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Search Results for " hmg-coa-reductase "

Targets

86

Compounds

12

Natural Products

7

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T14342 Atorvastatin lactone HMG-CoA Reductase
Atorvastatin lactone is a prodrug form of atorvastatin. Which is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.
T20765 Atorvastatin HMG-CoA Reductase , Autophagy
Atorvastatin is an orally active HMG-CoA reductase inhibitor that has the ability to effectively lower blood lipids by activating liver cytochrome p450 to accelerate metabolism. Atorvastatin inhibited proliferation and i...
T79520 HMG-CoA Reductase-IN-1
HMG-CoA Reductase-IN-1 is an inhibitor of HMG-CoA reductase, demonstrating strong inhibitory activity on HMGR and affinity for OATP1B1, with pIC50 and pKm values of 8.54 and 1.98, respectively. It is utilized in hypercho...
T1487 Fluvastatin sodium XU 62320 sodium,XU-62-320,Fluvastatin sodium salt Ferroptosis , HMG-CoA Reductase , Autophagy
Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent.
T6450 Clinofibrate S-8527,Lipoclin HMG-CoA Reductase , Autophagy
Clinofibrate (Lipoclin)(IC50 of 0.47 mM), a lipid-lowering agent, inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR). It is utilized to control high cholesterol and triacylglyceride levels in the blood.
T6994 SR12813 SR-12813,SR 12813,GW 485801 HMG-CoA Reductase , Autophagy
SR12813 (GW 485801) is a pregnane X receptor (PXR) agonist.
T12092 Monacolin J Antibiotic MB 530A,Lovastatin diol lactone HMG-CoA Reductase , Autophagy
Monacolin J (Antibiotic MB 530A) is a cholesterol biosynthesis inhibitor.
T1676 Rosuvastatin ZD 4522 Potassium Channel , HMG-CoA Reductase , Autophagy
Rosuvastatin (ZD 4522) is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting...
T3116 Atorvastatin hemicalcium salt Lipitor,Atorvastatin hemicalcium,Atorvastatin Calcium,CI-981,Sortis Ferroptosis , HMG-CoA Reductase , Autophagy
Atorvastatin hemicalcium salt (Atorvastatin Calcium), an effective HMG-CoA reductase inhibitor (IC50 = 8 nM), is utilized as a cholesterol-lowering medication.
T2534 Pitavastatin calcium P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,NK-104 Apoptosis , Mitophagy , Endogenous Metabolite , HMG-CoA Reductase , Autophagy
Pitavastatin calcium (NK-104) is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cyt...
T1510 Rosuvastatin calcium ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium Potassium Channel , HMG-CoA Reductase , Autophagy
Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity.
T21405 Fluvastatin Canef,XU-62320,Vastin,Cranoc,Lescol HMG-CoA Reductase
Fluvastatin (XU-62320) is a potent and competitive HMG-CoA reductase inhibitor (IC50: 8 nM) that inhibits oxidative stress in vascular smooth muscle cells through an Nrf2-dependent pathway, and is used for the reduction ...
T10324 Anhydrosimvastatin Dehydro simvastatin HMG-CoA Reductase
Anhydrosimvastatin (Dehydro simvastatin) is an impurity of Simvastatin. Simvastatin is an HMG-CoA reductase inhibitor.
TQ0045 2-Hydroxy atorvastatin calcium salt Drug Metabolite
2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt which is a potent HMG-CoA reductase inhibitor (IC50 = 8 nM).
