T0174 |
Cyproheptadine hydrochloride |
Cyproheptadine hydrochloride sesquihydrate, an antihistamine, is an antagonist of serotonin and histamine2. |
T1775 |
GSK503 |
GSK-503, a potent EZH2 inhibitor, has potential antitumor activity. |
T1788 |
EPZ6438 |
Tazemetostat is an orally available, small molecule selective and S-adenosyl methionine (SAM) competitive inhibitor of histone methyltransferase EZH2, with pote...
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T1841 |
UNC0379 |
UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. |
T1868 |
JIB-04 |
JIB-04 is a pan-selective Jumonji histone demethylase inhibitor. |
T1905 |
EPZ005687 |
EPZ005687 is a potent and selective inhibitor of EZH2. |
T1923 |
BRD4770 |
BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence. |
T1959 |
BIX 01294 Trihydrochloride |
BIX01294 is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase. |
T1987 |
PFI-2 |
PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferas...
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T2079 |
GSK126 |
GSK126 is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM). |
T2097 |
C7280948 |
C-7280948 is a PRMT1 inhibitor. |
T2352 |
AMI-1 |
AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0/8.8 μM, for yeast Hmt1p, and human PRMT1). |
T2354 |
UNC0631 |
UNC0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM). |
T2435 |
EPZ011989 |
EPZ011989 is a effective, specific orally bioavailable EZH2 inhibitor with Ki < 3 nM for EZH2 Y646 and EZH2 wt; 15-fold selectivity over EZH1 and >3000-fold sel...
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T2649 |
MI-2 |
MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM. |
T3057 |
UNC1999 |
UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45). |
T3081 |
EPZ004777 |
EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM. |
T3082 |
SGC0946 |
SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells. |
T3084 |
SGC707 |
SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3. |
T3099 |
Pinometostat |
EPZ5676 has been used in trials studying the treatment of Leukemia, Acute Leukemias, Acute Myeloid Leukemia, Myelodysplastic Syndrome, and Acute Lymphocytic Leu...
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T3257 |
UNC0638 |
UNC0638 is an inhibitor of β-protein lysine methyltransferases G9a(IC50<15 nM) and GLP(IC50=19 nM) with excellent potency and selectivity over a wide range of ...
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T3458 |
EED226 |
EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM. |
T3624 |
A-366 |
Potent and selective G9a/GLP histone lysine methyltransferase inhibitor (IC50 = 3.3 nM). Exhibits >1000-fold selectivity for G9a/GLP over 21 other methyltransf...
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T3896 |
Shanzhiside methyl ester |
Shanzhiside methylester reduces neuropathic pain by activating spinal GLP-1 receptors and subsequently stimulating microglial β-endorphin expression via the p3...
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T3984 |
GLP-1(7-36) |
GLP-1 (7-36) amide is a peptide hormone released from intestinal L-cells upon nutrient consumption. It binds the GLP-1 receptor in the pancreas and displays var...
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T4013 |
SGC2085 HCl |
SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectiv...
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T4021 |
UNC3866 |
UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen. |
T4166 |
UNC-0642 |
UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM). |
T6059 |
GSK343 |
GSK343,a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity against ot...
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T6076 |
EPZ015666 |
EPZ015666 is an orally available inhibitor of PRMT5 enzymatic activity. |
T6333 |
MM102 |
MM-102 is a high-affinity peptidomimetic MLL1 inhibitor with IC50 of 0.4 μM. |
T6484 |
EI1 |
EI1 is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively. |
T6790 |
BMS-911543 |
BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2. |
T6809 |
CPI-169 |
CPI-169 is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively. |
T6853 |
GSK591 |
GSK591,Alternative Names are EPZ015866, GSK3203591, is a potent selective inhibitor of the arginine methyltransferase PRMT5 (IC50=11 nM). |
T6857 |
HLCL-61 hydrochloride |
HLCL-61 hydrochloride is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia. |
T6876 |
Liraglutide |
Liraglutide is a long-acting GLP-1 receptor agonist. |
T6879 |
LLY-507 |
LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2. |
T6900 |
MS023 |
MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, ...
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T4314 |
EPZ020411 |
EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM). |
T4334 |
EPZ020411 2HCl (1700663-41-7(free base)) |
EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM). |
T4378 |
MS049 |
MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively. |
T4393 |
MS049 2HCl (1502816-23-0(free base)) |
MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM). It is less active against additional type I PRMTs (IC50s = >130, >22...
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T4343 |
A-196 |
A-196 is a potent and selective inhibitor of SUV420 h1 and SUV420 h2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective over ot...
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T4583 |
(R)-PFI-2 hydrochloride |
PFI-2 hydrochloride is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM), 500 fold active than (S)-P...
|
T7089 |
SGC2085 |
SGC2085 is an effective and selective coactivator-associated arginine methyltransferase 1 (CARM1) inhibitor (IC50: 50 nM). |
T5322 |
BCI-121 |
BCI-121 is a substrate-competitive SMYD3 inhibitor that inhibits the proliferation of the cancer cell. |
T5605 |
EZM 2302 |
EZM2302 is a selective, and orally available arginine methyltransferase CARM1 inhibitor (IC50: 6 nM). |
T5745 |
GSK3326595 |
GSK3326595 is an inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50:6.2 nM.). |
T7157 |
XY1 |
XY1 is a very close analogue of SGC707 (a potent, selective, and non-competitive inhibitor of PRMT3 with IC50 of 31 nM), It is intended to be used as a negative...
