| Fr14115 |
Terpineol |
α-Terpineol possesses antifungal activity against Trichophyton mentagrophytes, it also exhibits strong antimicrobial activity against periodontopathic and cari...
|
| T0117 |
Suplatast tosilate |
Suplatast Tosilate is a novel capsular anti-asthmatic drug. It ( IC50 above 100 μM) inhibits both IgE production, IL-4 and IL-5 synthesis. |
| T0122 |
Bengenin |
Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action. |
| T0694 |
Pranlukast |
Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction t...
|
| T0947 |
Dexamethason acetate |
Dexamethasone Acetate is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to bin...
|
| T10317 |
Anakinra |
Anakinra (Raleukin) is an antagonist of recombinant, nonglycosylated human IL-1R. It is the first biological agent to block the pro-inflammatory effects. |
| T10497 |
Benralizumab |
Benralizumab (MEDI-563) is an IL-5Rα-directed cytolytic monoclonal antibody that induces rapid, direct and nearly complete depletion of eosinophils via enhance...
|
| T1076 |
DexamethasoneHOT |
Dexamethasone is a glucocorticoid receptor agonist and an IL receptor modulator.Dexamethasone inhibits production of exosomes containing inflammatory microRNA-1...
|
| T11034 |
Di-O-methyldemethoxycurcumin |
Di-O-methyldemethoxycurcumin is a Curcumin analog isolated from medicinal plant turmeric di-orthomethyldemethoxycurcumin, anti-inflammatory and antioxidant prop...
|
| T11357 |
Gamma-glutamylcysteine (TFA) |
Gamma-glutamylcysteine (TFA) also upregulates the level of the anti-inflammatory cytokine IL-10 and reduces the levels of the pro-inflammatory cytokines (TNF-...
|
| T11634 |
IL-15-IN-1 |
IL-15-IN-1 is a selective and potent Interleukin 15 (IL-15) inhibitor, inhibiting the proliferation of IL-15-dependent cells with an IC50 of 0.8 μM. |
| T11635 |
IL-17A antagonist 1 |
IL-17A antagonist 1 is an IL-17A antagonist, with a Kd of 0.66 μM and an IC50 of 1.14 μM. |
| T11636 |
IL-17A antagonist 3 |
IL-17A antagonist 3 is an IL-17A antagonist. |
| T12218 |
NFAT Transcription Factor Regulator-1 |
NFAT Transcription Factor Regulator-1 is an synthesis inhibitor of IL-2 (IC50 of 182 nM). |
| T12245 |
Nosantine racemate |
Nosantine racemate is the racemate of Nosantine which is a IL-2 inducer or enhancer of IL-2 induction by phytohemagglutinin (PHA). |
| T1246 |
Bornyl acetate |
Bornyl acetate has an anti-inflammatory effect. It is the primary volatile ingredient in some Chinese traditional herbs and numerous conifer oils. |
| T12706 |
Reslizumab |
Reslizumab is humanized monoclonal antibodies that target interleukin-5 (IL-5) for the treatment of eosinophilic asthma. |
| T1273 |
Diacerein |
Diacerein is a prodrug which is metabolized to rhein. It is currently approved in France for the treatment of osteoarthritis although the use of diacerein is re...
|
| T12982 |
SP4206 |
SP4206 is an interaction inhibitor of IL-2/IL-2Rα (IL-2 and IL-2Rα with Kd of 70 nM and 10 nM,respectively) |
| T13377 |
(Z)-10-Hydroxy Nortriptyline |
(Z)-10-Hydroxy Nortriptyline is a Nortriptyline metabolite, and is a tricyclic antidepressant,and is used to relieve the symptoms of depression. |
| T1347 |
2-Benzothiazolamine |
2-Aminobenzothiazole is an organic compound. |
| T13666 |
Dupilumab |
Dupilumab (RegN-668) can inhibit IL-4 and IL-13 signaling pathways and significantly improve moderate to severe atopic dermatitis.It is a human monoclonal antib...
|
| T14778 |
BRD6989 |
BRD6989, an analog of the natural product cortistatin A (dCA), inhibits CDK8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant CDK8 or ...
|
| T15777 |
Loxoribine |
Loxoribine is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activi...
|
| T1639 |
Amlexanox |
Amlexanox is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mas...
