T79608 |
DPP
|
2668267-47-6
|
98%
|
|
DPP, a Platinum(IV) complex with a pterostilbene-derived axial ligand, inhibits the JAK2-STAT3 pathway in breast cancer (BC) cells, demonstrating antiproliferati...
|
T79609 |
STAT3-IN-18
|
2668267-41-0
|
98%
|
|
STAT3-IN-18 (compound SPP), a platinum (IV) complex featuring an axial ligand from sandalwood, suppresses the JAK2-STAT3 pathway in breast cancer (BC) cells and ...
|
T79807 |
JAK kinase-IN-1
|
2698389-43-2
|
98%
|
|
JAK kinase-IN-1 (Example 1) functions as a potent inhibitor targeting the JAK family, which includes TYK2, JAK1, JAK2, and JAK3, with IC50 values of 4.2 nM, 32 n...
|
T79882 |
JAK-IN-31
|
2597016-88-9
|
98%
|
|
JAK-IN-31 (Example 75), a JAK inhibitor, demonstrates IC50 values of ≤0.01 µM for JAK1, ≤0.01 µM for JAK2, 0.01-0.1 µM for JAK3, and ≤0.01 µM for Tyk2, indicatin...
|
T81331 |
QL-1200186
|
2848664-42-4
|
98%
|
|
QL-1200186 is an orally active, selective TYK2 inhibitor that, upon dose-dependent oral administration, suppresses interferon-γ (IFNγ) production following inter...
|
T82017 |
JAK-IN-34
|
2068766-90-3
|
98%
|
|
JAK-IN-34 (compound 11n) is a potent inhibitor of Janus kinases (JAKs), demonstrating IC50 values of 0.40 nM for JAK1, 0.83 nM for JAK2, 2.10 nM for JAK3, and...
|
T82018 |
JAK-IN-33
|
|
98%
|
|
JAK-IN-33 (Compound 3 (R)) is a selective inhibitor of the Janus kinase (JAK) family [1].
|
T83218 |
ABBV-712
|
2368945-27-9
|
98%
|
|
ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 μM, and is implicated in the regulation of autoimmune diseases [...
|
T9814 |
JAK3/BTK-IN-1
|
2674036-91-8
|
98%
|
|
JAK3/ BTk-in-1 is a dual JAK3/BTK inhibitor that specifically targets and inhibits Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), two important target...
|
T15606 |
JAK1-IN-4
|
2091134-35-7
|
98%
|
|
JAK1-IN-4 is a selective JAK1 inhibitor (IC50s: 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively). JAK1-IN-4 inhibits STAT3 phosphorylation in NC...
|
TN2511 |
Britannilactone diacetate
|
1286694-67-4
|
98%
|
|
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
|
T3066 |
S-Ruxolitinib
|
1160597-27-2
|
98%
|
|
S-Ruxolitinib is a useful organic compound for research related to life sciences. The catalog number is T3066 and the CAS number is 1160597-27-2.
|
T11721L |
JDTic dihydrochloride
|
785835-79-2
|
98%
|
|
JDTic is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception.
|
TN4774 |
Physalin A
|
23027-91-0
|
98%
|
|
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
|
T11708 |
JAK2-IN-4
|
1438284-00-4
|
98%
|
|
JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.
|
T5049 |
NVP-BSK805
|
1092499-93-8
|
98%
|
|
NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.
|
TMA1743 |
Ergosterol peroxide
|
2061-64-5
|
98%
|
|
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
|
T15037 |
Momelotinib Mesylate
|
1056636-07-7
|
98%
|
|
Momelotinib Mesylate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.
|
T4S1499 |
Ginsenoside Rk1
|
494753-69-4
|
98%
|
|
Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures. Ginsenoside Rk1 has an anti-inflammatory effect, suppresses the acti...
|
T11714 |
JBJ-04-125-02
|
2060610-53-7
|
98%
|
|
JBJ-04-125-02 can inhibit cancer cell proliferation and EGFRL858R/T790M/C797S signaling. JBJ-04-125-02 has anti-tumor activities. JBJ-04-125-02 is a potent, muta...
|