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DNA Damage/DNA Repair MTH1

MTH1

2-hydroxy-dATP diphosphatase , also known as oxidized purine nucleoside triphosphatase, or (2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase, or Nudix hydrolase 1 (NUDT1), or MutT homolog 1 (MTH1), or 7,8-dihydro-8-oxoguanine triphosphatase) is an enzyme that in humans is encoded by the NUDT1 gene. During DNA repair, the enzyme hydrolyses oxidized purines and prevents their addition onto the DNA chain. As such it has important role in aging and cancer development.
Cat No. product name
T2037 TH588 TH588 is nudix hydrolase family inhibitor that effectively and selectively engages and inhibits the MTH1(IC50: 5 nM) in cells.
T2069 TH287 hydrochloride TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.
T6357 (S)-crizotinib (S)-crizotinib(IC50 of 72 nM),an effective MTH1 (NUDT1) inhibitor, is the (S)-enantiomer of crizotinib.
T12122 MTH1-IN-2 MTH1-IN-2 is an inhibitor of MutT homolog 1 (MTH1), with anti-tumor activity.
TH588
T2037CAS 1609960-31-7
TH588 is nudix hydrolase family inhibitor that effectively and selectively engages and inhibits the MTH1(IC50: 5 nM) in cells.
TH287 hydrochloride
T2069CAS 1609960-30-6
TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.
(S)-crizotinib
T6357CAS 1374356-45-2
(S)-crizotinib(IC50 of 72 nM),an effective MTH1 (NUDT1) inhibitor, is the (S)-enantiomer of crizotinib.
MTH1-IN-2
T12122CAS 901044-91-5
MTH1-IN-2 is an inhibitor of MutT homolog 1 (MTH1), with anti-tumor activity.