| T0031 |
Ziprasidone hydrochloride monohydrate |
Ziprasidone(CP88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity. |
| T0031L |
Ziprasidone hydrochloride |
Ziprasidone (hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity. |
| T0031L2 |
Ziprasidone |
Ziprasidone is an a typical antipsychotic used in the treatment of schizophrenia and bipolar disorder. Use of ziprasidone has not been consistently associate...
|
| T0053 |
Hydroxyzine Pamoate |
Hydroxyzine pamoate is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. ...
|
| T0059 |
Diphenylpyraline hydrochloride |
Diphenylpyraline Hcl is used in the treatment of Parkinsonism.It is a first-generation antihistamine with anticholinergic effects, functions as a dopamine reupt...
|
| T0074 |
Chlorprothixene |
Chlorprothixene is a typical antipsychotic drug of the thioxanthene class，which was the first of the series to be synthesized. |
| T0074L |
Chlorprothixene hydrochloride |
Chlorprothixene brings strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene is a ...
|
| T0076 |
Paliperidone |
Paliperidone(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the p...
|
| T0089 |
Cetirizine dihydrochloride |
Cetirizine dihydrochloride is an effective second-generation histamine H1 antagonist that is potent in the therapy of allergic rhinitis, confirmed urticaria, an...
|
| T0092 |
Antazoline hydrochloride |
Antazoline hydrochloride, a first-generation antihistamine, can bind to the histamine H1 receptor and block the action of endogenous histamine. |
| T0118 |
Mizolastine |
Mizolastine (IC50= 47 nM) is a histamine H1-receptor antagonist.It is used in the treatment of allergic reactions such as hay fever (seasonal allergic rhinitis)...
|
| T0147 |
Clemastine fumarate |
Clemastine Fumarate is a synthetic ethanolamine with anticholinergic, sedative, and histamine H1 antagonistic properties. |
| T0157 |
Roxatidine Acetate hydrochloride |
Roxatidine Acetate hydrochloride is a specific and competitive histamin H2-receptor antagonist. It inhibits gastric acid secretion and ulcer formation. |
| T0162 |
Quetiapin |
Quetiapine is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapi...
|
| T0172 |
Maprotiline hydrochloride |
Maprotiline hydrochloride is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, i...
|
| T0211L |
Azelastine hydrochloride |
Azelastine Hydrochloride is a phthalazinone derivative with antihistaminergic activity. |
| T0246 |
Betahistine dihydrochloride |
Betahistine hydrochloride is a histamine analog and H1 receptor agonist that serves as a vasodilator. |
| T0246L |
Betahistine mesylate |
Betahistine mesilate is a histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may...
|
| T0263 |
Chloropyramine hydrochloride |
Chloropyramine hydrochloride is a histamine receptor H1 antagonist. |
| T0298 |
Dimenhydrinate |
Dimenhydrinate is an ethanolamine and histamine antagonist with anti-allergic activity. |
| T0330 |
Diphenhydramine hydrochloride |
Diphenhydramine HCl (Benadryl) is a histamine H1 antagonist used as an antitussive and antiemetic. It is also used for pruritus and dermatoses, for hypersensiti...
|
| T0381 |
Amodiaquine hydrochloride |
Amodiaquine Hydrochloride is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory propert...
|
| T0445 |
Promethazine |
Tafluprost(AFP-168) is an analogue of anti-glaucoma prostaglandin (PG) . |
| T0445L |
Promethazine hydrochloride |
Promethazine HCl(NSC-231688), the first-generation antihistamine, is a strong antagonist of the H1 receptor and a moderate antagonist of the mACh receptor, mode...
|
| T0468 |
Xylocaine |
Lidocaine is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation of intracellu...
|
| T0785 |
Dexchlorpheniramine Maleate |
Dexchlorpheniramine (trade name Polaramine) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria...
|
| T0797 |
Cimetidine |
Cimetidine is a histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It...