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T7305 |
JQEZ5 |
JQEZ5 is an inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM). |
T7378 |
BRD9539 |
BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μM |
T7403 |
BAY-598 |
BAY-598 is a selective inhibitor of SMYD2 with IC50 values of 27 nM. |
T7697 |
BIX-01294 |
BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM). |
TQ0058 |
MI-463 |
MI-463 is a potent and orally bioavailable inhibitor of the menin-mLL interaction (IC50: 15.3 nM). |
TQ0069 |
MI-503 |
MI-503 is a highly effective and orally bioavailable inhibitor of the menin-mLL interaction. |
TQ0100 |
AZ505 |
AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM). |
TQ0232 |
UNC 0646 |
UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646 potently b...
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TQ0263 |
EPZ031686 |
EPZ031686 is a selective and orally available SMYD3 inhibitor (IC50: 3 nM). |
T8201 |
Gambogenic acid |
Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity. |
T13780 |
MS1943 |
MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM). |
T12428 |
PF-06726304 acetate |
PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity. |
T12541 |
PRMT5-IN-1 |
PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for PRMT5/MEP50). |
T11081 |
Dot1L-IN-1 |
The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor. |
T11082 |
Dot1L-IN-2 |
Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively...
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T11083 |
Dot1L-IN-4 |
Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.11 nM. |
T11084 |
Dot1L-IN-5 |
Dot1L-IN-5 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.17 nM. |
T10427 |
AZ505 ditrifluoroacetate |
AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM). |
T10840L |
CM-579 |
CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells. |
T8510 |
CPI-1205 |
CPI-1205 is a highly potent and selective inhibitor of EZH2(IC50 : 0.002 μM, EC50 : 0.032 μM) . |
T15080 |
DC-05 |
DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50: 10.3 μM; Kd: 1.09 μM). |
T15194 |
EBI-2511 |
EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines). |
T15240 |
Tazemetostat trihydrochloride |
Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing...
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T12939 |
SMYD2-IN-1 |
SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM). |
T12940 |
SMYD3-IN-1 |
SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM). |
T12943 |
SNDX-5613 |
SNDX-5613 is a potent and specific inhibitor of Menin-MLL(Ki of 0.149 nM and a cell based IC50 of 10-20 nM). SNDX-5613 can be used for the research of MLL-rearr...
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T11131 |
DW14800 |
DW14800 reduces H4R3me2s levels and enhances the transcription of HNF4α, but does not alter PRMT5 expression. Anti-cancer activity.DW14800 is a protein arginin...
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T11185 |
EML741 |
EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain ...
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T11436 |
GNA002 |
GNA002 can specifically and covalently bind to Cys668 within the EZH2-SET domain, triggering EZH2 degradation through COOH terminus of Hsp70-interacting prote...
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T11486 |
GSK2807 Trifluoroacetate |
GSK2807 Trifluoroacetate is a selective, potent and SAM-competitive inhibitor of SMYD3, with a Ki of 14 nM and an IC50 of 130 nM. |
T11500L |
GSK3368715 dihydrochloride |
GSK3368715 dihydrochloride produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity.GSK3368715 dihydrochloride ...
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T11500 |
GSK3368715 |
GSK3368715 produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity. GSK3368715 is an orally active, reversible...
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T13279 |
Valemetostat tosylate |
Valemetostat tosylate is a dual inhibitor of EZH1/2, and used in the research of relapsed/refractory peripheral T-cell lymphoma. |
T15624 |
JNJ-64619178 |
JNJ-64619178 has effective activity In lung cancer. JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltran...
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T16072 |
MI-538 |
MI-538 is an interaction between menin and MLL fusion proteins inhibitor(IC50 of 21 nM). |
T10882 |
CPUY074020 |
CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity. |
T15775 |
Lotilaner |
Lotilaner is a parasiticide. It is used as a potent non-competitive antagonist of insects GABACl receptors (IC50 of 23.84 nM for Drosophila melanogaster GABA re...
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T16435 |
PBIT |
PBIT inhibits JARID1B histone demethylase (IC50 of about 3 μM). PBIT also inhibits JARID1A and JARID1C (IC50s of 6 μM and 4.9 μM, respectively). PBIT is a sp...
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T12428L |
PF-06726304 |
PF-06726304 shows robust antitumor growth activity. PF-06726304 is an effective and selective EZH2 inhibitor. PF-06726304 inhibits wild-type and Y641N mutant EZ...
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T16577 |
PRMT5-IN-2 |
PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5. |
T17002 |
Tazemetostat hydrobromide |
Tazemetostat hydrobromide is a potent and selective EZH2 inhibitor. Tazemetostat hydrobromide inhibits the activity of human polycomb repressive complex 2 (PRC2...
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T17203 |
UNC0224 |
UNC0224 is inactive against SET7/9, SET8/PreSET7, PRMT3, and JMJD2E. UNC0224 is a potent and selective histone methyltransferase G9a inhibitor (Ki: 2.6 nM, an I...
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T17204 |
UNC0321 |
UNC0321 is inactive against SET7/9, SET8/PreSET7, PRMT3, and JMJD2E. UNC0321 is an effective and selective histone methyltransferase G9a inhibitor (Ki: 63 pM) a...
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T22325 |
EPZ020411 2HCl |
EPZ020411 is a selective and potent small molecule PRMT6 inhibitor with an IC50 value of 10 nM. |
T22342 |
GSK3368715 3HCl |
GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81...
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TN5096 |
Tanshindiol B |
Tanshindiol B possesses a unique anti-cancer activity whose mechanism involves the inhibition of EZH2 activity and would provide chemically valuable information...
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TN5097 |
Tanshindiol C |
Tanshindiol C protects macrophages from oxLDL induced foam cell formation via activation of Prdx1/ABCA1 signaling and that Prdx1 may be a novel target for thera...
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