T0465 |
Ellagic acid |
Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clot...
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T1094 |
Tolnaftate |
Tolnaftate is a synthetic antifungal agent. |
T1543 |
Naftifine hydrochloride |
Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exac...
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T1810 |
Purmorphamine |
Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of osteoblast differentiation. |
T1926 |
Sonidegib |
LDE225 (NVP-LDE225; Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. |
T2299 |
BMS-833923 |
BMS-833923, an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM). |
T2450 |
SANT-1 |
SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM). |
T2590 |
VismodegibHOT |
Vismodegib is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM). |
T2666 |
Taladegib |
Taladegib is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic a...
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T2825 |
CyclopamineHOT |
Cyclopamine, a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids. |
T3070 |
GANT61 |
GANT 61 is an inhibitor for Gli1 and Gli2. |
T3156 |
Ciliobrevin A |
Ciliobrevin A is a hedgehog (Hh) signaling pathway inhibitor with IC50 less than 10 μM. |
T3363 |
Jervine |
The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothen...
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T3460 |
HhAntag |
HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity...
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T3588 |
JK184 |
JK184 is a potent Hedgehog (Hh) pathway inhibitor. |
T4211 |
SAG hydrochloride (912545-86-9(free base)) |
SAG hydrochloride is a chlorobenzothiophene-containing compound which acts as a SMO agonist. |
T6514 |
Glasdegib |
Glasdegib (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2. |
T6891 |
MK-4101 |
MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of extensive apoptosis and inhibition of proliferation in...
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T15370 |
GANT 58 |
GANT 58 is a potent antagonist of Gli. It inhibits GLI1-induced transcription (IC50: 5 μM). |