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Cat No. | Product Name | Synonyms | Targets |
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T39729 | HIV Protease Substrate 1 | ||
HIV Protease Substrate 1 is a fluorogenic compound that offers insights into the enzymatic activity of HIV protease, making it a valuable tool for studying this aspect. | |||
T1883 | Des(benzylpyridyl) Atazanavi | HIV Protease | |
The N-dealkylated metabolite (M1) of Atazanavir, a HIV protease inhibitor. | |||
T7779 | Nelfinavir | AG1341 | HIV Protease |
Nelfinavir (AG1341) is an antiretroviral drug used in the treatment of the human immunodeficiency virus (HIV) (Ki=2 nM). Nelfinavir is a broad-spectrum, anticancer agent. | |||
T7903 | Saquinavir | Ro 31-8959 | SARS-CoV , HIV Protease |
Saquinavir (Ro 31-8959) is a potent HIV protease inhibitor, is an antiretroviral drug used together with other medications to treat or prevent HIV/AIDS. | |||
T76502 | HIV-1, HIV-2 Protease Substrate | ||
HIV-1, HIV-2 Protease Substrate is a compound serving as the substrate for the proteases of both HIV-1 and HIV-2, featuring four residues that allow for conservative substitutions at the substrate binding sites of these ... | |||
T76485 | HIV Protease Substrate I | ||
HIV Protease Substrate I, a chromogenic substrate for HIV-1 protease, contains the protease's cleavage site [1]. | |||
T76511 | HIV Protease Substrate IV | ||
HIV Protease Substrate IV, a substrate for HIV (human immunodeficiency virus) protease, facilitates the measurement of HIV-1 protease activity [1]. | |||
T74939 | HIV protease-IN-1 | ||
HIV protease-IN-1 (compound 1·succinate), a potent non-peptidic inhibitor of HIV protease, is utilized for AIDS research [1]. | |||
T1623 | Lopinavir | ABT-378 | SARS-CoV , HIV Protease |
Lopinavir (ABT-378) is a peptidomimetic HIV protease inhibitor that retains activity against HIV protease with the Val 82 mutation. Lopinavir is less affected by binding to serum proteins than the structurally-related dr... | |||
T9854 | HIV-1 inhibitor-6 | 3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo- | HIV Protease |
HIV-1 inhibitor-6 (3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-) is a potent HIV-1 pre-mRNA selective splicing inhibitor that blocks HIV replication. | |||
T63949 | HIV-1 protease-IN-2 | ||
HIV-1 protease-IN-2 is a potent inhibitor of HIV-1 protease (IC50: 2.53 nM). HIV-1 protease-IN-2 exhibits antiviral effects against DRV (Darunavir) sensitive or drug resistant HIV-1 mutants. | |||
T76074 | HIV Protease Substrate 1 TFA | ||
HIV Protease Substrate 1 TFA, a fluorogenic substrate for HIV protease, facilitates the investigation of the enzyme's activity [1]. | |||
T79537 | HIV-1 protease-IN-12 | HIV Protease | |
HIV-1 protease-IN-12 (compound 35b) serves as a potent inhibitor of HIV-1 protease, exhibiting an IC50 value of 0.51 nM, and demonstrates efficacy against drug-resistant variant [1]. | |||
T74942 | HIV-1 protease-IN-7 | HIV Protease | |
HIV-1 protease-IN-7 (compound 16) is an orally active inhibitor of HIV-1 protease, exhibiting an IC50 of 3.52 nM and an EC50 of 37 nM [1]. | |||
T78950 | HIV-1 protease-IN-8 | HIV Protease | |
HIV-1 protease-IN-8 (compound 34b) is a potent inhibitor of the HIV-1 protease enzyme, exhibiting an IC50 of 0.32 nM. It demonstrates IC50 values of 0.29 μM for the wild-type HIV-1 (HIV-1 NL4-3) and 1.90 μM against a dru... | |||
T2324 | Darunavir | TMC114 | HIV Protease |
Darunavir (TMC114) is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alone, it is administered in combination with other AN... | |||
T64112 | HIV-1 protease-IN-5 | ||
HIV-1 protease-IN-5 is an HIV-1 protease inhibitor (IC50: 1.64 nM). HIV-1 protease-IN-5 exhibits significant effects on wild-type and DRV-resistant HIV-1. | |||
T63453 | HIV-1 protease-IN-1 | ||
HIV-1 protease-IN-1 is a potent inhibitor of HIV-1 protease (IC50: 90 pM). HIV-1 protease-IN-1 has antiviral activity against B-HIV (EC50: 89 nM): HIV-1 protease-IN-1 was able to act on C-HIV strain ZM246 (EC50: 13.59 nM... | |||
T63733 | HIV-1 protease-IN-6 | ||
