HDAC

Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins.

Cat. No.	Product name	CAS No.	Purity
T14305	Apicidin	183506-66-3	99.68%
T14305	Apicidin (OSI 2040) is a histone deacetylase (HDAC) inhibitor with antiparasitic activity and antiproliferative activity.Apicidin attenuates memory deficits, inh...
T10841	CM-675	1872466-47-1	99.67%
T10841	CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential to tre...
T2078	Fimepinostat	1339928-25-4	99.66%
T2078	Fimepinostat (CUDC 907) is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan-histone deacetylase (HDAC) enzymes, with pot...
T1083	Theophylline	58-55-9	99.65%
T1083	Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervo...
T1890	Pracinostat	929016-96-6	99.65%
T1890	Pracinostat (SB939) is a novel HDAC inhibitor with improved in vivo properties compared to other HDAC inhibitors currently in Clinicalal trials, allowing oral do...
T3509	ACY-738	1375465-91-0	99.64%
T3509	ACY-738 demonstrates inhibitory activity against recombinant HDAC6 (IC50: 1.7 nM), with respective average selectivity over class I HDACs being 100-fold.
T8508	HDAC-IN-3	1018673-42-1	99.62%
T8508	HDAC-IN-3 (GSK3117391A) is a potent histone deacetylase (HDAC) inhibitor, and treatment chronic inflammatory disorders.
TN1273	7,4'-Dihydroxyflavone	2196-14-7	99.6%
TN1273	7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-...
T2489	Ricolinostat	1316214-52-4	99.57%
T2489	Ricolinostat (Rocilinostat) is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity.
T20080	Exifone	52479-85-3	99.57%
T20080	Exifone (NSC-680919) is a mixed, nonessential activator of HDAC1 that is capable of binding to both free and substrate-bound enzyme, resulting in an increased re...
T6362	Domatinostat	910462-43-0	99.57%
T6362	Domatinostat (4SC202) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays i...
T26897	BRD2492	1821669-43-5	99.56%
T26897	BRD2492 is a selective and potent dual inhibitor of HDAC1 and HDAC2 with potential anticancer, antitumour and antiproliferative activities, inhibiting HDAC1/2, H...
T2266	SantacruzaMate A	1477949-42-0	99.55%
T2266	SantacruzaMate A (CAY-10683) is a potent and selective HDAC inhibitor.
T10603	BRD-6929	849234-64-6	99.54%
T10603	BRD-6929 is a selective, brain-penetrant HDAC1 and HDAC2 inhibitor (IC50: 1 and 8 nM). BRD-6929 (Cpd-60) shows high-affinity to HDAC1 and HDAC2 (Kis: 0.2 and 1....
T6006	Romidepsin	128517-07-7	99.53%
T6006	Romidepsin (FR 901228) is an HDAC inhibitor that inhibits HDAC1/2/4/6 (IC50=36/47/510/1400 nM). Romidepsin has antitumor activity and can be used for the treatme...
TN4220	Homobutein	34000-39-0	99.50%
TN4220	Homobutein (3-O-Methylbutein) is a dual inhibitor of HDACs and NF-κB with IC50s of 190 and 38 μM. Homobutein is an iron chelator with anticancer, anti-inflammato...
T7064	Valproic Acid	99-66-1	99.49%
T7064	Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be u...
T6392	AR42	935881-37-1	99.46%
T6392	AR42 (OSU-HDAC42) is an HDAC inhibitor (IC50: 30 nM).
T10777	CG347B	1598426-03-9	99.45%
T10777	CG347B is a selective inhibitor of HDAC6.
T17028	Tefinostat	914382-60-8	99.41%
T17028	Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor. Tefinostat is cleaved to the active acid CHR-2847 by the int...