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HIV Protease

HIV-1 protease (PR) is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol[3]) at nine cleavage sites to create the mature protein components of an HIV virion, the infectious form of a virus outside of the host cell. Without effective HIV protease, HIV virions remain uninfectious.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T14831 Bryostatin 1 83314-01-6 98%
Bryostatin 1
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS)permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain...
T15683 L-689502 138483-63-3 98%
L-689502
L-689502 is a potent HIV-l protease inhibitor (IC50: 1 nM).
TN3119 5-Hydroxy-7,8-dimethoxyflavanone 113981-49-0 98%
5-Hydroxy-7,8-dimethoxyflavanone
5-Hydroxy-7,8-dimethoxyflavanone is isolated from Andrographis paniculata Nees. leaves and roots with anti-inflammatory activity.
TN4705 Oleoside 178600-68-5 98%
Oleoside
Oleoside can be extracted from Olea europaea and Zizyphus lotus L. twigs and may be used to inhibit HIV-1 protease.
T35617 Mitoguazone 459-86-9 98%
Mitoguazone
Mitoguazone (Methyl-GAG) is a selective S-adenosyl-methionine decarboxylase inhibitor that penetrates the blood-brain barrier and disrupts polyamine biosynthesis...
TN4605 Myriceric acid B 55497-79-5 98%
Myriceric acid B
Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41 and can serve as a lead compound for developing novel anti-HIV-1 drug. Myriceric acid B scaveng...
T8156 Saquinavir mesylate 149845-06-7 98%
Saquinavir mesylate
Saquinavir mesylate (Ro 31-8959/003) is an Inhibitor of HIV Proteaseused in antiretroviral therapy
TN5191 Tsugafolin 66568-97-6 98%
Tsugafolin
Tsugafolin has weak anti-HIV activity.
TN1194 16beta,17-Dihydroxy-ent-kaurane-19-oic acid 74365-74-5 98%
16beta,17-Dihydroxy-ent-kaurane-19-oic acid
16beta,17-Dihydroxy-ent-kaurane-19-oic acid as an anti-HIV principle, it showed significant activity against HIV replication in H9 lymphocyte cells with an EC50 ...
T10111L 3-Deazaadenosine 6736-58-9 98%
3-Deazaadenosine
3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 µM, and it has anti-inflammatory, anti-proliferative and anti-HIV activity...
T22468 1-Deoxymannojirimycin hydrochloride 73465-43-7 98%
1-Deoxymannojirimycin hydrochloride
α-mannosidase I inhibitor
TN5133 3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone 125537-92-0 98%
3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone
5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it sho...
TN1348 8-Prenylluteone 125002-91-7 98%
8-Prenylluteone
8-Prenylluteone can potently inhibit HIV-1 PR activity.
TN1708 Gomisin M2 82425-45-4 98%
Gomisin M2
Gomisin M2 is an anti-HIV agent.
TN3152 6-Acetonyldihydrochelerythrine 22864-92-2 98%
6-Acetonyldihydrochelerythrine
6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therape...
T10928 Cytochalasin A 14110-64-6 98%
Cytochalasin A
Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM), ...
TN4584 Morolic acid 559-68-2 98%
Morolic acid
Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent change...
T14307 Aplaviroc 461443-59-4 98%
Aplaviroc
Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.
T14559 BI 224436 1155419-89-8 98%
BI 224436
BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.
TN3777 Daurichromenic acid 82003-90-5 98%
Daurichromenic acid
Daurichromenic acid is a terpenophenol with a potent anti-HIV activity.
Bryostatin 1
T14831
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS)permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain...
L-689502
T15683
L-689502 is a potent HIV-l protease inhibitor (IC50: 1 nM).
5-Hydroxy-7,8-dimethoxyflavanone
TN3119
5-Hydroxy-7,8-dimethoxyflavanone is isolated from Andrographis paniculata Nees. leaves and roots with anti-inflammatory activity.
Oleoside
TN4705
Oleoside can be extracted from Olea europaea and Zizyphus lotus L. twigs and may be used to inhibit HIV-1 protease.
Mitoguazone
T35617
Mitoguazone (Methyl-GAG) is a selective S-adenosyl-methionine decarboxylase inhibitor that penetrates the blood-brain barrier and disrupts polyamine biosynthesis...
Myriceric acid B
TN4605
Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41 and can serve as a lead compound for developing novel anti-HIV-1 drug. Myriceric acid B scaveng...
Saquinavir mesylate
T8156
Saquinavir mesylate (Ro 31-8959/003) is an Inhibitor of HIV Proteaseused in antiretroviral therapy
Tsugafolin
TN5191
Tsugafolin has weak anti-HIV activity.
16beta,17-Dihydroxy-ent-kaurane-19-oic acid
TN1194
16beta,17-Dihydroxy-ent-kaurane-19-oic acid as an anti-HIV principle, it showed significant activity against HIV replication in H9 lymphocyte cells with an EC50 ...
3-Deazaadenosine
T10111L
3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 µM, and it has anti-inflammatory, anti-proliferative and anti-HIV activity...
1-Deoxymannojirimycin hydrochloride
T22468
α-mannosidase I inhibitor
3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone
TN5133
5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it sho...
8-Prenylluteone
TN1348
8-Prenylluteone can potently inhibit HIV-1 PR activity.
Gomisin M2
TN1708
Gomisin M2 is an anti-HIV agent.
6-Acetonyldihydrochelerythrine
TN3152
6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therape...
Cytochalasin A
T10928
Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM), ...
Morolic acid
TN4584
Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent change...
Aplaviroc
T14307
Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.
BI 224436
T14559
BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.
Daurichromenic acid
TN3777
Daurichromenic acid is a terpenophenol with a potent anti-HIV activity.
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TargetMol