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Histone Demethylase

Histone demethylase proteins have a variety of domains that serve different functions. These functions include binding to the histone (or sometimes the DNA on the nucleosome), recognizing the correct methylated amino acid substrate and catalyzing the reaction, and binding cofactors. Cofactors include: alpha-keto glutarate (JmjC-domain containing demethylases), CoREST (LSD), FAD, Fe (II) or NOG (N-oxalylglycine).
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T3552 CPI-455 1628208-23-0 99.02%
CPI-455
CPI-455 is a specific KDM5 inhibitor.
T39252 TAK-418 1818252-53-7 98.87%
TAK-418
TAK-418 is a selective and orally active inhibitor of LSD1/KDM1A enzyme with an IC50 of 2.9 nM. TAK-418 unlocks abnormal epigenetic mechanisms and improves autis...
T63140 LSD1-IN-20 1239589-91-3 98.72%
LSD1-IN-20
Lsd1-in-20 is a potent dual inhibitor of LSD1/G9a with Ki values of 0.44 and 0.68 μM, respectively. LSD1-IN-20 showed antiproliferative activity against THP-1 le...
T27723L KDM5-C49 HCl 98.59%
KDM5-C49 HCl
KDM5-C49 HCl (KDOAM-20 hydrochloride) is a potent and selective inhibitor of KDM5 demethylase. KDM5-C49 HCL(1596348-16-1 Free base) is a candidate compound for t...
T4383 GSK-J4 Hydrochloride 1797983-09-5 98.36%
GSK-J4 Hydrochloride
GSK-J4 Hydrochloride (GSK J4 HCl) is a cell permeable, potent and selective histone demethylase(JMJD3 )inhibitor. is an ethyl ester derivative of the GSK-J1 with...
T10864 Corin 1808113-09-8 98.22%
Corin
Corin is an irreversible inhibitor of HDAC1(IC50 = 147 nM) and LSD1(Ki = 110 nM).
T4527 Seclidemstat 1423715-37-0 98.03%
Seclidemstat
Seclidemstat (SP-2577) is an effective LSD1 inhibitor, with a mean IC50 of 127 nM.
T1868 JIB-04 199596-05-9 98.02%
JIB-04
JIB-04 (NSC 693627) is a pan-selective Jumonji histone demethylase inhibitor.
T4418 GSK2879552 2HCl (1401966-69-5(free base)) T4418 98%
GSK2879552 2HCl (1401966-69-5(free base))
GSK2879552 is an orally available, irreversible inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity.
T0802 Procaine hydrochloride 51-05-8 98%
Procaine hydrochloride
Procaine hydrochloride (Novocaine HCl) is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties....
T5825 Iadademstat dihydrochloride 1431303-72-8 98%
Iadademstat dihydrochloride
Iadademstat dihydrochloride (ORY-1001(trans)) , a Potent and Selective Covalent KDM1A/LSD1 Inhibitor, for the Treatment of Acute Leukemia.
T11882 Pulrodemstat benzenesulfonate 2097523-60-7 97.73%
Pulrodemstat benzenesulfonate
Pulrodemstat benzenesulfonate (CC-90011 benzenesulfonate) is a potent and orally active inhibitor of lysine specific demethylase-1 (LSD1) with anticancer activit...
T39389 KDM2B-IN-2 1965248-01-4 97.57%
KDM2B-IN-2
KDM2B-IN-2 is a potent histone demethylase (kdm2b) inhibitor.
T6593 ML324 1222800-79-4 97.49%
ML324
ML324(IC50=920 nM) is a specific inhibitor of jumonji histone demethylase (JMJD2).
T1025 Tranylcypromine (2-PCPA) hydrochloride 1986-47-6 97.19%
Tranylcypromine (2-PCPA) hydrochloride
Tranylcypromine (2-PCPA) hydrochloride (SKF-385 HCl), a Monoamine Oxidase inhibitor, is effective in the treatment of major depression, dysthymic disorder, and a...
T3100 GSK-J4 1373423-53-0 97.07%
GSK-J4
GSK-J4 (GSK J4 HCl) is a potent H3K27me3 demethylase inhibitor, with IC50s of 8.6 μM and 6.6 μM towards KDM6B and KDM6A respectively. It is the first selective i...
