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GPCR/G Protein Hedgehog/Smoothened

Hedgehog/Smoothened

The Hedgehog signaling pathway is a signaling pathway that transmits information to embryonic cells required for proper cell differentiation. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include basal cell carcinoma.Smoothened is a protein that in humans is encoded by the SMO gene. Smoothened is a Class Frizzled (Class F) G protein-coupled receptor that is a component of the hedgehog signaling pathway and is conserved from flies to humans. It is the molecular target of the natural teratogen cyclopamine. It also is the target of Vismodegib, the first hedgehog pathway inhibitor to be approved by the U.S. Food and Drug Administration (FDA).
Cat No. Product Name
T0465 Ellagic acid Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clot...
T1094 Tolnaftate Tolnaftate is a synthetic antifungal agent.
T15370 GANT 58 GANT 58 is a potent antagonist of Gli. It inhibits GLI1-induced transcription (IC50: 5 μM).
T1543 Naftifine hydrochloride Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exac...
T1810 Purmorphamine Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of osteoblast differentiation.
T1926 Sonidegib LDE225 (NVP-LDE225; Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.
T2299 BMS-833923 BMS-833923, an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).
T2450 SANT-1 SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).
T2590 VismodegibHOT Vismodegib is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).
T2666 Taladegib Taladegib is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic a...
T2825 CyclopamineHOT Cyclopamine, a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.
T3070 GANT61 GANT 61 is an inhibitor for Gli1 and Gli2.
T3156 Ciliobrevin A Ciliobrevin A is a hedgehog (Hh) signaling pathway inhibitor with IC50 less than 10 μM.
T3363 Jervine The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothen...
T3460 HhAntag HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity...
T3588 JK184 JK184 is a potent Hedgehog (Hh) pathway inhibitor.
T4211 SAG hydrochloride (912545-86-9(free base)) SAG hydrochloride is a chlorobenzothiophene-containing compound which acts as a SMO agonist.
T6891 MK-4101 MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in...
Ellagic acid
T0465CAS 476-66-4
Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clot...
Tolnaftate
T1094CAS 2398-96-1
Tolnaftate is a synthetic antifungal agent.
GANT 58
T15370CAS 64048-12-0
GANT 58 is a potent antagonist of Gli. It inhibits GLI1-induced transcription (IC50: 5 μM).
Naftifine hydrochloride
T1543CAS 65473-14-5
Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exac...
Purmorphamine
T1810CAS 483367-10-8
Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of osteoblast differentiation.
Sonidegib
T1926CAS 956697-53-3
LDE225 (NVP-LDE225; Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.
BMS-833923
T2299CAS 1059734-66-5
BMS-833923, an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM).
SANT-1
T2450CAS 304909-07-7
SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).
Vismodegib HOT
T2590CAS 879085-55-9
Vismodegib is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).
Taladegib
T2666CAS 1258861-20-9
Taladegib is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic a...
Cyclopamine HOT
T2825CAS 4449-51-8
Cyclopamine, a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.
GANT61
T3070CAS 500579-04-4
GANT 61 is an inhibitor for Gli1 and Gli2.
Ciliobrevin A
T3156CAS 302803-72-1
Ciliobrevin A is a hedgehog (Hh) signaling pathway inhibitor with IC50 less than 10 μM.
Jervine
T3363CAS 469-59-0
The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothen...
HhAntag
T3460CAS 496794-70-8
HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity...
JK184
T3588CAS 315703-52-7
JK184 is a potent Hedgehog (Hh) pathway inhibitor.
SAG hydrochloride (912545-86-9(free base))
T4211CAS T4211
SAG hydrochloride is a chlorobenzothiophene-containing compound which acts as a SMO agonist.
MK-4101
T6891CAS 935273-79-3
MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in...