LRRK2|Targetmol

Cat No.	product name
T1770	GNE9605	GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).
T1945	GNE7915	GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.
T2022	CZC54252	CZC-54252 is a potent inhibitor of LRRK2.
T2050	PF06447475	PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.
T2240	GSK2578215A	GSK2578215A is a potent and selective LRRK2 kinase inhibitor.
T2246	LRRK2-IN-1	LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.
T3053	CZC25146	CZC-25146 is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat kinase-2) and G20...
T6031	GNE0877	GNE-0877 is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).
T6057	URMC099	URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM...
T5139	CZC-25146 hydrochloride	CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.
T7196	HG-10-102-01	HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).
T7155	JH-II-127	JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM,...
T7729	PF-06454589	PF-06454589 is a potent inhibitor of LRRK2.
T2014	CCG1423	CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
T5428	BIX 02565	BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).
T16128	MP-A08	MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, resp...
T16512	PFE-360	PFE-360 is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).
T11878	LRRK2 inhibitor 1	LRRK2 inhibitor 1 is a selective, potent and oral LRRK2 inhibitor with an pIC50 of 6.8 nM.
T6176	IKK16	IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
T16115	MLi-2	MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in ...
T16115	MLi-2	MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in ...

GNE9605

T1770CAS 1536200-31-3

GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).

GNE7915

T1945CAS 1351761-44-8

GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.

CZC54252

T2022CAS 1191911-27-9

CZC-54252 is a potent inhibitor of LRRK2.

PF06447475

T2050CAS 1527473-33-1

PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.

GSK2578215A

T2240CAS 1285515-21-0

GSK2578215A is a potent and selective LRRK2 kinase inhibitor.

LRRK2-IN-1

T2246CAS 1234480-84-2

LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.

CZC25146

T3053CAS 1191911-26-8

CZC-25146 is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat kinase-2) and G20...

GNE0877

T6031CAS 1374828-69-9

GNE-0877 is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).

URMC099

T6057CAS 1229582-33-5

URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM...

CZC-25146 hydrochloride

T5139CAS 1330003-04-7

CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.

HG-10-102-01

T7196CAS 1351758-81-0

HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).

JH-II-127

T7155CAS 1700693-08-8

JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM,...

PF-06454589

T7729CAS 1527473-30-8

PF-06454589 is a potent inhibitor of LRRK2.

CCG1423

T2014CAS 285986-88-1

CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.

BIX 02565

T5428CAS 1311367-27-7

BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).

MP-A08

T16128CAS 219832-49-2

MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, resp...

PFE-360

T16512CAS 1527475-61-1

PFE-360 is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).

LRRK2 inhibitor 1

T11878CAS 1802525-61-6

LRRK2 inhibitor 1 is a selective, potent and oral LRRK2 inhibitor with an pIC50 of 6.8 nM.

IKK16

T6176CAS 873225-46-8

IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.

MLi-2

T16115CAS 1627091-47-7

MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in ...

MLi-2

T16115CAS 1627091-47-7

MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in ...