T5368 Eicosapentaenoic Acid 10417-94-4 96.20%
Eicosapentaenoic Acid
Eicosapentaenoic Acid (EPA) is a ω-3 fatty acid abundantly available in marine organisms.
T5484 GSK467 1628332-52-4 100%
GSK467
GSK467 is a potent and selective inhibitor of KDM5 (JARID1)(Ki : 10 nM).
T22821 GSK J5 1394854-51-3 100%
GSK J5
GSK J5 is an inhibitor of schistosomes and helminths and is often used as a trematode insecticide.GSK J5 promotes schistosome mortality in a dose- and time-depen...
T13748 L-2-Hydroxyglutaric acid disodium 63512-50-5
L-2-Hydroxyglutaric acid disodium
L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium) is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutari...
CPI-455
T3552
CPI-455 is a specific KDM5 inhibitor.
TAK-418
T39252
TAK-418 is a selective and orally active inhibitor of LSD1/KDM1A enzyme with an IC50 of 2.9 nM. TAK-418 unlocks abnormal epigenetic mechanisms and improves autis...
LSD1-IN-20
T63140
Lsd1-in-20 is a potent dual inhibitor of LSD1/G9a with Ki values of 0.44 and 0.68 μM, respectively. LSD1-IN-20 showed antiproliferative activity against THP-1 le...
KDM5-C49 HCl
T27723L
KDM5-C49 HCl (KDOAM-20 hydrochloride) is a potent and selective inhibitor of KDM5 demethylase. KDM5-C49 HCL(1596348-16-1 Free base) is a candidate compound for t...
GSK-J4 Hydrochloride
T4383
GSK-J4 Hydrochloride (GSK J4 HCl) is a cell permeable, potent and selective histone demethylase(JMJD3 )inhibitor. is an ethyl ester derivative of the GSK-J1 with...
Corin
T10864
Corin is an irreversible inhibitor of HDAC1(IC50 = 147 nM) and LSD1(Ki = 110 nM).
Seclidemstat
T4527
Seclidemstat (SP-2577) is an effective LSD1 inhibitor, with a mean IC50 of 127 nM.
JIB-04
T1868
JIB-04 (NSC 693627) is a pan-selective Jumonji histone demethylase inhibitor.
GSK2879552 2HCl (1401966-69-5(free base))
T4418
GSK2879552 is an orally available, irreversible inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity.
Procaine hydrochloride
T0802
Procaine hydrochloride (Novocaine HCl) is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties....
Iadademstat dihydrochloride
T5825
Iadademstat dihydrochloride (ORY-1001(trans)) , a Potent and Selective Covalent KDM1A/LSD1 Inhibitor, for the Treatment of Acute Leukemia.
Pulrodemstat benzenesulfonate
T11882
Pulrodemstat benzenesulfonate (CC-90011 benzenesulfonate) is a potent and orally active inhibitor of lysine specific demethylase-1 (LSD1) with anticancer activit...
KDM2B-IN-2
T39389
KDM2B-IN-2 is a potent histone demethylase (kdm2b) inhibitor.
ML324
T6593
ML324(IC50=920 nM) is a specific inhibitor of jumonji histone demethylase (JMJD2).
Tranylcypromine (2-PCPA) hydrochloride
T1025
Tranylcypromine (2-PCPA) hydrochloride (SKF-385 HCl), a Monoamine Oxidase inhibitor, is effective in the treatment of major depression, dysthymic disorder, and a...
GSK-J4
T3100
GSK-J4 (GSK J4 HCl) is a potent H3K27me3 demethylase inhibitor, with IC50s of 8.6 μM and 6.6 μM towards KDM6B and KDM6A respectively. It is the first selective i...
Eicosapentaenoic Acid
T5368
Eicosapentaenoic Acid (EPA) is a ω-3 fatty acid abundantly available in marine organisms.
GSK467
T5484
GSK467 is a potent and selective inhibitor of KDM5 (JARID1)(Ki : 10 nM).
GSK J5
T22821
GSK J5 is an inhibitor of schistosomes and helminths and is often used as a trematode insecticide.GSK J5 promotes schistosome mortality in a dose- and time-depen...
L-2-Hydroxyglutaric acid disodium
T13748
L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium) is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutari...
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