|
| T1813 |
VGX-1027 |
VGX-1027(GIT27) is an isoxazole compound with various immunomodulatory properties. |
| T1846 |
Y320 |
Y-320 is a new phenylpyrazoleanilide immunomodulator. |
| T19480 |
NO-prednisolone |
NO-prednisolone is a potently stimulates IL-10 production in vivo, and isnitric oxide (NO)-releasing derivative of Prednisolone. |
| T2018 |
Apilimod |
Apilimod inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis. |
| T2S0501 |
Ilexgenin A |
Ilexgenin A exerts anti-inflammation and anti-angiogenesis effects through inhibition of STAT3 and PI3K pathways and exhibits synergistic effects with Sorafenib...
|
| T2S0606 |
Bakkenolide A |
Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sig...
|
| T2S1040 |
Jolkinolide B |
Jolkinolide B has potent anti-inflammatory, and antitumor activities, it is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part,...
|
| T2S2363 |
Corydine |
Corydine is the adrenolytic and weak cholinergic agent, it shows antimicrobial, and antineoplastic activities. Corydine shows irritant and respiratory stimulant...
|
| T3133 |
YM-90709 |
YM-90709 is a new-type antagonist inhibiting the binding of interleukin-5 to the interleukin-5 receptor. |
| T3280 |
Disodium clodronate tetrahydrate |
Disodium clodronate tetrahydrate inhibits bone resorption and soft tissue calcification. |
| T3332 |
Isosteviol |
Isosteviol, a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolys...
|
| T3416 |
Aucubin |
Aucubin is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities. |
| T3533 |
Apilimod mesylate |
Apilimod mesylate is a potent IL-12/IL-23 inhibitor. |
| T3614 |
Isoprinosine |
Isoprinosine has a number of immunomodulatory effects, including inducing T-lymphocyte differentiation, augmenting macrophage and NK cell functions, and stimul...
|
| T3830 |
20R-Ginsenoside Rg2 |
20R-Ginsenoside Rg2 is a compound with anti-oxidant and anti-apoptosis. |
| T3910 |
Anemoside B4 |
Anemoside B4 inhibits the secretion of IL-10. |
| T3S0006 |
Methyl ferulate |
Methyl ferulate is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflammatory agent isolated for the first...
|
| T3S0364 |
L-Arginine |
1. L-Arginine exhibits anti-atherosclerotic effect. 2. L-Arginine and soy enriched diet are effective in prevention of osteoporosis associated with diabetes m...
|
| T4140 |
IRAK4-IN-1 |
IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM. |
| T4279 |
Esonarimod |
Esonarimod is an antirheumatic drug. |
| T4450 |
GIBH-130 |
GIBH-130 markedly inhibits the IL-1β secretion by activated microglia (IC50: 3.4 nM). GIBH-130 is an effective inhibitor of neuroinflammation. |
| T4A2399 |
Cinobufotalin |
Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide p...
|
| T4S0795 |
Berberrubine |
1. Berberrubine has antitumor activity. 2. Berberrubine has antidiabetic activity. 3. Berberrubine dose-dependently inhibits IL-8 and MCP-1 protein levels in th...
|
| T4S1057 |
Tripdiolide |
Tripdiolide has cytotoxic, and anti-rheumatic activities, it suppresses pro-inflammatory gene expression, may be effective therapy for lupus nephritis. |
| T4S1114 |
Dryocrassin ABBA |
Dryocrassin ABBA can significantly suppress tumor growth, without major side effects, it may induce apoptosis in human hepatocellular carcinoma cells through a ...
|
| T5660 |
Menthone |
Menthone has anti-inflammary activity,, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor n...
|
| T5680 |
ALOIN |
ALOIN Inhibits Interleukin (IL)-1β-Stimulated IL-8 Production in KB Cells. |
| T5779 |
MOSLOFLAVONE |
MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and 7.8 μM, respectively. |
| T5788 |
XYLOBIOSE |
XYLOBIOSE ia a natural product,and exhibited therapeutic potential for treating obesity which involved suppression of fat deposition and obesity-related metabol...
|
| T5S0167 |
Atractylenolide I |
1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome,liver and kidney functions by reducti...
