T16779 |
Rodatristat ethyl
|
1673571-51-1
|
98%
|
|
Rodatristat ethyl (KAR5585) is a first-of-its-kind orally active and potent tryptophan hydroxylase 1 (TPH1) inhibitor that significantly reduces 5-hydroxytryptam...
|
T6356 |
(R)-Nepicastat HCl
|
195881-94-8
|
98%
|
|
(R)-Nepicastat HCl (RS-25560-198 HCl), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and hu...
|
T15786 |
LPA2 antagonist 1
|
1017606-66-4
|
98%
|
|
LPA2 antagonist 1 is an LPA2 antagonist (IC50: 17 nM).
|
T15426 |
GSK180
|
1799725-26-0
|
98%
|
|
GSK180 is a selective competitive inhibitor of kynurenine 3-monooxygenase (KMO; IC50: ~6 nM), an enzyme involved in tryptophan metabolism.
|
T11470 |
GSK 366
|
1953157-39-5
|
98%
|
|
GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).
|
T7117 |
Sapropterin dihydrochloride
|
69056-38-8
|
99.88%
|
|
Sapropterin dihydrochloride (6R-BH4 dihydrochloride) is phenylalanine hydroxylase agonist that is approved for the treatment of BH4 responsive PKU.
|
T6004 |
Tetrahydropapaverine hydrochloride
|
6429-04-5
|
99.83%
|
|
Tetrahydropapaverine hydrochloride (Norlaudanosine HCl) , an analogue of salsolinol and tetrahydropapaveroline, has neurotoxicity on dopamine neurons.
|
T0679 |
Ketoconazole
|
65277-42-1
|
99.62%
|
|
Ketoconazole (R-41400), a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
|
T41274 |
P-Fluoro-L-phenylalanine
|
1132-68-9
|
99.53%
|
|
p-Fluoro-L-phenylalanine is a substrate for tyrosine hydroxylase (TH) that can be used to study the regulation of that enzyme. p-Fluoro-L-phenylalanine binds to ...
|
T21506 |
Telotristat
|
1033805-28-5
|
99.49%
|
|
Telotristat is the active metabolite of LX1606(Telotristat etiprate), which is an orally bioavailable tryptophan hydroxylase (TPH) inhibitor and shows potential ...
|
T14119 |
ACT-678689
|
1783256-96-1
|
99.45%
|
|
ACT-678689 (Compound Example 1.53.4) (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].
|
T6044 |
Telotristat Etiprate
|
1137608-69-5
|
99.21%
|
|
Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.
|
T4277 |
Osilodrostat
|
928134-65-0
|
99.10%
|
|
Osilodrostat (LCI699) (LCI699) is an effective inhibitor of human 11β-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM).
|
T41143 |
PCPA methyl ester hydrochloride
|
14173-40-1
|
99.08%
|
|
pCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) is an inhibitor of tryptophan hydroxylase inhibitor and 5-HT synthesis. pC...
|
T15124 |
Diethyl-pythiDC
|
1821370-70-0
|
98.87%
|
|
Diethyl-pythiDC is an collagen prolyl 4-hydroxylase inhibitor.
|
T1896 |
Ro 61-8048
|
199666-03-0
|
98.86%
|
|
Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.
|
T1447 |
Fenclonine
|
7424-00-2
|
98.81%
|
|
Fenclonine (CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYP...
|
T10142 |
P-Ethynylphenylalanine
|
278605-15-5
|
98.04%
|
|
p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine), a tryptophan hydroxylase (TPH) inhibitor, is competitive, effective, selective, and reversible, with a Ki of ...
|
T3268 |
Mildronate
|
76144-81-5
|
98%
|
|
Mildronate (Meldonium) is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine ...
|
T15796 |
LX-1031
|
945976-76-1
|
97.97%
|
|
LX-1031 is an effective inhibitor of tryptophan 5-hydroxylase. LX-1031 decreases serotonin (5-HT) synthesis peripherally.
|