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Microbiology&virology HIV Protease

HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.
Cat No. product name
T0100 Atazanavir sulfate Atazanavir sulfate is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENT...
T0100L Atazanavir Atazanavir(BMS-232632) is an highly effective HIV-1 protease inhibitor.
T0110 Zalcitabine Zalcitabine(Dideoxycytidine;ddC; 2',3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, It can potently in...
T10111 3-Deazaadenosine hydrochloride 3-Deazaadenosine hydrochloride is an inhibitor of S-adenosylhomocysteine hydrolase (Ki: 3.9 µM). It has anti-inflammatory, anti-proliferative, and anti-HIV act...
T10111L 3-Deazaadenosine 3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 µM, and it has anti-inflammatory, anti-proliferative and anti-HIV activi...
T10296 Mavorixafor trihydrochloride Mavorixafor trihydrochloride is a selective and orally available CXCR4 antagonist (IC50: 13 nM against CXCR4 125I-SDF binding) and also inhibits the replication...
T10570 Fostemsavir Tris Fostemsavir Tris is the prodrug of BMS-626529. Fostemsavir Tris is an attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells.
T10658 CA inhibitor 1 CA inhibitor 1 (GS-6207 analog) is a potent inhibitor of the HIV capsid.
T10714 CCR5 antagonist 1 CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.
T10928 Cytochalasin A Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM)...
T11189 Emtricitabine S-oxide Emtricitabine is a potent nucleoside reverse transcriptase inhibitor used for the treatment of HIV infection.Emtricitabine S-oxide (Emtricitabine sulfoxide) is ...
T12420 Pentosan Polysulfate Pentosan Polysulfate is a potent and selective anti-HIV agent.with anti-inflammatory and pro-chondrogenic properties,and used for treatment of interstitial cyst...
T12420L Pentosan Polysulfate Sodium Pentosan Polysulfate Sodium is a potent and selective anti-HIV agent.with anti-inflammatory and pro-chondrogenic properties,and used for treatment of interstiti...
T1267 Abacavir Abacavir is a nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune...
T12715 Reverse transcriptase-IN-1 Reverse transcriptase-IN-1 is a diarylbenzopyrimidine (DABP) analogue and a potent, orally active HIV-1 nonnucleoside reverse transcriptase inhibitor.
T12953 Sodium copper chlorophyllin B Sodium copper chlorophyllin B exerts antiviral activities against Influenza virus and HIV (IC50s of 50 to 100 μM).
T13796 Nigranoic acid Nigranoic acid is a natural product,and inhibits HIV-1 reverse transcriptase.
T14208 AMD 3465 AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM). However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) ...
T14307 Aplaviroc Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.
T14313 Apricitabine Apricitabine (SPD754; AVX754) shows promising antiretroviral efficacy, good tolerability and a low propensity for resistance selection in antiretroviral-naive H...
T14488 Azt-pmap Azt-pmap shows anti-HIV activity[1]. Azt-pmap, a nucleoside analogue, is an aryl phosphate derivative of AZT. AZT is a nucleoside reverse transcriptase inhibito...
T14559 BI 224436 BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.
T14831 Bryostatin 1 Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS)permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domai...
T15210 Elsulfavirine Elsulfavirine is an HIV-1 infection reverse transcriptase inhibitor. It is a new anti-HIV drug.
T1525 Ritonavir Ritonavir is a peptidomimetic agent that inhibits both HIV-1 and HIV-2 proteases. Ritonavir is highly inhibited by serum proteins but boosts the effect of other...
T15371 Gardiquimod Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection ...
T15683 L-689502 L-689502 is a potent HIV-l protease inhibitor (IC50: 1 nM).
T1595 Nevirapine Nevirapine is a benzodiazepine non-nucleoside reverse transcriptase inhibitor. In combination with other antiretroviral drugs, nevirapine reduces HIV viral load...
T16096 Filorexant Filorexant is an orally bioavailable effective and selective reversible OX1 and OX2 receptor antagonist (<3 nM in binding).
T16112 ML67-33 ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) (EC50s: 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively). ML67-33 is a selective activat...
T1623 Lopinavir Lopinavir is a peptidomimetic HIV protease inhibitor that retains activity against HIV protease with the Val 82 mutation. Lopinavir is less affected by binding ...
T16500 PF-3450074 PF-3450074 acts at an early stage of HIV-1 infection inhibits viral replication by directly competing with the binding of CPSF6 (nuclear host factors cleavage a...
T16548 PKF050-638 PKF050-638 inhibits the CRM1-mediated Rev nuclear export by disrupting CRM1-NES interaction. PKF050-638 is an effective and selective inhibitor of HIV-1 Rev (IC...
T16555 PNU-103017 PNU-103017 is an inhibitor of HIV protease.
T16829 (S)-BI-1001 (S)-BI-1001 is an active S-enantiomer of BI-1001. (S)-BI-1001 has antiviral potency against HIV-1 integrase (IC50: 28 nM, and EC50: 450 nM and a Kd: 4.7 μM).
T16973 TAK-220 TAK-220 is a selective and orally bioavailable CCR5 antagonist (IC50s: 3.5 nM and 1.4 nM for inhibition on the binding of RANTES and MIP-1α to CCR5, respective...
T1815 Dapivirine Dapivirine is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.
