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GPCR/G Protein Histamine Receptor

Histamine Receptor

The histamine receptors are a class of G protein–coupled receptors which bind histamine as their primary endogenous ligand.There are four known histamine receptors:H1 receptor,H2 receptor,H3 receptor,H4 receptor.
Cat No. product name
T0031 Ziprasidone hydrochloride monohydrate Ziprasidone(CP88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity.
T0031L Ziprasidone hydrochloride Ziprasidone (hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity.
T0031L2 Ziprasidone Ziprasidone is an a typical antipsychotic used in the treatment of schizophrenia and bipolar disorder. Use of ziprasidone has not been consistently associate...
T0053 Hydroxyzine Pamoate Hydroxyzine pamoate is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. ...
T0059 Diphenylpyraline hydrochloride Diphenylpyraline Hcl is used in the treatment of Parkinsonism.It is a first-generation antihistamine with anticholinergic effects, functions as a dopamine reupt...
T0074 Chlorprothixene Chlorprothixene is a typical antipsychotic drug of the thioxanthene class,which was the first of the series to be synthesized.
T0074L Chlorprothixene hydrochloride Chlorprothixene brings strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene is a ...
T0076 Paliperidone Paliperidone(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the p...
T0089 Cetirizine dihydrochloride Cetirizine dihydrochloride is an effective second-generation histamine H1 antagonist that is potent in the therapy of allergic rhinitis, confirmed urticaria, an...
T0092 Antazoline hydrochloride Antazoline hydrochloride, a first-generation antihistamine, can bind to the histamine H1 receptor and block the action of endogenous histamine.
T0118 Mizolastine Mizolastine (IC50= 47 nM) is a histamine H1-receptor antagonist.It is used in the treatment of allergic reactions such as hay fever (seasonal allergic rhinitis)...
T0147 Clemastine fumarate Clemastine Fumarate is a synthetic ethanolamine with anticholinergic, sedative, and histamine H1 antagonistic properties.
T0157 Roxatidine Acetate hydrochloride Roxatidine Acetate hydrochloride is a specific and competitive histamin H2-receptor antagonist. It inhibits gastric acid secretion and ulcer formation.
T0162 Quetiapin Quetiapine is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapi...
T0172 Maprotiline hydrochloride Maprotiline hydrochloride is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, i...
T0211L Azelastine hydrochloride Azelastine Hydrochloride is a phthalazinone derivative with antihistaminergic activity.
T0246 Betahistine dihydrochloride Betahistine hydrochloride is a histamine analog and H1 receptor agonist that serves as a vasodilator.
T0246L Betahistine mesylate Betahistine mesilate is a histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may...
T0263 Chloropyramine hydrochloride Chloropyramine hydrochloride is a histamine receptor H1 antagonist.
T0298 Dimenhydrinate Dimenhydrinate is an ethanolamine and histamine antagonist with anti-allergic activity.
T0330 Diphenhydramine hydrochloride Diphenhydramine HCl (Benadryl) is a histamine H1 antagonist used as an antitussive and antiemetic. It is also used for pruritus and dermatoses, for hypersensiti...
T0381 Amodiaquine hydrochloride Amodiaquine Hydrochloride is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory propert...
T0445 Promethazine Tafluprost(AFP-168) is an analogue of anti-glaucoma prostaglandin (PG) .
T0445L Promethazine hydrochloride Promethazine HCl(NSC-231688), the first-generation antihistamine, is a strong antagonist of the H1 receptor and a moderate antagonist of the mACh receptor, mode...
T0468 Xylocaine Lidocaine is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation of intracellu...
T0785 Dexchlorpheniramine Maleate Dexchlorpheniramine (trade name Polaramine) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria...
T0797 Cimetidine Cimetidine is a histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It...
T0865 Ranitidine Hydrochloride Ranitidine Hydrochloride is a member of the class of histamine H2-receptor antagonists with antacid activity. Ranitidine is a competitive and reversible in...
T0903 Stugeron Cinnarizine is a piperazine derivative having histamine H1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it ind...
T0942 Quinacrine dihydrochloride Quinacrine Hydrochloride is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities.
T0994 Ketotifen fumarate Ketotifen is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators.
T1030 Triprolidine hydrochloride Triprolidine Hydrochloride is a histamine H1 antagonist used in allergic rhinitis, asthma.
T1045 Trimipramine maleate Trimipramine maleate appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin a...
T1097 Loratadine Loratadine is a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamine...
T1110 Meclizine dihydrochloride Meclizine hydrochloride is a histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.
T1115 Doxylamine succinate Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate competitively blocks the histamine...
T1182 Propionyl-L-carnitine hydrochloride Propionyl-L-carnitine hydrochloride is used for the treatment of the deterioration of renal function, congestive heart failure, intermittent claudication, and o...
T1232 Pyrilamine maleate Pyrilamine maleate is a histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin erup...
T1269 Tripelennamine hydrochloride Tripelennamine hydrochloride is a histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation.
T1278 Astemizole Astemizole is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, acts as a reversible competitive inhibitor of histamine H1 receptors...
T1308 Orphenadrine hydrochloride Orphenadrine hydrochloride is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
T1327 Nortriptyline hydrochloride Nortriptyline hydrochloride is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia,...
T1393 Sodium butanoate Sodium Butyrate is the sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites...
T1425 Pemirolast potassium Pemirolast Potassium is the potassium salt form of pemirolast, a pyrimidinone derivative with antiallergic property. Pemirolast potassium exerts its action by b...
T1469 Levocetirizine Levocetirizine is a Histamine-1 Receptor Antagonist. The mechanism of action of levocetirizine is as a Histamine H1 Receptor Antagonist.
T1470L Fexofenadine hydrochloride Fexofenadine Hydrochloride is a carboxylated metabolic derivative of terfenadine and long-lasting selective histamine H1 receptor antagonist, with antihistamini...
T1553 Chlorpheniramine maleate Chlorphenamine is a histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma.
T1575 Nizatidine Nizatidine is a competitive and reversible histamine H2-receptor antagonist with antacid activity.
T1619 Trazodone hydrochloride Trazodone hydrochloride is a serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depres...
T1627 Famotidine Famotidine is a propanimidamide and histamine H2-receptor antagonist with antacid activity. As a competitive inhibitor of histamine H2-receptors located on the ...
T1822 Clemizole Clemizole is an H1 histamine receptor antagonist, can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.
T1822L Clemizole hydrochloride Clemizole hydrochloride is an antagonist for H1 histamine receptor. According to the research, Clemizole hydrochloride can inhibit hepatitis C virus (HCV) repli...
T2004 Ciproxifan maleate Ciproxifan maleate(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other re...
T2200 Hydroxyzine dihydrochloride Hydroxyzine hydrochloride is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated prur...
T2222 Carbinoxamine Maleate Salt Carbinoxamine Maleate is an ethanolamine class of H1 antihistamines with mild antimuscarinic and sedative properties.
T2232 JNJ-7777120 JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other h...
T2335 Ebastine Ebastine (trade names Evastin, Kestine, Ebastel, Aleva) is a non-sedating H1 antihistamine. It does not penetrate the blood-brain barrier and thus allows an eff...
T2520 Desloratadine Desloratadine is a long-acting piperidine derivate with selective H1 antihistaminergic and non-sedating properties. Desloratadine diminishes the typical histami...
T2533 Alcaftadine Alcaftadine is an H1 histamine receptor antagonist indicated for the prevention of itching associated with allergic conjunctivitis.
T2848 Osthole Osthole, a potential inhibitor of histamine H1 receptor, has been shown to stimulate osteoblast proliferation and differentiation.
T3037 Cyclizine dihydrochloride Cyclizine Dihydrochloride is a histamine H1 antagonist. It is given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in m...
T3429 Protopine Protopine is a benzylisoquinoline alkaloid. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic.
T3610 Ranitidin Ranitidine is a non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.
T3723 Dioxopromethazine hydrochloride Dioxopromethazine is a target-based classification of drug and available in a number of countries worldwide.
T3963 VUF10460 VUF10460 is a non-imidazole histamine H4 receptor agonist.
T3979 Emedastine Emedastine is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histam...
T4099 S-38093 S-38093 is a brain-penetrant antagonist of the H3 receptor (Ki: 8.8/1.44/1.2 μM, for rat/mouse/human).
T4195 Betahistine Betahistine is a histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerba...
T6164 Ciproxifan Ciproxifan is a highly effective and specific histamin H3-receptor antagonist (IC50: 9.2 nM).
T6242 Rupatadine Fumarate Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM.
T6405 Bepotastine Besilate Bepotastine is a non-sedating and selective H1 receptor antagonist (pIC50: 5.7).
T6534 Histamine 2HCl Histamine, an organic nitrogen compound, works on target cells in the mammalian brain by stimulating of Histamine 1/2.
T6535 Histamine Phosphate Histamine acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors.
T4250 Bilastine Bilastine is a novel new-generation antihistamine that is highly selective for the H1 histamine receptor, has a rapid onset and prolonged duration of action.
T7085 Mebhydroline Mebhydrolin is a specific histamine H1 receptor antagonist.
T4362 MOZ-IN-3 MOZ-IN-3 is an inhibitor of MOZ(IC50=55 nM), a member of histone acetyltransferases.
T4380 Ac-CoA Synthase Inhibitor1 ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2).
T4247 I-CBP112 hydrochloride I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 ...
T4563 Thonzylamine Thonzylamine is an antihistamine and anticholinergic drug. It is available as combination products with Clofedanol or Phenylephrine for temporary relief of symp...