HIV-1 protease-IN-6 (compound 17d) is a potent inhibitor of HIV-1 protease (IC50: 21 pM, Ki: 4.7 pM). HIV-1 protease-IN-6 showed significant antiviral activity against DRV (darunavir) resistant mutants, even exceeding th... | |||
T79536 | HIV-1 protease-IN-11 | HIV Protease | |
HIV-1 protease-IN-11 (compound 34a), an HIV-1 protease inhibitor, demonstrates potent inhibition with an IC50 of 0.41 nM and maintains substantial efficacy against drug-resistant variant [1]. | |||
T79493 | HIV-1 protease-IN-10 | PKC | |
HIV-1 protease-IN-10 (Compound 2), exhibiting HIV-1 latency reversing activity (IC50: 0.22 μM), selectively binds to the PKCδ C1b domain (IC50: 0.69 μM) and demonstrates stability against esterase-mediated hydrolysis [1]... | |||
T6001 | Nelfinavir Mesylate | Viracept,Nelfin,AG1343,AG 1343 Mesylate | HIV Protease |
Nelfinavir Mesylate (Viracept) is an effective HIV protease inhibitor (Ki: 2 nM). | |||
T79295 | HIV-1 protease-IN-9 | HIV Protease | |
HIV-1 protease-IN-9 (compound 5b), a potent HIV-1 protease inhibitor, exhibits strong antiviral efficacy with a dissociation constant (K_i) of 0.028 nM and a half-maximal inhibitory concentration (IC_50) of 66.8 nM [1]. | |||
T74488 | HIV-1 protease-IN-4 | ||
HIV-1 protease-IN-4 (Compound II-22), a potent inhibitor of the HIV-1 protease, acts as a prodrug for atazanavir. It notably enhances the bioavailability of atazanavir in rat plasma, achieving a 5-fold increase in the ar... | |||
T6388 | Amprenavir | 141W94,Prozei,KVX-478,VX-478 | SARS-CoV , HIV Protease |
Amprenavir (KVX-478) is a synthetic derivative of hydroxyethylamine sulfonamide that selectively binds to and inhibits human immunodeficiency virus (HIV) protease. | |||
T1525 | Ritonavir | RTV,Abbott 84538,A 84538,ABT 538 | Apoptosis , SARS-CoV , HIV Protease |
Ritonavir (ABT 538) is a peptidomimetic agent that inhibits both HIV-1 and HIV-2 proteases. Ritonavir is highly inhibited by serum proteins but boosts the effect of other HIV proteases by blocking their degradation by cy... | |||
T3335 | Darunavir Ethanolate | UIC 94017,Darunavir Ethanolate,TMC114 | HIV Protease |
Darunavir Ethanolate (UIC 94017) is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alone, it is administered in combination... | |||
T3695 | Pepstatin | Pepstatin A,Pepsin Inhibitor S 735A,Ahpatinin C | Amino Acids and Derivatives , Proteasome , HIV Protease , Autophagy |
Pepstatin (Pepsin Inhibitor S 735A) is a specific aspartic proteases inhibitor produced by actinomycetes, and inhibits the aspartic proteases cathepsin D, pepsin and renin. | |||
T0100L | Atazanavir | Zrivada,Reyataz,Latazanavir,BMS-232632 | P450 , SARS-CoV , HIV Protease , P-gp |
Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor. | |||
T5863 | Indinavir sulfate | L735524 sulfate,MK-639 sulfate | SARS-CoV , HIV Protease |
Indinavir sulfate (L735524 sulfate) is a HIV protease inhibitor.It inhibits the HIV-1 protease with an IC50 value of 0.41 nM and Ki value of 0.24 nM. | |||
T0100 | Atazanavir sulfate | BMS-232632,BMS-232632 sulfate | P450 , SARS-CoV , HIV Protease , P-gp |
Atazanavir sulfate (BMS-232632 sulfate) is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS. | |||
T0825 | Ebselen | SPI-1005,PZ-51,CCG-39161 | Phosphatase , Virus Protease , Calcium Channel , COX , HIV Protease |
Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced b... | |||
T8156 | Saquinavir mesylate | Ro 31-8959/003 | HIV Protease , Autophagy |
Saquinavir mesylate (Ro 31-8959/003) is an Inhibitor of HIV Proteaseused in antiretroviral therapy | |||
T1776L | Plerixafor octahydrochloride | JM3100 octahydrochloride,Plerixafor 8HCl (AMD3100 8HCl),Plerixafor 8HCl,SID791 octahydrochloride,AMD 3100 octahydrochloride,JM 3100 8HCl | Virus Protease , HIV Protease , CXCR |
Plerixafor octahydrochloride (JM3100 octahydrochloride) blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow a... | |||
T4578 | Tipranavir | PNU-140690 | SARS-CoV , HIV Protease |
Tipranavir is a protease inhibitor that inhibits HIV-1 resistant to more than 1 protease inhibitor .Tipranavir effectively inhibits HIV-1 protease enzyme activity and dimerisation and has potent activity against multiple... | |||
