Indoleamine 2,3-Dioxygenase (IDO)

Indoleamine-pyrrole 2,3-dioxygenase (IDO or INDO) is a heme-containing enzyme physiologically expressed in a number of tissues and cells, such as the small intestine, lungs, female genital tract or placenta. In humans is encoded by the IDO1 gene. IDO is involved in tryptophan metabolism. It is one of three enzymes that catalyze the first and rate-limiting step in the kynurenine pathway, the O2-dependent oxidation of L-tryptophan to N-formylkynurenine, the others being indolamine-2,3-dioxygenase 2 (IDO2) and tryptophan 2,3-dioxygenase (TDO). IDO is an important part of the immune system and plays a part in natural defense against various pathogens. It is produced by the cells in response to inflammation and has an immunosuppressive function because of its ability to limit T-cell function and engage mechanisms of immune tolerance. Emerging evidence suggests that IDO becomes activated during tumor development, helping malignant cells escape eradication by the immune system. Expression of IDO has been described in a number of types of cancer, such as acute myeloid leukemia, ovarian cancer or colorectal cancer. IDO is part of the malignant transformation process and plays a key role in suppressing the anti-tumor immune response in the body, so inhibiting it could increase the effect of chemotherapy as well as other immunotherapeutic protocols.

Cat. No.	Product name	CAS No.	Purity
T7660	IDO inhibitor 1	1204669-37-3	99.16%
T7660	IDO inhibitor 1 is an potent inhibitor of indoleamine-2,3 dioxygenase (IDO) ( IC50 <100 nM).with potential immunomodulating and antineoplastic activities.
T39476	NLG802	2071683-99-1	99.08%
T39476	NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.
T5S0056	Coptisine chloride	6020-18-4	98.85%
T5S0056	1. Coptisine chloride (NSC-119754) can be absorbed across intestinal epithelial cells, and completely absorbed compounds.
T3548	Epacadostat	1204669-58-8	98.56%
T3548	Epacadostat (INCB 024360) is an oral-available inhibitor of indoleamine 2, 3-dioxygenase (IDO1), increasing the proliferation and activation of various immune ce...
T9164	BMS-986242	1923844-48-7	98.25%
T9164	BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.
T7181	IDO-IN-1	914638-30-5	98%
T7181	IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor( IC50 values of 59 and 12 nM for human IDO enzymatic activity and HeLa cell assays, respectively...
T4S0051	Coptisine sulfate	1198398-71-8	98%
T4S0051	1. Coptisine sulfate has growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program.
T11901	IDO1-IN-5	2166616-75-5	96.7%
T11901	IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.
T3S1967	(S)-Indoximod	21339-55-9	95.39%
T3S1967	(S)-Indoximod (L-Abrine) exhibits inhibition of rabbit small intestine indoleamine 2, 3-dioxygenase, competitive inhibition of IDO, reduction of Foxp3 protein ex...
T2647	IDO5L	914471-09-3	100%
T2647	IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM).