IGF-1R

The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF-1 plays an important role in growth and continues to have anabolic effects in adults – meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Mice lacking the IGF-1 receptor die late in development, and show a dramatic reduction in body mass, testifying to the strong growth-promoting effect of this receptor.

Cat. No.	Product name	CAS No.	Purity
T6943	Picropodophyllin	477-47-4	99.41%
T6943	Picropodophyllin (Picropodophyllin (PPP)) (PPP) is a specific IGF-1R inhibitor (IC50: 1 nM). Picropodophyllin specifically inhibits the activity and downregulate...
T2693	AG1024	65678-07-1	99.37%
T2693	AG1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).
T8221	Insulin (human)	11061-68-0	99.34%
T8221	Insulin (human) is a peptide hormone that promotes glycogen synthesis and regulates glucose levels in the blood. Insulin (human) has hypoglycemic activity and is...
T6057	URMC-099	1229582-33-5	99.32%
T6057	URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
T24398	Lenaldekar	418800-15-4	99.25%
T24398	Lenaldekar (LDK) inhibits T-cell expansion and autoimmune encephalomyelitis. Lenaldekar causes dephosphorylation of members of the PI3 kinase/AKT/mTOR pathway an...
T6419	BMS-536924	468740-43-4	99.19%
T6419	BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for ...
T6932	PD168393	194423-15-9	99.13%
T6932	PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.
T2085	PQ401	196868-63-0	99.13%
T2085	PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).
T1967	AZD-3463	1356962-20-3	99.13%
T1967	AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.
T21761	HNMPA	132541-52-7	99.11%
T21761	HNMPA is a membrane impermeable inhibitor of insulin receptor tyrosine kinase. HNMPA inhibits tyrosine and serine autophosphorylation by the human insulin recep...
T68405	KW-2450 free base	904899-25-8	99.11%
T68405	KW-2450 free base is a multiple inhibitor of IGF-1R/IR and tyrosine kinases with antitumor activity.KW-2450 free base shows modest growth inhibitory activity and...
T6017	Linsitinib	867160-71-2	98.98%
T6017	OSI-906 (Linsitinib (OSI-906)) is an orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineopla...
T17267	XL228	898280-07-4	98.92%
T17267	XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).
T6003	GSK1904529A	1089283-49-7	98.89%
T6003	GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .
T2755	Rhoifolin	17306-46-6	98.87%
T2755	Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves.
T2349	BMS-754807	1001350-96-4	98.86%
T2349	Dual IGF-1R/InsR Inhibitor BMS-754807 is an oral small molecule inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine ...
TP2018L	GIP (human) acetate	TP2018L	98.65%
TP2018L	GIP (human) acetate is a stimulator of glucose-dependent insulin secretion and a weak inhibitor of gastric acid secretion. GIP (human) acetate plays a vital role...
T10285	ALK inhibitor 1	761436-81-1	98.55%
T10285	ALK inhibitor 1 is a selective ALK kinase inhibitor.
T37588L	GIP (1-30) amide, porcine acetate		98.50%
T37588L	GIP (1-30) amide, porcine acetate is an agonist of fully glucose-dependent insulinotropic polypeptide (GIP) receptor. GIP (1-30) amide, porcine acetate can weakl...
T2642	PD173074	219580-11-7	98.15%
T2642	PD173074 is an effective FGFR1 inhibitor (IC50: 25 nM) and also inhibits VEGFR2 (IC50: 100-200 nM) in cell-free assays. The selectivity is higher ~1000-fold for ...