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Autophagy LRRK2

LRRK2

Leucine-rich repeat kinase 2 (LRRK2), also known as dardarin (from the Basque word "dardara" which means trembling) and PARK8 (from early identified association with Parkinson's disease), is a kinase enzyme that in humans is encoded by the LRRK2 gene. LRRK2 is a member of the leucine-rich repeat kinase family. Variants of this gene are associated with an increased risk of Parkinson's disease and also Crohn's disease.
Cat No. product name
T1770 GNE9605 GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).
T1945 GNE7915 GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.
T2022 CZC-54252 CZC-54252 is a potent inhibitor of LRRK2.
T2050 PF-06447475 PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.
T2240 GSK2578215A GSK2578215A is a potent and selective LRRK2 kinase inhibitor.
T2246 LRRK2-IN-1 LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.
T3053 CZC-25146 CZC-25146 is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat kinase-2) and G20...
T6031 GNE-0877 GNE-0877 is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).
T6057 URMC-099 URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM...
T5139 CZC-25146 hydrochloride CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.
T7196 HG-10-102-01 HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).
T7155 JH-II-127 JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM, re...
T7729 PF-06454589 PF-06454589 is a potent inhibitor of LRRK2.
T2014 CCG-1423 CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
T5428 BIX 02565 BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).
T16128 MP-A08 MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, resp...
T16512 PFE-360 PFE-360 is an effective, selective, brain penetrated leucine-rich repeat kinase 2 (IC50: 2.3 nM in vivo).
T11878 LRRK2 inhibitor 1 LRRK2 inhibitor 1 is a selective, potent and oral LRRK2 inhibitor with an pIC50 of 6.8 nM. 
GNE9605
T1770CAS 1536200-31-3
GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).
GNE7915
T1945CAS 1351761-44-8
GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.
CZC-54252
T2022CAS 1191911-27-9
CZC-54252 is a potent inhibitor of LRRK2.
PF-06447475
T2050CAS 1527473-33-1
PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.
GSK2578215A
T2240CAS 1285515-21-0
GSK2578215A is a potent and selective LRRK2 kinase inhibitor.
LRRK2-IN-1
T2246CAS 1234480-84-2
LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.
CZC-25146
T3053CAS 1191911-26-8
CZC-25146 is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat kinase-2) and G20...
GNE-0877
T6031CAS 1374828-69-9
GNE-0877 is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).
URMC-099
T6057CAS 1229582-33-5
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM...
CZC-25146 hydrochloride
T5139CAS 1330003-04-7
CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.
HG-10-102-01
T7196CAS 1351758-81-0
HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).
JH-II-127
T7155CAS 1700693-08-8
JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM, re...
PF-06454589
T7729CAS 1527473-30-8
PF-06454589 is a potent inhibitor of LRRK2.
CCG-1423
T2014CAS 285986-88-1
CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
BIX 02565
T5428CAS 1311367-27-7
BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).
MP-A08
T16128CAS 219832-49-2
MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, resp...
PFE-360
T16512CAS 1527475-61-1
PFE-360 is an effective, selective, brain penetrated leucine-rich repeat kinase 2 (IC50: 2.3 nM in vivo).
LRRK2 inhibitor 1
T11878CAS 1802525-61-6
LRRK2 inhibitor 1 is a selective, potent and oral LRRK2 inhibitor with an pIC50 of 6.8 nM.