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NF-Κb IκB/IKK

IκB/IKK

The IκB kinase (IKK) is an enzyme complex that is involved in propagating the cellular response to inflammation.The IκB kinase enzyme complex is part of the upstream NF-κB signal transduction cascade. The IκBα (inhibitor of nuclear factor kappa B) protein inactivates the NF-κB transcription factor by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm. Specifically, IKK phosphorylates the inhibitory IκBα protein. This phosphorylation results in the dissociation of IκBα from NF-κB. NF-κB, which is now free, migrates into the nucleus and activates the expression of at least 150 genes; some of which are anti-apoptotic.
Cat No. product name
T0097 MRT67307 Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-...
T1558 ResveratrolHOT Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc. Resv...
T1902 BAY 11-7082 BAY 11-7082, a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21.
T1934 Bay 11-7085 BAY 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).
T2055 WS3 WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
T2081 LY2409881 trihydrochloride LY2409881 trihydrochloride is a novel specific inhibitor of IKK2 (IC50: 30 nM); IC50 for IKK1 and other common kinases is at least one log higher.
T2106 WS6 WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
T2118 SC-514 SC-514 is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
T3049 TPCA-1 TPCA-1 is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinases and en...
T3094 PS-1145 PS-1145 is a specific IKK inhibitor with IC50 of 88 nM.
T3736 Olivetol Olivetol (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is also a precursor in various syntheses o...
T6141 IMD 0354 IMD-0354 is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.
T6165 Bardoxolone Methyl Bardoxolone Methyl, an IKK inhibitor, exhibits effective proapoptotic and anti-inflammatory activities.
T6176 IKK-16 IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
T6186 TRAM-34 TRAM-34(Kd=20 nM),an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1),does not block cytochrome P450. ...
T6326 BMS-345541 BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.
T6771 AZD3264 AZD3264 is a new type IKK2 inhibitor.
T7081 CCCP CCCP inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-β production via disrupting mitochon...
T5162 MRT67307 HCl (1190378-57-4(free base)) MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).
T3775 Armepavine Armepavine exerted both in vitro and in vivo antifibrotic effects in rats, with inhibition of NF-κB, JunD and C/EBP pathways. It improves experimental autoimmu...
T5209 INH14 INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).
T5540 GSK8612 GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1, pIC50: 6.8).
TQ0306 MLN120B MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).
T1639 Amlexanox Amlexanox is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mas...
T2765 Rosmarinic acid Rosmarinic acid has shown to contain antioxidant,anti-inflammatory and antimicrobial activities. Possesses promising physiological actions related to cognitive ...
TN1828 Kahweol Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degra...
T7951 TBK1/IKKε-IN-5 TBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor(IC50 of 1 nM and 5.6 nM, respectively).
T10472L Bay 65-1942 free base Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.
T14508 Bay 65-1942 hydrochloride Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.
T14567 BI605906 BI605906 is an inhibitor of IKKβ. When assayed at 0.1 mM ATP, the IC50 value is 380 nM.
T14669 BMS-066 BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.
T12659 (Rac)-BAY-985 (Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.
T15559 TBK1/IKKε-IN-2 TBK1/IKKε-IN-2 is a TBK1 and IKKε dual inhibitor.
T13097 TBK1/IKKε-IN-1 TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).
T10477 BAY-985 BAY-985 is a potent, selective, and orally active ATP-competitive dual inhibitor of TBK1 and IKKε (IC50s: 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε) with...
T11633 IKK-IN-1 IKK-IN-1 is an inhibitor of IKK.
T15558 GSK319347A GSK319347A is a TBK1 and IKKε dual inhibitor (IC50s: 93 nM and 469 nM, respectively). GSK319347A inhibits IKK2 (IC50: 790 nM).
T15564 IMD-0560 IMD-0560 is a novel inhibitor of IκB kinase β.
T8542 BMS-345541 hydrochloride BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).
T2S0606 Bakkenolide A Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sig...
T5S0689 Demethylwedelolactone Demethylwedelolactone has trypsin inhibitory effect, it exerts anti-invasive growth effect on breast cancer cells.
