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Search Results for " hedgehog-smoothened "

Targets

30

Compounds

3

Natural Products

6

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T9531 MRT-14 Smo
MRT-14 is a potent Smo antagonist and can be used in several types of cancers linked to abnormal Hh signaling studies.
T6891 MK-4101 Apoptosis , Hedgehog/Smoothened , Smo
MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in tumor cells.
T2450 SANT-1 SANT 1 Hedgehog/Smoothened , Smo
SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).
T22814 GSA-10 Hedgehog/Smoothened
Smoothened (Smo) receptor agonist
T1779 SAG Smoothened Agonist (SAG) HCl,Smoothened Agonist Hedgehog/Smoothened , Smo
SAG (Smoothened Agonist) is a potent Smo receptor agonist and activates the Hedgehog signaling pathway.
T15019 CUR61414 Hedgehog/Smoothened
CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).
T2666 Taladegib LY2940680 Hedgehog/Smoothened , Smo
Taladegib (LY2940680) is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity.
T9532 MRT-81 Others
MRT-81 inhibits human and rodent smoothened Smo receptors effectively with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 also can be used for the research of cance...
T40465 SAG dihydrochloride Hedgehog/Smoothened
SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist ( EC 50 =3 nM; K d =59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine inhibition of Smo.
T64351 GI-560192 RL-0070933 Smo
GI-560192 is a potent smo cilial modulator with an EC50 value of 0.02 µM. GI-560192 modulates the translocation and/or accumulation of smoothened to the primary cilia by hedgehog signaling pathway.
T1926 Sonidegib Erismodegib,NVP-LDE225,LDE225 Hedgehog/Smoothened , Smo
Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.
T63429 SMO-IN-2 Hedgehog/Smoothened
SMO-IN-2 is a potent smoothened (SMO) inhibitor of hedgehog (Hh) signaling.SMO-IN-2 shows antiproliferative activity and anticancer activity against human medulloblastoma cell lines.SMO-IN-2 can be used in the study of c...
T15019L CUR61414 hydrochloride CUR61414 hydrochloride (334998-36-6 Free base) Hedgehog/Smoothened
CUR61414 hydrochloride is a potent and cell permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM). CUR61414 hydrochloride is a small-molecule aminoproline class compound. CUR61414 hydrochloride selectively...
T24754 Hh-Ag1.5 SAG-1.5,SAG1.5,SAG 1.5 Hedgehog/Smoothened
Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quies...
T23027 MRT-10 Hedgehog/Smoothened
MRT-10 is a Smoothened (Smo) receptor antagonist.
T71299 M-25
M-25 is a Smoothened antagonist and inhibitor of the Hedgehog pathway.
T23307 SANT 2 SANT-2 Others
SANT-2 is an inhibitor of Sonic hedgehog signaling and also antagonizes smoothened receptor activity (KD = 12 nM).
T16843 Saridegib IPI-926,Patidegib Others
Saridegib is an effective and specific inhibitor of Smoothened and a key signaling transmembrane protein in the Hedgehog pathway.
T25918 Palmitoyl-L-aspartic acid L-N-Palmitoylaspartic acid
Palmitoyl-L-aspartic acid is a natural N-acylaspartate that suppresses Hedgehog signaling after stimulation with Smoothened agonist or non-sterol-modified Sonic Hedgehog. It does not alter the activity of cannabinoid rec...
T71520 LEQ-506
LEQ506, also known as NPV-LEQ506, is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Smoothened antagonist LEQ506 selectively binds to the Hedgehog (Hh)-ligand ce...
T38767 MRT-83 hydrochloride
MRT-83 (hydrochloride) is a potent antagonist of the Smoothened (Smo) receptor, effectively inhibiting the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. With its potential applications in t...
T63387 SMO-IN-3
SMO-IN-3 is a potent inhibitor of smoothened (SMO) that acts on the hedgehog (Hh) signaling pathway (IC50: 34.09 nM). SMO-IN-3 inhibits the proliferation of Daoy, a human medulloblastoma cell line, and exhibits anticance...
T62772 TPB15
TPB15 is an orally active inhibitor of Hh (Hedgehog) signalling. TPB15 significantly blocks the MDA-MB-468 cell cycle and induces apoptosis. TPB15 blocks Smo (Smoothened) translocation into cilia and reduces Smo protein ...
T35537 Hedgehog Antagonist VIII
Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcript...
T35538 HPI-1 (hydrate) HPI-1 hydrate
HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50= 1.5 μM) without significantly affecting Wnt signaling (IC50≥ 30 μM).1HPI-1 suppresses Hh activation induced by loss o...
T35539 IHR-Cy3 IHR-Cy3
Potent fluorescent Smo antagonist (IC50 = 100 nM). Non-fluorescent analog also available. Fan et al (2014) The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Ch...
T70195 NL-103
NL-103 is a novel dual-targeted inhibitor of histone deacetylases and hedgehog pathway, effectively overcomes vismodegib resistance conferred by Smo mutations. NL-103 comprises structural elements of Hh pathway inhibito...
T35562 Nat-20(S)-yne
Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. 20(S)-hydroxy Cholesterol (20(S)-OHC) is an oxysterol which bin...
T35558 KAAD-Cyclopamine
Cyclopamine-KAAD is a potent inhibitor of hedgehog signaling with an IC50 value of 20 nM in a Shh-LIGHT2 assay. It blocks binding of BODIPY-cyclopamine to cells expressing Smoothened (Smo) in a dose-dependent manner. Cyc...
T36910 PF 04449913 maleate
Potent Smo antagonist (IC50 = 5 nM). Attenuates the leukemia-initiation potential of AML cells in a serial transplantation mouse model. Also eliminates self-propagation capacity of AML cells. Munchhof et al (2011) Discov...

