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Search Result

Search Results for " histone acetylation "

Targets

Epigenetic Reader Domain Histone Acetyltransferase

29

Compounds

14

Recombinant Proteins

2

Libraries

Cat No. Product Name Synonyms Targets
T11563 Histone Acetyltransferase Inhibitor II Epigenetic Reader Domain , Histone Acetyltransferase
Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 μM).with anti-acetylase activity in mammalian cells.
T11807 L002 Others , Histone Acetyltransferase , STAT
L002, a potent, cell-permeable, reversible, and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM, directly binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain. By ...
T6421 BRD73954 HDAC
BRD73954, an effective and specific HDAC inhibitor, which is with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.
T5347 CXD101 CXD-101 HDAC
CXD101 is a novel class I-selective HDACi (HDAC1 (IC50 : 63nM), HDAC2 (IC50 :570nM), HDAC3 (IC50 :550nM)). CXD101(CXD-101) has no activity against HDAC class II
T13996 1-Naphthohydroxamic acid HDAC
1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid d...
T27083 Crebinostat Epigenetic Reader Domain , Histone Acetyltransferase , HDAC
Crebinostat is a potent histone deacetylase (HDAC) inhibitor, inhibiting HDAC1, HDAC2, HDAC3, and HDAC6 with IC50s of 0.7 nM, 1.0 nM, 2.0 nM, and 9.3 nM, respectively.Crebinostat increases the density of synapsin-1 punct...
T69879 Bavarostat
Bavarostata is a highly brain penetrant HDAC6 inhibitor (IC50=60nM). Bavarostat exhibits excellent HDAC6 selectivity (>80-fold over all other Zn-containing HDAC paralogues), modulates tubulin acetylation selectively over...
T24998 AC-93253 iodide AC93253 iodide
AC-93253 iodide is a selective inhibitor of SIRT2. It significantly enhances the acetylation of tubulin p53 and histone H4.
T39580 Histone H3 (23-34) Histone H3 (23-34)
Histone H3 (23-34) is a peptide consisting of amino acid residues 23 to 34 of the histone H3 protein. This peptide specifically includes lysine residues at positions 23 and 27, which can undergo methylation and acetylati...
T36576 Histone H3 (21-44)-GK-biotin (trifluoroacetate salt) Histone H3 (21-44)-GK-biotin (trifluoroacetate salt)
Histone H3 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.1 and 3.2 sequences and is biotinylated via a C-terminal GK linker. Histone H3 (21-44...
T35818 CAY10669
CAY10669 is an inhibitor of the histone acetyltransferase PCAF (p300/CREB-binding protein-associated factor; IC50 = 662 μM), displaying a 2-fold improvement in inhibitory potency over anacardic acid . At 30-60 μM, CAY106...
T35825 Trichostatin C
Trichostatin C is a glycosylated derivative of trichostatin A , the antifungal antibiotic that reversibly inhibits histone deacetylase. Trichostatin C is reported to be the first example of a glucopyranosyl hydroxamate i...
TP1836 BMf-BH3
BMf-BH3 belongs to the Bcl-2 apoptosis mediator family. This peptide belongs to the Bcl-2 apoptosis mediator family. Bmf is a key player in histone deacetylase (HDAC) inhibition, which alters the balance between deacetyl...
T36577 K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt) K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt)
Histone H2B (108-125) is a peptide fragment of histone H2B that corresponds to amino acid residues 109-126 of the human histone H2B sequence. It contains an N-terminal biotinylated lysine followed by a tryptophan linker....
T36979 Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt) Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt)
Histone H3 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.3 sequence and is biotinylated via a C-terminal GK linker. Unlike histone H3.1 and H3...
T24131 HDAC3-IN-T247 HDAC3 inhibitor T247,HDAC3 inhibitor-T247,HDAC3 IN T247,T247 Histone Demethylase , Antiviral
HDAC3-IN-T247 (HDAC3 inhibitor T247) is a selective and potent histone deacetylase 3 (HDAC3) inhibitor with anticancer and antiviral activities.HDAC3-IN-T247 induces NF-κB acetylation in human colon cancer HCT116 cells i...
T23095 NU 9056 NU9056 Histone Acetyltransferase
NU 9056 is an effective and selective inhibitor of KAT5 histone acetyltransferase with an IC50 of 2 µM. NU 9056 blocks DNA damage response and inhibits protein acetylation in prostate cancer cell lines.
T61433 HDAC1-IN-5
HDAC1-IN-5, a potent inhibitor of HDAC1 with an IC50 value of 15 nM, also exhibits inhibitory activity towards HDAC6 with an IC50 value of 20 nM. In cancer cells, HDAC1-IN-5 enhances the acetylation of both histone H3 an...
T82342 Gamma-Glutamyl Transferase-IN-2
Gamma-Glutamyl Transferase-IN-2 (compound 4dq), a β-carboline 1-hydrazide inhibitor, exhibits both antifungal and antibacterial properties by targeting glutamyltransferase. Its mode of action includes inducing reactive o...
T82343 Gamma-Glutamyl Transferase-IN-1
Gamma-Glutamyl Transferase-IN-1 (compound 4de), a β-carboline 1-hydrazide inhibitor, exhibits antifungal and antibacterial properties by targeting glutamyltransferase. Its mechanism of action involves inducing the accumu...
T62708 HDAC-IN-37
HDAC-IN-37 is a potent inhibitor of HDAC, acting on HDAC1 (IC50: 0.0551 μM), HDAC3 (IC50: 1.24 μM), HDAC8 (IC50: 0.948 μM) and HDAC6 (IC50: 34.2 μM). HDAC-IN-37 is able to slowly induce histone acetylation. HDAC-IN-37 pr...
T80212 Lunasin Parasite
Lunasin, a bioactive peptide derived from soybean, exhibits antioxidant, anti-inflammatory, anticancer, and anti-aging properties. It operates through an epigenetic mechanism linked to histone acetylation and has the abi...
T63260 Snail/HDAC-IN-1
Snail/HDAC-IN-1 is a potent dual-target inhibitor of Snail/HDAC that strongly inhibits the activity of Snail (Kd: 0.18 μM) and HDAC1 (IC50: 0.405 μM). Snail/HDAC-IN-1 was able to increase histone H4 acetylation and inhib...
T36626 Lys-CoA
Selective p300 histone acetyltransferase (HAT) inhibitor (IC50 = 50-500 nM). Exhibits approximately 100-fold selectivity for p300 over PCAF (IC50 = 200 μM). Inhibits p300-dependent transcription. Active in vivo. Lau et a...
T62920 HDAC-IN-38
HDAC-IN-38 is a potent inhibitor of HDAC. HDAC-IN-38 has similar micromolar inhibitory effects on HDAC1, 2, 3, 5, 6 and 8, and also increases histone acetylation levels (H3K14 or H4K5). HDAC-IN-38 increases cerebral bloo...
T78715 MS78
MS78, an acetylation targeting chimera (AceTAC), specifically acetylates the p53Y220C mutant by recruiting the histone acetyltransferase p300/CBP. This compound enhances the expression of TRAIL apoptotic genes while conc...
T79407 HL23 Others
HL23 is a histone deacetylase (HDAC) inhibitor that effectively targets hepatocellular carcinoma (HCC). It promotes acetylation at the TXNIP promoter and increases TXNIP expression, which in turn modulates potassium chan...
T9644 Triciferol
Triciferol acts as a multiple ligand with combined VDR agonist and HDAC antagonist activities. Triciferol binds directly to the VDR ( IC 50 =87 nM), and functions as an agonist with 1,25D-like potency on several 1,25D ta...
T36629 Givinostat
Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF30...

