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Kinesin

A kinesin is a protein belonging to a class of motor proteins found in eukaryotic cells. Kinesins move along microtubule (MT) filaments, and are powered by the hydrolysis of adenosine triphosphate (ATP) (thus kinesins are ATPases). The active movement of kinesins supports several cellular functions including mitosis, meiosis and transport of cellular cargo, such as in axonal transport.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T4048 Monastrol 329689-23-8 98.744%
Monastrol
Monastrol ((±)-Monastrol) is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.
T6209 CW-069 1594094-64-0 98.57%
CW-069
CW-069 (IC50=75 μM), an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.
T12237 NMS-P715 1202055-32-0 98.41%
NMS-P715
NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
T1839 Mps1-IN-2 1228817-38-6 98.07%
Mps1-IN-2
Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.
T3118 Dimethylenastron 863774-58-7 98.07%
Dimethylenastron
Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.
T2689 AZ3146 1124329-14-1 98.03%
AZ3146
AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.
T11155 Eg5 Inhibitor V, trans-24 869304-55-2 97.45%
Eg5 Inhibitor V, trans-24
Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.
T8342 BRD9876 32703-82-5 97.22%
BRD9876
BRD9876 is a selective inhibitor of MM1S growth.
T36816 S-trityl-L-Cysteine 2799-07-7 97.02%
S-trityl-L-Cysteine
S-trityl-L-Cysteine is a non-natural amino acid and an inhibitor of Eg5, also known as KSP and Kif11, a mitotic kinesin necessary for mitotic spindle formation. ...
T22289 CFI-402257 1610759-22-2 96.66%
CFI-402257
CFI-402257 is a selective inhibitor of Mps1/TTK kinase (Mps1 Ki = 0.09 nM; EC50 = 6.5 nM)and can be used in studies about hepatocellular carcinoma diseases.
T3434 BAY1217389 1554458-53-5 95.71%
BAY1217389
BAY 1217389 is an effective and selective inhibitor of the monopolar spindle 1 (MPS1) kinase (IC50<10 nM).
T29059 UMK57 342595-74-8 98%
UMK57
UMK57 is a CENP-Ei and MCAK enhancer, selectively promoting k-MT attachment error correction to inhibit chromosome missegregation of small molecule compounds, an...
T77586 Eg5-IN-1 98%
Eg5-IN-1
Eg5-IN-1 is a potent inhibitor of the kinesin family of motor proteins (Eg5) with an IC50 value of 1.97 µM for Eg5.Eg5-IN-1 can be used in cancer research.
T8487 Empesertib 1443763-60-7 98%
Empesertib
Empesertib (BAY 1161909) is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.
T6393 ARQ 621 1095253-39-6 98%
ARQ 621
ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.
Monastrol
T4048
Monastrol ((±)-Monastrol) is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.
CW-069
T6209
CW-069 (IC50=75 μM), an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.
NMS-P715
T12237
NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
Mps1-IN-2
T1839
Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.
Dimethylenastron
T3118
Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.
AZ3146
T2689
AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.
Eg5 Inhibitor V, trans-24
T11155
Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.
BRD9876
T8342
BRD9876 is a selective inhibitor of MM1S growth.
S-trityl-L-Cysteine
T36816
S-trityl-L-Cysteine is a non-natural amino acid and an inhibitor of Eg5, also known as KSP and Kif11, a mitotic kinesin necessary for mitotic spindle formation. ...
CFI-402257
T22289
CFI-402257 is a selective inhibitor of Mps1/TTK kinase (Mps1 Ki = 0.09 nM; EC50 = 6.5 nM)and can be used in studies about hepatocellular carcinoma diseases.
BAY1217389
T3434
BAY 1217389 is an effective and selective inhibitor of the monopolar spindle 1 (MPS1) kinase (IC50<10 nM).
UMK57
T29059
UMK57 is a CENP-Ei and MCAK enhancer, selectively promoting k-MT attachment error correction to inhibit chromosome missegregation of small molecule compounds, an...
Eg5-IN-1
T77586
Eg5-IN-1 is a potent inhibitor of the kinesin family of motor proteins (Eg5) with an IC50 value of 1.97 µM for Eg5.Eg5-IN-1 can be used in cancer research.
Empesertib
T8487
Empesertib (BAY 1161909) is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.
ARQ 621
T6393
ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.
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