LRRK2

Leucine-rich repeat kinase 2 (LRRK2), also known as dardarin (from the Basque word "dardara" which means trembling) and PARK8 (from early identified association with Parkinson's disease), is a kinase enzyme that in humans is encoded by the LRRK2 gene. LRRK2 is a member of the leucine-rich repeat kinase family. Variants of this gene are associated with an increased risk of Parkinson's disease and also Crohn's disease.

Cat. No.	Product name	CAS No.	Purity
T11878	LRRK2 inhibitor 1	1802525-61-6	98%
T11878	LRRK2 inhibitor 1 is a selective, potent and oral LRRK2 inhibitor with an pIC50 of 6.8 nM.
T39972	EB-42486	2390475-81-5	98%
T39972	EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.
T7155	JH-II-127	1700693-08-8
T7155	JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM, re...
T7729	PF-06454589	1527473-30-8	96.29%
T7729	PF-06454589 is a potent inhibitor of LRRK2.
T3053	CZC-25146	1191911-26-8	98.2%
T3053	CZC-25146 is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat kinase-2) and G201...
T39202	CZC-54252 hydrochloride	1784253-05-9	98.21%
T39202	CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuropr...
T2246	LRRK2-IN-1	1234480-84-2	98.44%
T2246	LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.
T1770	GNE-9605	1536200-31-3	98.75%
T1770	GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).
T5139	CZC-25146 hydrochloride	1330003-04-7	99.06%
T5139	CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.
T6057	URMC-099	1229582-33-5	99.32%
T6057	URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
T16115	MLi-2	1627091-47-7	99.33%
T16115	MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a ...
T2022	CZC-54252	1191911-27-9	99.39%
T2022	CZC-54252 is a potent inhibitor of LRRK2.
T6176	IKK 16	873225-46-8	99.61%
T6176	IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
T2050	PF-06447475	1527473-33-1	99.62%
T2050	PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.
T1945	GNE-7915	1351761-44-8	99.7%
T1945	GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.
T16512	PFE-360	1527475-61-1	99.73%
T16512	PFE-360 is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).
T7196	HG-10-102-01	1351758-81-0	99.73%
T7196	HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).
T2240	GSK2578215A	1285515-21-0	99.94%
T2240	GSK2578215A is a potent and selective LRRK2 kinase inhibitor.
T6031	GNE0877	1374828-69-9	99.96%
T6031	GNE-0877 is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).
T2014	CCG-1423	285986-88-1	99.98%
T2014	CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.