T5S0993 Kurarinone Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong inhibitory effect on immune responses. Kurarinone may amelior...
TJS1779 Protosappanin A Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB infl...
TN2534 1-Hydroxy-2,3,5-trimethoxyxanthone 1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-indepen...
TN2775 2-Methoxystypandrone 2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the infl...
TN3219 7,8-Didehydrocimigenol 7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity o...
TN3486 Bakkenolide IIIa Bakkenolide IIIa has antioxidant, and neuroprotective effects, it protects against cerebral damage by inhibiting AKT and ERK1/2 activation and inactivated NF-Î...
TN3517 Bisacurone Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppress...
TN3539 Broussonin A Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, tr...
TN3614 Cearoin Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing th...
TN3635 Chlojaponilactone B Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 26...
TN3726 Cudraflavone B Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and m...
TN3806 Dehydroglyasperin C Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemo...
TN4162 Goshonoside F5 Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
TN4318 Isophysalin A Isophysalin A exhibits anti-inflammatory activitiy, it exhibits conjugating abilities with glutathione and also shows significant nitric oxide (NO) production i...
TN4383 Kazinol U Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduc...
TN4420 Latifolin Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Lati...
TN4635 Neoechinulin A Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block t...
TN4683 Nyasol Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory...
TN4779 Physalin O Physalin O possesses anti-inflammatory activity, it exhibited conjugating abilities with GSH and also showed significant nitric oxide (NO) production inhibiting...
TN4986 Selinidin Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.
TN5153 Torilin Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linoleni...
MRT67307
T0097CAS 1190378-57-4
Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-...
Resveratrol HOT
T1558CAS 501-36-0
Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc. Resv...
BAY 11-7082
T1902CAS 19542-67-7
BAY 11-7082, a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21.
Bay 11-7085
T1934CAS 196309-76-9
BAY 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).
WS3
T2055CAS 1421227-52-2
WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
LY2409881 trihydrochloride
T2081CAS 946518-60-1
LY2409881 trihydrochloride is a novel specific inhibitor of IKK2 (IC50: 30 nM); IC50 for IKK1 and other common kinases is at least one log higher.
WS6
T2106CAS 1421227-53-3
WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
SC-514
T2118CAS 354812-17-2
SC-514 is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
TPCA-1
T3049CAS 507475-17-4
TPCA-1 is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinases and en...
PS-1145
T3094CAS 431898-65-6
PS-1145 is a specific IKK inhibitor with IC50 of 88 nM.
Olivetol
T3736CAS 500-66-3
Olivetol (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is also a precursor in various syntheses o...
IMD 0354
T6141CAS 978-62-1
IMD-0354 is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.
Bardoxolone Methyl
T6165CAS 218600-53-4
Bardoxolone Methyl, an IKK inhibitor, exhibits effective proapoptotic and anti-inflammatory activities.
IKK-16
T6176CAS 873225-46-8
IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
TRAM-34
T6186CAS 289905-88-0
TRAM-34(Kd=20 nM),an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1),does not block cytochrome P450. ...
BMS-345541
T6326CAS 445430-58-0
BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.
AZD3264
T6771CAS 1609281-86-8
AZD3264 is a new type IKK2 inhibitor.
CCCP
T7081CAS 555-60-2
CCCP inhibits activation of STING and its downstream signalling molecules, TBK1 and IRF3. CCCP inhibits STING-mediated IFN-β production via disrupting mitochon...
MRT67307 HCl (1190378-57-4(free base))
T5162CAS T5162
MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKKε, and NUAK1 (IC50: 19, 27-52, 160, and 230 nM, respectively).
Armepavine
T3775CAS 524-20-9
Armepavine exerted both in vitro and in vivo antifibrotic effects in rats, with inhibition of NF-κB, JunD and C/EBP pathways. It improves experimental autoimmu...
INH14
T5209CAS 200134-22-1
INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).
GSK8612
T5540CAS 2361659-62-1
GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1, pIC50: 6.8).
MLN120B
TQ0306CAS 783348-36-7
MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).
Amlexanox
T1639CAS 68302-57-8
Amlexanox is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mas...