T4499 Mequitazine Mequitazine is an effective, nonsedative and long-acting histamine H1 antagonist.
T4551 Acrivastine Acrivastine is a short-acting histamine 1 receptor antagonist.
T4507 Chlorphenesin Chlorphenesin is an antigen-associated immunosuppressant that inhibits IgE-mediated histamine release. It is also used as an antimycotic agent.
T4566 Lodoxamide Lodoxamide is an antiallergic drug acting as a mast-cell stabilizer. It is effective in the treatment of asthma and allergic conjunctivitis.
T5495 Decloxizine dihydrochloride Decloxizine dihydrochloride is a histamine 1 receptor antagonist.
T5829 H4 Receptor antagonist 1 H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM.
T7176 Pitolisant hydrochloride Pitolisant hydrochloride is a potent and selective inverse agonist of the histamine H3 receptor(Ki : 0.16 nM).
T7413 JNJ-5207852 JNJ-5207852 is a novel, non-imidazole histamine H3 receptor antagonist, with high affinity at the rat (pKi=8.9) and human (pKi=9.24) H3 receptor.
T7524 Metiamide Metiamide is a histamine H2-receptor antagonist .
TQ0046 Bavisant Bavisant (JNJ-31001074) is a selective and orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cogniti...
TQ0066 GSK189254A GSK189254A (GSK189254) is a new, potent and specific histamine H3 receptor antagonist (pKi values: 9.59-9.90 and 8.51-9.17 for human and rat H3).
T1090 Perphenazine Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
TN1661 Ganoderic acid C2 Ganoderic acid C2 has anti-inflammatory,and anti-tumor-promoting activities. Ganoderic acid C2 can inhibit histamine release, it also has inhibitory effects on ...
TN2155 Rhodiocyanoside A Rhodiocyanoside A has antiallergic activity, it exhibits inhibitory activity on the histamine release from rat peritoneal exudate cells sensitized with anti-DNP...
TN1154 6-Methoxyluteolin 6-Methoxyluteolin has antioxidant activity, it is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain.
TN1901 (-)-Maackiain (-)-Maackiain, a phytoalexin, which is an anti-allergic compound that suppresses the up-regulation of the histamine H1 receptor (H1R) gene.
TN1913 Marmin Marmin have anti-ulcer effects, which are ascribed primarily to the maintenance of the mucosal barrier integrity and inhibition of gastric motor activity and se...
T12054 MK-0249 MK-0249 is a potent antagonist of histamine H3 receptor (human H3, Ki : 1.7 nM).
T12228 Niperotidine Niperotidine is an antagonist of histamine H2-receptor.
T12416 PF-03654746 Tosylate PF-03654746 Tosylate is selective antagonist of histamine H3 receptor with high brain penetration.
T10000 (±)-Tazifylline (±)-Tazifylline is a specific and long-acting antagonist of histamine H1 receptor.
T10911 H3 receptor antagonist 1 H3 receptor antagonist 1 is used in the study of neurological diseases, histamine H3 receptor antagonist.
T11088 Doxepin D3 Hydrochloride Doxepin D3 Hydrochloride is a deuterium-labeled doxepin hydrochloride.Doxepin hydrochloride is an oral active tricyclic antidepressant used as a sedative.Doxepi...
T12630 (R)-(-)-α-Methylhistamine dihydrobromide (R)-(-)-α-Methylhistamine dihydrobromide is a potent and selective agonist of H3 histamine receptor( Kd of 50.3 nM).
T12703 ReN-1869 hydrochloride ReN 1869 hydrochloride is a novel, selective antagonist of histamine H1 receptor.
T12756 ROS 234 dioxalate ROS 234 dioxalate is a potent antagonist of H3(pKB of 9.46 for Guinea-pig ileum H3-receptor)
T13040 SUN 1334H SUN 1334H is a potent, orally active, highly selective antagonist of H1 receptor(Ki of 9.7 nM).
T11324 FRG8701 FRG8701 is a new Histamine H2-receptor antagonist with an IC50 of ranging from 0.25 to 0.43 μM. 
T10575 BMY-25271 BMY-25271 is an antagonist of histamine H2 receptor.
T10680 Carebastine Carebastine, the active metabolite of Ebastine, is an antagonist of the histamine H1 receptor.
T11531 H3R-IN-1 Hydrochloride H3R-IN-1 Hydrochloride is a histamine receptor 3 (H3R) inverse agonist.
T11532 H4R antagonist 1 H4R antagonist 1 does not show any noticeable binding affinity to other subtypes of histamine receptors, H1R, H2R, and H3R.H4R antagonist 1 is a potent and high...
T10769 Cetirizine D4 Cetirizine D4 is a deuterium-labeled Cetirizine. Cetirizine is a second-generation antihistamine and a long-acting histamine H1-receptor antagonist.
T10770 Cetirizine D8 Cetirizine D8 is a deuterium-labeled Cetirizine. Cetirizine is a second-generation antihistamine and a long-acting histamine H1-receptor antagonist.
T19234 Cetirizine D8 dihydrochloride Cetirizine D8 dihydrochloride is a deuterium-labeled Cetirizine. Cetirizine is a second-generation antihistamine and a long-acting histamine H1-receptor antagon...
T10794 Chlorcyclizine hydrochloride Chlorcyclizine hydrochloride is an antagonist of histamine H1.
T15565 Imetit dihydrobromide Imetit mimics the histamine effect in triggering a shape change in eosinophils (EC50=25 nM). Imetit dihydrobromide is a high affinity and effective agonist of h...
T15590 Iodophenpropit dihydrobromide Iodophenpropit dihydrobromide is an effective and selective antagonist of the histamine H3 receptor. The binding of [125I]Iodophenpropit is readily reversible, ...
T11723L JNJ-39758979 JNJ-39758979 displays good anti-inflammatory and antipruritic activity. JNJ-39758979 is a selective and high-affinity histamine H4 receptor antagonist (Kis: 12....
T15722 Lavoltidine Lavoltidine strongly suppresses gastric acid secretion and also induces hypergastrinemia. Lavoltidine is an orally active, irreversible, and highly effective hi...
T19604 WZ4141 WZ4141 is an intermediate in compound synthesis.
T11729 JTE-952 JTE-952 is a oral, potent active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), wi...
T16759 Ritanserin Ritanserin is a highly effective, relatively selective, long-acting antagonist of 5-HT2 receptor (IC50: 0.9 nM).
T8514 LML-134 LML-134 is an inverse agonist of Histamine 3 receptor (H3R)(hH3R cAMP and hH3R bdg with Kis of 0.3 nM and 12 nM).
T8548 Metoprine Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.
T17118 Toreforant Toreforant is an effective and selective histamine H4 receptor antagonist (Ki at the human receptor: 8.4 nM).
T22354 Levocetirizine Dihydrochloride Levocetirizine, the active R-enantiomer of cetirizine, represents a new second-generation histamine H1 antagonist.
T8599 Betazole hydrochloride Betazole hydrochloride is an agonist of H2 receptor.
T2S0118 Daurinoline Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a...
TN2895 3,5-Dicaffeoyl-epi-quinic acid 3,5-Dicaffeoyl-epi-quinic acid shows anti-inflammatory activity, it may improve mast cell-mediated inflammatory diseases.
TN3062 4'-O-Methylnyasol 4'-O-Methylnyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells.
TN3483 Bakkenolide D Bakkenolide D has anti-allergic effect, it and bakkenolide D demonstrates inhibitory effect on the trachea contraction induced by histamine in vitro, they have ...
TN3699 Corchoionoside C Corchoionoside C has antioxidant activity, shows strong scavenging activities on DPPH radical, it also shows weak antifungal activity. Corchoionosides A, B, and...
TN4918 Roseoside Roseoside possesses strong antioxidant properties, inhibiting lipid oxidation by 86.4, at 50 microg/mL. Roseoside has insulinotropic activity, enhances insulin ...
TN5279 Zeorin Zeorin shows strong inhibition activity against bacteria and fungi. It markedly exhibits inhibitory activity on histamine release from mast cell induced by DNP2...
Ziprasidone hydrochloride monohydrate
T0031CAS 138982-67-9
Ziprasidone(CP88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity.
Ziprasidone hydrochloride
T0031LCAS 122883-93-6
Ziprasidone (hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity.
Ziprasidone
T0031L2CAS 146939-27-7
Ziprasidone is an a typical antipsychotic used in the treatment of schizophrenia and bipolar disorder. Use of ziprasidone has not been consistently associate...
Hydroxyzine Pamoate
T0053CAS 10246-75-0
Hydroxyzine pamoate is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. ...
Diphenylpyraline hydrochloride
T0059CAS 132-18-3
Diphenylpyraline Hcl is used in the treatment of Parkinsonism.It is a first-generation antihistamine with anticholinergic effects, functions as a dopamine reupt...
Chlorprothixene
T0074CAS 113-59-7
Chlorprothixene is a typical antipsychotic drug of the thioxanthene class,which was the first of the series to be synthesized.
Chlorprothixene hydrochloride
T0074LCAS 6469-93-8
Chlorprothixene brings strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene is a ...
Paliperidone
T0076CAS 144598-75-4
Paliperidone(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the p...
Cetirizine dihydrochloride
T0089CAS 83881-52-1
Cetirizine dihydrochloride is an effective second-generation histamine H1 antagonist that is potent in the therapy of allergic rhinitis, confirmed urticaria, an...
Antazoline hydrochloride
T0092CAS 2508-72-7
Antazoline hydrochloride, a first-generation antihistamine, can bind to the histamine H1 receptor and block the action of endogenous histamine.