|
| T5S1467 |
Cucurbitacin E |
Cucurbitacin E has prevention of neurodegeneration, it has potent anti-proliferative, antineoplastic, anti-inflammatory and analgesic actions, it also exhibits ...
|
| T5S1988 |
Isorhamnetin-3-O-beta-D-Glucoside |
Isorhamnetine-3-O-rutinoside inhibits the activity of alpha-glucosidase from rat intestine; it exhibits a potent rat lens aldose reductase (RLAR) inhibition in ...
|
| T6465 |
Dexamethasone Sodium Phosphate |
Dexamethasone, an interleukin receptor modulator, has anti-inflammatory and immunosuppressant effects. It belongs to a potent glucocorticoid class of steroid s...
|
| T6761 |
AS101 |
AS101, a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme. |
| T7009 |
Soyacerebroside II |
Soyacerebroside II exhibits ionophoretic activity for Ca2+ ion. Soyacerebrosides I and II have modulating the cellular immune response effects, they show obviou...
|
| T8280 |
Desacetyl asperulosidic acid |
Deacetylasperulosidic acid is a natural compound of Morinda citrifolia fruit. It has antioxidant activity by increasing superoxide dismutase activity. It also p...
|
| T9113 |
Myristicin |
Myristicin has anti-cholinergic, antibacterial, and hepatoprotective effects, it also has anti-inflammatory properties related with its inhibition of NO, cytoki...
|
| T9911 |
Tocilizumab |
Tocilizumab (anti-IL-6R) is a humanized monoclonal antibody that binds to the interleukin-6 receptor |
| TJS1779 |
Protosappanin A |
Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB infl...
|
| TMA1570 |
Sappanone A |
Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2...
|
| TMA1777 |
Hydrangenol 8-O-glucoside |
Hydrangenol 8-O-glucoside may have anti-inflammary activity. |
| TMA2576 |
Episappanol |
Episappanol has anti-inflammatory activity , it can significantly inhibit the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis ...
|
| TN1012 |
Febrifugine |
Febrifugine is an effective coccidiostat, possesses schizonticide props; it and its derivatives shows high degree of antimalarial activity but use limited by to...
|
| TN1013 |
Cucurbitacin D |
Cucurbitacin D has anticancer effects, it induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells. |
| TN1035 |
Irisolidone |
Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM. |
| TN1059 |
Ganoderic acid B |
Ganoderic acid B is a chemical marker in quality control of G. lucidum and related products. Ganoderic acid B-containing herbs has potential influence towards t...
|
| TN1088 |
3,3',4',5,6,7,8-heptamethoxyflavone |
3,3',4',5,6,7,8-Heptamethoxyflavone(HMF) has neuroprotective, chemopreventive, anti-allergic, anti-inflammatory, immunomodulatory, anti-aging and photoprotectiv...
|
| TN1093 |
Ginsenoside F4 |
Ginsenoside F4 has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis, the mechanism is related to the mitochondrial dysfunction and the ...
|
| TN1097 |
Beta-boswellic acid |
Beta-boswellic acid and its derivatives (the major constituents of Boswellin) have anti-carcinogenic, anti-tumor, and anti-hyperlipidemic activities. |
| TN1110 |
Shanzhiside |
Shanzhiside has immunosuppressive activity, it shows significant inhibition of IL-2 secretion by phorbol myristate acetate and anti-CD28 monoclonal antibody co-...
|
| TN1132 |
Procyanidin A2 |
Procyanidin A2 is a potential precursor of 5-(3',4'-dihydroxyphenyl)-γ-valerolactone, exhibits antioxidant, anti-inflammary, anti-hyperglycemia, and anti-type ...
|
| TN1139 |
Dehydrocavidine |
Dehydrocorydaline has antitumor activity, it inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as we...
|
| TN1141 |
Isodeoxyelephantopin |
Isodeoxyelephantopin exerts antitumor effects on several cancer cells by inducing apoptosis , cell cycle arrest , and inhibiting proliferation. It enhances apop...
|
| TN1150 |
Procyanidin B3 |
Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity. |
| TN1232 |
(2R)-5,7-Dimethoxyflavanone |
5,7-Dimethoxyflavanone has anti-inflammatory activity. |
| TN1266 |
3-O-Methylquercetin |
3-O-Methylquercetin is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low K(m) value; it inhibits total cAMP- and cGMP-phos...