Rosmarinic acid
T2765CAS 20283-92-5
Rosmarinic acid has shown to contain antioxidant,anti-inflammatory and antimicrobial activities. Possesses promising physiological actions related to cognitive ...
Kahweol
TN1828CAS 6894-43-5
Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degra...
TBK1/IKKε-IN-5
T7951CAS 1893397-65-3
TBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor(IC50 of 1 nM and 5.6 nM, respectively).
Bay 65-1942 free base
T10472LCAS 600734-02-9
Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.
Bay 65-1942 hydrochloride
T14508CAS 600734-06-3
Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.
BI605906
T14567CAS 960293-88-3
BI605906 is an inhibitor of IKKβ. When assayed at 0.1 mM ATP, the IC50 value is 380 nM.
BMS-066
T14669CAS 914946-88-6
BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.
(Rac)-BAY-985
T12659CAS 2101925-20-4
(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.
TBK1/IKKε-IN-2
T15559CAS 1292310-49-6
TBK1/IKKε-IN-2 is a TBK1 and IKKε dual inhibitor.
TBK1/IKKε-IN-1
T13097CAS 2058264-32-5
TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).
BAY-985
T10477CAS 2409479-29-2
BAY-985 is a potent, selective, and orally active ATP-competitive dual inhibitor of TBK1 and IKKε (IC50s: 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε) with...
IKK-IN-1
T11633CAS 406211-06-1
IKK-IN-1 is an inhibitor of IKK.
GSK319347A
T15558CAS 862812-98-4
GSK319347A is a TBK1 and IKKε dual inhibitor (IC50s: 93 nM and 469 nM, respectively). GSK319347A inhibits IKK2 (IC50: 790 nM).
IMD-0560
T15564CAS 439144-66-8
IMD-0560 is a novel inhibitor of IκB kinase β.
BMS-345541 hydrochloride
T8542CAS 547757-23-3
BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).
Bakkenolide A
T2S0606CAS 19906-72-0
Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sig...
Demethylwedelolactone
T5S0689CAS 6468-55-9
Demethylwedelolactone has trypsin inhibitory effect, it exerts anti-invasive growth effect on breast cancer cells.
Kurarinone
T5S0993CAS 34981-26-5
Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong inhibitory effect on immune responses. Kurarinone may amelior...
Protosappanin A
TJS1779CAS 102036-28-2
Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB infl...
1-Hydroxy-2,3,5-trimethoxyxanthone
TN2534CAS 22804-49-5
1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-indepen...
2-Methoxystypandrone
TN2775CAS 85122-21-0
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the infl...
7,8-Didehydrocimigenol
TN3219CAS 150972-72-8
7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity o...
Bakkenolide IIIa
TN3486CAS 915289-60-0
Bakkenolide IIIa has antioxidant, and neuroprotective effects, it protects against cerebral damage by inhibiting AKT and ERK1/2 activation and inactivated NF-Î...
Bisacurone
TN3517CAS 120681-81-4
Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppress...
Broussonin A
TN3539CAS 73731-87-0
Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, tr...
Cearoin
TN3614CAS 52811-37-7
Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing th...
Chlojaponilactone B
TN3635CAS 1449382-91-5
Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 26...
Cudraflavone B
TN3726CAS 19275-49-1
Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and m...
Dehydroglyasperin C
TN3806CAS 199331-35-6
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemo...
Goshonoside F5
TN4162CAS 90851-28-8
Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
Isophysalin A
TN4318CAS 1363398-67-7
Isophysalin A exhibits anti-inflammatory activitiy, it exhibits conjugating abilities with glutathione and also shows significant nitric oxide (NO) production i...
Kazinol U
TN4383CAS 1238116-48-7
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduc...
Latifolin
TN4420CAS 10154-42-4
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Lati...
Neoechinulin A
TN4635CAS 51551-29-2
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block t...
Nyasol
TN4683CAS 96895-25-9
Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory...
Physalin O
TN4779CAS 120849-18-5
Physalin O possesses anti-inflammatory activity, it exhibited conjugating abilities with GSH and also showed significant nitric oxide (NO) production inhibiting...
Selinidin
TN4986CAS 19427-82-8
Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.
Torilin
TN5153CAS 13018-10-5
Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linoleni...