T0672 |
Pravastatin sodium |
Pravastatin sodium, an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM. |
T0683 |
Mevastatin |
Mevastatin is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials...
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T0687 |
Simvastatin |
Simvastatin is a HMG-CoA Reductase Inhibitor. The mechanism of action of simvastatin is as a Hydroxymethylglutaryl-CoA Reductase Inhibitor. |
T1207 |
Lovastatin |
Lovastatin is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol. |
T1487 |
Fluvastatin sodium salt |
Fluvastatin sodium, a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent. |
T1510 |
Rosuvastatin calcium |
Rosuvastatin, a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity. |
T1664 |
Meglutol |
Meglutol is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic s...
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T1676 |
Rosuvastatin |
Rosuvastatin is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversi...
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T3116 |
Atorvastatin Calcium |
Atorvastatin hemicalcium salt, an effective HMG-CoA reductase inhibitor (IC50 = 8 nM), is utilized as a cholesterol-lowering medication. |
T3698 |
alpha-Asarone |
Alpha-Asarone is a psychoactive compound with antidepressant-like activity in mice. |
T6450 |
Clinofibrate |
Clinofibrate(IC50 of 0.47 mM), a lipid-lowering agent, inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR). It is utilized to control high cholester...
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T6994 |
SR12813 |
SR-12813 is a pregnane X receptor (PXR) agonist. |
T4717 |
25-Hydroxycholesterol |
25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase...
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TN1377 |
alpha-Spinasterol |
α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects....
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TN1733 |
Hesperetin 7-O-glucoside |
Hesperetin 7-O-glucoside and prunin are direct precursors of naringin and neohesperidin, respectively, in C. aurantium. Hesperetin 7-O-glucoside shows inhibitio...
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TN2111 |
Prunin |
Prunin possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate glucose uptake in insulin-r...
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T12092 |
Monacolin J |
Monacolin J is a cholesterol biosynthesis inhibitor. |
T10070 |
2'-Ethyl Simvastatin |
2'-Ethyl Simvastatin is a Mevinolin analog with HMG-CoA reductase inhibition. |
T20765 |
Atorvastatin |
Atorvastatin is an orally active inhibitor of HMG-CoA reductase,is a lipid-lowering agent (human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2....
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T11572 |
HMG499 |
HMG499 is a potent and selective HMG-CoA reductase inhibitor (IC50: 0.41 μM). HMG499 can prevent the statins-induced accumulation of HMGCR, reduce serum choles...
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T10767 |
Cerivastatin sodium |
Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent and orally active HMG-CoA reductase inhibitor (Ki: 1.3 nM). It also inhibits the pro...
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