T13131 Tert-Buthyl Pitavastatin HMG-CoA Reductase
tert-Buthyl Pitavastatin is Pitavastatin metabolite. Pitavastatin is a potent inhibitor of HMG-CoA reductase.
T25285 Dalvastatin RG-12561,RG 12561,RG12561 HMG-CoA Reductase
Dalvastatin (RG-12561) is an orally available inhibitor of HMG-CoA reductase and cholesterol-lowering synthesis.Dalvastatin competitively inhibits rat hepatic HMG-CoA reductase with an IC50 value of 3.4 nmol / l. Dalvast...
T12652 (Rac)-5-Keto Fluvastatin 5-Ketofluvastatin,3-Hydroxy-5-Keto Fluvastatin,rac 5-Keto Fluvastatin Others
(Rac)-5-Keto Fluvastatin (rac 5-Keto Fluvastatin) is an impurity of Fluvastatin which is an inhibitor of HMG-CoA reductase.
T20887 Atorvastatin Sodium Lipitor LDL , Aquaporin , HMG-CoA Reductase
Atorvastatin Sodium (Lipitor) is a competitive inhibitor of HMG-CoA reductase and increases the expression of low density lipoprotein (LDL) receptors on hepatocytes. Atorvastatin Sodium treatment inhibits aquaporin 4 to ...
T24865 Tenivastatin L-654969,L654969,Simvastatin acid,L 654969,Simvastatin hydroxy acid ROS , HMG-CoA Reductase
Tenivastatin (Simvastatin acid) is an anti-hyperlipidemic HMG-CoA reductase inhibitor that inhibits the production of reactive oxygen species (ROS) and can be used in the study of primary hyperlipidemia.
T12490 Pitavastatin lactone Others
Pitavastatin lactone is a major Pitavastatin metabolite in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase little metabolized in hepatic microsomes.
T26644 Apomine SK&F-99085,APB-231-A2,APB-231-A-2,SR-9223i,SK&F-99085,SR-45023A HMG-CoA Reductase
Apomine (SR-9223i), an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and has been implicated in the regulation of myeloma in vivo. Apomine accelerates the degradation of 3-hydroxy-3-methylg...
T19918 Lovastatin hydroxy acid sodium 6-α-Methylcompactin sodium,Lovastatin Na,Lovastatin Sodium,Mevinolin sodium
Lovastatin Sodium is an HMG-CoA reductase inhibitor.
T14931 Cerivastatin Others
Cerivastatin is a highly potent, well-tolerated, and orally active HMG-CoA reductase inhibitor (Ki: 1.3 nM/L). Cerivastatin also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition with...
T11572 HMG499 HMG-CoA Reductase
HMG499 is a potent and selective HMG-CoA reductase inhibitor with an IC 50 of 0.41 μM. HMG499 can eliminate statins-induced accumulation of HMGCR, lower serum cholesterol levels and decrease atherosclerosis [1].
T24323 L 669262 L-669,262,L 669,262,L669,262,L-669262,L669262
L 669262 is a potent inhibitor of HMG-CoA reductase.
T28440 PPD 10558 PPD-10558,RBx10558,RBx-10558,PPD10558,RBx 10558
PPD 10558, a HMG-CoA reductase inhibitor, is used potentially for treatment of primary hypercholesterolemia.
T22405 Pravastatin Others
Pravastatin is a lipoprotein-lowering drug via reversibly inhibiting hydroxymethylglutaryl-CoA (HMG-CoA) reductase and the synthesis of very-low-density lipoproteins.
T10070 2'-Ethyl Simvastatin HMG-CoA Reductase
2'-Ethyl Simvastatin is a Mevinolin analog with HMG-CoA reductase inhibition.
T21042 Fluvastatin Methyl Ester
Fluvastatin Methyl Ester is a precursor of Fluvastatin, a blocker of the enzyme HMG-CoA reductase in liver.
T21080 (3S,5S)-Atorvastatin ent-Atorvastatin,3S,5S-Atorvastatin
ent-Atorvastatin is a selective and competitive inhibitor of HMGCR (HMG-CoA reductase).
T71040 GR-95030X
GR-95030X is a a novel HMG-CoA reductase inhibitor.
T70633 GR-92549
GR-92549 is an HMG-CoA reductase inhibitor.
T21363 Atorvastatin calcium trihydrate CI-981,atorvastatin, calcium salt,CI981,Atorvastatin,CI 981
Atorvastatin is used to inhibits HMG-CoA reductase for lowering blood cholesterol and for prevention of events associated with cardiovascular disease.
T10126 (3R,5R)-Rosuvastatin Others
(3R,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM).
T26044 Rawsonol
Rawsonol is a HMG-CoA reductase inhibitor from the tropical green alga Avrainvillea rawsoni.
T40913 3α-Hydroxy pravastatin sodium
3α-Hydroxy pravastatin sodium, the primary metabolite of Pravastatin, is a potent competitive inhibitor of HMG-CoA reductase.
T71705 Glenvastatin
Glenvastatin is a HMG-CoA reductase inhibitor which has a pyridine-based structure.
T13380 (Z)-Pitavastatin calcium Others
(Z)-Pitavastatin calcium is the Z-Isomer of Pitavastatin hemicacium. Pitavastatin calcium is a potent of hydroxymethylglutaryl-CoA (HMG-CoA) reductase.
T69006 Atorvastatin lysine
Atorvastatin lysine is a selective and competitive HMGCR (HMG-CoA reductase) inhibitor.
T10136 4-Acetylsimvastatin Others
4-Acetylsimvastatin is acetylated simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki: 0.2 nM).
T10132 (3S,5S)-Pitavastatin calcium Others
(3S,5S)-Pitavastatin calcium is the 3-epimer of Pitavastatin which is a potent HMG-CoA reductase inhibitor.
T10130 (3S,5R)-Pitavastatin calcium Others
(3S,5R)-Pitavastatin calcium is the enantiomer of Pitavastatin which is a potent HMG-CoA reductase inhibitor.
T10131 (3S,5R)-Rosuvastatin Others
(3S,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM).
T24461 Mevinolinic acid L 154819,L-154819,MK 819,MSD 803 acid,Monacolinic K acid
Mevinolinic acid is an active metabolite of Lovastatin. Lovastatin is an HMG-CoA reductase inhibitor.
T70419 Cerivastatin lactone
Cerivastatin lactone is a metabolite of a competitive inhibitor of HMG-CoA reductase, Cerivastatin. Cerivastatin lactone shows inhibitory effects on CYP3A4/5 activity.
T68566 Pitavastatin methyl ester
Pitavastatin methyl ester is the methyl ester derivative of Pitavastatin -- a competitive inhibitor of HMG-CoA reductase and an anti-lipemic agent.
T40557 Simvastatin Acyl-β-D-glucuronide
Simvastatin Acyl-β-D-glucuronide, a metabolite formed from Simvastatin, acts as a competitive inhibitor of HMG-CoA reductase, showcasing a potent Ki of 0.2 nM.
T38249 2-Hydroxy atorvastatin lactone
2-Hydroxy atorvastatin lactone, a metabolite of Atorvastatin, is an orally active HMG-CoA reductase inhibitor that efficiently reduces blood lipids [1][2].
T10401 Atorvastatin acetonide Others
Atorvastatin acetonide is an impurity of Atorvastatin. Atorvastatin is an HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids.
T10767 Cerivastatin sodium HMG-CoA Reductase
Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent and orally active HMG-CoA reductase inhibitor (Ki: 1.3 nM). It also inhibits the proliferation and invasiveness of MDA-MB-231 cells, mainly by R...