|
| TN1291 |
5-Hydroxy-3',4',7-trimethoxyflavone |
5-Hydroxy-3',4',7-trimethoxyflavone has anti-inflammatory, antibacterial and antifungal activities, it also shows moderate antitrypanosomal activity with MIC va...
|
| TN1295 |
5-O-Caffeoylshikimic acid |
5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation o...
|
| TN1374 |
alpha-Chaconine |
Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis. A...
|
| TN1403 |
Arjunolic acid |
Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the deve...
|
| TN1407 |
Artocarpin |
Artocarpin has anti- bactericidal effect, can reduce the viability of pneumococci by a factor of >1000, without obvious harm to lung epithelial cells. |
| TN1412 |
Astringin |
Astringinin is a potent antiarrhythmic agent with cardioprotective activity in ischemic and ischemic-reperfused rat heart, the beneficial effects of astringinin...
|
| TN1416 |
Ayanin |
Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma.The IC(50) value of Ayanin (quercetin-3,7,4'-O-trimethyleth...
|
| TN1445 |
Bisabolangelone |
Bisabolangelone has anti-tumor, anti-inflammatory, anti-microbial, and antioxidant activities, it inhibits dendritic cell functions by blocking MAPK and NF-κB ...
|
| TN1493 |
Chrysosplenol D |
Chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials. |
| TN1507 |
Clematichinenoside AR |
Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α± associ...
|
| TN1543 |
Cynaropicrin |
Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, and could therefore be applied to prevention of UVB-induced photo aging; it may be a potential ...
|
| TN1549 |
Damnacanthal |
Damnacanthal possesses anti-cancer, immunomodulatory, antinociceptive and anti-inflammatory actions, it can treat or prevent hepatocellular carcinoma through it...
|
| TN1576 |
Diallyl disulfide |
Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22. |
| TN1579 |
Dihydrocucurbitacin B |
Dihydrocucurbitacin B has anti-cancer activity, it reduces cell proliferation due to a decrease in the expression of cyclins, mainly cyclin-B1 and disruption of...
|
| TN1778 |
Isoformononetin |
Isoformononetin shows fungitoxic activity against Cladosporium sphaerospermum; it also has immunomodulatory activity, it inhibits the differentiation of Th17 ce...
|
| TN1806 |
Isotetrandrine |
Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. It dose-dependently suppresses the severity o...
|
| TN1829 |
Kakkalide |
Kakkalide is a potent lactate dehydrogenase (LDH) inhibitor, it has anti-inflammatory effects. |
| TN1894 |
Luteolin-4'-O-glucoside |
Luteolin 4'-O-glucoside as a IL-5 inhibitor, it has anti-complementary,and anti-oxdiant activities. |
| TN1923 |
Mesaconine |
Mesaconine has cardiac effect, it also has anti-NF-κB activity. Mesaconine may be part of material basis of Mahuang Fuzi Xixin decoction on anti-inflammation a...
|
| TN1933 |
Mitraphylline |
Mitraphylline has antiproliferative effects on human glioma and neuroblastoma cell lines. It also has anti-inflammatory activity, it inhibits lipopolysaccharide...
|
| TN1936 |
Mogroside IIIe |
Mogroside IIIe has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in mice partly through regulation of the TLR4/MAPK/NF-κB axis via AM...
|
| TN1953 |
Morusinol |
Morusinol may significantly inhibit arterial thrombosis in vivo due to antiplatelet activity, may exert beneficial effects on transient ischemic attacks or stro...
|
| TN1960 |
Mussaenoside |
Mussaenoside has anti-inflammatory action, the mechanism associated with downregulation of nuclear factor-κB. |
| TN1983 |
Neoisoastilbin |
Neoisoastilbin may have antioxidant and anti-inflammatory activities. |
| TN1996 |
Nothofagin |
Nothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of CAMs, and adhe...
|
| TN2010 |
Ombuin |
Ombuin has anti-inflammary activity, it inhibits some macrophage functions involved in the inflammatory process. |
| TN2082 |
Pinostrobin |
Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibit...
|
| TN2088 |
Platycodin D2 |
Platycodin D2 , a less hemolytic saponin, can improve specific cellular and humoral responses to hepatitis B surface antigen in mice, it could be safely used as...
