JAK

The JAK-STAT signalling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death and tumour formation. There are 4 JAK proteins: JAK1, JAK2, JAK3 and TYK2. JAKs contains a FERM domain (approximately 400 residues), an SH2-related domain (approximately 100 residues), a kinase domain (approximately 250 residues) and a pseudokinase domain (approximately 300 residues). The kinase domain is vital for JAK activity, since it allows JAKs to phosphorylate (add phosphate groups to) proteins.

Cat. No.	Product name	CAS No.	Purity
T13571	JAK-IN-10	916741-98-5	98.88%
T13571	JAK-IN-10 is a JAK inhibitor. JAK-IN-10 can be used for the research of dry eye disorders.
T22142	RO8191	691868-88-9	98.85%
T22142	RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.
T10009	JAK3-IN-7	1263774-57-7	98.81%
T10009	JAK3-IN-7 is a potent and selective JAK3 inhibitor (IC50<0.01 μM) for the treatment of rejection in organ transplantation, graft-versus-host reaction after organ...
T6122	CEP-33779	1257704-57-6	98.81%
T6122	CEP-33779 is a novel and selective inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.
T20742	TG-89	936091-56-4	98.8%
T20742	TG-89 is an inhibitor of JAK2, JAK3, RET and FLT3, and has an IC50 value of 11.2 μM against JAK2, showing anticancer activity in the treatment of ovarian and cer...
T11710	JAK-IN-5	2096999-92-5	98.78%
T11710	JAK-IN-5 is a JAK inhibitor.
T1849	Momelotinib	1056634-68-4	98.75%
T1849	Momelotinib (LM-1149) is an orally bioavailable small-molecule inhibitor of Janus kinases 1 and 2 (JAK1/2) with IC50 of 11 nM/18 nM. JAK1/2 inhibitor CYT387 comp...
T6294	NVP-BSK805 2HCl (1092499-93-8(free base))	T6294	98.75%
T6294	NVP-BSK805 2HCl (1092499-93-8(free base)) (BSK 805)(IC50=0.5 nM), a specific and effective ATP-competitive JAK2 inhibitor, is more than 20-fold specificity over ...
T67894	Butyzamide	1110767-45-7	98.71%
T67894	Butyzamide is an effective and oral Mpl activator. It is a novel non-peptide-based molecule with antagonistic effects on thrombopoietin (TPO) receptors, which pr...
T3080	Pyridone 6	457081-03-7	98.7%
T3080	Pyridone 6 (JAK Inhibitor)(CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM); ...
T2853	Curcumol	4871-97-0	98.57%
T2853	Curcumol ((-)-Curcumol), a pure monomer isolated extracted from Rhizoma Curcumaeis, has antitumor activities.
T3069	AZD-1480	935666-88-9	98.55%
T3069	AZD1480 is a novel ATP-competitive JAK2 inhibitor (IC50: 0.26 nM), selectivity act against Tyk2 and JAK3, and to a smaller extent against JAK1. AZD1480 has been ...
T4657L	WHI-P97 HCl 211555-05-4(free base)	T4657L	98.55%
T4657L	WHI-P97 HCl is a potent and selective JAK-3 inhibitor. WHI-P97 had an estimated Ki value of 0.09 microM from modeling studies and a measured IC50 value of 2.5 mi...
T14687	Deucravacitinib	1609392-27-9	98.52%
T14687	Deucravacitinib (BMS-986165) inhibits IL-12/23 and type I IFN pathways[1][2]. BMS-986165 is a highly selective, orally bioavailable allosteric TYK2 inhibitor for...
T6309	AZ960	905586-69-8	98.51%
T6309	AZ960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM).
T3398	Icaritin	118525-40-9	98.50%
T3398	Icaritin (Anhydroicaritin) has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase...
T4227	SB1317 hydrochloride (1204918-72-8(free base))	T4227	98.39%
T4227	SB1317 hydrochloride (1204918-72-8(free base)) (TG-02 hydrochloride) is an effective inhibitor of CDK2/JAK2/FLT3 (IC50: 13/73/56 nM).
T35899	JAK1-IN-8	1973485-18-5	98.36%
T35899	JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).
TQ0196	Cucurbitacin I	2222-07-3	98.2%
TQ0196	Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.
T2012	Oclacitinib	1208319-26-9	98.12%
T2012	Oclacitinib (PF-03394197)(PF03394197) is a potent and selective JAKs inhibitor with IC50 of 10-99 nM; not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000 n...