Mizolastine
T0118CAS 108612-45-9
Mizolastine (IC50= 47 nM) is a histamine H1-receptor antagonist.It is used in the treatment of allergic reactions such as hay fever (seasonal allergic rhinitis)...
Clemastine fumarate
T0147CAS 14976-57-9
Clemastine Fumarate is a synthetic ethanolamine with anticholinergic, sedative, and histamine H1 antagonistic properties.
Roxatidine Acetate hydrochloride
T0157CAS 93793-83-0
Roxatidine Acetate hydrochloride is a specific and competitive histamin H2-receptor antagonist. It inhibits gastric acid secretion and ulcer formation.
Quetiapin
T0162CAS 111974-69-7
Quetiapine is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapi...
Maprotiline hydrochloride
T0172CAS 10347-81-6
Maprotiline hydrochloride is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, i...
Azelastine hydrochloride
T0211LCAS 79307-93-0
Azelastine Hydrochloride is a phthalazinone derivative with antihistaminergic activity.
Betahistine dihydrochloride
T0246CAS 5579-84-0
Betahistine hydrochloride is a histamine analog and H1 receptor agonist that serves as a vasodilator.
Betahistine mesylate
T0246LCAS 54856-23-4
Betahistine mesilate is a histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may...
Chloropyramine hydrochloride
T0263CAS 6170-42-9
Chloropyramine hydrochloride is a histamine receptor H1 antagonist.
Dimenhydrinate
T0298CAS 523-87-5
Dimenhydrinate is an ethanolamine and histamine antagonist with anti-allergic activity.
Diphenhydramine hydrochloride
T0330CAS 147-24-0
Diphenhydramine HCl (Benadryl) is a histamine H1 antagonist used as an antitussive and antiemetic. It is also used for pruritus and dermatoses, for hypersensiti...
Amodiaquine hydrochloride
T0381CAS 6398-98-7
Amodiaquine Hydrochloride is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory propert...
Promethazine
T0445CAS 60-87-7
Tafluprost(AFP-168) is an analogue of anti-glaucoma prostaglandin (PG) .
Promethazine hydrochloride
T0445LCAS 58-33-3
Promethazine HCl(NSC-231688), the first-generation antihistamine, is a strong antagonist of the H1 receptor and a moderate antagonist of the mACh receptor, mode...
Xylocaine
T0468CAS 137-58-6
Lidocaine is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation of intracellu...
Dexchlorpheniramine Maleate
T0785CAS 2438-32-6
Dexchlorpheniramine (trade name Polaramine) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria...
Cimetidine
T0797CAS 51481-61-9
Cimetidine is a histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It...
Ranitidine Hydrochloride
T0865CAS 66357-59-3
Ranitidine Hydrochloride is a member of the class of histamine H2-receptor antagonists with antacid activity. Ranitidine is a competitive and reversible in...
Stugeron
T0903CAS 298-57-7
Cinnarizine is a piperazine derivative having histamine H1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it ind...
Quinacrine dihydrochloride
T0942CAS 69-05-6
Quinacrine Hydrochloride is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities.
Ketotifen fumarate
T0994CAS 34580-14-8
Ketotifen is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators.
Triprolidine hydrochloride
T1030CAS 6138-79-0
Triprolidine Hydrochloride is a histamine H1 antagonist used in allergic rhinitis, asthma.
Trimipramine maleate
T1045CAS 521-78-8
Trimipramine maleate appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin a...
Loratadine
T1097CAS 79794-75-5
Loratadine is a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamine...
Meclizine dihydrochloride
T1110CAS 1104-22-9
Meclizine hydrochloride is a histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.
Doxylamine succinate
T1115CAS 562-10-7
Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate competitively blocks the histamine...
Propionyl-L-carnitine hydrochloride
T1182CAS 119793-66-7
Propionyl-L-carnitine hydrochloride is used for the treatment of the deterioration of renal function, congestive heart failure, intermittent claudication, and o...
Pyrilamine maleate
T1232CAS 59-33-6
Pyrilamine maleate is a histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin erup...
Tripelennamine hydrochloride
T1269CAS 154-69-8
Tripelennamine hydrochloride is a histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation.
Astemizole
T1278CAS 68844-77-9
Astemizole is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, acts as a reversible competitive inhibitor of histamine H1 receptors...
Orphenadrine hydrochloride
T1308CAS 341-69-5
Orphenadrine hydrochloride is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
Nortriptyline hydrochloride
T1327CAS 894-71-3
Nortriptyline hydrochloride is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia,...
Sodium butanoate
T1393CAS 156-54-7
Sodium Butyrate is the sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites...
Pemirolast potassium
T1425CAS 100299-08-9
Pemirolast Potassium is the potassium salt form of pemirolast, a pyrimidinone derivative with antiallergic property. Pemirolast potassium exerts its action by b...
Levocetirizine
T1469CAS 130018-77-8
Levocetirizine is a Histamine-1 Receptor Antagonist. The mechanism of action of levocetirizine is as a Histamine H1 Receptor Antagonist.
