Histone Acetyltransferase

Histone acetyltransferases (HATs) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl-CoA to form ε-N-acetyllysine. DNA is wrapped around histones, and, by transferring an acetyl group to the histones, genes can be turned on and off. In general, histone acetylation increases gene expression.

Cat. No.	Product name	CAS No.	Purity
T6584	MG 149	1243583-85-8	99.1%
T6584	MG 149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).
T3969	I-CBP112	1640282-31-0	99.1%
T3969	I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
T6668	SGC-CBP30	1613695-14-9	99.03%
T6668	SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
T1516	Curcumin	458-37-7	98.98%
T1516	Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide...
T6389	Anacardic Acid	16611-84-0	98.84%
T6389	Anacardic Acid (6-pentadecylsalicylic Acid) is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial...
T11807	L002	321695-57-2	98.59%
T11807	L002, a potent, cell-permeable, reversible, and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM, directly binds the acetyl-CoA pocket a...
T11366	Garcinol	78824-30-3	98.59%
T11366	Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-...
T8658	NEO2734	2081072-29-7	98.56%
T8658	NEO2734 (EP31670) is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains).
T14073	A-485	1889279-16-6	98.32%
T14073	A-485 is a potent and selective catalytic p300/CBP inhibitor(IC50s of 9.8 nM and 2.6 nM for p300 and CBP, respectively).
T9373	DCH36_06	593273-05-3	98.32%
T9373	DCH36_06 ((5E)-1-(3-chloro-4-methylphenyl)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione) as a bona fide is a potent p30...
T6133	Remodelin hydrobromide	1622921-15-6	98%
T6133	Remodelin hydrobromide (Remodelin HBR) is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.
T28471	PU139	158093-65-3	97.61%
T28471	PU139 is a novel inhibitor of histone acetyltransferase (HAT).
T9102	WM-3835	2229025-70-9	97.47%
T9102	WM-3835 is a novel and high-specific small molecule inhibitor of Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) , able to potently suppressed OS cell proliferati...
T27083	Crebinostat	1092061-61-4	94.96%
T27083	Crebinostat is a potent histone deacetylase (HDAC) inhibitor, inhibiting HDAC1, HDAC2, HDAC3, and HDAC6 with IC50s of 0.7 nM, 1.0 nM, 2.0 nM, and 9.3 nM, respect...
T15216	EML 425	1675821-32-5	100%
T15216	EML 425 is a potent and selective inhibitor of CREB binding protein (CBP)/p300 (IC50s: 2.9 and 1.1 μM, respectively).
T11563	Histone Acetyltransferase Inhibitor II	932749-62-7	100%
T11563	Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 μM).with anti-acetylase activity in...
T4679	WM-1119	2055397-28-7
T4679	WM-1119 is a highly potent, selective KAT6A/B inhibitor
T9167	PF-9363	2569009-58-9
T9167	PF-9363 (CTX-3648) is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.
T3217	PF-CBP1 hydrochloride	2070014-93-4
T3217	PF-CBP1 hydrochloride (PF-CBP1 HCl) is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains w...
T82008	JG-2016	2887480-87-5	98%
T82008	JG-2016, as a small molecule histone acetyltransferase 1 (HAT1) inhibitor, inhibits the growth of human cancer cell lines, inhibits enzyme activity in cellulose,...