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LRRK2

Leucine-rich repeat kinase 2 (LRRK2), also known as dardarin (from the Basque word "dardara" which means trembling) and PARK8 (from early identified association with Parkinson's disease), is a kinase enzyme that in humans is encoded by the LRRK2 gene. LRRK2 is a member of the leucine-rich repeat kinase family. Variants of this gene are associated with an increased risk of Parkinson's disease and also Crohn's disease.
Cat No. product name
T39972 EB-42486 EB-42486 是一种有效且高度选择性的 G2019S-LRRK2 抑制剂,IC50 < 0.2 nM。
T2240 GSK2578215A GSK2578215A is a potent and selective LRRK2 kinase inhibitor.
T6057 URMC-099 URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
T2246 LRRK2-IN-1 LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.
T2014 CCG-1423 CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
T1945 GNE-7915 GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.
T2022 CZC-54252 CZC-54252 is a potent inhibitor of LRRK2.
T2050 PF-06447475 PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.
T7729 PF-06454589 PF-06454589 is a potent inhibitor of LRRK2.
T7196 HG-10-102-01 HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).
T7155 JH-II-127 JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM, re...
T11878 LRRK2 inhibitor 1 LRRK2 inhibitor 1 is a selective, potent and oral LRRK2 inhibitor with an pIC50 of 6.8 nM.
T3053 CZC-25146 CZC-25146 is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat kinase-2) and G201...
T5428 BIX 02565 BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).
T5139 CZC-25146 hydrochloride CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.
T6176 IKK 16 IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
T6031 GNE0877 GNE-0877 is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).
T1770 GNE-9605 GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).
T16512 PFE-360 PFE-360 is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).
T16115 MLi-2 MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a ...
EB-42486
T39972
EB-42486 是一种有效且高度选择性的 G2019S-LRRK2 抑制剂,IC50 < 0.2 nM。
GSK2578215A
T2240
GSK2578215A is a potent and selective LRRK2 kinase inhibitor.
URMC-099
T6057
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
LRRK2-IN-1
T2246
LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.
CCG-1423
T2014
CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
GNE-7915
T1945
GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.
CZC-54252
T2022
CZC-54252 is a potent inhibitor of LRRK2.
PF-06447475
T2050
PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.
PF-06454589
T7729
PF-06454589 is a potent inhibitor of LRRK2.
HG-10-102-01
T7196
HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).
JH-II-127
T7155
JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM, re...
LRRK2 inhibitor 1
T11878
LRRK2 inhibitor 1 is a selective, potent and oral LRRK2 inhibitor with an pIC50 of 6.8 nM.
CZC-25146
T3053
CZC-25146 is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat kinase-2) and G201...
BIX 02565
T5428
BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).
CZC-25146 hydrochloride
T5139
CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.
IKK 16
T6176
IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
GNE0877
T6031
GNE-0877 is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).
GNE-9605
T1770
GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).
PFE-360
T16512
PFE-360 is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).
MLi-2
T16115
MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a ...