T1883 Des(benzylpyridyl) Atazanavi Atazanavir is a highly effective HIV-1 protease inhibitor.
T2239 Raltegravir potassium Raltegravir potassium salt(MK0518 potassium salt) is a potent integrase (IN) inhibitor, used to treat HIV infection.
T2324 Darunavir Darunavir is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alo...
T2329 Dolutegravir sodium Dolutegravir sodium salt(DTG; GSK1349572) is an HIV integrase inhibitor(IC50: 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q1...
T2332 Elvitegravir Elvitegravir is a Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor. The mechanism of action of elvitegravir is as an HIV Integrase Inhibitor, an...
T2393 Efavirenz Efavirenz is a Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of efavirenz is as a Non-Nucleoside...
T2409L Tenofovir Disoproxil Fumarate Tenofovir Disoproxil Fumarate is a pro-drug, fumaric acid salt form of tenofovir, a nucleoside reverse transcriptase inhibitor analog of adenosine. Tenofovir di...
T2728 Limonin Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.
T2830 Betulinic acid Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretro...
T2S0223 Isosinensetin 1. Isosinensetin shows antioxidant and HIV-1 protease inhibiting activities.
T2S0605 Liquidambaric lactone Liquidambaric lactone may have inhibitory HIV-1 reverse transcriptase activity.
T3172 Trovirdine Trovirdine is a thiourea non-nucleoside reverse transcriptase inhibitor.
T3335 Darunavir Ethanolate Darunavir ethanolate is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE wh...
T3523 Fostemsavir BMS-663068 is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection.
T3632 Doravirine Doravirine is a non-nucleoside reverse transcriptase inhibitor, used in the treatment of HIV/AIDS.
T3683 lithospermic acid lithospermic acid is a potent anti-HIV agent and shows anti-gonadotrophic and anti-thyroidal effects.
T3732 Sebacic acid Sebacic acid is a saturated, straight-chain naturally occurring dicarboxylic acid.
T3S2007 MRE-269 Ursonic acid belongs to the family of Ursane Triterpenes whose structure is based on the pentacyclic ursane skeleton. It has potential as HIV-1 Protease Inhibit...
T4493 Bictegravir Bictegravir is a potent inhibitor of HIV-1 integrase (IC50: 7.5 nM).
T4537 SodiumCholate SodiumCholate exhibits a strong spermicidal and antiviral [anti-human immunodeficiency virus (HIV)-1] activity.
T4962 Ginsenoside Z-R1 Zingibroside R1 has anti-HIV-1 activity.
T4S0295 Cosmosiin 1. Cosmosiin is a anti-HIV agent. 2. Cosmosiin may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylati...
T4S1383 Escin IA;Aescin IA Escin IA is a triterpene saponin isolated from horse chestnut, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activ...
T4S1718 Punicalin Punicalin exerts anti-inflammatory, antioxidative, and anti-hepatotoxic activities, it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-depend...
T4S1999 Valepotriate Valepotriate fraction can have sedative effects and affect behavioral parameters related to recognition memory. Valepotriates, a new class of cytotoxic and anti...
T5782 Bevirimat Bevirimat(PA-457) is a first-in-class inhibitor of HIV-1 maturation, blocking the cleavage of the Gag capsid (CA) precursor, CA-SPI, to mature CA protein during...
T5863 Indinavir sulfate Indinavir is a HIV protease inhibitor.It inhibits the HIV-1 protease with an IC50 value of 0.41 nM and Ki value of 0.24 nM.
T5965 Ditiocarb sodium Ditiocarb sodium (Sodium diethyldithiocarbamate) is an accelerator of the rate of copper cementation. Sodium diethyldithiocarbamate reduces the incidence of HIV...
T6001 Nelfinavir Mesylate Nelfinavir Mesylate is an effective HIV protease inhibitor (Ki: 2 nM).
T6065 Triciribine Triciribine is a DNA synthesis inhibitor, and it also inhibits Akt and HIV-1/2.
T6098 Cabotegravir Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM).
T6198 Dolutegravir Dolutegravir (IC50=2.7 nM), a two-metal-binding HIV integrase inhibitor, exhibits medium activity against raltegravir-resistant signature mutants Y143R, Q148K, ...
T6256 YYA-021 YYA-021 inhibits HIV entry, with high anti-HIV activity and low cytotoxicity.
T6367 Abacavir sulfate Abacavir, a nucleoside analogue,effectively utilize its antiviral activity
T6388 Amprenavir Amprenavir is a synthetic derivative of hydroxyethylamine sulfonamide that selectively binds to and inhibits human immunodeficiency virus (HIV) protease.
T6420 BMS-707035 BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2.
T6653 Salmeterol Xinafoate Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstr...
T7111 Tenofovir Disoproxil Tenofovir Disoproxil is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.
T7212 Delavirdine (mesylate) Delavirdine (mesylate) is a non-nucleoside reverse transcriptase inhibitor (NNRTI).
T7282 Tenofovir alafenamide fumarate Tenofovir alafenamide fumarate (TAF) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV)
T7382 NBD-557 NBD-557 is a potentially HIV-1 inhibitor.
T7455 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is an inhibitor of HIV-1 RT (HIV reverse transcriptase) .
T7700 Lersivirine(UK 453061) Lersivirine(UK 453061) is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) under development for HIV infection therapy. 
