HIF/HIF Prolyl-Hydroxylase

HIF prolyl-hydroxylase is an enzyme involved in the HIF (Hypoxia-inducible factor) signalling pathways, and is the target for a set of therapeutic drugs called HIF prolyl-hydroxylase inhibitors. Hypoxia-inducible factor (HIF) is an evolutionarily conserved transcription factor that allows the cell to respond physiologically to low concentrations of oxygen. A class of prolyl hydroxylases which act specifically on HIF has been identified; hydroxylation of HIF allows the protein to be targeted for degradation.

Cat. No.	Product name	CAS No.	Purity
T6S1315	Oroxylin A	480-11-5	99.67%
T6S1315	1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses...
T2488	BAY 87-2243	1227158-85-1	99.65%
T2488	BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
T15219	Enarodustat	1262132-81-9	99.61%
T15219	Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.
T5S2347	Deoxyshikonin	43043-74-9	99.58%
T5S2347	1. Deoxyshikonin (Arnebin 7) may be a new drug candidate for wound healing and treatment of lymphatic diseases. 2. Deoxyshikonin enhances the ability of human de...
T0153	Oltipraz	64224-21-1	99.56%
T0153	Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes...
T2792	Glucosamine sulfate	29031-19-4	99.49%
T2792	Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.
T5392	TP0463518	1558021-37-6	99.43%
T5392	TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively).
T2805	Chlorogenic Acid	327-97-9	99.43%
T2805	Chlorogenic Acid (NSC-407296) is a naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidat...
T7848	PT-2385	1672665-49-4	99.39%
T7848	PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).
T6S0071	Fraxinellone	28808-62-0	99.35%
T6S0071	1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhib...
T11561	HIF-2α-IN-2	1672666-82-8	99.33%
T11561	HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).
T13289	EHP-101	1818428-24-8	99.22%
T13289	EHP-101 (VCE-004.8) is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. EHP-101 attenuates adipogenesis and prevents die...
T3169	KC7F2	927822-86-4	99.11%
T3169	KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.
T3494	LW6	934593-90-5	99.10%
T3494	LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.
T13050	SYP-5	1384268-04-5	99.1%
T13050	SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.
T1613	Hydralazine hydrochloride	304-20-1	99.1%
T1613	Hydralazine hydrochloride (Apresoline) is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic acti...
T17105	TM6089	863421-32-3	99.07%
T17105	TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.
T12675L	PT2399	1672662-14-4	99.07%
T12675L	PT2399 shows effective antitumor activity in vivo. PT2399 is an effective and selective HIF-2α antagonist, which directly binds to the HIF-2α PAS B domain (IC50:...
T2941	Glucosamine hydrochloride	66-84-2	99.07%
T2941	Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.
T7880	IOX4	1154097-71-8	98.87%
T7880	IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)