TN1879 |
Lucideric acid A
|
95311-94-7
|
98.05%
|
|
Lucideric acid A (Lucidenic acid A) is a modulator of JNK and p38 and enhances LPS-induced immune responses in monocytic THP-1 cells possibly via the modulation ...
|
T4592 |
TOMATIDINE HYDROCHLORIDE
|
6192-62-7
|
98%
|
|
Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway. May be used as a neg...
|
T5574 |
Guggulsterone
|
95975-55-6
|
98%
|
|
Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.
|
T5833 |
CC-401 Hydrochloride
|
1438391-30-0
|
98%
|
|
CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor (Ki of 25 to 50 nM.)with potenti...
|
T3627 |
IQ-1S free acid
|
23146-22-7
|
97.82%
|
|
IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity. IQ-1S can reduce inf...
|
T5094 |
IRAK inhibitor 1
|
1042224-63-4
|
97.78%
|
|
IRAK inhibitor 1 is an effective IRAK-4 inhibitor (IC50: 216 nM), is poorly active against JNK-1 (IC50: 3.801 μM) and JNK-2 (IC50>10 μM).
|
TN1702 |
Glycycoumarin
|
94805-82-0
|
97.64%
|
|
Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.
|
T73182 |
BSJ-04-122
|
2513289-74-0
|
97.58%
|
|
BSJ-04-122 is a covalent MKK4/7 dual inhibitor that inhibits MKK4 and MKK7 with IC50 values of 4 nM and 181 nM, respectively.BSJ-04-122 can be used for cancer re...
|
T13018 |
SU3327
|
40045-50-9
|
97.13%
|
|
SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).
|
T2675 |
Bentamapimod
|
848344-36-5
|
95.21%
|
|
Bentamapimod (AS 602801) is a novel, orally active inhibitor of JNK.
|
T4S2326 |
Cornuside
|
131189-57-6
|
100%
|
|
1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in t...
|
T6784 |
BI-78D3
|
883065-90-5
|
100%
|
|
BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.
|
TP1897L1 |
JIP-1 (153-163) acetate(438567-88-5 free base)
|
TP1897L1
|
100%
|
|
JIP-1 (153-163) acetate is a peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1).
|
T3S0209 |
Vincristine
|
57-22-7
|
100%
|
|
Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-...
|
T7190 |
Actein
|
18642-44-9
|
|
|
Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblast...
|
T2234 |
TCS JNK 5a
|
312917-14-9
|
|
|
TCS JNK 5a (SC202671) is an effective, specific inhibitor of JNK3(pIC50= 6.7), JNK2(pIC50=6.5).
|
T9688 |
CC-90001
|
1403859-14-2
|
|
|
CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.
|
TN1448 |
(-)-Bornyl acetate
|
5655-61-8
|
|
|
(-)-Bornyl acetate (L-(-)-Bornyl acetate) is a less active enantiomer of (+)-Bornyl acetate. (-)-Bornyl acetate isolates from hyssop oil and possesses antifungal...
|
TN3967 |
Epieriocalyxin A
|
191545-24-1
|
|
|
Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.
|
T8477 |
IQ-3
|
312538-03-7
|
|
|
IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in ...
|