|
| TN2169 |
Saikogenin D |
Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation o...
|
| TN2178 |
Sanggenone H |
Sanggenone H may have antiphlogistic activity, it attenuated the secretion of TNF-α± and IL-1α² and inhibited the NF-κB nuclear translocation in LPS-stimul...
|
| TN2180 |
Sappanchalcone |
Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor. |
| TN2223 |
Soyacerebroside I |
Soyacerebroside I demonstrates a potent tyrosinase inhibitory activity. |
| TN2243 |
Sugiol |
Sugiol has antioxidant efficacy, it has significant scavenging activities of 1,1-diphenyl-2-picryl hydrazyl, nitric oxide, superoxide and hydroxyl free radicals...
|
| TN2511 |
1,6-O,O-Diacetylbritannilactone |
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airw...
|
| TN2539 |
1beta-Hydroxyalantolactone |
1beta-Hydroxyalantolactone has protective effect against AD-like skin inflammation, can as a potential therapeutic agent for AD. |
| TN2641 |
15-Methoxypinusolidic acid |
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Metho...
|
| TN2895 |
3,5-Dicaffeoyl-epi-quinic acid |
3,5-Dicaffeoyl-epi-quinic acid shows anti-inflammatory activity, it may improve mast cell-mediated inflammatory diseases. |
| TN2911 |
3,9-Dihydroeucomin |
(+/-)-3,9-Dihydroeucomin has immunomodulatory effects, it shows inhibitory effects on PBMC proliferation activated by PHA with the IC(50) value of 19.4 microM. |
| TN2974 |
3-O-Methylquercetin tetraacetate |
Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsi...
|
| TN3119 |
5-Hydroxy-7,8-dimethoxyflavanone |
5-Hydroxy-7,8-dimethoxyflavanone shows anti-inflammatory activity, it can significantly decrease TNF-alpha, IL-6, macrophage inflammatory protein-2 (MIP-2), and...
|
| TN3144 |
6,4'-Dihydroxy-7-methoxyflavanone |
6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. It shows inhibition of osteoclasts differentiation and functio...
|
| TN3325 |
9-O-Feruloyl-5,5'-dimethoxylariciresinol |
(+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol may have anti-allergic inflammatory effect, it can inhibit release of histamine from mast cells. It shows cy...
|
| TN3364 |
Agrimonolide |
Agrimonolide is a potential α1 adrenergic receptor antagonist, it exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation o...
|
| TN3366 |
Ailanthoidol |
Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potenti...
|
| TN3410 |
Anatabine |
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheim...
|
| TN3483 |
Bakkenolide D |
Bakkenolide D has anti-allergic effect, it and bakkenolide D demonstrates inhibitory effect on the trachea contraction induced by histamine in vitro, they have ...
|
| TN3517 |
Bisacurone |
Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppress...
|
| TN3537 |
Braylin |
Braylin has anti-inflammatory, antinociceptive and immunomodulatory effects, which possibly act through the glucocorticoid receptor activation and by inhibition...
|
| TN3539 |
Broussonin A |
Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, tr...
|
| TN3587 |
Capillarisin |
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cel...
|
| TN3603 |
Carpinontriol B |
Carpinontriol B has antimicrobial activity, it at 40 ug/disk caused the formation of zones of inhibition. It also has anti-inflammatory activity, it shows consi...
|
| TN3609 |
Catalposide |
Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties. Catalposide is a potent inducer of HO-1 and H...
|
| TN3635 |
Chlojaponilactone B |
Chlojaponilactone B has anti-inflammatory activity, it exhibits pronounced inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 26...
|
| TN3779 |
De-O-methyllasiodiplodin |
De-O-methyllasiodiplodin exhibits radical scavenging, moderate antibacterial, and potential anti-inflammatory effects, it shows moderate suppression effects on ...
|
| TN3802 |
Dehydrodiconiferyl alcohol |
Dehydrodiconiferyl alcohol shows anti-adipogenic and anti-lipogenic effects in 3T3-L1 cells and primary mouse embryonic fibroblasts. Dehydrodiconiferyl alcohol ...
|
| TN3839 |
Desoxo-narchinol A |
Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity again...
|
| TN3914 |
Echinatine |
Echinatin exerts a protective effect against ischemia/reperfusion (I/R)-induced myocardial injury on hearts, this effect may be attributed to the antioxidant an...