|
| T0865 |
Ranitidine Hydrochloride |
Ranitidine Hydrochloride is a member of the class of histamine H2-receptor antagonists with antacid activity. Ranitidine is a competitive and reversible in...
|
| T0903 |
Stugeron |
Cinnarizine is a piperazine derivative having histamine H1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it ind...
|
| T0942 |
Quinacrine dihydrochloride |
Quinacrine Hydrochloride is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities. |
| T0994 |
Ketotifen fumarate |
Ketotifen is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. |
| T1030 |
Triprolidine hydrochloride |
Triprolidine Hydrochloride is a histamine H1 antagonist used in allergic rhinitis, asthma. |
| T1045 |
Trimipramine maleate |
Trimipramine maleate appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin a...
|
| T1097 |
Loratadine |
Loratadine is a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamine...
|
| T1110 |
Meclizine dihydrochloride |
Meclizine hydrochloride is a histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness. |
| T1115 |
Doxylamine succinate |
Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate competitively blocks the histamine...
|
| T1182 |
Propionyl-L-carnitine hydrochloride |
Propionyl-L-carnitine hydrochloride is used for the treatment of the deterioration of renal function, congestive heart failure, intermittent claudication, and o...
|
| T1232 |
Pyrilamine maleate |
Pyrilamine maleate is a histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin erup...
|
| T1269 |
Tripelennamine hydrochloride |
Tripelennamine hydrochloride is a histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. |
| T1278 |
Astemizole |
Astemizole is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, acts as a reversible competitive inhibitor of histamine H1 receptors...
|
| T1308 |
Orphenadrine hydrochloride |
Orphenadrine hydrochloride is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. |
| T1327 |
Nortriptyline hydrochloride |
Nortriptyline hydrochloride is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia,...
|
| T1393 |
Sodium butanoate |
Sodium Butyrate is the sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites...
|
| T1425 |
Pemirolast potassium |
Pemirolast Potassium is the potassium salt form of pemirolast, a pyrimidinone derivative with antiallergic property. Pemirolast potassium exerts its action by b...
|
| T1469 |
Levocetirizine |
Levocetirizine is a Histamine-1 Receptor Antagonist. The mechanism of action of levocetirizine is as a Histamine H1 Receptor Antagonist. |
| T1470L |
Fexofenadine hydrochloride |
Fexofenadine Hydrochloride is a carboxylated metabolic derivative of terfenadine and long-lasting selective histamine H1 receptor antagonist, with antihistamini...
|
| T1553 |
Chlorpheniramine maleate |
Chlorphenamine is a histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. |
| T1575 |
Nizatidine |
Nizatidine is a competitive and reversible histamine H2-receptor antagonist with antacid activity. |
| T1619 |
Trazodone hydrochloride |
Trazodone hydrochloride is a serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depres...
|
| T1627 |
Famotidine |
Famotidine is a propanimidamide and histamine H2-receptor antagonist with antacid activity. As a competitive inhibitor of histamine H2-receptors located on the ...
|
| T1822 |
Clemizole |
Clemizole is an H1 histamine receptor antagonist, can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication. |
| T1822L |
Clemizole hydrochloride |
Clemizole hydrochloride is an antagonist for H1 histamine receptor. According to the research, Clemizole hydrochloride can inhibit hepatitis C virus (HCV) repli...
|
| T2004 |
Ciproxifan maleate |
Ciproxifan maleate(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other re...
|
| T2200 |
Hydroxyzine dihydrochloride |
Hydroxyzine hydrochloride is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated prur...
|
| T2222 |
Carbinoxamine Maleate Salt |
Carbinoxamine Maleate is an ethanolamine class of H1 antihistamines with mild antimuscarinic and sedative properties. |
| T2232 |
JNJ-7777120 |
JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other h...
|
| T2335 |
Ebastine |
Ebastine (trade names Evastin, Kestine, Ebastel, Aleva) is a non-sedating H1 antihistamine. It does not penetrate the blood-brain barrier and thus allows an eff...