Fexofenadine hydrochloride
T1470LCAS 138452-21-8
Fexofenadine Hydrochloride is a carboxylated metabolic derivative of terfenadine and long-lasting selective histamine H1 receptor antagonist, with antihistamini...
Chlorpheniramine maleate
T1553CAS 113-92-8
Chlorphenamine is a histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma.
Nizatidine
T1575CAS 76963-41-2
Nizatidine is a competitive and reversible histamine H2-receptor antagonist with antacid activity.
Trazodone hydrochloride
T1619CAS 25332-39-2
Trazodone hydrochloride is a serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depres...
Famotidine
T1627CAS 76824-35-6
Famotidine is a propanimidamide and histamine H2-receptor antagonist with antacid activity. As a competitive inhibitor of histamine H2-receptors located on the ...
Clemizole
T1822CAS 442-52-4
Clemizole is an H1 histamine receptor antagonist, can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.
Clemizole hydrochloride
T1822LCAS 1163-36-6
Clemizole hydrochloride is an antagonist for H1 histamine receptor. According to the research, Clemizole hydrochloride can inhibit hepatitis C virus (HCV) repli...
Ciproxifan maleate
T2004CAS 184025-19-2
Ciproxifan maleate(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other re...
Hydroxyzine dihydrochloride
T2200CAS 2192-20-3
Hydroxyzine hydrochloride is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated prur...
Carbinoxamine Maleate Salt
T2222CAS 3505-38-2
Carbinoxamine Maleate is an ethanolamine class of H1 antihistamines with mild antimuscarinic and sedative properties.
JNJ-7777120
T2232CAS 459168-41-3
JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other h...
Ebastine
T2335CAS 90729-43-4
Ebastine (trade names Evastin, Kestine, Ebastel, Aleva) is a non-sedating H1 antihistamine. It does not penetrate the blood-brain barrier and thus allows an eff...
Desloratadine
T2520CAS 100643-71-8
Desloratadine is a long-acting piperidine derivate with selective H1 antihistaminergic and non-sedating properties. Desloratadine diminishes the typical histami...
Alcaftadine
T2533CAS 147084-10-4
Alcaftadine is an H1 histamine receptor antagonist indicated for the prevention of itching associated with allergic conjunctivitis.
Osthole
T2848CAS 484-12-8
Osthole, a potential inhibitor of histamine H1 receptor, has been shown to stimulate osteoblast proliferation and differentiation.
Cyclizine dihydrochloride
T3037CAS 5897-18-7
Cyclizine Dihydrochloride is a histamine H1 antagonist. It is given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in m...
Protopine
T3429CAS 130-86-9
Protopine is a benzylisoquinoline alkaloid. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic.
Ranitidin
T3610CAS 66357-35-5
Ranitidine is a non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.
Dioxopromethazine hydrochloride
T3723CAS 15374-15-9
Dioxopromethazine is a target-based classification of drug and available in a number of countries worldwide.
VUF10460
T3963CAS 1028327-66-3
VUF10460 is a non-imidazole histamine H4 receptor agonist.
Emedastine
T3979CAS 87233-61-2
Emedastine is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histam...
S-38093
T4099CAS 862896-30-8
S-38093 is a brain-penetrant antagonist of the H3 receptor (Ki: 8.8/1.44/1.2 μM, for rat/mouse/human).
Betahistine
T4195CAS 5638-76-6
Betahistine is a histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerba...
Ciproxifan
T6164CAS 184025-18-1
Ciproxifan is a highly effective and specific histamin H3-receptor antagonist (IC50: 9.2 nM).
Rupatadine Fumarate
T6242CAS 182349-12-8
Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM.
Bepotastine Besilate
T6405CAS 190786-44-8
Bepotastine is a non-sedating and selective H1 receptor antagonist (pIC50: 5.7).
Histamine 2HCl
T6534CAS 56-92-8
Histamine, an organic nitrogen compound, works on target cells in the mammalian brain by stimulating of Histamine 1/2.
Histamine Phosphate
T6535CAS 51-74-1
Histamine acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors.
Bilastine
T4250CAS 202189-78-4
Bilastine is a novel new-generation antihistamine that is highly selective for the H1 histamine receptor, has a rapid onset and prolonged duration of action.
Mebhydroline
T7085CAS 524-81-2
Mebhydrolin is a specific histamine H1 receptor antagonist.
MOZ-IN-3
T4362CAS 2055397-18-5
MOZ-IN-3 is an inhibitor of MOZ(IC50=55 nM), a member of histone acetyltransferases.
Ac-CoA Synthase Inhibitor1
T4380CAS 508186-14-9
ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2).
I-CBP112 hydrochloride
T4247CAS 2147701-33-3
I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 ...