T7779 Nelfinavir Nelfinavir is an antiretroviral drug used in the treatment of the human immunodeficiency virus (HIV) (Ki=2 nM). Nelfinavir is a broad-spectrum, anticancer agen...
T7789 DRB DRB is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II (IC50 range of 4-10 µM)
T7903 Saquinavir Saquinavir is a potent HIV protease inhibitor, is an antiretroviral drug used together with other medications to treat or prevent HIV/AIDS.
T8156 Saquinavir mesylate Saquinavir mesylate is an  Inhibitor of HIV Proteaseused in antiretroviral therapy
T8238 Fosamprenavir Calcium Salt Fosamprenavir Calcium Salt (GW433908G) is a phosphate ester prodrug of the antiretroviral protease inhibitor Amprenavir, with improved solubility[1]. Anti-HIV i...
T8311 ABX-464 ABX-464 is a potent anti-HIV agent. ABX464 inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) (IC50 : 0.1 μM - 0.5 μM) 
T8689 CHLOROQUINE Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria an...
TL0006 Chicoric Acid Chicoric Acid is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a class of cannabinomimetic...
TMA1012 Ganoderiol F Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency vir...
TN1047 Ingenol mebutate Ingenol mebutate shows anticancer activity, and P-gp-mediated absorptive transport, dermal penetration, and vascular damage contribute to the anticancer activit...
TN1194 16beta,17-Dihydroxy-ent-kaurane-19-oic acid 16beta,17-Dihydroxy-ent-kaurane-19-oic acid as an anti-HIV principle, it showed significant activity against HIV replication in H9 lymphocyte cells with an EC50...
TN1235 3,4,5-Tricaffeoylquinic acid 3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like r...
TN1302 6,8-Diprenylorobol 6,8-Diprenylorobol possesses weaker anti-H. pylori activity, it may be a useful chemopreventive agent for peptic ulcer or gastric cancer in H. pylori-infected i...
TN1348 8-Prenylluteone 8-Prenylluteone can potently inhibit HIV-1 PR activity.
TN1587 Dihydroseselin Dihydroseselin type of pyranocoumarin possessing a 4'-isovaleryl group is important to suksdorfin's enhanced anti-HIV activity.
TN1670 Ganodermanondiol Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated ant...
TN1708 Gomisin M2 Gomisin M2 is an anti-HIV agent.
TN1727 Helichrysetin Helichrysetin has mild anti-HIV-1 PR activity. Helichrysetin has great potentials for development as an anticancer agent, it has cytotoxic effect on four select...
TN1767 Interiotherin A Interiotherin A inhibits HIV replication with the EC50 value of 3.1 micrograms/mL.
TN1852 Lancifodilactone F Lancifodilactone F exerts minimal cytotoxicity against C8166 cells (CC50 > 200 microg/mL) and shows anti-HIV activity with EC50 = 20.69 +/- 3.31 microg/mL and a...
TN1866 Licoricesaponin G2 Licoricesaponin G2 has the anti-inflammatory effects as NF-κB inhibitors, it has anti-HIV activity via significantly interacted with R15K.
TN2097 Pomolic acid Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-media...
TN2158 Robinetin Robinetin has antioxidant and antiradical activities, inhibits EYPC membrane lipid peroxidation and HbA glycosylation with high efficiency.
TN2186 Schisantherin D Schisantherin D shows good anti-HIV activity with the EC50 value of 0.5 micrograms/mL, and the therapeutic index (TI) value of 110.
TN2231 Soyasaponin II Soyasaponin II has antiviral effects, it can inhibit the replication of human cytomegalovirus, influenza virus, and human immunodeficiency virus type 1.
TN2283 Tripterifordin Tripterifordin shows anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 1 microgram/ml.
TN2284 Triptonine B Triptonine B demonstrates potent anti-HIV activity with an EC(50) value of <0.10 microg/mL and an in vitro therapeutic index value of >1000.
TN2839 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid has anti-HIV activity. It shows an inhibitory effect on the activation of Epstein-Barr virus early antigen ...
TN3119 5-Hydroxy-7,8-dimethoxyflavanone 5-Hydroxy-7,8-dimethoxyflavanone shows anti-inflammatory activity, it can significantly decrease TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2), and...
TN3152 6-Acetonyldihydrochelerythrine 6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therap...
TN3444 Aristolactam BII Aristolactam BII exhibits antimicrobial and antiinflammatory activity, it shows significant activity towards DPPH radical scavenging and potent inhibitory effec...
TN3567 Calanolide E Calanolide E2 has anti-HIV activity.
TN3704 Coronalolide Coronalolide shows significant cytotoxic activities in P-388 cell line, it also displays significant anti-HIV activities in the HIV-1RT assay. Coronalolide and ...
TN3705 Coronalolide methyl ester Coronalolide methyl ester displays significant anti-HIV activities in the HIV-1RT assay. It and coronalolide show broad cytotoxic activity against a panel of hu...
TN3777 Daurichromenic acid Daurichromenic acid is a terpenophenol with a potent anti-HIV activity.
TN4109 Ganolucidic acid A Ganolucidic acid A exhibits cytotoxicity, has inhibitory activities against human HeLa cervical cancer cell lines. It shows significant anti-human immunodeficie...
TN4264 Isoapetalic acid Isoapetalic acid and apetalic acid exhibit cytotoxic activities towards both cancer cell lines(human breast cancer (MCF-7) and human lung carcinoma (A-549) cell...
TN4347 Jacoumaric acid Jacoumaric acid is a lead molecule from the library or database of natural compounds as a HIV-1 protease inhibitor.
TN4433 Licoarylcoumarin Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE s...
TN4539 Methyl chanofruticosinate Methyl chanofruticosinate has weak anti-HIV-1 activity.
TN4555 Methyl salvionolate A Methyl salvionolate A has anti-HIV-1 activity.
TN4584 Morolic acid Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent chang...
TN4585 Moronic acid Moronic acid shows oral therapeutic efficacy in HSV-infected mice and possessed novel anti-HSV activity. It also shows significant anti-HIV activity (EC(50) 186...
TN4605 Myriceric acid B Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41 and can serve as a lead compound for developing novel anti-HIV-1 drug. Myriceric acid B scaven...
TN4646 Neotripterifordin Neotripterifordin shows potent anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 25 nM and TI of 125.
TN4673 (+)-Nortrachelogenin (+)-Nortrachelogenin is moderately active against HIV-1 in vitro; it also can induce morphological deformation of P. oryzae mycelia with the MMDC value of 31.3 ...
TN4675 Nortrachelogenin Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth...
TN4820 Pre-schisanartanin B Pre-schisanartanin B has cytotoxicity, it also has anti-HIV-1 activity.
TN4835 Przewalskin Przewalskin A and Przewalskin B showed modest anti-HIV-1 activity with EC50 = 41 and 30 microg/mL, respectively.
TN4911 Rhuscholide A Rhuscholide A possesses significant anti-HIV-1 activity with an EC50 value of 1.62 microM and a therapeutic index (TI) of 42.40.
TN4934 Salaspermic acid Salaspermic acid is an inhibitor of HIV reverse transcriptase and HIV replication in H9 lymphocyte cells.
TN5011 Shizukaol B Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinf...
TN5012 Shizukaol C 1. Shizukaol C shows anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains. <br/> 2. Shizukaol C has significant cytotoxici...
TN5133 3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone 5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it ...
TN5177 Trigothysoid N Trigothysoid N may have anti-HIV activity.
TN5191 Tsugafolin Tsugafolin has weak anti-HIV activity.
TN5243 Vitexilactone Vitexilactone is a HIV-1 reverse transcriptase inhibitor in virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse tran...
TN5263 Xanthohumol Xanthohumol has anti-hepatitis C virus, anti-carcinogenic, free radical-scavenging, and anti-inflammatory activities, it can inhibit HIV-1 induced cytopathic ef...
TP1348 FC131 TFA FC131 TFA is an antagonist of CXCR4 that inhibits the binding of [125I] -sdf-1 to CXCR4(IC50 : 4.5 nM ), and has anti-hiv activity.
TP1809 TAT TAT (YGRKKRRQRRR) is derived from the transactivator of transcription (TAT) of human immunodeficiency virus-1 (HIV-1) and is a cell-penetrating peptide. TAT can...
TQ0217 Gomisin G Gomisin G is a natural compound and exhibits potent anti-HIV activity (EC50: 0.006 μg/mL; therapeutic index: 300). It is a good substrate of CYP2C9.
TQ0297 Cenicriviroc Cenicriviroc is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-inflammatory ...
Atazanavir sulfate
T0100CAS 229975-97-7
Atazanavir sulfate is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENT...
Atazanavir
T0100LCAS 198904-31-3
Atazanavir(BMS-232632) is an highly effective HIV-1 protease inhibitor.
Zalcitabine
T0110CAS 7481-89-2
Zalcitabine(Dideoxycytidine;ddC; 2',3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, It can potently in...
3-Deazaadenosine hydrochloride
T10111CAS 86583-19-9
3-Deazaadenosine hydrochloride is an inhibitor of S-adenosylhomocysteine hydrolase (Ki: 3.9 µM). It has anti-inflammatory, anti-proliferative, and anti-HIV act...
3-Deazaadenosine
T10111LCAS 6736-58-9
3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 µM, and it has anti-inflammatory, anti-proliferative and anti-HIV activi...
Mavorixafor trihydrochloride
T10296CAS 2309699-17-8
Mavorixafor trihydrochloride is a selective and orally available CXCR4 antagonist (IC50: 13 nM against CXCR4 125I-SDF binding) and also inhibits the replication...
Fostemsavir Tris
T10570CAS 864953-39-9
Fostemsavir Tris is the prodrug of BMS-626529. Fostemsavir Tris is an attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells.
CA inhibitor 1
T10658CAS 2189684-45-3
CA inhibitor 1 (GS-6207 analog) is a potent inhibitor of the HIV capsid.
CCR5 antagonist 1
T10714CAS 716354-86-8
CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.
Cytochalasin A
T10928CAS 14110-64-6
Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM)...
Emtricitabine S-oxide
T11189CAS 152128-77-3
Emtricitabine is a potent nucleoside reverse transcriptase inhibitor used for the treatment of HIV infection.Emtricitabine S-oxide (Emtricitabine sulfoxide) is ...
Pentosan Polysulfate
T12420CAS 37300-21-3
Pentosan Polysulfate is a potent and selective anti-HIV agent.with anti-inflammatory and pro-chondrogenic properties,and used for treatment of interstitial cyst...
Pentosan Polysulfate Sodium
T12420LCAS 140207-93-8
Pentosan Polysulfate Sodium is a potent and selective anti-HIV agent.with anti-inflammatory and pro-chondrogenic properties,and used for treatment of interstiti...
Abacavir
T1267CAS 136470-78-5
Abacavir is a nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune...
Reverse transcriptase-IN-1
T12715CAS 2380001-43-2
Reverse transcriptase-IN-1 is a diarylbenzopyrimidine (DABP) analogue and a potent, orally active HIV-1 nonnucleoside reverse transcriptase inhibitor.
Sodium copper chlorophyllin B
T12953CAS 28302-36-5
Sodium copper chlorophyllin B exerts antiviral activities against Influenza virus and HIV (IC50s of 50 to 100 μM).
Nigranoic acid
T13796CAS 39111-07-4
Nigranoic acid is a natural product,and inhibits HIV-1 reverse transcriptase.
AMD 3465
T14208CAS 185991-24-6
AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM). However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) ...
Aplaviroc
T14307CAS 461443-59-4
Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.
Apricitabine
T14313CAS 160707-69-7
Apricitabine (SPD754; AVX754) shows promising antiretroviral efficacy, good tolerability and a low propensity for resistance selection in antiretroviral-naive H...
Azt-pmap
T14488CAS 142629-81-0
Azt-pmap shows anti-HIV activity[1]. Azt-pmap, a nucleoside analogue, is an aryl phosphate derivative of AZT. AZT is a nucleoside reverse transcriptase inhibito...
BI 224436
T14559CAS 1155419-89-8
BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.
Bryostatin 1
T14831CAS 83314-01-6
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS)permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domai...
Elsulfavirine
T15210CAS 868046-19-9
Elsulfavirine is an HIV-1 infection reverse transcriptase inhibitor. It is a new anti-HIV drug.
Ritonavir
T1525CAS 155213-67-5
Ritonavir is a peptidomimetic agent that inhibits both HIV-1 and HIV-2 proteases. Ritonavir is highly inhibited by serum proteins but boosts the effect of other...
Gardiquimod
T15371CAS 1020412-43-4
Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection ...
L-689502
T15683CAS 138483-63-3
L-689502 is a potent HIV-l protease inhibitor (IC50: 1 nM).
Nevirapine
T1595CAS 129618-40-2
Nevirapine is a benzodiazepine non-nucleoside reverse transcriptase inhibitor. In combination with other antiretroviral drugs, nevirapine reduces HIV viral load...
Filorexant
T16096CAS 1088991-73-4
Filorexant is an orally bioavailable effective and selective reversible OX1 and OX2 receptor antagonist (<3 nM in binding).
ML67-33
T16112CAS 1443290-89-8
ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) (EC50s: 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively). ML67-33 is a selective activat...
Lopinavir
T1623CAS 192725-17-0
Lopinavir is a peptidomimetic HIV protease inhibitor that retains activity against HIV protease with the Val 82 mutation. Lopinavir is less affected by binding ...
PF-3450074
T16500CAS 1352879-65-2
PF-3450074 acts at an early stage of HIV-1 infection inhibits viral replication by directly competing with the binding of CPSF6 (nuclear host factors cleavage a...
PKF050-638
T16548CAS 528893-52-9
PKF050-638 inhibits the CRM1-mediated Rev nuclear export by disrupting CRM1-NES interaction. PKF050-638 is an effective and selective inhibitor of HIV-1 Rev (IC...
PNU-103017
T16555CAS 166335-18-8
PNU-103017 is an inhibitor of HIV protease.
(S)-BI-1001
T16829CAS 957889-73-5
(S)-BI-1001 is an active S-enantiomer of BI-1001. (S)-BI-1001 has antiviral potency against HIV-1 integrase (IC50: 28 nM, and EC50: 450 nM and a Kd: 4.7 μM).
TAK-220
T16973CAS 333994-00-6
TAK-220 is a selective and orally bioavailable CCR5 antagonist (IC50s: 3.5 nM and 1.4 nM for inhibition on the binding of RANTES and MIP-1α to CCR5, respective...
Dapivirine
T1815CAS 244767-67-7
Dapivirine is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.
Des(benzylpyridyl) Atazanavi
T1883CAS 1192224-24-0
Atazanavir is a highly effective HIV-1 protease inhibitor.
Raltegravir potassium
T2239CAS 871038-72-1
Raltegravir potassium salt(MK0518 potassium salt) is a potent integrase (IN) inhibitor, used to treat HIV infection.
Darunavir
T2324CAS 206361-99-1
Darunavir is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alo...
Dolutegravir sodium
T2329CAS 1051375-19-9
Dolutegravir sodium salt(DTG; GSK1349572) is an HIV integrase inhibitor(IC50: 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q1...
Elvitegravir
T2332CAS 697761-98-1
Elvitegravir is a Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor. The mechanism of action of elvitegravir is as an HIV Integrase Inhibitor, an...
Efavirenz
T2393CAS 154598-52-4
Efavirenz is a Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of efavirenz is as a Non-Nucleoside...
Tenofovir Disoproxil Fumarate
T2409LCAS 202138-50-9
Tenofovir Disoproxil Fumarate is a pro-drug, fumaric acid salt form of tenofovir, a nucleoside reverse transcriptase inhibitor analog of adenosine. Tenofovir di...
Limonin
T2728CAS 1180-71-8
Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.
Betulinic acid
T2830CAS 472-15-1
Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretro...
Isosinensetin
T2S0223CAS 17290-70-9
1. Isosinensetin shows antioxidant and HIV-1 protease inhibiting activities.
Liquidambaric lactone
T2S0605CAS 185051-75-6
Liquidambaric lactone may have inhibitory HIV-1 reverse transcriptase activity.
Trovirdine
T3172CAS 149488-17-5
Trovirdine is a thiourea non-nucleoside reverse transcriptase inhibitor.
Darunavir Ethanolate
T3335CAS 635728-49-3
Darunavir ethanolate is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE wh...
Fostemsavir
T3523CAS 864953-29-7
BMS-663068 is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection.
Doravirine
T3632CAS 1338225-97-0
Doravirine is a non-nucleoside reverse transcriptase inhibitor, used in the treatment of HIV/AIDS.
lithospermic acid
T3683CAS 28831-65-4
lithospermic acid is a potent anti-HIV agent and shows anti-gonadotrophic and anti-thyroidal effects.
Sebacic acid
T3732CAS 111-20-6
Sebacic acid is a saturated, straight-chain naturally occurring dicarboxylic acid.
MRE-269
T3S2007CAS 475085-57-5
Ursonic acid belongs to the family of Ursane Triterpenes whose structure is based on the pentacyclic ursane skeleton. It has potential as HIV-1 Protease Inhibit...
Bictegravir
T4493CAS 1611493-60-7
Bictegravir is a potent inhibitor of HIV-1 integrase (IC50: 7.5 nM).
SodiumCholate
T4537CAS 361-09-1
SodiumCholate exhibits a strong spermicidal and antiviral [anti-human immunodeficiency virus (HIV)-1] activity.
Ginsenoside Z-R1
T4962CAS 80930-74-1
Zingibroside R1 has anti-HIV-1 activity.
Cosmosiin
T4S0295CAS 578-74-5
1. Cosmosiin is a anti-HIV agent. 2. Cosmosiin may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylati...
Escin IA;Aescin IA
T4S1383CAS 123748-68-5
Escin IA is a triterpene saponin isolated from horse chestnut, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activ...
Punicalin
T4S1718CAS 65995-64-4
Punicalin exerts anti-inflammatory, antioxidative, and anti-hepatotoxic activities, it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-depend...
Valepotriate
T4S1999CAS 18296-44-1
Valepotriate fraction can have sedative effects and affect behavioral parameters related to recognition memory. Valepotriates, a new class of cytotoxic and anti...
Bevirimat
T5782CAS 174022-42-5
Bevirimat(PA-457) is a first-in-class inhibitor of HIV-1 maturation, blocking the cleavage of the Gag capsid (CA) precursor, CA-SPI, to mature CA protein during...
Indinavir sulfate
T5863CAS 157810-81-6
Indinavir is a HIV protease inhibitor.It inhibits the HIV-1 protease with an IC50 value of 0.41 nM and Ki value of 0.24 nM.
Ditiocarb sodium
T5965CAS 148-18-5
Ditiocarb sodium (Sodium diethyldithiocarbamate) is an accelerator of the rate of copper cementation. Sodium diethyldithiocarbamate reduces the incidence of HIV...
Nelfinavir Mesylate
T6001CAS 159989-65-8
Nelfinavir Mesylate is an effective HIV protease inhibitor (Ki: 2 nM).
Triciribine
T6065CAS 35943-35-2
Triciribine is a DNA synthesis inhibitor, and it also inhibits Akt and HIV-1/2.
Cabotegravir
T6098CAS 1051375-10-0
Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM).
Dolutegravir
T6198CAS 1051375-16-6
Dolutegravir (IC50=2.7 nM), a two-metal-binding HIV integrase inhibitor, exhibits medium activity against raltegravir-resistant signature mutants Y143R, Q148K, ...
YYA-021
T6256CAS 144217-65-2
YYA-021 inhibits HIV entry, with high anti-HIV activity and low cytotoxicity.
Abacavir sulfate
T6367CAS 188062-50-2
Abacavir, a nucleoside analogue,effectively utilize its antiviral activity
Amprenavir
T6388CAS 161814-49-9
Amprenavir is a synthetic derivative of hydroxyethylamine sulfonamide that selectively binds to and inhibits human immunodeficiency virus (HIV) protease.
BMS-707035
T6420CAS 729607-74-3
BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2.
Salmeterol Xinafoate
T6653CAS 94749-08-3
Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstr...
Tenofovir Disoproxil
T7111CAS 201341-05-1
Tenofovir Disoproxil is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.
Delavirdine (mesylate)
T7212CAS 147221-93-0
Delavirdine (mesylate) is a non-nucleoside reverse transcriptase inhibitor (NNRTI).
Tenofovir alafenamide fumarate
T7282CAS 1392275-56-7
Tenofovir alafenamide fumarate (TAF) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV)
NBD-557
T7382CAS 333352-59-3
NBD-557 is a potentially HIV-1 inhibitor.
