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IDO

Indoleamine-pyrrole 2,3-dioxygenase (IDO) is a heme-containing enzyme physiologically expressed in several tissues and cells, such as the small intestine, lungs, female genital tract or placenta.IDO is involved in tryptophan metabolism. It is one of three enzymes that catalyze the first and rate-limiting step in the kynurenine pathway. IDO is an important part of the immune system and plays a part in natural defense against various pathogens. It is produced by the cells in response to inflammation and has an immunosuppressive function because of its ability to limit T-cell function and engage mechanisms of immune tolerance. IDO is part of the malignant transformation process and plays a key role in suppressing the anti-tumor immune response in the body, so inhibiting it could increase the effect of chemotherapy as well as other immunotherapeutic protocols.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T11620 IDO-IN-6 1402837-76-6 98%
IDO-IN-6
IDO-IN-6 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.
T11626 IACS-8968 2144425-14-7 98%
IACS-8968
IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
T8214 Kushenol E 99119-72-9 98%
Kushenol E
Kushenol E (Flemiphilippinin D) is a class of flavonoids isolated from Sophora flavescens. It is a non-competitive IDO1 inhibitor (IC50: 7.7 μM, Ki: 9.5 μM), has...
T11621 IDO-IN-8 1402837-77-7 98%
IDO-IN-8
IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
T11619 IDO-IN-5 1402837-79-9 98%
IDO-IN-5
IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
T11614 IDO-IN-11 1888378-32-2 98%
IDO-IN-11
IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell).
T11627 IACS-8968 R-enantiomer 2239305-67-8 98%
IACS-8968 R-enantiomer
IACS-8968 R-enantiomer is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
T11617 IDO-IN-3 2070018-30-1 98%
IDO-IN-3
IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 290 nM).
T11622 IDO-IN-9 1888378-12-8 98%
IDO-IN-9
IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).
T11624 IDO1-IN-2 2346614-58-0 98%
IDO1-IN-2
IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.
T11628 IACS-8968 S-enantiomer 2239305-70-3 98%
IACS-8968 S-enantiomer
IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
T4307 PF-06840003 198474-05-4 99.89%
PF-06840003
PF-06840003 (EOS200271) is a specific and oral active IDO-1 inhibitor.
T4532 Linrodostat 1923833-60-6 99.84%
Linrodostat
Linrodostat (BMS-986205) is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.
T6407 β-Lapachone 4707-32-8 99.72%
β-Lapachone
β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.
T20513 IDO1-IN-1 615-21-4 99.61%
IDO1-IN-1
IDO1-IN-1 (2 HzBTZ) is an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.
T11615 IDO-IN-12 1888341-29-4 99.61%
IDO-IN-12
IDO-IN-12 is an inhibitor of indoleamine 2,3-dioxygenase (IDO).
T11616 IDO-IN-13 2291164-02-6 99.57%
IDO-IN-13
IDO-IN-13 (GS-4361) is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).
T10199 GNF-PF-3777 77603-42-0 99.47%
GNF-PF-3777
GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).
T9164 BMS-986242 1923844-48-7 98.25%
BMS-986242
BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.
T3548 Epacadostat 1204669-58-8 98.08%
Epacadostat
Epacadostat (INCB 024360) is an oral-available inhibitor of indoleamine 2, 3-dioxygenase (IDO1), increasing the proliferation and activation of various immune ce...
IDO-IN-6
T11620
IDO-IN-6 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.
IACS-8968
T11626
IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
Kushenol E
T8214
Kushenol E (Flemiphilippinin D) is a class of flavonoids isolated from Sophora flavescens. It is a non-competitive IDO1 inhibitor (IC50: 7.7 μM, Ki: 9.5 μM), has...
IDO-IN-8
T11621
IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
IDO-IN-5
T11619
IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
IDO-IN-11
T11614
IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell).
IACS-8968 R-enantiomer
T11627
IACS-8968 R-enantiomer is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
IDO-IN-3
T11617
IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 290 nM).
IDO-IN-9
T11622
IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).
IDO1-IN-2
T11624
IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.
IACS-8968 S-enantiomer
T11628
IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
PF-06840003
T4307
PF-06840003 (EOS200271) is a specific and oral active IDO-1 inhibitor.
Linrodostat
T4532
Linrodostat (BMS-986205) is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.
β-Lapachone
T6407
β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.
IDO1-IN-1
T20513
IDO1-IN-1 (2 HzBTZ) is an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.
IDO-IN-12
T11615
IDO-IN-12 is an inhibitor of indoleamine 2,3-dioxygenase (IDO).
IDO-IN-13
T11616
IDO-IN-13 (GS-4361) is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).
GNF-PF-3777
T10199
GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).
BMS-986242
T9164
BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.
Epacadostat
T3548
Epacadostat (INCB 024360) is an oral-available inhibitor of indoleamine 2, 3-dioxygenase (IDO1), increasing the proliferation and activation of various immune ce...
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