Home Tools
Log in
Cart

HIF/HIF Prolyl-Hydroxylase

HIF prolyl-hydroxylase is an enzyme involved in the HIF (Hypoxia-inducible factor) signalling pathways, and is the target for a set of therapeutic drugs called HIF prolyl-hydroxylase inhibitors. Hypoxia-inducible factor (HIF) is an evolutionarily conserved transcription factor that allows the cell to respond physiologically to low concentrations of oxygen. A class of prolyl hydroxylases which act specifically on HIF has been identified; hydroxylation of HIF allows the protein to be targeted for degradation.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T2445 FG-2216 223387-75-5 98.32%
FG-2216
FG-2216 (YM-311) is a potent HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme (IC50: 3.9 uM); orally bioavailable and induced reversible and significant Epo ...
T67831 HIF-2α agonist 2 2750141-15-0 98.32%
HIF-2α agonist 2
HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structu...
T0256 Citric acid trilithium salt tetrahydrate 6080-58-6 98%
Citric acid trilithium salt tetrahydrate
Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of psychiat...
T5684 Ethyl 3,4-dihydroxybenzoate 3943-89-3 98%
Ethyl 3,4-dihydroxybenzoate
Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
TL0001 Dencichine 5302-45-4 98%
dencichine
Dencichine (ODAP) is a neurotoxic agent. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of the coagulation system, platelet aggre...
T5537 IDF-11774 1429054-28-3 98%
IDF-11774
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
T1823 IOX2 931398-72-0 98%
IOX2
IOX2 (IOX 2) is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in cells with the IC50 value of 21 nM for PHD2/ELGN...
T3180 JNJ-42041935 1193383-09-3 98%
JNJ-42041935
JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.
T5S1569 AKBA 67416-61-9 97.85%
AKBA
1. AKBA (3-O-Acetyl-11-keto-beta-boswellic acid) inhibits 5-lipoxygenase product formation with an IC(5) of 1.5 m muM.
T21653 1,4-DPCA 331830-20-7 97.75%
1,4-DPCA
1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HI...
T29797 AKB-6899 1007377-55-0 97.11%
AKB-6899
AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macr...
T11589 Hydroxycitric acid tripotassium hydrate 6100-05-6 95%
Hydroxycitric acid tripotassium hydrate
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-...
T1101 Minocycline hydrochloride 13614-98-7 100%
Minocycline hydrochloride
Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infe...
T7802 M1001 874590-32-6 100%
M1001
M1001 is a HIF-2α agonist.
T1141 Fenbendazole 43210-67-9 100%
Fenbendazole
Fenbendazole (Fenbendazol) is an antinematodal benzimidazole used in veterinary medicine.
T50099 HIF-2α-IN-4 882268-69-1
HIF-2α-IN-4
HIF-2a translation inhibitor is a compound used as a molecular building block.
T9627 PHD-1-IN-1 2009343-14-8 98%
PHD-1-IN-1
PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).
T3289 Amifostine 20537-88-6 98%
Amifostine
Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.
T3S2344 β,β-Dimethylacrylshikonin 24502-79-2 98%
β,β-Dimethylacrylshikonin
1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of D...
T6381 Amifostine trihydrate 112901-68-5 98%
Amifostine trihydrate
Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.
FG-2216
T2445
FG-2216 (YM-311) is a potent HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme (IC50: 3.9 uM); orally bioavailable and induced reversible and significant Epo ...
HIF-2α agonist 2
T67831
HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structu...
Citric acid trilithium salt tetrahydrate
T0256
Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of psychiat...
Ethyl 3,4-dihydroxybenzoate
T5684
Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
dencichine
TL0001
Dencichine (ODAP) is a neurotoxic agent. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of the coagulation system, platelet aggre...
IDF-11774
T5537
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
IOX2
T1823
IOX2 (IOX 2) is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in cells with the IC50 value of 21 nM for PHD2/ELGN...
JNJ-42041935
T3180
JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.
AKBA
T5S1569
1. AKBA (3-O-Acetyl-11-keto-beta-boswellic acid) inhibits 5-lipoxygenase product formation with an IC(5) of 1.5 m muM.
1,4-DPCA
T21653
1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HI...
AKB-6899
T29797
AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macr...
Hydroxycitric acid tripotassium hydrate
T11589
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-...
Minocycline hydrochloride
T1101
Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infe...
M1001
T7802
M1001 is a HIF-2α agonist.
Fenbendazole
T1141
Fenbendazole (Fenbendazol) is an antinematodal benzimidazole used in veterinary medicine.
HIF-2α-IN-4
T50099
HIF-2a translation inhibitor is a compound used as a molecular building block.
PHD-1-IN-1
T9627
PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).
Amifostine
T3289
Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.
β,β-Dimethylacrylshikonin
T3S2344
1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of D...
Amifostine trihydrate
T6381
Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.
1 2 3 4
TargetMol