|
| T2520 |
Desloratadine |
Desloratadine is a long-acting piperidine derivate with selective H1 antihistaminergic and non-sedating properties. Desloratadine diminishes the typical histami...
|
| T2533 |
Alcaftadine |
Alcaftadine is an H1 histamine receptor antagonist indicated for the prevention of itching associated with allergic conjunctivitis. |
| T2848 |
Osthole |
Osthole, a potential inhibitor of histamine H1 receptor, has been shown to stimulate osteoblast proliferation and differentiation. |
| T3037 |
Cyclizine dihydrochloride |
Cyclizine Dihydrochloride is a histamine H1 antagonist. It is given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in m...
|
| T3429 |
Protopine |
Protopine is a benzylisoquinoline alkaloid. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic. |
| T3610 |
Ranitidin |
Ranitidine is a non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers. |
| T3723 |
Dioxopromethazine hydrochloride |
Dioxopromethazine is a target-based classification of drug and available in a number of countries worldwide. |
| T3963 |
VUF10460 |
VUF10460 is a non-imidazole histamine H4 receptor agonist. |
| T3979 |
Emedastine |
Emedastine is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histam...
|
| T4099 |
S-38093 |
S-38093 is a brain-penetrant antagonist of the H3 receptor (Ki: 8.8/1.44/1.2 μM, for rat/mouse/human). |
| T4195 |
Betahistine |
Betahistine is a histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerba...
|
| T6164 |
Ciproxifan |
Ciproxifan is a highly effective and specific histamin H3-receptor antagonist (IC50: 9.2 nM). |
| T6242 |
Rupatadine Fumarate |
Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM. |
| T6405 |
Bepotastine Besilate |
Bepotastine is a non-sedating and selective H1 receptor antagonist (pIC50: 5.7). |
| T6534 |
Histamine 2HCl |
Histamine, an organic nitrogen compound, works on target cells in the mammalian brain by stimulating of Histamine 1/2. |
| T6535 |
Histamine Phosphate |
Histamine acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors. |
| T4250 |
Bilastine |
Bilastine is a novel new-generation antihistamine that is highly selective for the H1 histamine receptor, has a rapid onset and prolonged duration of action. |
| T7085 |
Mebhydroline |
Mebhydrolin is a specific histamine H1 receptor antagonist. |
| T4362 |
MOZ-IN-3 |
MOZ-IN-3 is an inhibitor of MOZ(IC50=55 nM), a member of histone acetyltransferases. |
| T4380 |
Ac-CoA Synthase Inhibitor1 |
ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2). |
| T4247 |
I-CBP112 hydrochloride |
I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 ...
|
| T4563 |
Thonzylamine |
Thonzylamine is an antihistamine and anticholinergic drug. It is available as combination products with Clofedanol or Phenylephrine for temporary relief of symp...
|
| T4499 |
Mequitazine |
Mequitazine is an effective, nonsedative and long-acting histamine H1 antagonist. |
| T4551 |
Acrivastine |
Acrivastine is a short-acting histamine 1 receptor antagonist. |
| T4507 |
Chlorphenesin |
Chlorphenesin is an antigen-associated immunosuppressant that inhibits IgE-mediated histamine release. It is also used as an antimycotic agent. |
| T4566 |
Lodoxamide |
Lodoxamide is an antiallergic drug acting as a mast-cell stabilizer. It is effective in the treatment of asthma and allergic conjunctivitis. |
| T5495 |
Decloxizine dihydrochloride |
Decloxizine dihydrochloride is a histamine 1 receptor antagonist. |
| T5829 |
H4 Receptor antagonist 1 |
H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM. |
| T7176 |
Pitolisant hydrochloride |
Pitolisant hydrochloride is a potent and selective inverse agonist of the histamine H3 receptor(Ki : 0.16 nM). |
| T7413 |
JNJ-5207852 |
JNJ-5207852 is a novel, non-imidazole histamine H3 receptor antagonist, with high affinity at the rat (pKi=8.9) and human (pKi=9.24) H3 receptor. |
| T7524 |
Metiamide |
Metiamide is a histamine H2-receptor antagonist . |
| TQ0046 |
Bavisant |
Bavisant (JNJ-31001074) is a selective and orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cogniti...
