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Microbiology&virology HIV Protease

HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.
Cat No. product name
T0100 Atazanavir sulfate Atazanavir sulfate is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENT...
T0100L Atazanavir Atazanavir(BMS-232632) is an highly effective HIV-1 protease inhibitor.
T0110 Zalcitabine Zalcitabine(Dideoxycytidine;ddC; 2',3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, It can potently in...
T1267 Abacavir Abacavir is a nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune...
T1525 Ritonavir Ritonavir is a peptidomimetic agent that inhibits both HIV-1 and HIV-2 proteases. Ritonavir is highly inhibited by serum proteins but boosts the effect of other...
T1595 Nevirapine Nevirapine is a benzodiazepine non-nucleoside reverse transcriptase inhibitor. In combination with other antiretroviral drugs, nevirapine reduces HIV viral load...
T1623 Lopinavir Lopinavir is a peptidomimetic HIV protease inhibitor that retains activity against HIV protease with the Val 82 mutation. Lopinavir is less affected by binding ...
T1815 Dapivirine Dapivirine is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.
T1883 Des(benzylpyridyl) Atazanavi Atazanavir is a highly effective HIV-1 protease inhibitor.
T2239 Raltegravir potassium Raltegravir potassium salt(MK0518 potassium salt) is a potent integrase (IN) inhibitor, used to treat HIV infection.
T2324 Darunavir Darunavir is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alo...
T2329 Dolutegravir sodium Dolutegravir sodium salt(DTG; GSK1349572) is an HIV integrase inhibitor(IC50: 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q1...
T2332 Elvitegravir Elvitegravir is a Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor. The mechanism of action of elvitegravir is as an HIV Integrase Inhibitor, an...
T2393 Efavirenz Efavirenz is a Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of efavirenz is as a Non-Nucleoside...
T2409L Tenofovir Disoproxil Fumarate Tenofovir Disoproxil Fumarate is a pro-drug, fumaric acid salt form of tenofovir, a nucleoside reverse transcriptase inhibitor analog of adenosine. Tenofovir di...
T2728 Limonin Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.
T2830 Betulinic acid Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretro...
T3172 Trovirdine Trovirdine is a thiourea non-nucleoside reverse transcriptase inhibitor.
T3335 Darunavir Ethanolate Darunavir ethanolate is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE wh...
T3523 Fostemsavir BMS-663068 is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection.
T3632 Doravirine Doravirine is a non-nucleoside reverse transcriptase inhibitor, used in the treatment of HIV/AIDS.
T3683 lithospermic acid lithospermic acid is a potent anti-HIV agent and shows anti-gonadotrophic and anti-thyroidal effects.
T3732 Sebacic acid Sebacic acid is a saturated, straight-chain naturally occurring dicarboxylic acid.
T6001 Nelfinavir Mesylate Nelfinavir Mesylate is an effective HIV protease inhibitor (Ki: 2 nM).
T6065 Triciribine Triciribine is a DNA synthesis inhibitor, and it also inhibits Akt and HIV-1/2.
T6098 Cabotegravir Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM).
T6198 Dolutegravir Dolutegravir (IC50=2.7 nM), a two-metal-binding HIV integrase inhibitor, exhibits medium activity against raltegravir-resistant signature mutants Y143R, Q148K, ...
T6367 Abacavir sulfate Abacavir, a nucleoside analogue,effectively utilize its antiviral activity
T6388 Amprenavir Amprenavir is a synthetic derivative of hydroxyethylamine sulfonamide that selectively binds to and inhibits human immunodeficiency virus (HIV) protease.
T6420 BMS-707035 BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2.
T6653 Salmeterol Xinafoate Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstr...
T3S2007 MRE-269 Ursonic acid belongs to the family of Ursane Triterpenes whose structure is based on the pentacyclic ursane skeleton. It has potential as HIV-1 Protease Inhibit...
T4S0295 Cosmosiin 1. Cosmosiin is a anti-HIV agent. 2. Cosmosiin may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylati...
T5S0983 Absinthiin 1. Absinthiin is a weak HIV-1 protease inhibitor.
T2S0223 Isosinensetin 1. Isosinensetin shows antioxidant and HIV-1 protease inhibiting activities.
T4493 Bictegravir Bictegravir is a potent inhibitor of HIV-1 integrase (IC50: 7.5 nM).
TL0006 Chicoric Acid Chicoric Acid is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a class of cannabinomimetic...
T4S1999 Valepotriate Valepotriate fraction can have sedative effects and affect behavioral parameters related to recognition memory. Valepotriates, a new class of cytotoxic and anti...
T4962 Ginsenoside Z-R1 Zingibroside R1 has anti-HIV-1 activity.
T4S1718 Punicalin Punicalin exerts anti-inflammatory, antioxidative, and anti-hepatotoxic activities, it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-depend...
T5965 Ditiocarb sodium Ditiocarb sodium (Sodium diethyldithiocarbamate) is an accelerator of the rate of copper cementation. Sodium diethyldithiocarbamate reduces the incidence of HIV...
T5863 Indinavir sulfate Indinavir is a HIV protease inhibitor.It inhibits the HIV-1 protease with an IC50 value of 0.41 nM and Ki value of 0.24 nM.
T7111 Tenofovir Disoproxil Tenofovir Disoproxil is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.
T7282 Tenofovir alafenamide fumarate Tenofovir alafenamide fumarate (TAF) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV)
T7212 Delavirdine (mesylate) Delavirdine (mesylate) is a non-nucleoside reverse transcriptase inhibitor (NNRTI).
T5782 Bevirimat Bevirimat(PA-457) is a first-in-class inhibitor of HIV-1 maturation, blocking the cleavage of the Gag capsid (CA) precursor, CA-SPI, to mature CA protein during...
T7382 NBD-557 NBD-557 is a potentially HIV-1 inhibitor.
T7455 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is an inhibitor of HIV-1 RT (HIV reverse transcriptase) .
TQ0217 Gomisin G Gomisin G is a natural compound and exhibits potent anti-HIV activity (EC50: 0.006 μg/mL; therapeutic index: 300). It is a good substrate of CYP2C9.
TQ0297 Cenicriviroc Cenicriviroc is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-inflammatory ...
Atazanavir sulfate
T0100CAS 229975-97-7
Atazanavir sulfate is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENT...
Atazanavir
T0100LCAS 198904-31-3
Atazanavir(BMS-232632) is an highly effective HIV-1 protease inhibitor.
Zalcitabine
T0110CAS 7481-89-2
Zalcitabine(Dideoxycytidine;ddC; 2',3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, It can potently in...
Abacavir
T1267CAS 136470-78-5
Abacavir is a nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune...
Ritonavir
T1525CAS 155213-67-5
Ritonavir is a peptidomimetic agent that inhibits both HIV-1 and HIV-2 proteases. Ritonavir is highly inhibited by serum proteins but boosts the effect of other...
Nevirapine
T1595CAS 129618-40-2
Nevirapine is a benzodiazepine non-nucleoside reverse transcriptase inhibitor. In combination with other antiretroviral drugs, nevirapine reduces HIV viral load...
Lopinavir
T1623CAS 192725-17-0
Lopinavir is a peptidomimetic HIV protease inhibitor that retains activity against HIV protease with the Val 82 mutation. Lopinavir is less affected by binding ...
Dapivirine
T1815CAS 244767-67-7
Dapivirine is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.
Des(benzylpyridyl) Atazanavi
T1883CAS 1192224-24-0
Atazanavir is a highly effective HIV-1 protease inhibitor.
Raltegravir potassium
T2239CAS 871038-72-1
Raltegravir potassium salt(MK0518 potassium salt) is a potent integrase (IN) inhibitor, used to treat HIV infection.
Darunavir
T2324CAS 206361-99-1
Darunavir is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alo...
Dolutegravir sodium
T2329CAS 1051375-19-9
Dolutegravir sodium salt(DTG; GSK1349572) is an HIV integrase inhibitor(IC50: 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q1...
Elvitegravir
T2332CAS 697761-98-1
Elvitegravir is a Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor. The mechanism of action of elvitegravir is as an HIV Integrase Inhibitor, an...
Efavirenz
T2393CAS 154598-52-4
Efavirenz is a Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of efavirenz is as a Non-Nucleoside...
Tenofovir Disoproxil Fumarate
T2409LCAS 202138-50-9
Tenofovir Disoproxil Fumarate is a pro-drug, fumaric acid salt form of tenofovir, a nucleoside reverse transcriptase inhibitor analog of adenosine. Tenofovir di...
Limonin
T2728CAS 1180-71-8
Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.
Betulinic acid
T2830CAS 472-15-1
Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretro...
Trovirdine
T3172CAS 149488-17-5
Trovirdine is a thiourea non-nucleoside reverse transcriptase inhibitor.
Darunavir Ethanolate
T3335CAS 635728-49-3
Darunavir ethanolate is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE wh...
Fostemsavir
T3523CAS 864953-29-7
BMS-663068 is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection.
Doravirine
T3632CAS 1338225-97-0
Doravirine is a non-nucleoside reverse transcriptase inhibitor, used in the treatment of HIV/AIDS.
lithospermic acid
T3683CAS 28831-65-4
lithospermic acid is a potent anti-HIV agent and shows anti-gonadotrophic and anti-thyroidal effects.
