Liver X Receptor

The liver X receptor (LXR) is a member of the nuclear receptor family of transcription factors and is closely related to nuclear receptors such as the PPARs, FXR and RXR. Liver X receptors (LXRs) are important regulators of cholesterol, fatty acid, and glucose homeostasis. LXRs were earlier classified as orphan nuclear receptors, however, upon discovery of endogenous oxysterols as ligands, they were subsequently deorphanized.Two isoforms of LXR have been identified and are referred to as LXRα and LXRβ.

Cat No.	product name
T14679	XL041	XL041 (BMS-852927) is an agonist of LXRβ-selective.
T15427	GSK2033	GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRα or LXRβ, respectively).
T16282	Nemorexant	Nemorexant is an effective orexin receptor antagonist. It also has IC50s of 2 nM and 3 nM for the Ox1 receptor and Ox2 receptor, respectively.
T16792	Rovazolac	Rovazolac is a liver x receptor modulator.
T16930	SR9238	SR9238 is a synthetic agonist of liver X receptor inverse (IC50s: 214 nM and 43 nM for LXRα and LXRβ, respectively).
T1783	LXR623	WAY-252623 (LXR-623) is an orally bioavailable and highly specifical synthetic modulator of LXR.
T1801	SR9243	SR9243, an LXR inverse agonist, can induce LXR-corepressor interaction; shows anticancer activity and selectively targets the lipogenesis and Warburg effect.
T2810	(20S)-Protopanaxatriol	(20S)-Protopanaxatriol(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.
T3970	XL652	BMS-779788 is an LXRα/β partial agonist (IC50: 68/14 nM).
T5128	RGX-104 HCl	RGX-104 is a liver X receptor (LXR) agonist with potential immunomodulating and antineoplastic activities. It modulates innate immunity via transcriptional acti...
T5178	AZ876	AZ876 is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively.
T5743	Gymnemagenin	Gymnemagenin is a potent and selective antagonist for the β isoform of LXR, it has antihyperglycemic activity.
T6310	GW3965 HCl	GW3965 HCl is an effective and specific LXR agonist for hLXRα/β (EC50: 190/30 nM).
T6690	T0901317	T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
T7768	RGX-104 free Acid	RGX-104 free Acid is an agonist of potent liver-X nuclear hormone receptor (LXR)
TN1055	Licochalcone E	Licochalcone E is a potential LXRβ agonist.
TN1719	Gymnestrogenin	Gymnestrogenin has a dual LXRα±/α² antagonistic profile.
TN4016	Ethyl 2,4,6-trihydroxybenzoate	Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing ...
TQ0274	25(R)-27-hydroxy Cholesterol	27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.

Cat No.

product name

T14679

XL041

XL041 (BMS-852927) is an agonist of LXRβ-selective.

T15427

GSK2033

GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRα or LXRβ, respectively).

T16282

Nemorexant

Nemorexant is an effective orexin receptor antagonist. It also has IC50s of 2 nM and 3 nM for the Ox1 receptor and Ox2 receptor, respectively.

T16792

Rovazolac

Rovazolac is a liver x receptor modulator.

T16930

SR9238

SR9238 is a synthetic agonist of liver X receptor inverse (IC50s: 214 nM and 43 nM for LXRα and LXRβ, respectively).

T1783

LXR623

WAY-252623 (LXR-623) is an orally bioavailable and highly specifical synthetic modulator of LXR.

T1801

SR9243

SR9243, an LXR inverse agonist, can induce LXR-corepressor interaction; shows anticancer activity and selectively targets the lipogenesis and Warburg effect.

T2810

(20S)-Protopanaxatriol

(20S)-Protopanaxatriol(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.

T3970

XL652

BMS-779788 is an LXRα/β partial agonist (IC50: 68/14 nM).

T5128

RGX-104 HCl

RGX-104 is a liver X receptor (LXR) agonist with potential immunomodulating and antineoplastic activities. It modulates innate immunity via transcriptional acti...

T5178

AZ876

AZ876 is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively.

T5743

Gymnemagenin

Gymnemagenin is a potent and selective antagonist for the β isoform of LXR, it has antihyperglycemic activity.

T6310

GW3965 HCl

GW3965 HCl is an effective and specific LXR agonist for hLXRα/β (EC50: 190/30 nM).

T6690

T0901317

T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).

T7768

RGX-104 free Acid

RGX-104 free Acid is an agonist of potent liver-X nuclear hormone receptor (LXR)

TN1055

Licochalcone E

Licochalcone E is a potential LXRβ agonist.

TN1719

Gymnestrogenin

Gymnestrogenin has a dual LXRα±/α² antagonistic profile.

TN4016

Ethyl 2,4,6-trihydroxybenzoate

Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing ...

TQ0274

25(R)-27-hydroxy Cholesterol

27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.