|
| TQ0066 |
GSK189254A |
GSK189254A (GSK189254) is a new, potent and specific histamine H3 receptor antagonist (pKi values: 9.59-9.90 and 8.51-9.17 for human and rat H3). |
| T1090 |
Perphenazine |
Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. |
| TN1661 |
Ganoderic acid C2 |
Ganoderic acid C2 has anti-inflammatory,and anti-tumor-promoting activities. Ganoderic acid C2 can inhibit histamine release, it also has inhibitory effects on ...
|
| TN2155 |
Rhodiocyanoside A |
Rhodiocyanoside A has antiallergic activity, it exhibits inhibitory activity on the histamine release from rat peritoneal exudate cells sensitized with anti-DNP...
|
| TN1154 |
6-Methoxyluteolin |
6-Methoxyluteolin has antioxidant activity, it is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain. |
| TN1901 |
(-)-Maackiain |
(-)-Maackiain, a phytoalexin, which is an anti-allergic compound that suppresses the up-regulation of the histamine H1 receptor (H1R) gene. |
| TN1913 |
Marmin |
Marmin have anti-ulcer effects, which are ascribed primarily to the maintenance of the mucosal barrier integrity and inhibition of gastric motor activity and se...
|
| T12054 |
MK-0249 |
MK-0249 is a potent antagonist of histamine H3 receptor (human H3, Ki : 1.7 nM). |
| T12228 |
Niperotidine |
Niperotidine is an antagonist of histamine H2-receptor. |
| T12416 |
PF-03654746 Tosylate |
PF-03654746 Tosylate is selective antagonist of histamine H3 receptor with high brain penetration. |
| T10000 |
(±)-Tazifylline |
(±)-Tazifylline is a specific and long-acting antagonist of histamine H1 receptor. |
| T10911 |
H3 receptor antagonist 1 |
H3 receptor antagonist 1 is used in the study of neurological diseases, histamine H3 receptor antagonist. |
| T11088 |
Doxepin D3 Hydrochloride |
Doxepin D3 Hydrochloride is a deuterium-labeled doxepin hydrochloride.Doxepin hydrochloride is an oral active tricyclic antidepressant used as a sedative.Doxepi...
|
| T12630 |
(R)-(-)-α-Methylhistamine dihydrobromide |
(R)-(-)-α-Methylhistamine dihydrobromide is a potent and selective agonist of H3 histamine receptor( Kd of 50.3 nM). |
| T12703 |
ReN-1869 hydrochloride |
ReN 1869 hydrochloride is a novel, selective antagonist of histamine H1 receptor. |
| T12756 |
ROS 234 dioxalate |
ROS 234 dioxalate is a potent antagonist of H3(pKB of 9.46 for Guinea-pig ileum H3-receptor) |
| T13040 |
SUN 1334H |
SUN 1334H is a potent, orally active, highly selective antagonist of H1 receptor(Ki of 9.7 nM). |
| T11324 |
FRG8701 |
FRG8701 is a new Histamine H2-receptor antagonist with an IC50 of ranging from 0.25 to 0.43 μM. |
| T10575 |
BMY-25271 |
BMY-25271 is an antagonist of histamine H2 receptor. |
| T10680 |
Carebastine |
Carebastine, the active metabolite of Ebastine, is an antagonist of the histamine H1 receptor. |
| T11531 |
H3R-IN-1 Hydrochloride |
H3R-IN-1 Hydrochloride is a histamine receptor 3 (H3R) inverse agonist. |
| T11532 |
H4R antagonist 1 |
H4R antagonist 1 does not show any noticeable binding affinity to other subtypes of histamine receptors, H1R, H2R, and H3R.H4R antagonist 1 is a potent and high...