Sebacic acid
T3732CAS 111-20-6
Sebacic acid is a saturated, straight-chain naturally occurring dicarboxylic acid.
Nelfinavir Mesylate
T6001CAS 159989-65-8
Nelfinavir Mesylate is an effective HIV protease inhibitor (Ki: 2 nM).
Triciribine
T6065CAS 35943-35-2
Triciribine is a DNA synthesis inhibitor, and it also inhibits Akt and HIV-1/2.
Cabotegravir
T6098CAS 1051375-10-0
Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM).
Dolutegravir
T6198CAS 1051375-16-6
Dolutegravir (IC50=2.7 nM), a two-metal-binding HIV integrase inhibitor, exhibits medium activity against raltegravir-resistant signature mutants Y143R, Q148K, ...
Abacavir sulfate
T6367CAS 188062-50-2
Abacavir, a nucleoside analogue,effectively utilize its antiviral activity
Amprenavir
T6388CAS 161814-49-9
Amprenavir is a synthetic derivative of hydroxyethylamine sulfonamide that selectively binds to and inhibits human immunodeficiency virus (HIV) protease.
BMS-707035
T6420CAS 729607-74-3
BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2.
Salmeterol Xinafoate
T6653CAS 94749-08-3
Salmeterol Xinafoate is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstr...
MRE-269
T3S2007CAS 475085-57-5
Ursonic acid belongs to the family of Ursane Triterpenes whose structure is based on the pentacyclic ursane skeleton. It has potential as HIV-1 Protease Inhibit...
Cosmosiin
T4S0295CAS 578-74-5
1. Cosmosiin is a anti-HIV agent. 2. Cosmosiin may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylati...
Absinthiin
T5S0983CAS 1362-42-1
1. Absinthiin is a weak HIV-1 protease inhibitor.
Isosinensetin
T2S0223CAS 17290-70-9
1. Isosinensetin shows antioxidant and HIV-1 protease inhibiting activities.
Bictegravir
T4493CAS 1611493-60-7
Bictegravir is a potent inhibitor of HIV-1 integrase (IC50: 7.5 nM).
Chicoric Acid
TL0006CAS 6537-80-0
Chicoric Acid is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a class of cannabinomimetic...
Valepotriate
T4S1999CAS 18296-44-1
Valepotriate fraction can have sedative effects and affect behavioral parameters related to recognition memory. Valepotriates, a new class of cytotoxic and anti...
Ginsenoside Z-R1
T4962CAS 80930-74-1
Zingibroside R1 has anti-HIV-1 activity.
Punicalin
T4S1718CAS 65995-64-4
Punicalin exerts anti-inflammatory, antioxidative, and anti-hepatotoxic activities, it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-depend...
Ditiocarb sodium
T5965CAS 148-18-5
Ditiocarb sodium (Sodium diethyldithiocarbamate) is an accelerator of the rate of copper cementation. Sodium diethyldithiocarbamate reduces the incidence of HIV...
Indinavir sulfate
T5863CAS 157810-81-6
Indinavir is a HIV protease inhibitor.It inhibits the HIV-1 protease with an IC50 value of 0.41 nM and Ki value of 0.24 nM.
Tenofovir Disoproxil
T7111CAS 201341-05-1
Tenofovir Disoproxil is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.
Tenofovir alafenamide fumarate
T7282CAS 1392275-56-7
Tenofovir alafenamide fumarate (TAF) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV)
Delavirdine (mesylate)
T7212CAS 147221-93-0
Delavirdine (mesylate) is a non-nucleoside reverse transcriptase inhibitor (NNRTI).
Bevirimat
T5782CAS 174022-42-5
Bevirimat(PA-457) is a first-in-class inhibitor of HIV-1 maturation, blocking the cleavage of the Gag capsid (CA) precursor, CA-SPI, to mature CA protein during...
NBD-557
T7382CAS 333352-59-3
NBD-557 is a potentially HIV-1 inhibitor.
4-Chloro-2-(trifluoroacetyl)aniline hydrochloride
T7455CAS 173676-59-0
4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is an inhibitor of HIV-1 RT (HIV reverse transcriptase) .
Gomisin G
TQ0217CAS 62956-48-3
Gomisin G is a natural compound and exhibits potent anti-HIV activity (EC50: 0.006 μg/mL; therapeutic index: 300). It is a good substrate of CYP2C9.
Cenicriviroc
TQ0297CAS 497223-25-3
Cenicriviroc is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-inflammatory ...