnifosbuvir hemisulfate (AT-527) is a potent inhibitor of HCV virus replication.
Methyl 2-amino-5-bromobenzoate
T78226
Methyl 2-amino-5-bromobenzoate (Methyl 5-Bromoanthranilate) is a hepatitis C virus NS5b RNA polymerase inhibitor with antimicrobial activity that inhibits Pseudo...
VCH-916 free acid(1200133-34-1 free base)
TQ0122L
VCH-916 is a novel nonnucleoside HCV NS5B polymerase inhibitor.
Platycodin D3
TN2089
Platycodin D3 is a NF-κB inhibitor, it could as expectorants in diverse inflammatory pulmonary diseases, it can regulate the production and secretion of airway m...
2′-O-Methylcytidine
T38237
2'-O-Methylcytidine is a nucleoside derivative and an inhibitor of hepatitis C virus (HCV) non-structural protein 5B (NS5B; IC50= 3.8 μM).1It inhibits HCV replic...
7-benzyl-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
T50024
7-benzyl-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a inhibitor of Hepatitis C Virus(HCV).
Coblopasvir dihydrochloride
T25268L
Coblopasvir dihydrochloride can be used to study chronic HCV infection and is a pan-genotypic nonstructural protein 5A (NS5A) inhibitor.
PSI-6130
T7607
PSI-6130 (R 1656) is a potent and selective HCV NS5B polymerase inhibitor. PSI-6130 inhibits HCV replication with a mean IC50 of 0.6 μM.
Myriocin
T16165
Myriocin (Thermozymocidin), a metabolite derived from Myriococcum albomyces, is a serine-palmitoyltransferase (SPT) inhibitor with potential antitumour, anticanc...
Trachelogenin
TN6508
Trachelogenin ((-)-Trachelogenin), an HCV entry inhibitor, has antiproliferative effects, and its mechanism is related to affecting the phosphorylation of key pr...
Chlorcyclizine
T9717
CHLORCYCLIZINE is a histamine H1 antagonist and a potent hepatitis C virus (HCV) entry inhibitor.
Tris(4-aminophenyl)methane
T19073
Tris(4-aminophenyl)methane (Leucopararosaniline), a triphenylmethane dye, is a weak HCV helicase inhibitor.
2'-MeCCPA
T22489
2'-MeCCPA is a potent and highly selective A1 adenosine receptor (A1AR) agonist with a K-value of 1.8 nM for AR.2'-MeCCPA inhibits trichostatin-stimulated adenyl...
4-Phenoxybenzylamine
T5938
4-Phenoxybenzylamine inhibits the function of the NS3 protein by stabilizing an inactive conformation with an IC50 of about 500 μM against HCV NS3/4a .
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TargetMol