T14679 |
XL041 |
XL041 (BMS-852927) is an agonist of LXRβ-selective. |
T15427 |
GSK2033 |
GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRα or LXRβ, respectively). |
T16282 |
Nemorexant |
Nemorexant is an effective orexin receptor antagonist. It also has IC50s of 2 nM and 3 nM for the Ox1 receptor and Ox2 receptor, respectively. |
T16792 |
Rovazolac |
Rovazolac is a liver x receptor modulator. |
T16930 |
SR9238 |
SR9238 is a synthetic agonist of liver X receptor inverse (IC50s: 214 nM and 43 nM for LXRα and LXRβ, respectively). |
T1783 |
LXR623 |
WAY-252623 (LXR-623) is an orally bioavailable and highly specifical synthetic modulator of LXR. |
T1801 |
SR9243 |
SR9243, an LXR inverse agonist, can induce LXR-corepressor interaction; shows anticancer activity and selectively targets the lipogenesis and Warburg effect. |
T2810 |
(20S)-Protopanaxatriol |
(20S)-Protopanaxatriol(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor. |
T3970 |
XL652 |
BMS-779788 is an LXRα/β partial agonist (IC50: 68/14 nM). |
T5128 |
RGX-104 HCl |
RGX-104 is a liver X receptor (LXR) agonist with potential immunomodulating and antineoplastic activities. It modulates innate immunity via transcriptional acti...
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T5178 |
AZ876 |
AZ876 is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively. |
T5743 |
Gymnemagenin |
Gymnemagenin is a potent and selective antagonist for the β isoform of LXR, it has antihyperglycemic activity. |
T6310 |
GW3965 HCl |
GW3965 HCl is an effective and specific LXR agonist for hLXRα/β (EC50: 190/30 nM). |
T6690 |
T0901317 |
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB). |
T7768 |
RGX-104 free Acid |
RGX-104 free Acid is an agonist of potent liver-X nuclear hormone receptor (LXR) |
TN1055 |
Licochalcone E |
Licochalcone E is a potential LXRβ agonist. |
TN1719 |
Gymnestrogenin |
Gymnestrogenin has a dual LXRα±/α² antagonistic profile. |
TN4016 |
Ethyl 2,4,6-trihydroxybenzoate |
Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing ...
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TQ0274 |
25(R)-27-hydroxy Cholesterol |
27-Hydroxycholesterol is a selective modulator of estrogen receptor and an agonist of the liver X receptor. |