|
| T10769 |
Cetirizine D4 |
Cetirizine D4 is a deuterium-labeled Cetirizine. Cetirizine is a second-generation antihistamine and a long-acting histamine H1-receptor antagonist. |
| T10770 |
Cetirizine D8 |
Cetirizine D8 is a deuterium-labeled Cetirizine. Cetirizine is a second-generation antihistamine and a long-acting histamine H1-receptor antagonist. |
| T19234 |
Cetirizine D8 dihydrochloride |
Cetirizine D8 dihydrochloride is a deuterium-labeled Cetirizine. Cetirizine is a second-generation antihistamine and a long-acting histamine H1-receptor antagon...
|
| T10794 |
Chlorcyclizine hydrochloride |
Chlorcyclizine hydrochloride is an antagonist of histamine H1. |
| T15565 |
Imetit dihydrobromide |
Imetit mimics the histamine effect in triggering a shape change in eosinophils (EC50=25 nM). Imetit dihydrobromide is a high affinity and effective agonist of h...
|
| T15590 |
Iodophenpropit dihydrobromide |
Iodophenpropit dihydrobromide is an effective and selective antagonist of the histamine H3 receptor. The binding of [125I]Iodophenpropit is readily reversible, ...
|
| T11723L |
JNJ-39758979 |
JNJ-39758979 displays good anti-inflammatory and antipruritic activity. JNJ-39758979 is a selective and high-affinity histamine H4 receptor antagonist (Kis: 12....
|
| T15722 |
Lavoltidine |
Lavoltidine strongly suppresses gastric acid secretion and also induces hypergastrinemia. Lavoltidine is an orally active, irreversible, and highly effective hi...
|
| T19604 |
WZ4141 |
WZ4141 is an intermediate in compound synthesis. |
| T11729 |
JTE-952 |
JTE-952 is a oral, potent active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), wi...
|
| T16759 |
Ritanserin |
Ritanserin is a highly effective, relatively selective, long-acting antagonist of 5-HT2 receptor (IC50: 0.9 nM). |
| T8514 |
LML-134 |
LML-134 is an inverse agonist of Histamine 3 receptor (H3R)(hH3R cAMP and hH3R bdg with Kis of 0.3 nM and 12 nM). |
| T8548 |
Metoprine |
Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity. |
| T17118 |
Toreforant |
Toreforant is an effective and selective histamine H4 receptor antagonist (Ki at the human receptor: 8.4 nM). |
| T22354 |
Levocetirizine Dihydrochloride |
Levocetirizine, the active R-enantiomer of cetirizine, represents a new second-generation histamine H1 antagonist. |
| T8599 |
Betazole hydrochloride |
Betazole hydrochloride is an agonist of H2 receptor. |
| T2S0118 |
Daurinoline |
Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a...
|
| TN2895 |
3,5-Dicaffeoyl-epi-quinic acid |
3,5-Dicaffeoyl-epi-quinic acid shows anti-inflammatory activity, it may improve mast cell-mediated inflammatory diseases. |
| TN3062 |
4'-O-Methylnyasol |
4'-O-Methylnyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. |
| TN3483 |
Bakkenolide D |
Bakkenolide D has anti-allergic effect, it and bakkenolide D demonstrates inhibitory effect on the trachea contraction induced by histamine in vitro, they have ...
|
| TN3699 |
Corchoionoside C |
Corchoionoside C has antioxidant activity, shows strong scavenging activities on DPPH radical, it also shows weak antifungal activity. Corchoionosides A, B, and...
|
| TN4918 |
Roseoside |
Roseoside possesses strong antioxidant properties, inhibiting lipid oxidation by 86.4, at 50 microg/mL. Roseoside has insulinotropic activity, enhances insulin ...
|
| TN5279 |
Zeorin |
Zeorin shows strong inhibition activity against bacteria and fungi. It markedly exhibits inhibitory activity on histamine release from mast cell induced by DNP2...
|
