Home Tools
Log in
Cart

Indoleamine 2,3-Dioxygenase (IDO)

Indoleamine-pyrrole 2,3-dioxygenase (IDO or INDO) is a heme-containing enzyme physiologically expressed in a number of tissues and cells, such as the small intestine, lungs, female genital tract or placenta. In humans is encoded by the IDO1 gene. IDO is involved in tryptophan metabolism. It is one of three enzymes that catalyze the first and rate-limiting step in the kynurenine pathway, the O2-dependent oxidation of L-tryptophan to N-formylkynurenine, the others being indolamine-2,3-dioxygenase 2 (IDO2) and tryptophan 2,3-dioxygenase (TDO). IDO is an important part of the immune system and plays a part in natural defense against various pathogens. It is produced by the cells in response to inflammation and has an immunosuppressive function because of its ability to limit T-cell function and engage mechanisms of immune tolerance. Emerging evidence suggests that IDO becomes activated during tumor development, helping malignant cells escape eradication by the immune system. Expression of IDO has been described in a number of types of cancer, such as acute myeloid leukemia, ovarian cancer or colorectal cancer. IDO is part of the malignant transformation process and plays a key role in suppressing the anti-tumor immune response in the body, so inhibiting it could increase the effect of chemotherapy as well as other immunotherapeutic protocols.
Cat No. product name
T10199 GNF-PF-3777 GNF-PF-3777 (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).
T4307 PF-06840003 PF-06840003 is a specific and oral active IDO-1 inhibitor.
T3S1967 (S)-Indoximod Abrine exhibits inhibition of rabbit small intestine indoleamine 2, 3-dioxygenase, competitive inhibition of IDO, reduction of Foxp3 protein expression in tumor ...
T6543 Indoximod Indoximod is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2, 3-dioxygenase (IDO), which degrades...
T2718 Palmatine chloride Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.
T5S0053 Coptisine 1. Coptisine treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine treats myoca...
T4142 PCC0208009 IDO-IN-2 is an IDO inhibitor extracted from patent WO/2015031295 A1, compound example 1.
T4532 Linrodostat BMS-986205 is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.
T7660 IDO inhibitor 1 IDO inhibitor 1 is an potent inhibitor of indoleamine-2,3 dioxygenase (IDO) ( IC50 <100 nM).with potential immunomodulating and antineoplastic activities.
T11901 IDO1-IN-5 IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.
T8214 Kushenol E Kushenol E is a class of flavonoids isolated from Sophora flavescens. It is a non-competitive IDO1 inhibitor (IC50: 7.7 μM, Ki: 9.5 μM), has anti-tumor activity....
T4S0051 Coptisine sulfate 1. Coptisine sulfate has growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program.
T1806 IDO-IN-7 NLG919 is a potent IDO (indoleamine-(2, 3)-dioxygenase) pathway inhibitor.
T3548 Epacadostat Epacadostat is an oral-available inhibitor of indoleamine 2, 3-dioxygenase (IDO1), increasing the proliferation and activation of various immune cells and reduci...
T11616 IDO-IN-13 IDO-IN-13 is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).
T1847 Necrostatin-1 Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis (EC50: 490 nM in Jurkat cells).
T2647 IDO5L IDO-IN-2 is an effective IDO1 inhibitor(IC50=10 nM).
T5S0802 Palmatine 1. Palmatine is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palmatine has bee...
T9164 BMS-986242 BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.
T5S0056 Coptisine chloride 1. Coptisine chloride can be absorbed across intestinal epithelial cells, and completely absorbed compounds.
T7181 IDO-IN-1 IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor( IC50 values of 59 and 12 nM for human IDO enzymatic activity and HeLa cell assays, respectively...
TQ0071 Navoximod Navoximod (NLG- 919, GDC-0919) is a potent indoleamine-(2,3)-dioxygenase (IDO) pathway inhibitor (Ki/EC50: 7 nM/75 nM).
T11615 IDO-IN-12 IDO-IN-12 是吲哚胺 2,3-双加氧酶抑制剂。
GNF-PF-3777
T10199
GNF-PF-3777 (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).
PF-06840003
T4307
PF-06840003 is a specific and oral active IDO-1 inhibitor.
(S)-Indoximod
T3S1967
Abrine exhibits inhibition of rabbit small intestine indoleamine 2, 3-dioxygenase, competitive inhibition of IDO, reduction of Foxp3 protein expression in tumor ...
Indoximod
T6543
Indoximod is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2, 3-dioxygenase (IDO), which degrades...
Palmatine chloride
T2718
Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.
Coptisine
T5S0053
1. Coptisine treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine treats myoca...
PCC0208009
T4142
IDO-IN-2 is an IDO inhibitor extracted from patent WO/2015031295 A1, compound example 1.
Linrodostat
T4532
BMS-986205 is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.
IDO inhibitor 1
T7660
IDO inhibitor 1 is an potent inhibitor of indoleamine-2,3 dioxygenase (IDO) ( IC50 <100 nM).with potential immunomodulating and antineoplastic activities.
IDO1-IN-5
T11901
IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.
Kushenol E
T8214
Kushenol E is a class of flavonoids isolated from Sophora flavescens. It is a non-competitive IDO1 inhibitor (IC50: 7.7 μM, Ki: 9.5 μM), has anti-tumor activit...
Coptisine sulfate
T4S0051
1. Coptisine sulfate has growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program.
IDO-IN-7
T1806
NLG919 is a potent IDO (indoleamine-(2, 3)-dioxygenase) pathway inhibitor.
Epacadostat
T3548
Epacadostat is an oral-available inhibitor of indoleamine 2, 3-dioxygenase (IDO1), increasing the proliferation and activation of various immune cells and reduci...
IDO-IN-13
T11616
IDO-IN-13 is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).
Necrostatin-1
T1847
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis (EC50: 490 nM in Jurkat cells).
IDO5L
T2647
IDO-IN-2 is an effective IDO1 inhibitor(IC50=10 nM).
Palmatine
T5S0802
1. Palmatine is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palmatine has bee...
BMS-986242
T9164
BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.
Coptisine chloride
T5S0056
1. Coptisine chloride can be absorbed across intestinal epithelial cells, and completely absorbed compounds.
IDO-IN-1
T7181
IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor( IC50 values of 59 and 12 nM for human IDO enzymatic activity and HeLa cell assays, respectively...
Navoximod
TQ0071
Navoximod (NLG- 919, GDC-0919) is a potent indoleamine-(2,3)-dioxygenase (IDO) pathway inhibitor (Ki/EC50: 7 nM/75 nM).
IDO-IN-12
T11615
IDO-IN-12 是吲哚胺 2,3-双加氧酶抑制剂。