JNK

JNK signaling pathway is such a death pathway that control cell death. There are two main downstream signaling of JNK pathway: one is activation of death signaling such c-Jun, Fos and apoptosis signaling such as BIM, BAD, BAX protein or active P53 transcription, to promote cell apoptosis; the other is inhibition of the cell survival signaling such as STATs and CREB .

Cat. No.	Product name	CAS No.	Purity
TQ0089	Juglanin	5041-67-8	99.33%
TQ0089	Juglanin is a JNK activator. Juglanin with inflammation and anti-tumor activities. It can induce apoptosis and autophagy on human breast cancer cells.
T4S1962	Beta-Asarone	5273-86-9	99.32%
T4S1962	1. beta-Asarone (Cis-Isoelemicin) may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing RO...
TN1918	Medicarpin	32383-76-9	99.32%
TN1918	Medicarpin, a legume phytoalexin, acts as an estrogen receptor (ER) agonist, can stimulate osteoblast differentiation likely via ERα², promote achievement of pea...
TN7121	D-Epigalbacin	84709-25-1	99.25%
TN7121	d-Epigalbacin ((-)-Zuonin A) is a naturally occurring lignin. d-Epigalbacin is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for J...
T2343	AS601245	345987-15-7	99.02%
T2343	AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK), with neuroprotective properties.
T7677	JNK Inhibitor VIII	894804-07-0	99.01%
T7677	JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2, resp...
T14895	Tanzisertib	899805-25-5	98.95%
T14895	Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity.
T3S1641	Esculentoside H	66656-92-6	98.9%
T3S1641	Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release.
T5S2283	Sesamolin	526-07-8	98.89%
T5S2283	1. Sesamolin and Sesamin has neuroprotective effect. 2. Sesamolin protects microglia against H2O2-induced cell injury, by inhibiting of p38 MAPK and caspase-3 ac...
T2973	Astragaloside IV	84687-43-4	98.85%
T2973	Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metall...
T39823L	Apelin-12 acetate	T39823L	98.82%
T39823L	Apelin-12 acetate possesses a high affinity to orphan receptor APJ receptor. Apelin-12 acetate inhibits the JNK and p38 MAPK signaling pathway of the apoptosis-r...
T6677	Sophocarpine	6483-15-4	98.67%
T6677	Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
T7008	Vacquinol-1	5428-80-8	98.67%
T7008	Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.
TMA0507	Tomatidine	77-59-8	98.38%
TMA0507	Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways. Additionally, it induces autophagy in both mammalian cells and C....
T26193	SKLB-163	1255099-06-9	98.31%
T26193	SKLB-163 acts by downregulating RhoGDI, activating JNK-1 signaling pathway and caspase-3, and reducing phosphorylated Akt and p44/42 MAPK.
TN2290	Uvaol	545-46-0	98.27%
TN2290	Uvaol is present in olives and virgin olive oil with anti-inflammatory, anti-proliferative, and vasorelaxant activities.
T9138	Indirubin-3′-oxime	667463-82-3	98.26%
T9138	Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.
T2668	JNK-IN-8	1410880-22-6	98.25%
T2668	JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM). The selectivity is higher 10-fold than MNK2, Fms and no inhibition of M...
T6S1371	Isovitexin	38953-85-4	98.24%
T6S1371	1. Isovitexin (Apigenin-6-C-Glucoside) exhibits a potential antioxidant activity. 2. Isovitexin shows a strong antihyperglycemic action, inhibits α-glucosidase i...
T3S0006	(E)-Ferulic acid methyl ester	22329-76-6	98.22%
T3S0006	(E)-Ferulic acid methyl ester (Methyl (E)-ferulate) is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflam...