MAPK

A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase). MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. They regulate cell functions including proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis.

Cat. No.	Product name	CAS No.	Purity
TN4300	Isojacareubin	50597-93-8	98%
TN4300	Isojacareubin displays potent activity against H. pylori HP40 clinical isolate with MIC 23.9 uM, which is approximately two times greater than that of the standa...
TN4956	Scandoside	18842-99-4	98%
TN4956	Scandoside exerts anti-inflammatory effect via suppressing NF-ÎºB and MAPK signaling pathways in LPS-induced RAW 264.7 macrophages.It also inhibits LDL-oxidation...
TN3144	6,4'-Dihydroxy-7-methoxyflavanone	189689-32-5	98%
TN3144	6,4'-Dihydroxy-7-methoxyflavanone is a biologically active compound isolated from the heartwood of Dalbergia odorifera T. Chen (Leguminosae) with antioxidant, an...
TN4194	Heliangin	13323-48-3	98%
TN4194	Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-ÎºB pathway on LPS-induced RAW 264.7 cells...
T14055	5Z-7-Oxozeaenol	253863-19-3	98%
T14055	5Z-7-Oxozeaenol (FR148083) is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK...
TN4315	Isonardosinone	27062-01-7	98%
TN4315	Isonardosinone shows potential role in the treatment of neuroinflammation conditions, it inhibits NF-ÎºB- and MAPK-mediated inflammatory pathways.
TL0017	Aristolactam AIIIa	97399-91-2	98%
TL0017	Aristolactam AIIIa is a new type of Plk1 inhibitors, targeting the Polo Box domain (PBD), it has anti-tumor activity. Aristolactam IIIa shows inhibition of plate...
TN4785	Picrasidine I	100234-59-1	98%
TN4785	Picrasidine I has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-ÎºB and ROS generation followed by suppressing the gene ...
TN4107	Ganoderic acid X	86377-53-9	98%
TN4107	Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
T11960	MBM-55	2083622-09-5	99.98%
T11960	MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing...
T60011	HS220	1570374-32-1	99.98%
T60011	HS220 is an inhibitor of TAK1 which plays a key role in the signaling pathways of inflammation and cell survival.
T8152	6-Demethoxytangeretin	6601-66-7	99.89%
T8152	6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa.
T39321	CC-99677	1887069-10-4	99.87%
T39321	CC-99677 (Gamcemetinib) is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular pot...
T3603	Sodium lauryl sulfoacetate	1847-58-1	99.83%
T3603	Sodium lauryl sulfoacetate (Sodium houttuyfonate) is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.
TN1441	Beta-Tocopherol	148-03-8	99.81%
TN1441	Beta-Tocopherol shows effect on human erythroleukemia cell (HEL) adhesion induced by phorbol 12-myristate 13-acetate (PMA).
T67942	Antimicrobial agent-21	724746-07-0	99.72%
T67942	Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment of c...
T13099	TC ASK 10	1005775-56-3	99.71%
T13099	TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1)(IC50 of 14 nM).
T38796L	MBP MAPK Substrate acetate		99.71%
T38796L	MBP MAPK Substrate acetate can be used as an exogenous substrate for MAPK.
T14988	CMPD1	41179-33-3	99.67%
T14988	CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).
T4442	MK2-IN-1 hydrochloride	1314118-94-9	99.67%
T4442	MK2-IN-1 hydrochloride (MK 25) is a highly selective, non-ATP competitive inhibitor of p38/mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2 ...