Histone Demethylase

Histone demethylase proteins have a variety of domains that serve different functions. These functions include binding to the histone (or sometimes the DNA on the nucleosome), recognizing the correct methylated amino acid substrate and catalyzing the reaction, and binding cofactors. Cofactors include: alpha-keto glutarate (JmjC-domain containing demethylases), CoREST (LSD), FAD, Fe (II) or NOG (N-oxalylglycine).

Cat No.	product name
T1868	JIB04	JIB-04 is a pan-selective Jumonji histone demethylase inhibitor.
T2304	SP2509	SP2509 is a specific histone demethylase LSD1 inhibitor(IC50 =13 nM).
T2315	GSK-LSD1 dihydrochloride	GSK-LSD1 2HCl is a specificity irreversible LSD1 inhibitor (IC50: 16 nM). The selectivity of GSK-LSD1 for LSD1 is >1000 fold over other closely related FAD util...
T3100	GSK J4	GSK-J4 is a potent H3K27me3 demethylase inhibitor, with IC50s of 8.6 μM and 6.6 μM towards KDM6B and KDM6A respectively. It is the first selective inhibitor o...
T3552	CPI455	CPI-455 is a specific KDM5 inhibitor.
T3576	KDM5-inhibitor	KDM5 inhibitor
T3719	Daminozide	Daminozide is a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.
T4214	KDM4D-IN-1	KDM4D-IN-1 is a KDM4D inhibitor (IC50: 0.41±0.03 μM).
T6073	OG-L002	OG-L002 is an effective and selective LSD1 inhibitor (IC50: 20 nM), showing 69- and 36-fold selectivity over MAO-A and MAO-B, respectively.
T6545	IOX1	IOX1 is the most effective broad-spectrum 2OG oxygenases(including the JmjC demethylases) inhibitor. The IC50 of IOX1 for KDM4A, KDM3A, is 0.6 and 0.1 uM, respe...
T6593	ML324	ML324(IC50=920 nM) is a specific inhibitor of jumonji histone demethylase (JMJD2).
T6847	GSK J1	GSK-J1 is a highly potent H3K27 histone demethylase inhibitor with IC50 of 28 nM and 53 nM in cell-free assays for JMJD3 (KDM6B) and UTX (KDM6A), respectively, ...
T6922	ORY1001	ORY-1001 (RG-6016) is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor, with high selectivity against related FAD dependent amino...
T4418	GSK2879552 2HCl (1401966-69-5(free base))	GSK2879552 is an orally available, irreversible inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity.
T4383	GSK-J4 Hydrochloride	GSK-J4 is a cell permeable, potent and selective histone demethylase(JMJD3 )inhibitor. is an ethyl ester derivative of the GSK-J1 with an IC50 value greater tha...
T4527	Seclidemstat	Seclidemstat is an effective LSD1 inhibitor, with a mean IC50 of 127 nM.
T5825	ORY-1001(trans)	ORY-1001, a Potent and Selective Covalent KDM1A/LSD1 Inhibitor, for the Treatment of Acute Leukemia.
TQ0050	NCGC00244536	NCGC00244536 is a potent KDM4B inhibitor (IC50: 10 nM).
T1025	Tranylcypromine (2-PCPA) hydrochloride	Tranylcypromine Hydrochloride, a monoamine oxidase inhibitor, is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It...
T7942	Tranylcypromine (hemisulfate)	Tranylcypromine is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1) with a rapid onset of activity.
T5484	GSK467	GSK467 is a potent and selective inhibitor of KDM5 (JARID1)(Ki : 10 nM).
T13055	T-3775440 hydrochloride	T-3775440 hydrochloride is an irreversible inhibitor of lysine-specific histone demethylase (LSD1)(IC50 : 2.1 nM).
T12701	(rel)-Tranylcypromine D5 hydrochloride	(rel)-Tranylcypromine D5 hydrochloride is a deuterium labeled (rel)-Tranylcypromine hydrochloride. (rel)-Tranylcypromine hydrochloride is an irreversible, nonse...
T13052	S 2101	S 2101 is an inhibitor of lysine-specific demethylase 1 (LSD1)(IC50 of 0.99 μM, Ki of 0.61 μM and Kinact/Ki of 4560 M/s).
T13056	T-448 free base	T-448 free base is a specific, orally active and irreversible lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) inhibitor(IC50 of 22 nM).
T13057	T-448	T-448 is a specific, orally active and irreversible lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) inhibitor(IC50 of 22 nM).
T11475	GSK-J1 lithium salt	GSK-J1 lithium salt is a potent inhibitor of me2-demethylases JMJD3/H3K27me3/KDM6B and UTX/KDM6A (IC50: 60 nM towards KDM6B).
T11503	GSK 690 Hydrochloride	GSK 690 is a reversible inhibitor of lysine-specific demethylase 1 (LSD1) (Kd: 9 nM; biochemical IC50: 37 nM).
T15649	KDM5-IN-1	KDM5-IN-1 is an effective, selective, and orally bioavailable inhibitor of KDM5 (IC50: 15.1 nM).
T15650	KDM5A-IN-1	KDM5A-IN-1 is a potent and orally bioavailable inhibitor of pan-histone lysine demethylases 5 (IC50s: 45 nM, 56 nM, and 55 nM for KDM5A, KDM5B, and KDM5C) and (...
T10864	Corin	Corin is a dual inhibitor of histone lysine-specific demethylase (LSD1) and HDAC (Ki(inact): 110 nM for LSD1; IC50: 147 nM for HDAC1).
T13745	KF21213	KF21213 shows a high affinity for the adenosine A2A receptors (Ki=3.0 nM). KF21213 is a highly selective ligand for mapping CNS adenosine A2A receptors.
T11755	KF 13218	KF 13218 is a selective, potent and long lasting thromboxane B2 (TXB2) synthase inhibitor with an IC50 value of 5.3±1.3 nM.
T11756	Kgp-IN-1	Kgp-IN-1 is an arginine-specific gingipain (Rgp) inhibitor.
T11757	KHK-IN-2	KHK-IN-2 is a selective and potent ketohexokinase (KHK) inhibitor with an IC50 of 0.45 μM.
T11758	KI696 isomer	KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction. KI696 isomer is the less active isomer of KI696 .
T16700	QC6352	QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM).
T11880	LSD1-IN-5	LSD1-IN-5 increases dimethylated Lys4 of histone H3, shows no effect on expression of LSD1. LSD1-IN-5 is a potent and reversible inhibitor of lysine-specific...
T11881	LSD1-IN-6	LSD1-IN-6 increases dimethylated Lys4 of histone H3, shows no effect on expression of LSD1. LSD1-IN-6 is a potent and reversible inhibitor of lysine-specific d...
T17278	YUKA1	YUKA1 is a potent and cell-permeable Lysine demethylase 5A inhibitor (IC50: 2.66 μM) and less active on KDM5C (IC50, 7.12 μM). YUKA1 is inactive on KDM5B, KDM...
T22299	CPI-455 HCl	CPI-455 is a specific KDM5 inhibitor with IC50 value of 10 ± 1 nM for full-length KDM5A in enzymatic assays, elevating global levels of H3K4 trimethylation (H...
T13748	L-2-Hydroxyglutaric acid disodium	L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid inhibits mitochondrial creatin...
T4100	AS8351	AS-8351 is a histone demethylase inhibitor. It has been used in combination with CHIR99021, A 83-01, BIX01294, SC-1, Y-27632, OAC2, SU 16f, and JNJ-10198409 to ...