4-Chloro-2-(trifluoroacetyl)aniline hydrochloride
T7455CAS 173676-59-0
4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is an inhibitor of HIV-1 RT (HIV reverse transcriptase) .
Lersivirine(UK 453061)
T7700CAS 473921-12-9
Lersivirine(UK 453061) is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) under development for HIV infection therapy. 
Nelfinavir
T7779CAS 159989-64-7
Nelfinavir is an antiretroviral drug used in the treatment of the human immunodeficiency virus (HIV) (Ki=2 nM). Nelfinavir is a broad-spectrum, anticancer agen...
DRB
T7789CAS 53-85-0
DRB is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II (IC50 range of 4-10 µM)
Saquinavir
T7903CAS 127779-20-8
Saquinavir is a potent HIV protease inhibitor, is an antiretroviral drug used together with other medications to treat or prevent HIV/AIDS.
Saquinavir mesylate
T8156CAS 149845-06-7
Saquinavir mesylate is an  Inhibitor of HIV Proteaseused in antiretroviral therapy
Fosamprenavir Calcium Salt
T8238CAS 226700-81-8
Fosamprenavir Calcium Salt (GW433908G) is a phosphate ester prodrug of the antiretroviral protease inhibitor Amprenavir, with improved solubility[1]. Anti-HIV i...
ABX-464
T8311CAS 1258453-75-6
ABX-464 is a potent anti-HIV agent. ABX464 inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) (IC50 : 0.1 μM - 0.5 μM) 
CHLOROQUINE
T8689CAS 54-05-7
Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria an...
Chicoric Acid
TL0006CAS 6537-80-0
Chicoric Acid is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a class of cannabinomimetic...
Ganoderiol F
TMA1012CAS 114567-47-4
Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency vir...
Ingenol mebutate
TN1047CAS 75567-37-2
Ingenol mebutate shows anticancer activity, and P-gp-mediated absorptive transport, dermal penetration, and vascular damage contribute to the anticancer activit...
16beta,17-Dihydroxy-ent-kaurane-19-oic acid
TN1194CAS 74365-74-5
16beta,17-Dihydroxy-ent-kaurane-19-oic acid as an anti-HIV principle, it showed significant activity against HIV replication in H9 lymphocyte cells with an EC50...
3,4,5-Tricaffeoylquinic acid
TN1235CAS 86632-03-3
3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like r...
6,8-Diprenylorobol
TN1302CAS 66777-70-6
6,8-Diprenylorobol possesses weaker anti-H. pylori activity, it may be a useful chemopreventive agent for peptic ulcer or gastric cancer in H. pylori-infected i...
8-Prenylluteone
TN1348CAS 125002-91-7
8-Prenylluteone can potently inhibit HIV-1 PR activity.
Dihydroseselin
TN1587CAS 2221-66-1
Dihydroseselin type of pyranocoumarin possessing a 4'-isovaleryl group is important to suksdorfin's enhanced anti-HIV activity.
Ganodermanondiol
TN1670CAS 107900-76-5
Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated ant...
Gomisin M2
TN1708CAS 82425-45-4
Gomisin M2 is an anti-HIV agent.
Helichrysetin
TN1727CAS 62014-87-3
Helichrysetin has mild anti-HIV-1 PR activity. Helichrysetin has great potentials for development as an anticancer agent, it has cytotoxic effect on four select...
Interiotherin A
TN1767CAS 181701-06-4
Interiotherin A inhibits HIV replication with the EC50 value of 3.1 micrograms/mL.
Lancifodilactone F
TN1852CAS 850878-47-6
Lancifodilactone F exerts minimal cytotoxicity against C8166 cells (CC50 > 200 microg/mL) and shows anti-HIV activity with EC50 = 20.69 +/- 3.31 microg/mL and a...
Licoricesaponin G2
TN1866CAS 118441-84-2
Licoricesaponin G2 has the anti-inflammatory effects as NF-κB inhibitors, it has anti-HIV activity via significantly interacted with R15K.
Pomolic acid
TN2097CAS 13849-91-7
Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-media...
Robinetin
TN2158CAS 490-31-3
Robinetin has antioxidant and antiradical activities, inhibits EYPC membrane lipid peroxidation and HbA glycosylation with high efficiency.
Schisantherin D
TN2186CAS 64917-82-4
Schisantherin D shows good anti-HIV activity with the EC50 value of 0.5 micrograms/mL, and the therapeutic index (TI) value of 110.
Soyasaponin II
TN2231CAS 55319-36-3
Soyasaponin II has antiviral effects, it can inhibit the replication of human cytomegalovirus, influenza virus, and human immunodeficiency virus type 1.
Tripterifordin
TN2283CAS 139122-81-9
Tripterifordin shows anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 1 microgram/ml.
Triptonine B
TN2284CAS 168009-85-6
Triptonine B demonstrates potent anti-HIV activity with an EC(50) value of <0.10 microg/mL and an in vitro therapeutic index value of >1000.
2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid
TN2839CAS 176983-21-4
2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid has anti-HIV activity. It shows an inhibitory effect on the activation of Epstein-Barr virus early antigen ...
5-Hydroxy-7,8-dimethoxyflavanone
TN3119CAS 113981-49-0
5-Hydroxy-7,8-dimethoxyflavanone shows anti-inflammatory activity, it can significantly decrease TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2), and...
