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Liver X Receptor

The liver X receptor (LXR) is a member of the nuclear receptor family of transcription factors and is closely related to nuclear receptors such as the PPARs, FXR and RXR. Liver X receptors (LXRs) are important regulators of cholesterol, fatty acid, and glucose homeostasis. LXRs were earlier classified as orphan nuclear receptors, however, upon discovery of endogenous oxysterols as ligands, they were subsequently deorphanized.Two isoforms of LXR have been identified and are referred to as LXRα and LXRβ.
Cat No. product name
T1783 LXR623 WAY-252623 (LXR-623) is an orally bioavailable and highly specifical synthetic modulator of LXR.
T1801 SR9243 SR9243, an LXR inverse agonist, can induce LXR-corepressor interaction; shows anticancer activity and selectively targets the lipogenesis and Warburg effect.
T3970 XL-652 BMS-779788 is an LXRα/β partial agonist (IC50: 68/14 nM).
T6310 GW3965 HCl GW3965 HCl is an effective and specific LXR agonist for hLXRα/β (EC50: 190/30 nM).
T6690 T0901317 T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
T5178 AZ876 AZ876 is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively.
T5128 RGX-104 HCl RGX-104 is a liver X receptor (LXR) agonist with potential immunomodulating and antineoplastic activities. It modulates innate immunity via transcriptional acti...
T5743 Gymnemagenin Gymnemagenin is a potent and selective antagonist for the β isoform of LXR, it has antihyperglycemic activity.
T7768 RGX-104 free Acid RGX-104 free Acid is an agonist of potent liver-X nuclear hormone receptor (LXR) 
TQ0274 25(R)-27-hydroxy Cholesterol 27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
TN1055 Licochalcone E Licochalcone E is a potential LXRβ agonist.
TN1719 Gymnestrogenin Gymnestrogenin has a dual LXRα±/α² antagonistic profile.
T14679 XL041 XL041 (BMS-852927) is an agonist of LXRβ-selective.
T15427 GSK2033 GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRα or LXRβ, respectively).
T16282 Nemorexant Nemorexant is an effective orexin receptor antagonist. It also has IC50s of 2 nM and 3 nM for the Ox1 receptor and Ox2 receptor, respectively.
T16792 Rovazolac Rovazolac is a liver x receptor modulator.
T16930 SR9238 SR9238 is a synthetic agonist of liver X receptor inverse (IC50s: 214 nM and 43 nM for LXRα and LXRβ, respectively).
TN4016 Ethyl 2,4,6-trihydroxybenzoate Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing ...
LXR623
T1783CAS 875787-07-8
WAY-252623 (LXR-623) is an orally bioavailable and highly specifical synthetic modulator of LXR.
SR9243
T1801CAS 1613028-81-1
SR9243, an LXR inverse agonist, can induce LXR-corepressor interaction; shows anticancer activity and selectively targets the lipogenesis and Warburg effect.
XL-652
T3970CAS 918348-67-1
BMS-779788 is an LXRα/β partial agonist (IC50: 68/14 nM).
GW3965 HCl
T6310CAS 405911-17-3
GW3965 HCl is an effective and specific LXR agonist for hLXRα/β (EC50: 190/30 nM).
T0901317
T6690CAS 293754-55-9
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
AZ876
T5178CAS 898800-26-5
AZ876 is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively.
RGX-104 HCl
T5128CAS 610318-03-1
RGX-104 is a liver X receptor (LXR) agonist with potential immunomodulating and antineoplastic activities. It modulates innate immunity via transcriptional acti...
Gymnemagenin
T5743CAS 22467-07-8
Gymnemagenin is a potent and selective antagonist for the β isoform of LXR, it has antihyperglycemic activity.
RGX-104 free Acid
T7768CAS 610318-54-2
RGX-104 free Acid is an agonist of potent liver-X nuclear hormone receptor (LXR) 
25(R)-27-hydroxy Cholesterol
TQ0274CAS 20380-11-4
27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
Licochalcone E
TN1055CAS 864232-34-8
Licochalcone E is a potential LXRβ agonist.
Gymnestrogenin
TN1719CAS 19942-02-0
Gymnestrogenin has a dual LXRα±/α² antagonistic profile.
XL041
T14679CAS 1256918-39-4
XL041 (BMS-852927) is an agonist of LXRβ-selective.
GSK2033
T15427CAS 1221277-90-2
GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRα or LXRβ, respectively).
Nemorexant
T16282CAS 1505484-82-1
Nemorexant is an effective orexin receptor antagonist. It also has IC50s of 2 nM and 3 nM for the Ox1 receptor and Ox2 receptor, respectively.
Rovazolac
T16792CAS 1454288-88-0
Rovazolac is a liver x receptor modulator.
SR9238
T16930CAS 1416153-62-2
SR9238 is a synthetic agonist of liver X receptor inverse (IC50s: 214 nM and 43 nM for LXRα and LXRβ, respectively).
Ethyl 2,4,6-trihydroxybenzoate
TN4016CAS 90536-74-6
Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing ...