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Search Results for " lim-kinase "

Targets

9

Compounds

2

Natural Products

Cat No. Product Name Synonyms Targets
T7128 TH-257 TH 257 LIM Kinase
TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).
T4600 BMS-3 LIM Kinase
BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.
T12609 R-10015 LIM Kinase , Reverse Transcriptase
R-10015 is a highly potent and selective LIMK inhibitor that blocks LIMK by binding to the ATP-binding pocket. It inhibits human LIMK1 with an IC50 value of 38 nM. It also exerts broad-spectrum antiviral effects and may ...
T60783 Aurora/LIM kinase-IN-1
Aurora/LIM kinase-IN-1 (Compound F114) is a potent aurora and lim kinase dual inhibitor. Aurora/LIM kinase-IN-1 inhibits the proliferation and invasion of GBM that may be used in drug development efforts for GBM, further...
T4598 BMS-5 BMS5,LIMKi 3 LIM Kinase
BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.
T3960 T56-LIMKi T5601640 LIM Kinase
T56-LIMKi (T5601640) is a selective inhibitor of LIMK2.
T72399 LIMK1 inhibitor BMS-4
LIMK1 inhibitor BMS-4 is a compound targeting LIM Kinase (LIMK) 1/2, specifically inhibiting the phosphorylation of its substrate, cofilin, but it remains noncytotoxic on A549 cells.
T73545 TH470
TH470, a potent and highly selective inhibitor of LIM kinase 1/2 (LIMK1/2), demonstrates specificity with IC50 values of 9.8 nM for LIMK1 and 13 nM for LIMK2, making it applicable in orphan disease research.
T80253 S3 Fragment
S3 Fragment is a biologically active peptide featuring the amino-terminal phosphorylation site unique to Xenopus ADF/cofilin, which is the target of LIM kinase (LIMK) phosphorylation. LIMK1, a pivotal regulator of the ac...
Cat No. Product Name Synonyms Targets
TQ0183 Narciclasine Lycoricidinol ROCK
Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.
TN1533 Cucurbitacin A ROCK
Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-Kinase.
TargetMol