6-Acetonyldihydrochelerythrine
TN3152CAS 22864-92-2
6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therap...
Aristolactam BII
TN3444CAS 53948-09-7
Aristolactam BII exhibits antimicrobial and antiinflammatory activity, it shows significant activity towards DPPH radical scavenging and potent inhibitory effec...
Calanolide E
TN3567CAS 142566-61-8
Calanolide E2 has anti-HIV activity.
Coronalolide
TN3704CAS 268214-51-3
Coronalolide shows significant cytotoxic activities in P-388 cell line, it also displays significant anti-HIV activities in the HIV-1RT assay. Coronalolide and ...
Coronalolide methyl ester
TN3705CAS 268214-50-2
Coronalolide methyl ester displays significant anti-HIV activities in the HIV-1RT assay. It and coronalolide show broad cytotoxic activity against a panel of hu...
Daurichromenic acid
TN3777CAS 82003-90-5
Daurichromenic acid is a terpenophenol with a potent anti-HIV activity.
Ganolucidic acid A
TN4109CAS 98665-21-5
Ganolucidic acid A exhibits cytotoxicity, has inhibitory activities against human HeLa cervical cancer cell lines. It shows significant anti-human immunodeficie...
Isoapetalic acid
TN4264CAS 34366-34-2
Isoapetalic acid and apetalic acid exhibit cytotoxic activities towards both cancer cell lines(human breast cancer (MCF-7) and human lung carcinoma (A-549) cell...
Jacoumaric acid
TN4347CAS 63303-42-4
Jacoumaric acid is a lead molecule from the library or database of natural compounds as a HIV-1 protease inhibitor.
Licoarylcoumarin
TN4433CAS 125709-31-1
Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE s...
Methyl chanofruticosinate
TN4539CAS 14050-92-1
Methyl chanofruticosinate has weak anti-HIV-1 activity.
Methyl salvionolate A
TN4555CAS 1015171-69-3
Methyl salvionolate A has anti-HIV-1 activity.
Morolic acid
TN4584CAS 559-68-2
Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent chang...
Moronic acid
TN4585CAS 6713-27-5
Moronic acid shows oral therapeutic efficacy in HSV-infected mice and possessed novel anti-HSV activity. It also shows significant anti-HIV activity (EC(50) 186...
Myriceric acid B
TN4605CAS 55497-79-5
Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41 and can serve as a lead compound for developing novel anti-HIV-1 drug. Myriceric acid B scaven...
Neotripterifordin
TN4646CAS 149249-32-1
Neotripterifordin shows potent anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 25 nM and TI of 125.
(+)-Nortrachelogenin
TN4673CAS 61521-74-2
(+)-Nortrachelogenin is moderately active against HIV-1 in vitro; it also can induce morphological deformation of P. oryzae mycelia with the MMDC value of 31.3 ...
Nortrachelogenin
TN4675CAS 34444-37-6
Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth...
Pre-schisanartanin B
TN4820CAS 1033288-92-4
Pre-schisanartanin B has cytotoxicity, it also has anti-HIV-1 activity.
Przewalskin
TN4835CAS 119400-87-2
Przewalskin A and Przewalskin B showed modest anti-HIV-1 activity with EC50 = 41 and 30 microg/mL, respectively.
Rhuscholide A
TN4911CAS 944804-58-4
Rhuscholide A possesses significant anti-HIV-1 activity with an EC50 value of 1.62 microM and a therapeutic index (TI) of 42.40.
Salaspermic acid
TN4934CAS 71247-78-4
Salaspermic acid is an inhibitor of HIV reverse transcriptase and HIV replication in H9 lymphocyte cells.
Shizukaol B
TN5011CAS 142279-40-1
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinf...
Shizukaol C
TN5012CAS 142279-41-2
1. Shizukaol C shows anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains. <br/> 2. Shizukaol C has significant cytotoxici...
3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone
TN5133CAS 125537-92-0
5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it ...
Trigothysoid N
TN5177CAS 1501943-08-3
Trigothysoid N may have anti-HIV activity.
Tsugafolin
TN5191CAS 66568-97-6
Tsugafolin has weak anti-HIV activity.
Vitexilactone
TN5243CAS 61263-49-8
Vitexilactone is a HIV-1 reverse transcriptase inhibitor in virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse tran...
Xanthohumol
TN5263CAS 569-83-5
Xanthohumol has anti-hepatitis C virus, anti-carcinogenic, free radical-scavenging, and anti-inflammatory activities, it can inhibit HIV-1 induced cytopathic ef...
FC131 TFA
TP1348CAS TP1348
FC131 TFA is an antagonist of CXCR4 that inhibits the binding of [125I] -sdf-1 to CXCR4(IC50 : 4.5 nM ), and has anti-hiv activity.
TAT
TP1809CAS 191936-91-1
TAT (YGRKKRRQRRR) is derived from the transactivator of transcription (TAT) of human immunodeficiency virus-1 (HIV-1) and is a cell-penetrating peptide. TAT can...
Gomisin G
TQ0217CAS 62956-48-3
Gomisin G is a natural compound and exhibits potent anti-HIV activity (EC50: 0.006 μg/mL; therapeutic index: 300). It is a good substrate of CYP2C9.
Cenicriviroc
TQ0297CAS 497223-25-3
Cenicriviroc is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-inflammatory ...