HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.

Cat No.	product name
T0100	Atazanavir sulfate	Atazanavir sulfate is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENT...
T0100L	Atazanavir	Atazanavir(BMS-232632) is an highly effective HIV-1 protease inhibitor.
T0110	Zalcitabine	Zalcitabine(Dideoxycytidine;ddC; 2',3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, It can potently in...
T1267	Abacavir	Abacavir is a nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune...
T1525	Ritonavir	Ritonavir is a peptidomimetic agent that inhibits both HIV-1 and HIV-2 proteases. Ritonavir is highly inhibited by serum proteins but boosts the effect of other...
T1595	Nevirapine	Nevirapine is a benzodiazepine non-nucleoside reverse transcriptase inhibitor. In combination with other antiretroviral drugs, nevirapine reduces HIV viral load...
T1623	Lopinavir	Lopinavir is a peptidomimetic HIV protease inhibitor that retains activity against HIV protease with the Val 82 mutation. Lopinavir is less affected by binding ...
T1815	Dapivirine	Dapivirine is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.
T1883	Des(benzylpyridyl) Atazanavi	Atazanavir is a highly effective HIV-1 protease inhibitor.
T2239	Raltegravir potassium	Raltegravir potassium salt(MK0518 potassium salt) is a potent integrase (IN) inhibitor, used to treat HIV infection.
T2324	Darunavir	Darunavir is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alo...
T2329	Dolutegravir sodium	Dolutegravir sodium salt(DTG; GSK1349572) is an HIV integrase inhibitor(IC50: 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q1...
T2332	Elvitegravir	Elvitegravir is a Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor. The mechanism of action of elvitegravir is as an HIV Integrase Inhibitor, an...
T2393	Efavirenz	Efavirenz is a Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of efavirenz is as a Non-Nucleoside...
T2409L	Tenofovir Disoproxil Fumarate	Tenofovir Disoproxil Fumarate is a pro-drug, fumaric acid salt form of tenofovir, a nucleoside reverse transcriptase inhibitor analog of adenosine. Tenofovir di...
T2728	Limonin	Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.
T2830	Betulinic acid	Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretro...
T3172	Trovirdine	Trovirdine is a thiourea non-nucleoside reverse transcriptase inhibitor.
T3335	Darunavir Ethanolate	Darunavir ethanolate is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE wh...
T3523	Fostemsavir	BMS-663068 is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection.
T3632	Doravirine	Doravirine is a non-nucleoside reverse transcriptase inhibitor, used in the treatment of HIV/AIDS.
T3683	lithospermic acid	lithospermic acid is a potent anti-HIV agent and shows anti-gonadotrophic and anti-thyroidal effects.
T3732	Sebacic acid	Sebacic acid is a saturated, straight-chain naturally occurring dicarboxylic acid.
T6001	Nelfinavir Mesylate	Nelfinavir Mesylate is an effective HIV protease inhibitor (Ki: 2 nM).
T6065	Triciribine	Triciribine is a DNA synthesis inhibitor, and it also inhibits Akt and HIV-1/2.
T6098	Cabotegravir	Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM).
T6198	Dolutegravir	Dolutegravir (IC50=2.7 nM), a two-metal-binding HIV integrase inhibitor, exhibits medium activity against raltegravir-resistant signature mutants Y143R, Q148K, ...
T6367	Abacavir sulfate	Abacavir， a nucleoside analogue，effectively utilize its antiviral activity
T6388	Amprenavir	Amprenavir is a synthetic derivative of hydroxyethylamine sulfonamide that selectively binds to and inhibits human immunodeficiency virus (HIV) protease.
T6420	BMS-707035	BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2.
T6653	Salmeterol Xinafoate	Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstr...
T3S2007	MRE-269	Ursonic acid belongs to the family of Ursane Triterpenes whose structure is based on the pentacyclic ursane skeleton. It has potential as HIV-1 Protease Inhibit...
T4S0295	Cosmosiin	1. Cosmosiin is a anti-HIV agent. 2. Cosmosiin may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylati...
T5S0983	Absinthiin	1. Absinthiin is a weak HIV-1 protease inhibitor.
T2S0223	Isosinensetin	1. Isosinensetin shows antioxidant and HIV-1 protease inhibiting activities.
T4493	Bictegravir	Bictegravir is a potent inhibitor of HIV-1 integrase (IC50: 7.5 nM).
TL0006	Chicoric Acid	Chicoric Acid is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a class of cannabinomimetic...
T4S1999	Valepotriate	Valepotriate fraction can have sedative effects and affect behavioral parameters related to recognition memory. Valepotriates, a new class of cytotoxic and anti...
T4962	Ginsenoside Z-R1	Zingibroside R1 has anti-HIV-1 activity.
T4S1718	Punicalin	Punicalin exerts anti-inflammatory, antioxidative, and anti-hepatotoxic activities, it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-depend...
T5965	Ditiocarb sodium	Ditiocarb sodium (Sodium diethyldithiocarbamate) is an accelerator of the rate of copper cementation. Sodium diethyldithiocarbamate reduces the incidence of HIV...
T5863	Indinavir sulfate	Indinavir is a HIV protease inhibitor.It inhibits the HIV-1 protease with an IC50 value of 0.41 nM and Ki value of 0.24 nM.
T7111	Tenofovir Disoproxil	Tenofovir Disoproxil is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.
T7282	Tenofovir alafenamide fumarate	Tenofovir alafenamide fumarate (TAF) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV)
T7212	Delavirdine (mesylate)	Delavirdine (mesylate) is a non-nucleoside reverse transcriptase inhibitor (NNRTI).
T5782	Bevirimat	Bevirimat(PA-457) is a first-in-class inhibitor of HIV-1 maturation, blocking the cleavage of the Gag capsid (CA) precursor, CA-SPI, to mature CA protein during...
T7382	NBD-557	NBD-557 is a potentially HIV-1 inhibitor.
T7455	4-Chloro-2-(trifluoroacetyl)aniline hydrochloride	4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is an inhibitor of HIV-1 RT (HIV reverse transcriptase) .
TQ0217	Gomisin G	Gomisin G is a natural compound and exhibits potent anti-HIV activity (EC50: 0.006 μg/mL; therapeutic index: 300). It is a good substrate of CYP2C9.
TQ0297	Cenicriviroc	Cenicriviroc is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-inflammatory ...