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GPCR/G Protein LPA Receptor

LPA Receptor

Lysophosphatidic acid (LPA) receptors are a group of G-protein-coupled receptors that are currently divided into six subtypes: LPA1, LPA2, LPA3, LPA4, LPA5 and LPA6. They belong to a family of lysophospholipid receptors that include S1P receptors.
Cat No. product name
T2000 AM095 AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.
T4016 BMS-986020 BMS-986020 is a selective antagonist of LPA1.
T6108 Ki16425 Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively.
T4278 AM966 AM966, a excellent affinity, specific, oral LPA1(IC50=17 nM) antagonist, suppresses LPA-stimulated intracellular calcium release.
T7393 ONO-7300243 ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 μM).
T7689 Tetradecyl Phosphonate Tetradecyl phosphonate is a pan-antagonist of lysophosphatidic acid 1 (LPA1), LPA2, and LPA3 receptors.
T14335 ASP6432 ASP6432 is an antagonist of type 1 lysophosphatidic acid receptor (LPA1). For human LPA1 and rat LPA1, the IC50s are 11 nM and 30 nM , respectively.
T10293 AM095 free acid AM095 (free acid) is a potent LPA1 receptor antagonist (IC50s: 0.98 and 0.73 μM for recombinant human or mouse LPA1).
T15795 Luzindole Luzindole is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity. Lu...
T15796 LX-1031 LX-1031 is an effective and orally available inhibitor of tryptophan 5-hydroxylase (TPH). It also decreases serotonin (5-HT) synthesis peripherally.
T11875 LPA2 antagonist 2 LPA2 antagonist 2 is >480-fold more selective than LPA3 (IC50 of 13.85 μM).LPA2 antagonist 2 is a selective LPA2 antagonist with an IC50 of 28.3 nM and a Ki ...
T21654 1-Oleoyl lysophosphatidic acid sodium salt 1-Oleoyl lysophosphatidic acid sodium salt is an Endogenous agonist of LPA1 and LPA2
AM095
T2000CAS 1345614-59-6
AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.
BMS-986020
T4016CAS 1257213-50-5
BMS-986020 is a selective antagonist of LPA1.
Ki16425
T6108CAS 355025-24-0
Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively.
AM966
T4278CAS 1228690-19-4
AM966, a excellent affinity, specific, oral LPA1(IC50=17 nM) antagonist, suppresses LPA-stimulated intracellular calcium release.
ONO-7300243
T7393CAS 638132-34-0
ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 μM).
Tetradecyl Phosphonate
T7689CAS 4671-75-4
Tetradecyl phosphonate is a pan-antagonist of lysophosphatidic acid 1 (LPA1), LPA2, and LPA3 receptors.
ASP6432
T14335CAS 1282549-08-9
ASP6432 is an antagonist of type 1 lysophosphatidic acid receptor (LPA1). For human LPA1 and rat LPA1, the IC50s are 11 nM and 30 nM , respectively.
AM095 free acid
T10293CAS 1228690-36-5
AM095 (free acid) is a potent LPA1 receptor antagonist (IC50s: 0.98 and 0.73 μM for recombinant human or mouse LPA1).
Luzindole
T15795CAS 117946-91-5
Luzindole is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity. Lu...
LX-1031
T15796CAS 945976-76-1
LX-1031 is an effective and orally available inhibitor of tryptophan 5-hydroxylase (TPH). It also decreases serotonin (5-HT) synthesis peripherally.
LPA2 antagonist 2
T11875CAS 36840-10-5
LPA2 antagonist 2 is >480-fold more selective than LPA3 (IC50 of 13.85 μM).LPA2 antagonist 2 is a selective LPA2 antagonist with an IC50 of 28.3 nM and a Ki ...
1-Oleoyl lysophosphatidic acid sodium salt
T21654CAS 325465-93-8
1-Oleoyl lysophosphatidic acid sodium salt is an Endogenous agonist of LPA1 and LPA2