Compounds

Atorvastatin lactone
T14342
Synonym:
Target: HMG-CoA Reductase
Atorvastatin
T20765
Synonym:
Target: HMG-CoA Reductase, Autophagy
HMG-CoA Reductase-IN-1
T79520
Synonym:
Target:
Fluvastatin sodium
T1487
Synonym: XU 62320 sodium,XU-62-320,Fluvastatin sodium salt
Target: Ferroptosis, HMG-CoA Reductase, Autophagy
Clinofibrate
T6450
Synonym: S-8527,Lipoclin
Target: HMG-CoA Reductase, Autophagy
SR12813
T6994
Synonym: SR-12813,SR 12813,GW 485801
Target: HMG-CoA Reductase, Autophagy
Monacolin J
T12092
Synonym: Antibiotic MB 530A,Lovastatin diol lactone
Target: HMG-CoA Reductase, Autophagy
Rosuvastatin
T1676
Synonym: ZD 4522
Target: Potassium Channel, HMG-CoA Reductase, Autophagy
Atorvastatin hemicalcium salt
T3116
Synonym: Lipitor,Atorvastatin hemicalcium,Atorvastatin Calcium,CI-981,Sortis
Target: Ferroptosis, HMG-CoA Reductase, Autophagy
Pitavastatin calcium
T2534
Synonym: P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,NK-104
Target: Apoptosis, Mitophagy, Endogenous Metabolite, HMG-CoA Reductase, Autophagy
Rosuvastatin calcium
T1510
Synonym: ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium
Target: Potassium Channel, HMG-CoA Reductase, Autophagy
Fluvastatin
T21405
Synonym: Canef,XU-62320,Vastin,Cranoc,Lescol
Target: HMG-CoA Reductase
Anhydrosimvastatin
T10324
Synonym: Dehydro simvastatin
Target: HMG-CoA Reductase
2-Hydroxy atorvastatin calcium salt
TQ0045
Synonym:
Target: Drug Metabolite
Tert-Buthyl Pitavastatin
T13131
Synonym:
Target: HMG-CoA Reductase
Dalvastatin
T25285
Synonym: RG-12561,RG 12561,RG12561
Target: HMG-CoA Reductase
(Rac)-5-Keto Fluvastatin
T12652
Synonym: 5-Ketofluvastatin,3-Hydroxy-5-Keto Fluvastatin,rac 5-Keto Fluvastatin
Target: Others
Atorvastatin Sodium
T20887
Synonym: Lipitor
Target: LDL, Aquaporin, HMG-CoA Reductase
Tenivastatin
T24865
Synonym: L-654969,L654969,Simvastatin acid,L 654969,Simvastatin hydroxy acid
Target: ROS, HMG-CoA Reductase
Pitavastatin lactone
T12490
Synonym:
Target: Others
Apomine
T26644
Synonym: SK&F-99085,APB-231-A2,APB-231-A-2,SR-9223i,SK&F-99085,SR-45023A
Target: HMG-CoA Reductase
Lovastatin hydroxy acid sodium
T19918
Synonym: 6-α-Methylcompactin sodium,Lovastatin Na,Lovastatin Sodium,Mevinolin sodium
Target:
Cerivastatin
T14931
Synonym:
Target: Others
HMG499
T11572
Synonym:
Target: HMG-CoA Reductase
L 669262
T24323
Synonym: L-669,262,L 669,262,L669,262,L-669262,L669262
Target:
PPD 10558
T28440
Synonym: PPD-10558,RBx10558,RBx-10558,PPD10558,RBx 10558
Target:
Pravastatin
T22405
Synonym:
Target: Others
2'-Ethyl Simvastatin
T10070
Synonym:
Target: HMG-CoA Reductase
Fluvastatin Methyl Ester
T21042
Synonym:
Target:
(3S,5S)-Atorvastatin
T21080
Synonym: ent-Atorvastatin,3S,5S-Atorvastatin
Target:
GR-95030X
T71040
Synonym:
Target:
GR-92549
T70633
Synonym:
Target:
Atorvastatin calcium trihydrate
T21363
Synonym: CI-981,atorvastatin, calcium salt,CI981,Atorvastatin,CI 981
Target:
(3R,5R)-Rosuvastatin
T10126
Synonym:
Target: Others
Rawsonol
T26044
Synonym:
Target:
3α-Hydroxy pravastatin sodium
T40913
Synonym:
Target:
Glenvastatin
T71705
Synonym:
Target:
(Z)-Pitavastatin calcium
T13380
Synonym:
Target: Others
Atorvastatin lysine
T69006
Synonym:
Target:
4-Acetylsimvastatin
T10136
Synonym:
Target: Others
(3S,5S)-Pitavastatin calcium
T10132
Synonym:
Target: Others
(3S,5R)-Pitavastatin calcium
T10130
Synonym:
Target: Others
(3S,5R)-Rosuvastatin
T10131
Synonym:
Target: Others
Mevinolinic acid
T24461
Synonym: L 154819,L-154819,MK 819,MSD 803 acid,Monacolinic K acid
Target:
Cerivastatin lactone
T70419
Synonym:
Target:
Pitavastatin methyl ester
T68566
Synonym:
Target:
Simvastatin Acyl-β-D-glucuronide
T40557
Synonym:
Target:
2-Hydroxy atorvastatin lactone
T38249
Synonym:
Target:
Atorvastatin acetonide
T10401
Synonym:
Target: Others
Cerivastatin sodium
T10767
Synonym:
Target: HMG-CoA Reductase
1 2
Cat No. Product Name Synonyms Targets
