LRRK2

Leucine-rich repeat kinase 2 (LRRK2), also known as dardarin (from the Basque word "dardara" which means trembling) and PARK8 (from early identified association with Parkinson's disease), is a kinase enzyme that in humans is encoded by the LRRK2 gene. LRRK2 is a member of the leucine-rich repeat kinase family. Variants of this gene are associated with an increased risk of Parkinson's disease and also Crohn's disease.

Cat No.	product name
T1770	GNE9605	GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).
T1945	GNE7915	GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.
T2022	CZC-54252	CZC-54252 is a potent inhibitor of LRRK2.
T2050	PF-06447475	PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.
T2240	GSK2578215A	GSK2578215A is a potent and selective LRRK2 kinase inhibitor.
T2246	LRRK2-IN-1	LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.
T3053	CZC-25146	CZC-25146 is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat kinase-2) and G20...
T6031	GNE-0877	GNE-0877 is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).
T6057	URMC-099	URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM...
T5139	CZC-25146 hydrochloride	CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.
T7196	HG-10-102-01	HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).
T7155	JH-II-127	JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM, re...
T7729	PF-06454589	PF-06454589 is a potent inhibitor of LRRK2.
T2014	CCG-1423	CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
T5428	BIX 02565	BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).
T16128	MP-A08	MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, resp...
T16512	PFE-360	PFE-360 is an effective, selective, brain penetrated leucine-rich repeat kinase 2 (IC50: 2.3 nM in vivo).
T11878	LRRK2 inhibitor 1	LRRK2 inhibitor 1 is a selective, potent and oral LRRK2 inhibitor with an pIC50 of 6.8 nM.

Cat No.

product name

T1770

GNE9605

GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).

T1945

GNE7915

GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.

T2022

CZC-54252

CZC-54252 is a potent inhibitor of LRRK2.

T2050

PF-06447475

PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.

T2240

GSK2578215A

GSK2578215A is a potent and selective LRRK2 kinase inhibitor.

T2246

LRRK2-IN-1

LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.

T3053

CZC-25146

CZC-25146 is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat kinase-2) and G20...

T6031

GNE-0877

GNE-0877 is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).

T6057

URMC-099

URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM...

T5139

CZC-25146 hydrochloride

CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.

T7196

HG-10-102-01

HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).

T7155

JH-II-127

JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM, re...

T7729

PF-06454589

PF-06454589 is a potent inhibitor of LRRK2.

T2014

CCG-1423

CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.

T5428

BIX 02565

BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).

T16128

MP-A08

MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, resp...

T16512

PFE-360

PFE-360 is an effective, selective, brain penetrated leucine-rich repeat kinase 2 (IC50: 2.3 nM in vivo).

T11878

LRRK2 inhibitor 1

LRRK2 inhibitor 1 is a selective, potent and oral LRRK2 inhibitor with an pIC50 of 6.8 nM.