Compounds

MRT-14
T9531
Synonym:
Target: Smo
MK-4101
T6891
Synonym:
Target: Apoptosis, Hedgehog/Smoothened, Smo
SANT-1
T2450
Synonym: SANT 1
Target: Hedgehog/Smoothened, Smo
GSA-10
T22814
Synonym:
Target: Hedgehog/Smoothened
SAG
T1779
Synonym: Smoothened Agonist (SAG) HCl,Smoothened Agonist
Target: Hedgehog/Smoothened, Smo
CUR61414
T15019
Synonym:
Target: Hedgehog/Smoothened
Taladegib
T2666
Synonym: LY2940680
Target: Hedgehog/Smoothened, Smo
MRT-81
T9532
Synonym:
Target: Others
SAG dihydrochloride
T40465
Synonym:
Target: Hedgehog/Smoothened
GI-560192
T64351
Synonym: RL-0070933
Target: Smo
Sonidegib
T1926
Synonym: Erismodegib,NVP-LDE225,LDE225
Target: Hedgehog/Smoothened, Smo
SMO-IN-2
T63429
Synonym:
Target: Hedgehog/Smoothened
CUR61414 hydrochloride
T15019L
Synonym: CUR61414 hydrochloride (334998-36-6 Free base)
Target: Hedgehog/Smoothened
Hh-Ag1.5
T24754
Synonym: SAG-1.5,SAG1.5,SAG 1.5
Target: Hedgehog/Smoothened
MRT-10
T23027
Synonym:
Target: Hedgehog/Smoothened
M-25
T71299
Synonym:
Target:
SANT 2
T23307
Synonym: SANT-2
Target: Others
Saridegib
T16843
Synonym: IPI-926,Patidegib
Target: Others
Palmitoyl-L-aspartic acid
T25918
Synonym: L-N-Palmitoylaspartic acid
Target:
LEQ-506
T71520
Synonym:
Target:
MRT-83 hydrochloride
T38767
Synonym:
Target:
SMO-IN-3
T63387
Synonym:
Target:
TPB15
T62772
Synonym:
Target:
Hedgehog Antagonist VIII
T35537
Synonym:
Target:
HPI-1 (hydrate)
T35538
Synonym: HPI-1 hydrate
Target:
IHR-Cy3
T35539
Synonym: IHR-Cy3
Target:
NL-103
T70195
Synonym:
Target:
Nat-20(S)-yne
T35562
Synonym:
Target:
KAAD-Cyclopamine
T35558
Synonym:
Target:
PF 04449913 maleate
T36910
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T2825 Cyclopamine 11-Deoxojervine Hedgehog/Smoothened , Endogenous Metabolite , Smo
Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.
T3363 Jervine Iervin,11-Ketocyclopamine,Jerwiny Hedgehog/Smoothened , Smo
The biological activity of Jervine (Jerwiny) is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signa...
T3912 Saikosaponin B1 Others
Saponin activator. Activates release of Prostaglandin E2 in vitro. Anti-inflammatory agent. Orally active. Active in vivo and in vitro.

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-03345 Sonic Hedgehog Protein, Mouse, Recombinant (His) Mouse HEK293
Sonic HedgeHog, also known as sonic hedgehog protein, belongs to the hedgehog family. It cannot be detected in adult tissues while can be found in fetal intestine, liver, lung, and kidney. Sonic HedgeHog is a protein tha...
TMPY-02905 Sonic Hedgehog Protein, Human, Recombinant (aa 1-197, His) Human HEK293
Sonic HedgeHog, also known as sonic hedgehog protein, belongs to the hedgehog family. It cannot be detected in adult tissues while can be found in fetal intestine, liver, lung, and kidney. Sonic HedgeHog is a protein tha...
TMPY-02832 Sonic Hedgehog Protein, Human, Recombinant (aa 198-462, His) Human HEK293
Sonic HedgeHog, also known as sonic hedgehog protein, belongs to the hedgehog family. It cannot be detected in adult tissues while can be found in fetal intestine, liver, lung, and kidney. Sonic HedgeHog is a protein tha...
TMPJ-01128 SHH Protein, Human, Recombinant (C24II) Human E. coli
Sonic Hedgehog Homolog (SHH) belongs to a three-protein family called Hedgehog. The other two family members are Indian Hedgehog (IHH) and Desert Hedgehog (DHH). Hedgehog proteins are key signaling molecules in embryonic...
TMPJ-01127 SHH Protein, Human, Recombinant Human E. coli
Sonic Hedgehog Homolog (SHH) belongs to a three-protein family called hedgehog. The other two family members are Indian Hedgehog (IHH) and Desert Hedgehog (DHH). Hedgehog proteins are key signaling molecules in embryonic...
TMPH-02285 USP6 Protein, Human, Recombinant (His & KSI) Human E. coli
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to...
TargetMol