HIF/HIF Prolyl-Hydroxylase

HIF prolyl-hydroxylase is an enzyme involved in the HIF (Hypoxia-inducible factor) signalling pathways, and is the target for a set of therapeutic drugs called HIF prolyl-hydroxylase inhibitors. Hypoxia-inducible factor (HIF) is an evolutionarily conserved transcription factor that allows the cell to respond physiologically to low concentrations of oxygen. A class of prolyl hydroxylases which act specifically on HIF has been identified; hydroxylation of HIF allows the protein to be targeted for degradation.

Cat. No.	Product name	CAS No.	Purity
T78123	HIF-1α-IN-2 hydrochloride		98%
T78123	HIF-1α-IN-2 hydrochloride is a potent HIF-1α inhibitor exhibiting anticancer activity, demonstrated by IC50 values of 28 nM in MDA-MB-231 cells and 15 nM in MiaP...
T78834	HIV-IN-7		98%
T78834	Axl-IN-16 (Compound 4), an Axl inhibitor, not only suppresses Axl expression and HIF activity but also triggers fruiting body formation in Flammulina velutipes. ...
T78937	HIF-2α-IN-9	2648334-36-3	98%
T78937	HIF-2α-IN-9 (compound 35r) serves as an HIF-2α inhibitor, effectively suppressing VEGF-A with an IC50 of 305 nM, and modulating growth-promoting genes within tum...
T79241	PHD2-IN-1	2768219-28-7	98%
T79241	PHD2-IN-1, a potent and orally active HIF prolyl hydroxylase 2 (PHD2) inhibitor, exhibits an IC50 of 22.53 nM and is applicable in anemia research [1].
T79720	VHL-IN-1		98%
T79720	VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1α and enhanc...
T79797	PHD-IN-1	2924182-31-8	98%
T79797	PHD-IN-1 (compound 80) serves as a potent PHD2 inhibitor, exhibiting an IC50 value of ≤5 nM. It demonstrates EC50 values of 2.5 μM in EPO Elisa assays within bot...
T79798	PHD-IN-2	2924182-42-1	98%
T79798	PHD-IN-2 (Compound 91), a potent PHD antagonist with an IC50 of less than 5 nM, effectively stimulates erythropoietin synthesis in HEP3B cells with an EC50 of le...
T82198	HIF-1α-IN-6		98%
T82198	HIF-1α-IN-6 (compound 3s) is a potent inhibitor of HIF-1α, demonstrating IC50 values of 0.6 nM and 53.3 nM in MiaPaCa-2 and MDA-MB-231 cells, respectively. It su...
T82199	HIF-1 alpha (556-574) (TFA)		98%
T82199	HIF-1 alpha (556-574) TFA is a 19-residue fragment of hypoxia-inducible factor-1 (HIF-1), which serves as the master regulator of oxygen homeostasis [1].
T74217	Angiogenesis agent 1	2765218-28-6	98%
T74217	Angiogenesis Agent 1 (Compound C-31), a glycoside analogue derived from salidroside, acts as an activator of the HIF-1α pathway and shows potential in diabetic h...
T64336	Izilendustat	1303512-02-8	99.95%
T64336	Tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate inhibit of human recombinant EGLN-1 as substrate after 20 m...
T2763	Panaxadiol	19666-76-3	99.9%
T2763	Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.
T1205	Chloramphenicol	56-75-7	99.89%
T1205	Chloramphenicol (Chloromycetin), a broad-spectrum antibiotic, blocks bacterial protein synthesis.
T0244	Tilorone dihydrochloride	27591-69-1	99.84%
T0244	Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.
T1637	Deferoxamine Mesylate	138-14-7	99.8%
T1637	Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor. Deferoxamine Mesylate binds free iron into a stable complex and reduces iron accumulat...
T5761	Notoginsenoside Ft1	155683-00-4	99.75%
T5761	Notoginsenoside Ft1 is a saponin originally isolated from P. notoginseng with diverse biological activities
T0429	Glucosamine	3416-24-8	99.72%
T0429	Glucosamine (Chitosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine ...
T3816	Velutin	25739-41-7	99.69%
T3816	Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as ...
T6S1315	Oroxylin A	480-11-5	99.67%
T6S1315	1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses...
T2488	BAY 87-2243	1227158-85-1	99.65%
T2488	BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).