T22431 |
SU5204
|
186611-11-0
|
99.5%
|
|
SU5204 (3-[(2-Ethoxyphenyl)methylidene]-1H-indol-2-one), an analogue of SU5025, pharmacologically inhibits VEGFR2(IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) and ...
|
T1291 |
Cisapride
|
81098-60-4
|
99.5%
|
|
Cisapride (R 51619) is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote int...
|
T11213 |
Epertinib hydrochloride
|
2071195-74-7
|
99.36%
|
|
Epertinib hydrochloride (S-22611 hydrochloride) shows potent antitumor activity. Epertinib hydrochloride is a potent, orally active, reversible, and selective ty...
|
T1266 |
Terfenadine
|
50679-08-8
|
99.36%
|
|
Terfenadine ((±)-Terfenadine) is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist...
|
T6039 |
TAK-285
|
871026-44-7
|
99.17%
|
|
TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Auro...
|
T3108 |
CUDC-101
|
1012054-59-9
|
99.12%
|
|
CUDC-101 is a potent inhibitor of HDAC, EGFR and HER2 with IC50s of 4.4, 2.4 and 15.7 nM, respectively.
|
T33876L |
Panomifene HCl
|
|
99.09%
|
|
Panomifene HCl is a selective anti-estrogenic compound with antitumor activity for the treatment of breast cancer.
|
T6341 |
PF04929113
|
908115-27-5
|
99.06%
|
|
PF04929113 (SNX-5422) is a synthetic, novel, small molecule Hsp90 Inhibitor. As an oral formulation that demonstrates strong efficacy and tolerability, PF0492911...
|
T6712 |
Tyrphostin AG 879
|
148741-30-4
|
99.05%
|
|
Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.
|
T2047 |
AG-1478
|
153436-53-4
|
99.03%
|
|
AG-1478 (NSC-693255) (Tyrphostin AG-1478) is a selective EGFR inhibitor.
|
T16444 |
PD-118057
|
313674-97-4
|
98.97%
|
|
PD-118057 is a potent ether associated (hERG) potassium channel activator that shows no activity against hERG. PD-118057 inhibits the excitability of the membran...
|
T4694 |
AG-1557 hydrochloride (189290-58-2(free base))
|
T4694
|
98.95%
|
|
AG-1557 hydrochloride is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).
|
T4075 |
Sulfatinib
|
1308672-74-3
|
98.93%
|
|
Sulfatinib (KDR-IN-1) (HMPL-012) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3, FGFR1 and CSF1R with IC 50 s ranging from 1 to 24...
|
T9072 |
Tuxobertinib
|
2414572-47-5
|
98.86%
|
|
Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK a...
|
T6677 |
Sophocarpine
|
6483-15-4
|
98.67%
|
|
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
|
T2034 |
AG1557
|
189290-58-2
|
98.62%
|
|
AG1557 (AG-1557) is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).
|
T34760 |
SYR127063
|
871026-18-5
|
98.57%
|
|
SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.
|
T4342 |
PF-04929113 Mesylate
|
1173111-67-5
|
98.38%
|
|
PF-04929113 Mesylate (SNX-5422 Mesylate), a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37 ...
|
T3192 |
NS1643
|
448895-37-2
|
98.37%
|
|
NS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of 10.5 μM.
|
T4S0544 |
Furanodienone
|
24268-41-5
|
98.32%
|
|
1. Furanodienone has effects on MCF-7 cells are mediated, at least in part, by inhibiting ERα signaling. 2. Furanodienone inhibits EGFR/HER2 signaling pathway in...
|