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HIF

Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that is encoded by the HIF1A gene. It is a basic helix-loop-helix PAS domain containing protein, and is considered as the master transcriptional regulator of cellular and developmental response to hypoxia. The dysregulation and overexpression of HIF1A by either hypoxia or genetic alternations have been heavily implicated in cancer biology, as well as a number of other pathophysiologies, specifically in areas of vascularization and angiogenesis, energy metabolism, cell survival, and tumor invasion. Two other alternative transcripts encoding different isoforms have been identified.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T2488 BAY 87-2243 1227158-85-1 99.65%
BAY 87-2243
BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
T0153 Oltipraz 64224-21-1 99.56%
Oltipraz
Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes...
T9890 HIF1-IN-3  333314-79-7 99.48%
HIF1-IN-3 
HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used in antica...
T16679 Belzutifan 1672668-24-4 99.34%
Belzutifan
Belzutifan (MK-6482) is a potential treatment for clear cell renal cell carcinoma (ccRCC). Belzutifan is an orally active and selective HIF-2α inhibitor (IC50: 9...
T11561 HIF-2α-IN-2 1672666-82-8 99.33%
HIF-2α-IN-2
HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).
T67767 HIF-1 inhibitor-4 333357-56-5 99.17%
HIF-1 inhibitor-4
HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM. HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA lev...
T3169 KC7F2 927822-86-4 99.11%
KC7F2
KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.
T3494 LW6 934593-90-5 99.10%
LW6
LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.
T13050 SYP-5 1384268-04-5 99.1%
SYP-5
SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.
T6929 Pantoprazole sodium 138786-67-1 99.1%
Pantoprazole sodium
Pantoprazole sodium (Pantecta) is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole sodium is a lipophilic, w...
T3404 Cucurbitacin B 6199-67-3 99.08%
Cucurbitacin B
Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation throug...
T7836 ML228 1357171-62-0 99.03%
ML228
ML228 is a potent the Hypoxia Inducible Factor (HIF) pathway activator with EC50 of 1 μM. ML228 potently activates HIF in vitro as well as its downstream target ...
T7692 2,4-DPD 41438-38-4 98.98%
2,4-DPD
2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)
T7848 PT-2385 1672665-49-4 98.91%
PT-2385
PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).
T12675L PT2399 1672662-14-4 98.8%
PT2399
PT2399 shows effective antitumor activity in vivo. PT2399 is an effective and selective HIF-2α antagonist, which directly binds to the HIF-2α PAS B domain (IC50:...
T10233 Acetylarenobufagin 184673-79-8 98.54%
Acetylarenobufagin
Acetylarenobufagin is a steroidal hypoxia-inducible factor-1 (HIF-1) modulator.
T4S0800 Demethyleneberberine 25459-91-0 98.54%
Demethyleneberberine
Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either ...
T67831 HIF-2α agonist 2 2750141-15-0 98.32%
HIF-2α agonist 2
HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structu...
T15396 GN44028 1421448-26-1 98.20%
GN44028
GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 ...
T5537 IDF-11774 1429054-28-3 98%
IDF-11774
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
BAY 87-2243
T2488
BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
Oltipraz
T0153
Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes...
HIF1-IN-3 
T9890
HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used in antica...
Belzutifan
T16679
Belzutifan (MK-6482) is a potential treatment for clear cell renal cell carcinoma (ccRCC). Belzutifan is an orally active and selective HIF-2α inhibitor (IC50: 9...
HIF-2α-IN-2
T11561
HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).
HIF-1 inhibitor-4
T67767
HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM. HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA lev...
KC7F2
T3169
KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.
LW6
T3494
LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.
SYP-5
T13050
SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.
Pantoprazole sodium
T6929
Pantoprazole sodium (Pantecta) is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole sodium is a lipophilic, w...
Cucurbitacin B
T3404
Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation throug...
ML228
T7836
ML228 is a potent the Hypoxia Inducible Factor (HIF) pathway activator with EC50 of 1 μM. ML228 potently activates HIF in vitro as well as its downstream target ...
2,4-DPD
T7692
2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)
PT-2385
T7848
PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).
PT2399
T12675L
PT2399 shows effective antitumor activity in vivo. PT2399 is an effective and selective HIF-2α antagonist, which directly binds to the HIF-2α PAS B domain (IC50:...
Acetylarenobufagin
T10233
Acetylarenobufagin is a steroidal hypoxia-inducible factor-1 (HIF-1) modulator.
Demethyleneberberine
T4S0800
Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either ...
HIF-2α agonist 2
T67831
HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structu...
GN44028
T15396
GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 ...
IDF-11774
T5537
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
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TargetMol