Thonzylamine
T4563CAS 91-85-0
Thonzylamine is an antihistamine and anticholinergic drug. It is available as combination products with Clofedanol or Phenylephrine for temporary relief of symp...
Mequitazine
T4499CAS 29216-28-2
Mequitazine is an effective, nonsedative and long-acting histamine H1 antagonist.
Acrivastine
T4551CAS 87848-99-5
Acrivastine is a short-acting histamine 1 receptor antagonist.
Chlorphenesin
T4507CAS 104-29-0
Chlorphenesin is an antigen-associated immunosuppressant that inhibits IgE-mediated histamine release. It is also used as an antimycotic agent.
Lodoxamide
T4566CAS 53882-12-5
Lodoxamide is an antiallergic drug acting as a mast-cell stabilizer. It is effective in the treatment of asthma and allergic conjunctivitis.
Decloxizine dihydrochloride
T5495CAS 13073-96-6
Decloxizine dihydrochloride is a histamine 1 receptor antagonist.
H4 Receptor antagonist 1
T5829CAS 848217-00-5
H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM.
Pitolisant hydrochloride
T7176CAS 903576-44-3
Pitolisant hydrochloride is a potent and selective inverse agonist of the histamine H3 receptor(Ki : 0.16 nM).
JNJ-5207852
T7413CAS 398473-34-2
JNJ-5207852 is a novel, non-imidazole histamine H3 receptor antagonist, with high affinity at the rat (pKi=8.9) and human (pKi=9.24) H3 receptor.
Metiamide
T7524CAS 34839-70-8
Metiamide is a histamine H2-receptor antagonist .
Bavisant
TQ0046CAS 929622-08-2
Bavisant (JNJ-31001074) is a selective and orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cogniti...
GSK189254A
TQ0066CAS 720690-73-3
GSK189254A (GSK189254) is a new, potent and specific histamine H3 receptor antagonist (pKi values: 9.59-9.90 and 8.51-9.17 for human and rat H3).
Perphenazine
T1090CAS 58-39-9
Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
Ganoderic acid C2
TN1661CAS 103773-62-2
Ganoderic acid C2 has anti-inflammatory,and anti-tumor-promoting activities. Ganoderic acid C2 can inhibit histamine release, it also has inhibitory effects on ...
Rhodiocyanoside A
TN2155CAS 168433-86-1
Rhodiocyanoside A has antiallergic activity, it exhibits inhibitory activity on the histamine release from rat peritoneal exudate cells sensitized with anti-DNP...
6-Methoxyluteolin
TN1154CAS 520-11-6
6-Methoxyluteolin has antioxidant activity, it is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain.
(-)-Maackiain
TN1901CAS 2035-15-6
(-)-Maackiain, a phytoalexin, which is an anti-allergic compound that suppresses the up-regulation of the histamine H1 receptor (H1R) gene.
Marmin
TN1913CAS 14957-38-1
Marmin have anti-ulcer effects, which are ascribed primarily to the maintenance of the mucosal barrier integrity and inhibition of gastric motor activity and se...
MK-0249
T12054CAS 862309-06-6
MK-0249 is a potent antagonist of histamine H3 receptor (human H3, Ki : 1.7 nM).
Niperotidine
T12228CAS 84845-75-0
Niperotidine is an antagonist of histamine H2-receptor.
PF-03654746 Tosylate
T12416CAS 1039399-17-1
PF-03654746 Tosylate is selective antagonist of histamine H3 receptor with high brain penetration.
(±)-Tazifylline
T10000CAS 79712-55-3
(±)-Tazifylline is a specific and long-acting antagonist of histamine H1 receptor.
H3 receptor antagonist 1
T10911CAS 935840-13-4
H3 receptor antagonist 1 is used in the study of neurological diseases, histamine H3 receptor antagonist.
Doxepin D3 Hydrochloride
T11088CAS 347840-07-7
Doxepin D3 Hydrochloride is a deuterium-labeled doxepin hydrochloride.Doxepin hydrochloride is an oral active tricyclic antidepressant used as a sedative.Doxepi...
(R)-(-)-α-Methylhistamine dihydrobromide
T12630CAS 868698-49-1
(R)-(-)-α-Methylhistamine dihydrobromide is a potent and selective agonist of H3 histamine receptor( Kd of 50.3 nM).
ReN-1869 hydrochloride
T12703CAS 170149-76-5
ReN 1869 hydrochloride is a novel, selective antagonist of histamine H1 receptor.
ROS 234 dioxalate
T12756CAS 1781941-93-2
ROS 234 dioxalate is a potent antagonist of H3(pKB of 9.46 for Guinea-pig ileum H3-receptor)
SUN 1334H
T13040CAS 607736-84-5
SUN 1334H is a potent, orally active, highly selective antagonist of H1 receptor(Ki of 9.7 nM).
FRG8701
T11324CAS 108498-50-6
FRG8701 is a new Histamine H2-receptor antagonist with an IC50 of ranging from 0.25 to 0.43 μM. 