TN1733 Hesperetin 7-O-glucoside Anti-infection , Antibacterial , HMG-CoA Reductase
Hesperetin 7-O-glucoside and prunin are direct precursors of naringin and neohesperidin, respectively, in C. aurantium. Hesperetin 7-O-glucoside shows inhibition of human HMG-CoA reductase, it also exhibits effective inh...
TN6715 7-Ketocholesterol Others
7-Ketocholesterol is a metabolite of Cholesterol
TN1438 Beta-Amyrin acetate Antioxidant , HMG-CoA Reductase , Epoxide Hydrolase , Antifungal
beta-Amyrin acetate inhibits HMG-CoA Reductase (HMGCR) and sEH activity with IC50 of 3.4 μM. beta-Amyrin acetate has anti-inflammatory, antifungal, antioxidant, and anti-hyperlipidemic activities.
T1207 Lovastatin MK-803,Mevinolin Ferroptosis , HMG-CoA Reductase , Autophagy
Lovastatin (MK-803) is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.
T0683 Mevastatin Compactin,ML236B Apoptosis , Antibacterial , Antibiotic , HMG-CoA Reductase , Autophagy , Lipid
Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials.
T1664 Meglutol Dicrotalic acid,3-Hydroxy-3-methylglutaric acid Endogenous Metabolite , HMG-CoA Reductase , Autophagy
Meglutol (3-Hydroxy-3-methylglutaric acid) is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conve...
T0672 Pravastatin sodium CS-514 Sodium,CS-514 (sodium) Ferroptosis , HMG-CoA Reductase , Autophagy
Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.
T0687 Simvastatin MK-0733,MK 733 Apoptosis , Mitophagy , Ferroptosis , HMG-CoA Reductase , Autophagy
Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity. Simvastatin has hypolipidemic activity, inhibits hepatic production of cholesterol, and is also used for the prevention of cardiovasc...
T4717 25-Hydroxycholesterol Others , Endogenous Metabolite , HMG-CoA Reductase
25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase and so it also plays a significant role in the in vivo regu...
TN2111 Prunin Naringenin 7-0-glucoside Phosphatase , Anti-infection , Virus Protease
Prunin (Naringenin 7-0-glucoside) possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate glucose uptake in insulin-resistant HepG2 cells; it also can...
T75626 Ganoderenic acid K
Ganoderenic Acid K, isolated from the fruiting bodies of Ganoderma lucidum, exhibits potent inhibitory activity against HMG-CoA reductase (HMGCR), demonstrating an IC50 of 16.5 μM [1].
T35400 β-Muricholic Acid β-MCA,5β-Cholanic Acid-3α,6β,7β-triol,β-Muricholic Acid
β-Muricholic acid (β-MCA) is a murine-specific primary bile acid.[1],[2] Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet.[3] Di...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-00007 HMGCR Protein, Human, Recombinant (His) Human E. coli
The production of this recombinant Human HMGCR protein is just like all recombinant proteins. The process involved transfecting E.coli cells with DNA vector containing the template of recombinant DNA. The E.coli cells co...
TMPY-00989 LDLR Protein, Human, Recombinant (His) Human HEK293
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i...
TMPY-05809 LDLR Protein, Human, Recombinant (193D/A, His) Human HEK293
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i...
TMPY-05348 LDLR Protein, Mouse, Recombinant (His), Biotinylated Mouse HEK293
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i...
TMPY-05499 LDLR Protein, Human, Recombinant (His), Biotinylated Human HEK293
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i...
TMPY-01014 LDLR Protein, Mouse, Recombinant (His) Mouse HEK293
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i...
TMPY-05323 LDLR Protein, Human, Recombinant (mFc) Human HEK293
LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved i...
Cat No. Product Name
L2510 Lipid Metabolism Compound Library

496 compounds
A unique collection of 496 compounds targeting lipid metabolism, can be used for high-throughput screening (HTS) and high-content screening (HCS).
TargetMol