|
| TN4013 |
Esculentic acid |
Esculentic acid has anti-inflammatory effect, it has protective effects against LPS-induced endotoxic shock may be mediated, at least in part, by regulation the...
|
| TN4064 |
Flavoglaucin |
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or canna...
|
| TN4094 |
Gallocatechin gallate |
Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation thro...
|
| TN4130 |
Germacrone 4,5-epoxide |
(4S,5S)-(+)-Germacrone-4,5-epoxide inhibits certain subtypes of cytochrome P450 (CYP). |
| TN4171 |
Grossamide |
Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflamma...
|
| TN4190 |
Hedycoronen A |
Hedycoronen A and hedycoronen B have the potential anti-inflammatory benefits, they are potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, ...
|
| TN4194 |
Heliangin |
Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 ce...
|
| TN4213 |
Hirsutenone |
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid per...
|
| TN4288 |
Isoferulic acid |
Isoferulic acid is an effective natural antioxidant in both lipid and aqueous media, it may be a new promising anti-glycation agent for the prevention of diabet...
|
| TN4291 |
Isofuranodiene |
Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver dis...
|
| TN4374 |
Kaerophyllin |
Kaerophyllin has anti-fibrotic effects, it can protect the rat liver from TAA-caused injury and fibrogenesis by suppressing hepatic inflammation and inhibiting ...
|
| TN4383 |
Kazinol U |
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduc...
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| TN4392 |
Koaburaside |
Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity against influenza A neuraminidase. Koaburaside may hav...
|
| TN4420 |
Latifolin |
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Lati...
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| TN4437 |
Licorisoflavan A |
Licorisoflavan A shows weak scavenging activity against superoxide anion radical, it and licoricidin have potential for the development of novel host-modulating...
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| TN4471 |
Lysicamine |
Lysicamine shows significant antioxidant capacity in the ORAC(FL) assay and it is active against S. epidermidis and C. dubliniensis, with MIC values in the rang...
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| TN4561 |
Methylnissolin |
Methylnissolin is a natural product from A. membranaceus. |
| TN4583 |
Moringin |
Moringin is a modulator of neuroinflammation via the β-catenin-PPARγ axis, it can activate Wnt canonical pathway by inhibiting GSK3β in a mouse model of expe...
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| TN4584 |
Morolic acid |
Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent chang...
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| TN4592 |
Murrangatin |
Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the hi...
|
| TN4648 |
Nepetoidin B |
Nepetoidin B has anti-fungal, anti-bacterial, and antiinflammatory effects, it can inhibit LPS-stimulated NO production possibly via modulation of iNOS mediated...
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| TN4661 |
Nodosin |
Nodosin has anti-inflammatory function of Nodosin via inhibition of IL-2. Nodosin perfusion provides a potential protective effect through inducing HO-1 express...
|
| TN4675 |
Nortrachelogenin |
Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth...
|
| TN4679 |
Nudiposide |
Nudiposide has significant neuroprotective activities against glutamate-injured neurotoxicity in HT22 cells. It also exhibits protective effect against sepsis i...
|
| TN4683 |
Nyasol |
Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory...
|
| TN4819 |
(-)-Praeruptorin A |
(-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings depe...
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| TN4879 |
Questinol |
Questinol exhibits significant anti-obesity activity. It shows anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, it can inhibit t...
|
| TN5011 |
Shizukaol B |
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinf...
|
| TN5033 |
Skullcapflavone I |
Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages an...
|
| TN5147 |
Tilifodiolide |
Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decrea...
|
| TN5164 |
trans-Hinokiresinol |
Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphyl...
|
| TN5186 |
Triptoquinone A |
Triptoquinone A may be a useful candidate for the development of a drug as a potent inhibitor of iNOS gene over-expression. Triptoquinone A has anti-inflammator...
|
| TN5187 |
Triptoquinone B |
Triptoquinone B is a novel interleukin-1 inhibitor, shows extremely potent inhibitory activities against interleukin-lα and β releases for human peripheral mo...
|
| TN5238 |
Viscidulin II |
Viscidulin II can be potential therapeutic agents against P. acnes-induced skin inflammation, it can significantly suppress P. acnes-induced IL-8 and IL-1β pro...
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