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IDO

Indoleamine-pyrrole 2,3-dioxygenase (IDO) is a heme-containing enzyme physiologically expressed in several tissues and cells, such as the small intestine, lungs, female genital tract or placenta.IDO is involved in tryptophan metabolism. It is one of three enzymes that catalyze the first and rate-limiting step in the kynurenine pathway. IDO is an important part of the immune system and plays a part in natural defense against various pathogens. It is produced by the cells in response to inflammation and has an immunosuppressive function because of its ability to limit T-cell function and engage mechanisms of immune tolerance. IDO is part of the malignant transformation process and plays a key role in suppressing the anti-tumor immune response in the body, so inhibiting it could increase the effect of chemotherapy as well as other immunotherapeutic protocols.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T11901 IDO1-IN-5 2166616-75-5 96.7%
IDO1-IN-5
IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.
T2647 IDO5L 914471-09-3 100%
IDO5L
IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM).
IDO1-IN-5
T11901
IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.
IDO5L
T2647
IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM).
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TargetMol