Histone Methyltransferase

Histone methyltransferases (HMT) are histone-modifying enzymes , that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues of histone proteins. The attachment of methyl groups occurs predominantly at specific lysine or arginine residues on histones H3 and H4.

Cat No.	product name
T3081	EPZ004777	EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.
T3082	SGC0946	SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.
T3084	SGC707	SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.
T3099	Pinometostat	EPZ5676 has been used in trials studying the treatment of Leukemia, Acute Leukemias, Acute Myeloid Leukemia, Myelodysplastic Syndrome, and Acute Lymphocytic Leu...
T3257	UNC0638	UNC0638 is an inhibitor of β-protein lysine methyltransferases G9a(IC50<15 nM) and GLP(IC50=19 nM) with excellent potency and selectivity over a wide range of ...
T3458	EED226	EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.
T3624	A-366	Potent and selective G9a/GLP histone lysine methyltransferase inhibitor (IC50 = 3.3 nM). Exhibits >1000-fold selectivity for G9a/GLP over 21 other methyltransf...
T3896	Shanzhiside methyl ester	Shanzhiside methylester reduces neuropathic pain by activating spinal GLP-1 receptors and subsequently stimulating microglial β-endorphin expression via the p3...
T3984	GLP-1(7-36)	GLP-1 (7-36) amide is a peptide hormone released from intestinal L-cells upon nutrient consumption. It binds the GLP-1 receptor in the pancreas and displays var...
T4013	SGC2085 HCl	SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectiv...
T4021	UNC3866	UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.
T4166	UNC-0642	UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).
T4314	EPZ020411	EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).
T4334	EPZ020411 2HCl (1700663-41-7(free base))	EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM).
T4343	A-196	A-196 is a potent and selective inhibitor of SUV420 h1 and SUV420 h2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective over ot...
T4378	MS049	MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.
T4393	MS049 2HCl (1502816-23-0(free base))	MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM). It is less active against additional type I PRMTs (IC50s = >130, >22...
T4583	(R)-PFI-2 hydrochloride	PFI-2 hydrochloride is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM), 500 fold active than (S)-P...
T5322	BCI-121	BCI-121 is a substrate-competitive SMYD3 inhibitor that inhibits the proliferation of the cancer cell.
T5605	EZM 2302	EZM2302 is a selective, and orally available arginine methyltransferase CARM1 inhibitor (IC50: 6 nM).
T5745	GSK3326595	GSK3326595 is an inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50:6.2 nM.).
T6059	GSK343	GSK343，a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity against ot...
T6076	EPZ015666	EPZ015666 is an orally available inhibitor of PRMT5 enzymatic activity.
T6484	EI1	EI1 is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively.
T6790	BMS-911543	BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.
T6809	CPI-169	CPI-169 is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.
T6853	GSK591	GSK591，Alternative Names are EPZ015866, GSK3203591， is a potent selective inhibitor of the arginine methyltransferase PRMT5 (IC50=11 nM).
T6857	HLCL-61 hydrochloride	HLCL-61 hydrochloride is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.
T6876	Liraglutide	Liraglutide is a long-acting GLP-1 receptor agonist.
T6879	LLY-507	LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.
T6900	MS023	MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, ...
T7089	SGC2085	SGC2085 is an effective and selective coactivator-associated arginine methyltransferase 1 (CARM1) inhibitor (IC50: 50 nM).
T7157	XY1	XY1 is a very close analogue of SGC707 (a potent, selective, and non-competitive inhibitor of PRMT3 with IC50 of 31 nM), It is intended to be used as a negative...
T7305	JQEZ5	JQEZ5 is an inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM).
T7378	BRD9539	BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μM
T7403	BAY-598	BAY-598 is a selective inhibitor of SMYD2 with IC50 values of 27 nM.
T7697	BIX-01294	BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).
T8201	Gambogenic acid	Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity.
T8510	CPI-1205	CPI-1205 is a highly potent and selective inhibitor of EZH2(IC50 : 0.002 μM, EC50 : 0.032 μM) .
TN5096	Tanshindiol B	Tanshindiol B possesses a unique anti-cancer activity whose mechanism involves the inhibition of EZH2 activity and would provide chemically valuable information...
TN5097	Tanshindiol C	Tanshindiol C protects macrophages from oxLDL induced foam cell formation via activation of Prdx1/ABCA1 signaling and that Prdx1 may be a novel target for thera...
TQ0058	MI-463	MI-463 is a potent and orally bioavailable inhibitor of the menin-mLL interaction (IC50: 15.3 nM).
TQ0069	MI-503	MI-503 is a highly effective and orally bioavailable inhibitor of the menin-mLL interaction.
TQ0100	AZ505	AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).
TQ0232	UNC 0646	UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646 potently b...
TQ0263	EPZ031686	EPZ031686 is a selective and orally available SMYD3 inhibitor (IC50: 3 nM).