BMY-25271
T10575CAS 78441-82-4
BMY-25271 is an antagonist of histamine H2 receptor.
Carebastine
T10680CAS 90729-42-3
Carebastine, the active metabolite of Ebastine, is an antagonist of the histamine H1 receptor.
H3R-IN-1 Hydrochloride
T11531CAS T11531
H3R-IN-1 Hydrochloride is a histamine receptor 3 (H3R) inverse agonist.
H4R antagonist 1
T11532CAS 1429375-54-1
H4R antagonist 1 does not show any noticeable binding affinity to other subtypes of histamine receptors, H1R, H2R, and H3R.H4R antagonist 1 is a potent and high...
Cetirizine D4
T10769CAS 1219803-84-5
Cetirizine D4 is a deuterium-labeled Cetirizine. Cetirizine is a second-generation antihistamine and a long-acting histamine H1-receptor antagonist.
Cetirizine D8
T10770CAS 774596-22-4
Cetirizine D8 is a deuterium-labeled Cetirizine. Cetirizine is a second-generation antihistamine and a long-acting histamine H1-receptor antagonist.
Cetirizine D8 dihydrochloride
T19234CAS 2070015-04-0
Cetirizine D8 dihydrochloride is a deuterium-labeled Cetirizine. Cetirizine is a second-generation antihistamine and a long-acting histamine H1-receptor antagon...
Chlorcyclizine hydrochloride
T10794CAS 14362-31-3
Chlorcyclizine hydrochloride is an antagonist of histamine H1.
Imetit dihydrobromide
T15565CAS 32385-58-3
Imetit mimics the histamine effect in triggering a shape change in eosinophils (EC50=25 nM). Imetit dihydrobromide is a high affinity and effective agonist of h...
Iodophenpropit dihydrobromide
T15590CAS 145196-87-8
Iodophenpropit dihydrobromide is an effective and selective antagonist of the histamine H3 receptor. The binding of [125I]Iodophenpropit is readily reversible, ...
JNJ-39758979
T11723LCAS 1046447-90-8
JNJ-39758979 displays good anti-inflammatory and antipruritic activity. JNJ-39758979 is a selective and high-affinity histamine H4 receptor antagonist (Kis: 12....
Lavoltidine
T15722CAS 76956-02-0
Lavoltidine strongly suppresses gastric acid secretion and also induces hypergastrinemia. Lavoltidine is an orally active, irreversible, and highly effective hi...
WZ4141
T19604CAS 1222776-76-2
WZ4141 is an intermediate in compound synthesis.
JTE-952
T11729CAS 1255303-54-8
JTE-952 is a oral, potent active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), wi...
Ritanserin
T16759CAS 87051-43-2
Ritanserin is a highly effective, relatively selective, long-acting antagonist of 5-HT2 receptor (IC50: 0.9 nM).
LML-134
T8514CAS 1542135-76-1
LML-134 is an inverse agonist of Histamine 3 receptor (H3R)(hH3R cAMP and hH3R bdg with Kis of 0.3 nM and 12 nM).
Metoprine
T8548CAS 7761-45-7
Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.
Toreforant
T17118CAS 952494-46-1
Toreforant is an effective and selective histamine H4 receptor antagonist (Ki at the human receptor: 8.4 nM).
Levocetirizine Dihydrochloride
T22354CAS 130018-87-0
Levocetirizine, the active R-enantiomer of cetirizine, represents a new second-generation histamine H1 antagonist.
Betazole hydrochloride
T8599CAS 138-92-1
Betazole hydrochloride is an agonist of H2 receptor.
Daurinoline
T2S0118CAS 2831-75-6
Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a...
3,5-Dicaffeoyl-epi-quinic acid
TN2895CAS 879305-14-3
3,5-Dicaffeoyl-epi-quinic acid shows anti-inflammatory activity, it may improve mast cell-mediated inflammatory diseases.
4'-O-Methylnyasol
TN3062CAS 79004-25-4
4'-O-Methylnyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells.
Bakkenolide D
TN3483CAS 18456-03-6
Bakkenolide D has anti-allergic effect, it and bakkenolide D demonstrates inhibitory effect on the trachea contraction induced by histamine in vitro, they have ...
Corchoionoside C
TN3699CAS 185414-25-9
Corchoionoside C has antioxidant activity, shows strong scavenging activities on DPPH radical, it also shows weak antifungal activity. Corchoionosides A, B, and...
Roseoside
TN4918CAS 54835-70-0
Roseoside possesses strong antioxidant properties, inhibiting lipid oxidation by 86.4, at 50 microg/mL. Roseoside has insulinotropic activity, enhances insulin ...
Zeorin
TN5279CAS 22570-53-2
Zeorin shows strong inhibition activity against bacteria and fungi. It markedly exhibits inhibitory activity on histamine release from mast cell induced by DNP2...