T77347 | 2-Amino-6-bromopyridine | ||
2-Amino-6-bromopyridine has inhibitory effect on HIV-68 protease. | |||
T8238 | Fosamprenavir Calcium Salt | Diallyl Trisulfide,GW433908G | HIV Protease |
Fosamprenavir Calcium Salt (GW433908G) (GW433908G) is a phosphate ester prodrug of the antiretroviral protease inhibitor Amprenavir, with improved solubility. Fosamprenavir Calcium Salt has Anti-HIV infection. | |||
T24362 | L 756423 | L756423,MK-944a,MK944a,L-756,423,L-756423,MK 944a | HIV Protease |
L 756423 (L756423) is a novel potent and selective and competitive HIV protease inhibitor with a Ki value of 0.049 nM for HIV-1 PR.L 756423 blocks the spread of HIV(IIIb)-infected MT25 lymphocytes at 0.50-0.1 nM and can ... | |||
T15683 | L-689502 | HIV Protease | |
L-689502 is a potent HIV-l protease inhibitor (IC50: 1 nM). | |||
T39345 | Lopinavir Metabolite M-1 | ||
Lopinavir Metabolite M-1, an active metabolite derived from Lopinavir, effectively inhibits the HIV protease enzyme with a Ki value of 0.7 pM. Additionally, in vitro studies have revealed notable antiviral properties ass... | |||
T26552 | Acetylpepstatin | Ac-Val-Val-Sta-Ala-Sta-OH,Acetyl-pepstatin | |
Acetylpepstatin is an inhibitor of HIV-1 protease, HIV-2 protease, aspartyl protease. | |||
T26446 | A 77003 | A-77003,Abbott 77003,A77003 | |
A 77003 is a HIV-1 protease inhibitor. A77003 impairs HIV-1 protease-mediated Gag processing. | |||
T24331 | L 682679 | L-682679,L-682,679,L682,679,L 682,679,L682679 | |
L 682679 is an inhibitor of HIV protease. | |||
T24343 | L 694746 | L 694,746,L694746,L-694,746,L694,746,L-694746 | |
L 694746 is an inhibitor of HIV-1 protease. | |||
T21039 | PL 100 | MK-8122,PL-100,PPL-100,PPL 100,MX-100 | |
PL 100 could inhibit HIV-1 protease. | |||
T24536 | NIT | ||
NIT is an HIV-1 protease inhibitor. | |||
T24199 | JG 365 | JG-365,JG365 | |
JG 365 is an HIV protease inhibitor. | |||
T26024 | R 87366 | R87366,R-87366 | |
R 87366 is used as a water-soluble HIV protease inhibitor. | |||
T24336 | L 687908 | L687908,L-687,908,L 687,908,L-687908,L687,908 | |
L 687908 is a potent inhibitor of hydroxyethylene-containing HIV protease. | |||
T16555 | PNU-103017 | HIV Protease | |
PNU-103017 is an inhibitor of HIV protease. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5783 | Rosamultin | Antioxidant , HIV Protease | |
Rosamultin has antioxidant, antiinflammatory/antinociceptive properties,and has anti-human immunodeficiency virus (HIV) activity. | |||
TN1059 | Ganoderic acid B | IL Receptor , HIV Protease , JAK , STAT | |
Ganoderic acid B is a chemical marker in quality control of G. lucidum and related products. Ganoderic acid B-containing herbs has potential influence towards therapeutic window of trifluoperazine.Ganoderic acid B has an... | |||
T4S1383 | Escin IA | Aescin IA,Escin IA;Aescin IA,Escin IA | HIV Protease |
Escin IA (Escin IA;Aescin IA) is a triterpene saponin isolated from horse chestnut, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved ... | |||
T4S1387 | Isoescin IA | HIV Protease | |
Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. It has anti-HIV-1 protease activity. | |||
T5429 | Theaflavin 3,3'-digallate | 8-Gingerol,TFDG | Virus Protease , Antioxidant , HIV Protease , HSV |
Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregul... | |||
T2S0223 | Isosinensetin | 6-Demethoxynobiletin | Antioxidant , HIV Protease , Antibacterial , P-gp |
1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities. | |||
T3323 | Ursonic Acid | CCRIS 7123,NSC4060,Prunol,3-Ketoursolic acid,Malol,TOS-BB-0966 | Apoptosis , HIV Protease , Endogenous Metabolite |
Ursonic Acid (TOS-BB-0966) belongs to the family of Ursane Triterpenes whose structure is based on the pentacyclic ursane skeleton. It has potential as HIV-1 Protease Inhibitor. | |||
TQ0217 | Gomisin G | P450 , HIV Protease | |
Gomisin G is a natural compound and exhibits potent anti-HIV activity (EC50: 0.006 μg/mL; therapeutic index: 300). It is a good substrate of CYP2C9. | |||
