EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM. |
SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells. |
SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3. |
EPZ5676 has been used in trials studying the treatment of Leukemia, Acute Leukemias, Acute Myeloid Leukemia, Myelodysplastic Syndrome, and Acute Lymphocytic Leu...
UNC0638 is an inhibitor of β-protein lysine methyltransferases G9a(IC50<15 nM) and GLP(IC50=19 nM) with excellent potency and selectivity over a wide range of ...
EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM. |
Potent and selective G9a/GLP histone lysine methyltransferase inhibitor (IC50 = 3.3 nM). Exhibits >1000-fold selectivity for G9a/GLP over 21 other methyltransf...
||Shanzhiside methyl ester
Shanzhiside methylester reduces neuropathic pain by activating spinal GLP-1 receptors and subsequently stimulating microglial β-endorphin expression via the p3...
GLP-1 (7-36) amide is a peptide hormone released from intestinal L-cells upon nutrient consumption. It binds the GLP-1 receptor in the pancreas and displays var...
SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectiv...
UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen. |
UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM). |
EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM). |
||EPZ020411 2HCl (1700663-41-7(free base))
EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM). |
A-196 is a potent and selective inhibitor of SUV420 h1 and SUV420 h2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective over ot...
MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively. |
||MS049 2HCl (1502816-23-0(free base))
MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM). It is less active against additional type I PRMTs (IC50s = >130, >22...
PFI-2 hydrochloride is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM), 500 fold active than (S)-P...
BCI-121 is a substrate-competitive SMYD3 inhibitor that inhibits the proliferation of the cancer cell. |
EZM2302 is a selective, and orally available arginine methyltransferase CARM1 inhibitor (IC50: 6 nM). |
GSK3326595 is an inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50:6.2 nM.). |
GSK343，a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity against ot...
EPZ015666 is an orally available inhibitor of PRMT5 enzymatic activity. |
EI1 is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively. |
BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2. |
CPI-169 is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively. |
GSK591，Alternative Names are EPZ015866, GSK3203591， is a potent selective inhibitor of the arginine methyltransferase PRMT5 (IC50=11 nM). |
HLCL-61 hydrochloride is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia. |
Liraglutide is a long-acting GLP-1 receptor agonist. |
LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2. |
MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, ...
SGC2085 is an effective and selective coactivator-associated arginine methyltransferase 1 (CARM1) inhibitor (IC50: 50 nM). |
XY1 is a very close analogue of SGC707 (a potent, selective, and non-competitive inhibitor of PRMT3 with IC50 of 31 nM), It is intended to be used as a negative...
JQEZ5 is an inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM). |
BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μM |
BAY-598 is a selective inhibitor of SMYD2 with IC50 values of 27 nM. |
BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM). |
Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity. |
CPI-1205 is a highly potent and selective inhibitor of EZH2(IC50 : 0.002 μM, EC50 : 0.032 μM) . |
Tanshindiol B possesses a unique anti-cancer activity whose mechanism involves the inhibition of EZH2 activity and would provide chemically valuable information...
Tanshindiol C protects macrophages from oxLDL induced foam cell formation via activation of Prdx1/ABCA1 signaling and that Prdx1 may be a novel target for thera...
MI-463 is a potent and orally bioavailable inhibitor of the menin-mLL interaction (IC50: 15.3 nM). |
MI-503 is a highly effective and orally bioavailable inhibitor of the menin-mLL interaction. |
AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM). |
UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646 potently b...
EPZ031686 is a selective and orally available SMYD3 inhibitor (IC50: 3 nM). |