Compounds

Histone Acetyltransferase Inhibitor II
T11563
Synonym:
Target: Epigenetic Reader Domain, Histone Acetyltransferase
L002
T11807
Synonym:
Target: Others, Histone Acetyltransferase, STAT
BRD73954
T6421
Synonym:
Target: HDAC
CXD101
T5347
Synonym: CXD-101
Target: HDAC
1-Naphthohydroxamic acid
T13996
Synonym:
Target: HDAC
Crebinostat
T27083
Synonym:
Target: Epigenetic Reader Domain, Histone Acetyltransferase, HDAC
Bavarostat
T69879
Synonym:
Target:
AC-93253 iodide
T24998
Synonym: AC93253 iodide
Target:
Histone H3 (23-34)
T39580
Synonym: Histone H3 (23-34)
Target:
Histone H3 (21-44)-GK-biotin (trifluoroacetate salt)
T36576
Synonym: Histone H3 (21-44)-GK-biotin (trifluoroacetate salt)
Target:
CAY10669
T35818
Synonym:
Target:
Trichostatin C
T35825
Synonym:
Target:
BMf-BH3
TP1836
Synonym:
Target:
K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt)
T36577
Synonym: K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt)
Target:
Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt)
T36979
Synonym: Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt)
Target:
HDAC3-IN-T247
T24131
Synonym: HDAC3 inhibitor T247,HDAC3 inhibitor-T247,HDAC3 IN T247,T247
Target: Histone Demethylase, Antiviral
NU 9056
T23095
Synonym: NU9056
Target: Histone Acetyltransferase
HDAC1-IN-5
T61433
Synonym:
Target:
Gamma-Glutamyl Transferase-IN-2
T82342
Synonym:
Target:
Gamma-Glutamyl Transferase-IN-1
T82343
Synonym:
Target:
HDAC-IN-37
T62708
Synonym:
Target:
Lunasin
T80212
Synonym:
Target: Parasite
Snail/HDAC-IN-1
T63260
Synonym:
Target:
Lys-CoA
T36626
Synonym:
Target:
HDAC-IN-38
T62920
Synonym:
Target:
MS78
T78715
Synonym:
Target:
HL23
T79407
Synonym:
Target: Others
Triciferol
T9644
Synonym:
Target:
Givinostat
T36629
Synonym:
Target:

Recombinant Proteins

Species：
Human (12)
Mouse (2)
Expression System：
E. coli (9)
Baculovirus-Insect Cells (3)
Baculovirus (1)
Yeast (1)
Tag：
GST (3)
His (3)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (3)
N-terminal 6xHis-SUMO-tagged (2)
N-terminal 6xHis-tagged (2)
N-terminal GST-tagged (1)
Cat No. Product Name Species Expression System
TMPH-00009 OGT Protein, Human, Recombinant (His & SUMO) Human E. coli
Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc...
TMPY-03498 ING4 Protein, Human, Recombinant (His) Human E. coli
ING4 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. ING4 contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling...
TMPH-02311 WDR5 Protein, Human, Recombinant (His & SUMO) Human E. coli
Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histon...
TMPY-02981 ING5 Protein, Human, Recombinant (GST) Human E. coli
ING5 belongs to the ING family. It contains 1 PHD-type zinc finger and is a component of the HBO1 complex. HBO1 complex has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is re...
TMPY-03283 HBP1 Protein, Human, Recombinant (GST) Human E. coli
HBP1 is a sequence-specific DNA-binding transcription factor. It is involved in many biological processes. It was reported that HBP1 binds to p16(INK4A) promoter and activates p16(INK4A) expression. We found that trichos...
TMPY-02317 HDAC8 Protein, Mouse, Recombinant (His) Mouse Baculovirus-Insect Cells
Histone deacetylase 8, also known as HDAC8 and HDACL1, is a nucleus and cytoplasm protein that belongs to the histone deacetylase family and HD type 1 subfamily. Histone deacetylases (HDACs) are a growing family of enzym...
TMPY-01333 HDAC8 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
Histone deacetylase 8, also known as HDAC8 and HDACL1, is a nucleus and cytoplasm protein that belongs to the histone deacetylase family and HD type 1 subfamily. Histone deacetylases (HDACs) are a growing family of enzym...
TMPH-01742 SIRT6 Protein, Human, Recombinant (GST) Human E. coli
NAD-dependent protein deacetylase involved in various processes including telomere maintenance and gene expression, and consequently has roles in genomic stability, cell senescence and apoptosis. Has very weak deacetylas...
TMPY-03263 RUVBL1 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
RUVBL1, also known as RVB1, is a component of the NuA4 histone acetyltransferase complex and belongs to the RuvB family. RUVBL1 is ubiquitously expressed with high expression in heart, skeletal muscle and testis. It poss...
TMPH-02531 ARID5A Protein, Mouse, Recombinant (His) Mouse Yeast
DNA-binding protein that may regulate transcription and act as a repressor by binding to AT-rich stretches in the promoter region of target genes. May positively regulate chondrocyte-specific transcription such as of COL...
TMPH-01239 XPC Protein, Human, Recombinant (His) Human E. coli
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B an...
TMPH-01267 RNF13 Protein, Human, Recombinant (His & Myc) Human E. coli
E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair protein...
TMPH-01606 BAG6 Protein, Human, Recombinant (His & Myc) Human Baculovirus
ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which main...
TMPH-01605 BAG6 Protein, Human, Recombinant (E. coli, His & Myc) Human E. coli
ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which main...
Cat No. Product Name
L3500 Histone Modification Compound Library

480 compounds
A unique collection of 480 histone modification related compounds for high throughput screening (HTS) and high content screening (HCS);
L8300 Chromatin Modification Compound Library

256 compounds
A unique collection of 256 compounds targeting chromatin remodeling pathway for high throughput screening (HTS) and high content screening (HCS);

Libraries

Histone Modification Compound Library
L3500
Compounds: 480
Chromatin Modification Compound Library
L8300
Compounds: 256
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