T2488 |
BAY 87-2243
|
1227158-85-1
|
99.65%
|
|
BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
|
T0153 |
Oltipraz
|
64224-21-1
|
99.56%
|
|
Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes...
|
T9890 |
HIF1-IN-3
|
333314-79-7
|
99.48%
|
|
HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used in antica...
|
T16679 |
Belzutifan
|
1672668-24-4
|
99.34%
|
|
Belzutifan (MK-6482) is a potential treatment for clear cell renal cell carcinoma (ccRCC). Belzutifan is an orally active and selective HIF-2α inhibitor (IC50: 9...
|
T11561 |
HIF-2α-IN-2
|
1672666-82-8
|
99.33%
|
|
HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).
|
T67767 |
HIF-1 inhibitor-4
|
333357-56-5
|
99.17%
|
|
HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM. HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA lev...
|
T3169 |
KC7F2
|
927822-86-4
|
99.11%
|
|
KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.
|
T3494 |
LW6
|
934593-90-5
|
99.10%
|
|
LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.
|
T13050 |
SYP-5
|
1384268-04-5
|
99.1%
|
|
SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.
|
T6929 |
Pantoprazole sodium
|
138786-67-1
|
99.1%
|
|
Pantoprazole sodium (Pantecta) is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole sodium is a lipophilic, w...
|
T3404 |
Cucurbitacin B
|
6199-67-3
|
99.08%
|
|
Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation throug...
|
T7836 |
ML228
|
1357171-62-0
|
99.03%
|
|
ML228 is a potent the Hypoxia Inducible Factor (HIF) pathway activator with EC50 of 1 μM. ML228 potently activates HIF in vitro as well as its downstream target ...
|
T7692 |
2,4-DPD
|
41438-38-4
|
98.98%
|
|
2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)
|
T7848 |
PT-2385
|
1672665-49-4
|
98.91%
|
|
PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).
|
T12675L |
PT2399
|
1672662-14-4
|
98.8%
|
|
PT2399 shows effective antitumor activity in vivo. PT2399 is an effective and selective HIF-2α antagonist, which directly binds to the HIF-2α PAS B domain (IC50:...
|
T10233 |
Acetylarenobufagin
|
184673-79-8
|
98.54%
|
|
Acetylarenobufagin is a steroidal hypoxia-inducible factor-1 (HIF-1) modulator.
|
T4S0800 |
Demethyleneberberine
|
25459-91-0
|
98.54%
|
|
Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either ...
|
T67831 |
HIF-2α agonist 2
|
2750141-15-0
|
98.32%
|
|
HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structu...
|
T15396 |
GN44028
|
1421448-26-1
|
98.20%
|
|
GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 ...
|
T5537 |
IDF-11774
|
1429054-28-3
|
98%
|
|
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
|