TN5675 | Ganomycin I | ||
Ganomycin I inhibits the activity of HIV-1 protease. | |||
T5S0983 | Absinthin | Absinthiin,Absynthin | HIV Protease |
Absinthin (Absynthin) is a weak HIV-1 protease inhibitor. | |||
TN4705 | Oleoside | Others , HIV Protease | |
Oleoside can be extracted from Olea europaea and Zizyphus lotus L. twigs and may be used to inhibit HIV-1 protease. | |||
TN4347 | Jacoumaric acid | HIV Protease | |
Jacoumaric acid is a lead molecule from the library or database of natural compounds as a HIV-1 protease inhibitor. | |||
T75705 | Pepstatin Trifluoroacetate | ||
Pepstatin Trifluoroacetate (Pepstatin A), a specific and orally active aspartic protease inhibitor produced by actinomycetes, demonstrates inhibition efficacy with IC50 values of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM, a... | |||
T75562 | Ganoderic acid GS-1 | ||
Ganoderic acid GS-1, an extensively oxygenated lanostane-type triterpenoid, exhibits anti-HIV-1 protease activities, displaying an IC50 value of 58 μM [1]. | |||
T10928 | Cytochalasin A | HIV Protease | |
Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM), inhibits actin polymerization and interferes with microtubu... | |||
TN4109 | Ganolucidic acid A | HIV Protease | |
Ganolucidic acid A exhibits cytotoxicity, has inhibitory activities against human HeLa cervical cancer cell lines. It shows significant anti-human immunodeficiency virus (anti-HIV)-1 protease activity with IC50 values of... | |||
T79953 | Acetyl-binankadsurin A | HIV Protease | |
Acetyl-binankadsurin A (compound 5), a lignan obtained from Kadsura longipedunculata, exhibits weak inhibitory effects on HIV-1 protease, demonstrating an IC50 value exceeding 100 μg/mL [1]. | |||
TMA1012 | Ganoderiol F | Androgen Receptor , HIV Protease , Autophagy | |
Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency virus-1 protease with IC(50) values of 20-40 microM. It induced... | |||
TN1660 | Ganoderic acid C1 | IL Receptor , TNF , NF-κB , MAPK , COX , HIV Protease , DNA/RNA Synthesis | |
Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic acid C1 has anti-tumor-promoting activity. It is moderately a... | |||
TN1670 | Ganodermanondiol | HIV Protease , Nrf2 , AMPK | |
Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK. |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00767 | Cystatin C Protein, Human, Recombinant (His) | Human | HEK293 |
Cystatin C, also known as Cystatin-3 (CST3) is a secreted type 2 cysteine protease inhibitor synthesized in all nucleated cells, has been proposed as a replacement for serum creatinine for the assessment of renal functio... | |||
TMPY-01711 | Serpin B2 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
Serpins are the largest and most diverse family of serine protease inhibitors which are involved in some fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, infl... | |||
TMPY-00640 | Cystatin C Protein, Human, Recombinant | Human | HEK293 |
Cystatin C, also known as Cystatin-3 (CST3) is a secreted type 2 cysteine protease inhibitor synthesized in all nucleated cells, has been proposed as a replacement for serum creatinine for the assessment of renal functio... | |||
TMPY-01370 | Cystatin C Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Cystatin C, also known as Cystatin-3 (CST3) is a secreted type 2 cysteine protease inhibitor synthesized in all nucleated cells, has been proposed as a replacement for serum creatinine for the assessment of renal functio... | |||
TMPY-02056 | Cystatin C Protein, Rat, Recombinant (His) | Rat | HEK293 |
Cystatin C, also known as Cystatin-3 (CST3) is a secreted type 2 cysteine protease inhibitor synthesized in all nucleated cells, has been proposed as a replacement for serum creatinine for the assessment of renal functio... |
Cat No. | Product Name | ||
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L1100 | Protease Inhibitor Library | 344 compounds | |
A unique collection of 344 protease and proteasome inhibitors for research in chemical genomics, and drug screening; |