HDAC

Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins.

Cat. No.	Product name	CAS No.	Purity
T16729	Remetinostat	946150-57-8	98.67%
T16729	Remetinostat (SHP-141), a hydroxamic acid-based inhibitor of histone deacetylase enzymes, is currently being developed for the treatment of cutaneous T-cell lymp...
T3983	TMP195	1314891-22-9	98.66%
T3983	TMP195 (TFMO 2) is a selective class IIa histone deacetylase (HDAC) inhibitor.
T6678	Splitomicin	5690-03-9	98.64%
T6678	Splitomicin (1-Naphthalenepropanoic Acid) (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell...
T3516	EDO-S101	1236199-60-2	98.61%
T3516	EDO-S101 (Tinostamustine) is a pan HDAC inhibitor with IC50 values of 9, 9 and 25 nM for HDAC1, HDAC2 and HDAC3 , respectively.
T67878	HDAC-IN-52	2075787-77-6	98.5%
T67878	HDAC-IN-52 is a pyridine-containing HDAC inhibitor that inhibits HDAC1, HDAC2, HDAC3 and HDAC10 with IC50s of 0.189, 0.227, 0.440 and 0.446 μM, respectively. HDA...
T6865	Quisinostat dihydrochloride	875320-31-3	98.5%
T6865	Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a ...
T7691	NSC 3852	3565-26-2	98.44%
T7691	NSC 3852 is a potent inhibitor of histone deacetylase.
T0431	Abexinostat	783355-60-2	98.39%
T0431	PCI-24781 (Abexinostat (PCI24781)) is a new pan-HDAC inhibitor mainly targeting HDAC1 (Ki: 7 nM), also have moderate inhibitory for HDACs 2, 3, 6, and 10 and gre...
T77334	HDAC-IN-57	2716217-79-5	98.38%
T77334	HDAC-IN-57 is an orally active pan-inhibitor of histone deacetylase (HDAC), inhibiting HDAC1, HDAC2, HDAC6, and HDAC8 with IC50 values of 2.07 nM, 4.71 nM, 2.4 n...
T24133	HDAC8-IN-20a	1884231-52-0	98.38%
T24133	HDAC8-IN-20a (HDAC8 inhibitor-20a) is a potent and selective HDAC8 inhibitor with an IC50 of 27 nM. HDAC8-IN-20a blocks activation of growth receptor survival si...
T1966	Tubastatin A	1252003-15-8	98.36%
T1966	Tubastatin A (Tubastatin A BASE) is an effective and specific HDAC6 inhibitor (IC50: 15 nM, in a cell-free assay). Its selectivity is 1000-fold against all the o...
T6325	PCI-34051	950762-95-5	98.29%
T6325	PCI-34051 is an effective and selective HDAC8 inhibitor (IC50: 10 nM).
T10245	ACY-957	1609389-52-7	98.24%
T10245	ACY-957 (HDAC Inhibitor C001) is an orally active and selective inhibitor of HDAC1 and HDAC2 (IC50s: 7 nM, 18 nM, and 1300 nM against HDAC1/2/3) and shows no inh...
T10864	Corin	1808113-09-8	98.22%
T10864	Corin is an irreversible inhibitor of HDAC1(IC50 = 147 nM) and LSD1(Ki = 110 nM).
T3205	UF010	537672-41-6	98.11%
T3205	UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively.
T6279	Givinostat hydrochloride monohydrate	732302-99-7	98.09%
T6279	Givinostat hydrochloride monohydrate (ITF2357) is an HDAC inhibitor.
T1983	CAY10603	1045792-66-2	98.06%
T1983	CAY10603 (BML-281) is a potent and selective inhibitor of HDAC6.
T21806	HNHA	926908-04-5	98.04%
T21806	HNHA is an inhibitor of HDAC.
T6279L	Givinostat hydrochloride	199657-29-9	98.01%
T6279L	Givinostat hydrochloride (ITF2357 hydrochloride) is an inhibitor of HDAC with IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat hydrochloride ...
T5631	SIS17	2374313-54-7	98%
T5631	SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 s...